Clinical trials: Trauma and Stress-related Disorders
Stress Disorders, Post-Traumatic
The Effect of EFT on Psychological States in a Veterans Population
A need exists to find fast yet effective treatment protocols for the large number of US military service personnel coming back from Iraq with post traumatic stress disorder (PTSD), and a variety of co-occurring psychological…
- Trial name
- NCT00743041
- Testing
- Emotional Freedom Techniques (EFT)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Soul Medicine Institute
Pain, Stress Disorders, Post-Traumatic
Evaluating an eHealth Solution for Screening in Pediatric Care
This study will evaluate the predictive validity of a game-based screening system based on child self-report measures. The core study hypotheses are that (1) in-game assessments will predict problematic recovery (child pain and…
- Trial name
- NCT04506294
- Testing
- eScreen system
- Where
- 2 sites in United States
- Volunteers
- 320 people
- Sponsor
- Children's Hospital of Philadelphia
PTSD, Addiction
N-acetylcysteine in the Treatment of PTSD and Addiction
Examine the effects of N-acetylcysteine on PTSD symptoms, craving and substance use in veterans with PTSD and comorbid substance use disorders.
- Trial name
- NAC (NCT02499029)
- Testing
- N-acetylcysteine
- Volunteers
- 35 people
- Sponsor
- Medical University of South Carolina
Stress Disorder, Posttraumatic, Stress, Psychological
Neurological and Psychological Effects of Combat-Related Stress
The purpose of this study is to determine what is the neurological and cognitive impact of combat exposure and prolonged stress, in the form of service in the Israeli Defense Forces.
- Trial name
- NCT04651192
- Testing
- Combat Exposure
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel Aviv University
Posttraumatic Stress Disorder
Efficacy Trial of Stress Check-Up
Untreated posttraumatic stress disorder (PTSD) is associated with high societal and individual costs. Effective interventions for symptoms of posttraumatic stress (PTS) exist but are underutilized by those who could benefit…
- Trial name
- NCT03423394
- Testing
- Motivational Enhancement Therapy, Treatment as Usual
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- University of Washington
Post Traumatic Stress Disorder (PTSD), Addiction
Clinical Trial for Alcohol Use Disorder and Post Traumatic Stress Disorder (PTSD)
This is a randomized controlled Phase II clinical trial designed to evaluate the effects of N-acetylcysteine (NAC) in reducing Alcohol Use Disorder (AUD) severity and Post Traumatic Stress Disorder (PTSD) symptomatology among…
- Conditions
- Post Traumatic Stress Disorder (PTSD), Addiction, Alcohol Abuse
- Trial name
- NCT02966873
- Testing
- N-Acetylcysteine (NAC) Treatment, Cognitive Behavioral Therapy (CBT), Functional magnetic resonance imaging (fMRI)
- Where
- 2 sites in United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Post-Traumatic Stress Disorder
Role of Substance P in Post-Traumatic Stress Disorder
This study will examine the role of substance P, a chemical messenger in the brain, in post-traumatic stress disorder (PTSD), a chronic anxiety disorder.
- Trial name
- NCT00102102
- Testing
- [18F]SPA-RQ
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
PTSD
12-Week Open-Label Extension Study of TNX-102 SL in PTSD Patients
This is an open-label, extension trial designed to evaluate safety over 12 additional weeks of TNX-102 SL therapy taken daily at bedtime for the treatment of PTSD.
- Trial name
- NCT03110575
- Testing
- TNX-102 SL
- Where
- 32 sites in United States
- Volunteers
- 190 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Depression, Anxiety, PTSD
A Scalable Model for Promoting Functioning and Well-Being Among Veterans With a History of Mental Health Challenges Via Meaningful Social Interactions: Project V-SPEAK!
The goal of this study is to refine and test a strategy for engaging veterans with symptoms of depression and/or anxiety as volunteers to help English language learners (ELLs) improve their speaking skills via structured…
- Trial name
- V-SPEAK! (NCT05506839)
- Testing
- Intervention (videoconferencing)
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Post-Traumatic Stress Disorder, PTSD, Alcohol Use Disorder (AUD)
Imaging Phosphodiesterase 4B (PDE4B) in People With Psychiatric Disorders With Positron Emission Tomography (PET) and the Radiotracer [18F]PF974
Imaging PDE4B in people with psychiatric disorders with PET and the radiotracer [18F]PF974
- Trial name
- NCT07488819
- Testing
- PF974
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Yale University
Chronic Pain, PTSD
Internet-Delivered Acceptance and Commitment Therapy (iACT) for Youth With PTSD and Chronic Pain
The primary aim of this study is to investigate the effect of Internet-delivered Acceptance and commitment therapy for youth with PTSD and comorbid chronic pain.
- Trial name
- NCT07813728
- Testing
- iACT
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Skane University Hospital
Trauma and Stressor Related Disorders
A Trauma-Informed Intervention for Positive Youth Development and Teacher Wellness in Rural Montana Year 2
Compared to U.S. urban counterparts, rural residents face major barriers to using health care services. Challenges include shortages of services, long distances to existing services, and stigma regarding mental illness in…
- Trial name
- NCT05844007
- Testing
- Trauma-Informed Yoga
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Montana State University
Post-Traumatic Stress Disorder, PTSD
Software as a Medical Device for the Treatment of Patients With PTSD
To evaluate the efficacy and safety of Software as a Medical Device in patients with Post-Traumatic Stress Disorder (PTSD)
- Trial name
- NCT06589505
- Testing
- Software as a Medical Device
- Where
- 35 sites in Japan
- Volunteers
- 52 people
- Sponsor
- Otsuka Medical Devices Co., Ltd. Japan
Stress Disorders, Post-Traumatic, Depression
A School Program for Children Exposed to Violence
This study will develop a program to help school children deal with violence-related trauma.
- Trial name
- NCT00260195
- Testing
- School-based cognitive behavioral support group
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- RAND
PTSD
Biomarker Establishment for Superior Treatment of PTSD
The purpose of Biomarker Establishment for Superior Treatment of PTSD is to accelerate research on the discovery of biological, neurological and neuroimaging markers for Post- Traumatic Stress Disorder (PTSD).
- Trial name
- NCT03343028
- Testing
- Psychotherapy
- Where
- 2 sites in United States
- Volunteers
- 292 people
- Sponsor
- Stanford University
PTSD
Implementation of Truma-Focused Cognitive Behavioral Therapy (TF-CBT) in Norway
Trauma-focused cognitive behavioral therapy (TF-CBT) is an evidence-based treatment method for children and adolescents who have been exposed to traumatic experiences and who are experiencing posttraumatic stress symptoms.
- Trial name
- TF-CBT (NCT05248971)
- Testing
- Trauma-focused cognitive behavioral therapy (TF-CBT)
- Volunteers
- 26,500 people
- Sponsor
- Norwegian Center for Violence and Traumatic Stress Studies
Posttraumatic Stress Disorder, Substance Abuse
Cognitive Behavioral Treatment of Posttraumatic Stress Disorder Enhanced by Virtual Reality for Individuals With PTSD and Substance Abuse
This study is exploring the use of an intervention designed to treat PTSD in individuals with comorbid PTSD and substance abuse resulting from the attacks of September 11 or from military service in Iraq.
- Trial name
- NCT00656344
- Testing
- Cognitive behavioral treatment enhanced by virtual reality
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Weill Medical College of Cornell University
Post Traumatic Stress Disorder
Use of CBD Oil in the Treatment of Posttraumatic Stress Disorder
The overarching objective of the proposed project is to test the clinical efficacy of CBD in the treatment of post-traumatic stress disorder using a rigorous double-blind randomized clinical trial methodology.
- Trial name
- NCT04197102
- Testing
- CBD Isolate, CBD Broad Spectrum
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Texas at Austin
Post Traumatic Stress Disorder (PTSD)
A Randomized, Placebo-Controlled Trial of Stellate Ganglion Block in the Treatment of Post Traumatic Stress Disorder
Post Traumatic Stress Disorder (PTSD), is a devastating condition which causes distress or impairment in social, occupational or other important aspects of functioning. The occurrence of PTSD in the military is on the rise.
- Trial name
- NCT01629537
- Testing
- Stellate Ganglion Block injection with ropivicane
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- United States Naval Medical Center, San Diego
Critical Illness
Reducing Post-traumatic Stress Disorder After ICU Discharge With the IPREA3 Program
Reducing discomfort in the intensive care unit (ICU) should be beneficial to longterm outcomes. This study assesses whether a tailored multicomponent program for discomfort reduction may be effective in reducing post-traumatic…
- Trial name
- PTSD-REA (NCT03991611)
- Testing
- Administration of the IPREA3 questionnaire, Immediate feedback through electronic reminder messages, Targeted interventions in each ICU to reduce discomforts
- Where
- 33 sites in France
- Volunteers
- 3,312 people
- Sponsor
- Centre Hospitalier of Chartres
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