Clinical trials: Trauma and Stress-related Disorders
Post Traumatic Stress Disorder
Trauma Treatment in Norwegian Child Advocacy Centers
Norwegian child and advocacy centers´ core activities include both forensic services (e.g., forensic interviews) and follow-up services (e.g., treatment), aiming to coordinate the different services involved in each case to…
- Trial name
- NCT05314829
- Testing
- Trauma-focused cognitive behavioral therapy (TF-CBT)
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Norwegian Center for Violence and Traumatic Stress Studies
Depression, Anxiety
Adaptive Coping Skills Training to Improve Psychological Distress Among Cardiorespiratory Failure Survivors
Conditions treated in intensive care units (ICUs) such as the acute respiratory distress syndrome (ARDS), congestive heart failure, COVID pneumonia, and sepsis are common.
- Conditions
- Depression, Anxiety, Post-traumatic Stress Disorder, Stress
- Trial name
- Blueprint 2 (NCT06538246)
- Testing
- Blueprint, Education program
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Duke University
Influenza, Pneumonia, Viral
Long-term Outcome and Lung Capacity in Survivors of ARDS Due to Influenza A (H1N1) v2009 The RESPIFLU Study
Influenza A (H1N1) v2009 infection was responsible throughout the world of viral pneumonia and severe pulmonary edema requiring rescue therapeutics such as extracorporeal oxygenation.
- Conditions
- Influenza, Pneumonia, Viral, Pulmonary Fibrosis, Quality of Life
- Trial name
- RESPIFLU (NCT01271842)
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
PTSD and Trauma-related Symptoms
LIFU Mechanisms for PTSD in Healthcare Workers
The goal of this clinical trial is to evaluate whether low-intensity focused ultrasound (LIFU) of the ventral anterior cingulate cortex (vACC) can normalize dysfunctional brain activation patterns and behaviors in frontline…
- Trial name
- NCT07164105
- Testing
- Low intensity focused ultrasound
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Laureate Institute for Brain Research, Inc.
Posttraumatic Stress Disorder
Teaching Loved Ones to Help Veterans Optimize Their PTSD Care and Healing
PTSD occurs in as many as 17% of US military Veterans and is associated with a host of negative, long-term consequences to the individual, their families, and society at large.
- Trial name
- NCT04241094
- Testing
- Loved one assisted treatment
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- VA Office of Research and Development
PTSD (Childbirth-Related), Psychological Wellbeing
Feasibility and Efficacy of GTEP for Birth Trauma
This clinical study aims to evaluate the feasibility and initial efficacy of Group Traumatic Episode Protocol (GTEP) for reducing trauma symptoms (measured by the PCL-5 and City BiTS) for individuals following a traumatic…
- Conditions
- PTSD (Childbirth-Related), Psychological Wellbeing, Bonding
- Trial name
- NCT07246356
- Testing
- Group Traumatic Episode Protocol (GTEP)
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Birmingham
Pregnancy Early, PTSD
PTSD Screening in Pregnant Black Women
This study will compare the effectiveness of two active screening interventions in improving post-traumatic stress disorder (PTSD) symptoms, maternal perinatal care utilization, satisfaction utilization of mental healthcare…
- Trial name
- NCT06522022
- Testing
- Culturally Responsive SBIRT for OB, Brief Screening for PTSD
- Where
- 2 sites in United States
- Volunteers
- 804 people, healthy volunteers welcome
- Sponsor
- Emory University
Gunshot Entry Wound
Predictors of Treatment Failure Among Patients With Gunshot Wounds and Post-traumatic Stress Disorder
The 82.1% treatment failure of post-traumatic stress disorder(PTSD), associated with gunshot wounds, is related to high incidence of chronic pain syndrome as well as resistance to the PTSD treatment.
- Trial name
- NCT04689022
- Testing
- Mississippi Scale for Combat-Related PTSD (M-PTSD), visual analogue scale (VAS), Douleur Neuropathique 4 questions (DN4)
- Volunteers
- 218 people
- Sponsor
- Vasyl' Horoshko
Post Traumatic Stress Disorder, Intensive Care Psychiatric Disorder
Early EMDR Following Covid-19 Critical Illness: A Feasibility Trial
Primary objective is to evaluate the feasibility of delivering an online early Eye Movement Desensitisation Reprocessing (EMDR) Recent Traumatic Events Protocol (R-TEP) to patients who have survived Covid-19 related critical…
- Conditions
- Post Traumatic Stress Disorder, Intensive Care Psychiatric Disorder, Anxiety Disorders, Depression
- Trial name
- Cov-EMERALD (NCT04455360)
- Testing
- Eye Movement Desensitisation and Reprocessing Recent traumatic Event Protocol
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Posttraumatic Stress Disorder
Evaluating Safety and Efficacy of Cannabis in Participants With Chronic Posttraumatic Stress Disorder
The purpose of this study is to evaluate the safety and efficacy of vaporized cannabis in participants with chronic, treatment-resistant posttraumatic stress disorder.
- Trial name
- NCT02517424
- Testing
- High THC/Low CBD Cannabis, High THC/High CBD Cannabis, Low THC/Low CBD Cannabis
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Tilray
Post Traumatic Stress Disorder
Efficacy of Internet-delivered Cognitive-behavior Therapy for PTSD
The goal of this clinical trial is to compare therapist-guided internet delivered prolonged exposure to an active control condition( therapist-guided internet delivered cognitive behavioral therapy containing relaxation…
- Trial name
- NCT05934162
- Testing
- Therapist-supported internet-delivered prolonged exposure, Therapist-supported internet-delivered CBT
- Where
- Sweden
- Volunteers
- 286 people
- Sponsor
- Karolinska Institutet
Posttraumatic Stress Disorder
Effects of Delta9-tetrahydrocannabinol (THC) on Retention of Memory for Fear Extinction Learning in PTSD: R33 Study
The goal of this study is to look at how a type of drug called cannabinoids are related to the processing of fear signals, the experience of emotions and fear, and the pattern of activity in the brain that is involved in these…
- Trial name
- NCT04080427
- Testing
- Dronabinol 7.5 milligram oral capsule
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Wayne State University
Stress Disorders, Post-Traumatic
Meditation Interventions for Treatment of PTSD in Veterans
Posttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder which results in serious impairments in interpersonal, occupational and social functioning.
- Trial name
- VMP (NCT01548742)
- Testing
- Mindfulness-Based Stress Reduction (MBSR), Present-Centered Group Therapy (PCGT)
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- VA Office of Research and Development
Post Traumatic Stress Disorder, PTSD
Psilocybin-Assisted Therapy for Sexual Assault-Related PTSD
A Phase 2, Open-Label Study to explore the efficacy, safety, and tolerability of psilocybin-assisted therapy in women with sexual assault-related Posttraumatic Stress Disorder (PTSD).
- Trial name
- SUN004 (NCT06902974)
- Testing
- Psilocybin 25 mg
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Sunstone Medical
Childbirth Problems, Post Traumatic Stress Disorder
Eye Movement Desensitization and Reprocessing vs Supportive Expressive Dynamic Psychotherapy for Childbirth Trauma
There is increasing evidence that about 30% of women evaluate their childbirth as traumatic and that women could develop post-traumatic stress disorder (PTSD) in response to events of birth.
- Trial name
- NCT03972410
- Testing
- EMDR, SEDP
- Where
- 3 sites in Italy
- Volunteers
- 60 people
- Sponsor
- University of Turin, Italy
Cardiac Arrest, Cognitive Function
Brain Function After Cardiac Arrest (Measured With FMRI and Cognitive Tests)
The aim of this longitudinal study is to determine whether brain function is affected after a cardiac arrest. The primary question is whether cognitive function is affected after cardiac arrest and whether it changes over time…
- Trial name
- BRAINnHEART (NCT03579498)
- Where
- 2 sites in Norway, Sweden
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Major Depressive Disorder (MDD), Anxiety Disorders
Retrospective Observational Study of Intensity Effects in Psychedelic-assisted Treatment
This retrospective observational study examines the effects of psychedelic-assisted psychotherapy (PAP) with lysergic acid diethylamide (LSD) or psilocybin in patients with treatment-resistant depressive, anxiety, or addictive…
- Conditions
- Major Depressive Disorder (MDD), Anxiety Disorders, Substance Use Disorder (SUD), PTSD - Post Traumatic Stress Disorder
- Trial name
- NCT07164287
- Testing
- Lysergic Acid Diethylamide (LSD) or psilocybin
- Where
- Switzerland
- Volunteers
- 376 people
- Sponsor
- University Hospital, Geneva
PTSD
Evaluation of Effectiveness of a Group Yoga Intervention as Trauma Therapy for Adolescent Girls
Neuroscience evidence indicates that trauma is stored in the body, that trauma impairs the language centers found in the brain, and that emotion centers in the brain tend to override cognitive centers in the brain following…
- Trial name
- NCT02373358
- Testing
- Group yoga intervention
- Where
- 2 sites in United States, Canada
- Volunteers
- 34 people
- Sponsor
- Hamilton Health Sciences Corporation
Post Trauma Nightmares, Traumatic Stress
Exposure, Relaxation, & Rescripting Therapy-Child
The study implements a trauma-related nightmare treatment for children aged 8 to 13 years. Relevant outcome progress and outcome measures on symptoms, nightmare distress and duration, academic indicators, and sleep quality will…
- Trial name
- ERRT-C (NCT02184026)
- Testing
- Exposure, Relaxation, & Rescripting Therapy-Child
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Montana
Borderline Personality Disorder (BPD), Complex Post-Traumatic Stress Disorder (CPTSD)
Implementing a Therapy for Complex Trauma in French-Speaking Settings
Many individuals living with borderline personality disorder (BPD) have experienced childhood trauma, such as abuse or neglect. A significant number of them also meet the criteria for post-traumatic stress disorder (PTSD).
- Conditions
- Borderline Personality Disorder (BPD), Complex Post-Traumatic Stress Disorder (CPTSD), Post-Traumatic Stress Disorder, PTSD
- Trial name
- TRAUL (NCT07123974)
- Testing
- Dialectical Behaviour Therapy for Post-Traumatic Stress Disorder (DBT-PTSD)
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
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