Clinical trials: Trauma and Stress-related Disorders
Posttraumatic Stress Disorder (PTSD), Borderline Personality Disorder (BPD)
Effectiveness of PTSD-treatment Compared to Integrated PTSD-PD-treatment in Adult Patients With Comorbid PTSD and BPD
The goal of PROSPER-B is to study effectiveness of EMDR compared to integrated DBT-EMDR in treatment-seeking, adult patients with comorbid PTSD and Borderline Personality Disorder (BPD).
- Trial name
- PROSPER-B (NCT03833453)
- Testing
- EMDR, DBT
- Where
- Netherlands
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Arkin
Heat Stroke
The Relationship Between Normal Saline Infusion and Acute Kidney Injury in Heat Stroke
The goal of this clinical trial is to compare the effect of high chlorine solution such as normal saline and non-high chlorine solution such as sodium lactate ringer's solution on renal function in patients with heat stroke.
- Trial name
- NCT05921695
- Testing
- Normal Saline infusion and Ringer lactate infusion
- Where
- 7 sites in China
- Volunteers
- 104 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Convulsion, Non-Epileptic, Conversion Disorder
Treatment Trial for Psychogenic Nonepileptic Seizures
The investigators propose that patients who receive targeted pharmacotherapy (sertraline) or focused psychotherapy (cognitive behavioral therapy-informed psychotherapy (CBT-ip) for NES) or combined treatment (CBT-ip + sertraline)…
- Conditions
- Convulsion, Non-Epileptic, Conversion Disorder, Depression, Stress Disorders, Post-Traumatic
- Trial name
- NEST-T_1 (NCT00835627)
- Testing
- sertraline, CBT-ip, Combined (sertraline + CBT-ip)
- Where
- 3 sites in United States
- Volunteers
- 38 people
- Sponsor
- Rhode Island Hospital
Stress Disorders, Post-Traumatic
Examine the Preliminary Effect of an Evidence-Based Practice (EBP) Consultation Model on Staff Fidelity to EBP
Youth involved in the juvenile justice system report high rates of exposure to traumatic events (>90%) and posttraumatic stress disorder (PTSD; 20-50%).
- Trial name
- NCT03722745
- Testing
- TARGET, TAU
- Sponsor
- NYU Langone Health
Chronic Pain, PTSD - Post Traumatic Stress Disorder
Virtual Reality and Cranial Nerve Non-invasive Neuromodulation to Improve Quality of Life for Veterans
Veterans in Canada are twice as likely as the general population to experience chronic pain. This pain is often linked to post-traumatic stress disorder (PTSD), and both have a major impact on their quality of life.
- Conditions
- Chronic Pain, PTSD - Post Traumatic Stress Disorder, Quality of Life (QOL)
- Trial name
- VR & CN-NINM (NCT07137845)
- Testing
- Virtual reality, Cranial nerve non-invasive neuromodulation (CN-NINM)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Université de Sherbrooke
PTSD, Substance Use Disorders
COPEWeb Training for Providers
Post-traumatic stress disorder (PTSD) and substance use disorders (SUD) are two of the most common and debilitating mental health conditions afflicting military Veterans.
- Trial name
- COPEWeb (NCT05812131)
- Testing
- COPEWeb online training, COPE In Person
- Where
- United States
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Stress Disorders, Post-Traumatic, Helping Behavior
Clinical Trial of a Supporter-Targeted Intervention to Improve Outcomes in Recent Sexual Assault Survivors
Communication and Recovery Enhancement (CARE) is a 2-session early intervention for survivors of recent sexual assault and their supporters that aims to improve supporters' ability to respond effectively.
- Conditions
- Stress Disorders, Post-Traumatic, Helping Behavior, Help-Seeking Behavior, Stress
- Trial name
- CARE (NCT05345405)
- Testing
- Dyadic CARE, Supporter-Only CARE
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- University of Washington
Posttraumatic Headache, Posttraumatic Stress Disorder
Ketamine, SGB and Combination Treatment for TBI-associated Headache or PTSD
Post-Traumatic Stress Disorder (PTSD) and traumatic brain injury (TBI) with associated headache are amongst the most common injuries sustained by our deployed forces in Iraq and Afghanistan, as well as in more recent conflicts in…
- Trial name
- NCT06608277
- Testing
- Group A active comparator, Group B active comparator, Group C Experimental
- Where
- 3 sites in United States
- Volunteers
- 175 people
- Sponsor
- Northwestern University
PTSD
Exposure by Assessment: Effects of Daily AMQ-Based EMA of an Intrusive Trauma Memory in PTSD
Intrusive re-experiencing is a hallmark of PTSD. The study applies ecological momentary assessment (EMA) of participants' trauma memories (active group) vs.
- Trial name
- NCT07658157
- Testing
- AMQ-based ecological momentary assessment of an intrusive memory, AMQ-based ecological momentary assessment of an emotionally neutral memory
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Tel Aviv University
Posttraumatic Stress Disorder
Imaging Outcomes of Cognitive Behavioral Therapy (CBT) for Battered Women With Posttraumatic Stress Disorder
Identifying neural mechanisms of posttraumatic stress disorder (PTSD) treatment could help elucidate reasons for variable treatment response and identify novel treatment targets.
- Trial name
- NCT01517672
- Testing
- Cognitive Trauma Therapy for Battered Women (CTT-BW)
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Mild to Moderate TBI, Posttraumatic Stress Disorder
TTI-0102 for Veterans With TBI
Traumatic brain injury (TBI) is a signature wound of the recent wars. How chronic TBI symptoms develop after a mild brain injury is not fully understood, but it is now thought that injury results in damage that reduces brain…
- Trial name
- NCT04262895
- Testing
- TTI-0102
- Where
- United States
- Sponsor
- VA Office of Research and Development
Stress, Depression
Mission Reconnect: Promoting Resilience and Reintegration of Post-Deployment Veterans and Their Families
An urgent and growing need exists for interventions that support the long-term adjustment and mental health needs of OIF/OEF veterans and their relationship partners after the return from deployment.
- Conditions
- Stress, Depression, PTSD, Sleep
- Trial name
- NCT01680419
- Testing
- Mission Reconnect, PREP
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Collinge and Associates, Inc.
Post Traumatic Stress Disorder, Depression
Brief Peer Supported webSTAIR Compared to Enhanced Wait List
This study will enroll 180 Veterans at a 2:1 ratio where 120 Veterans will be enrolled into a brief transdiagnostic peer supported webSTAIR (BPS webSTAIR) and 60 will be supported into Waitlist.
- Conditions
- Post Traumatic Stress Disorder, Depression, Emotion Regulation
- Trial name
- BPSwS (NCT04286165)
- Testing
- Brief Peer Supported webSTAIR
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- Palo Alto Veterans Institute for Research
Posttraumatic Stress Disorder, Insomnia Disorder
Brief Behavioral Treatment for Insomnia in Veterans With Posttraumatic Stress Disorder
This study will investigate treatments for insomnia in Veterans who have posttraumatic stress disorder (PTSD). The purpose of this study is to compare a brief behavioral treatment for insomnia (BBTI) to a treatment that helps…
- Trial name
- BBTI & PTSD (NCT05780177)
- Testing
- Brief Behavioral Treatment for Insomnia (BBTI), Progressive Muscle Relaxation Training (PMRT)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Post Traumatic Stress Disorder
Silexan in the Treatment Of Posttraumatic Stress Disorder Trial
Posttraumatic stress disorder (PTSD) is a common and debilitating mental illness. Current treatments for PTSD include psychotherapy and antidepressant medications.
- Trial name
- STOP (NCT06412757)
- Testing
- Silexan
- Where
- 4 sites in Australia
- Volunteers
- 278 people
- Sponsor
- Deakin University
Post-Traumatic Stress Disorder
Implementation of an Evidence Based Post-Traumatic Stress Disorder (PTSD) Treatment in Public Sector Settings
Researchers hope to learn whether a flexibly applied cognitive behavioral treatment for Post-Traumatic Stress Disorder (PTSD) is more effective than the psychotherapy usually provided in the clinic (called Treatment as Usual or…
- Trial name
- NCT01488539
- Testing
- STAIR/NT treatment, Treatment as Usual (TAU)
- Where
- 5 sites in United States
- Volunteers
- 210 people
- Sponsor
- Palo Alto Veterans Institute for Research
Post Traumatic Stress Disorder PTSD, Suicidal Ideation
Deep TMS for PTSD With Suicidal Ideation
The goal of this clinical trial is to evaluate whether deep transcranial magnetic stimulation (DTMS) using the H1-coil can safely and effectively reduce suicidal ideation in adults diagnosed with post-traumatic stress disorder…
- Trial name
- DTMS-PTSD-SI (NCT07880340)
- Testing
- Deep Transcranial Magnetic Stimulation (DTMS)
- Where
- Israel
- Volunteers
- 72 people
- Sponsor
- D.R. Rut Zaks OHAYON
Psychiatric Disorder, Somatoform Disorders
Epigenetics of Posttraumatic Stress Disorder and Somatoform Disorders in the Course of Psychotherapy
This reported observational clinical study aims at identifying epigenetic markers in a sample of patients undergoing high dose inpatient psychotherapy suffering from a variety of psychiatric/psychosomatic diseases such as…
- Conditions
- Psychiatric Disorder, Somatoform Disorders, PTSD
- Trial name
- TREPS (NCT01391897)
- Testing
- psychotherapy
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Hannover Medical School
Diabetes, Depression
Self-Efficacy Enhancing Interviewing Techniques Study
Patient self-efficacy, or confidence in one's ability to take the necessary steps to achieve a goal, has been shown to influence a number of important health behaviors and outcomes.
- Conditions
- Diabetes, Depression, Anxiety, Asthma
- Trial name
- SEE-IT (NCT00643435)
- Testing
- Self-efficacy enhancing interviewing techniques training, Control intervention
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Depression, Posttraumatic Stress Disorder
Effectiveness of Group Focused Psychosocial Support for Adults Affected by Humanitarian Crises
This is an effectiveness study of group problem management plus, a low-intensity psychological intervention, delivered in five sessions to adults affected by humanitarian crises.
- Conditions
- Depression, Posttraumatic Stress Disorder, Psychological Distress
- Trial name
- GroupPM+ (NCT03747055)
- Testing
- Group problem management plus, Enhanced treatment as usual
- Where
- Nepal
- Volunteers
- 611 people
- Sponsor
- George Washington University
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