Clinical trials: Trauma and Stress-related Disorders
Stress Disorders, Post-Traumatic, Sleep Disorders
Randomized Clinical Trial of Imagery Rescripting Treatment In Veterans With Trauma-Related Nightmares And Posttraumatic Stress Disorder (PTSD)
Research shows that symptoms of posttraumatic stress disorder (PTSD) are particularly high in veterans, and that trauma-related nightmares and sleep disturbances are common in veterans with PTSD.
- Trial name
- NCT00837109
- Testing
- Veteran Nightmare Treatment, Treatment-as-usual
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- US Department of Veterans Affairs
Alcohol Use Disorder, Posttraumatic Stress Disorder
Advancing Couple and Family Alcohol Treatment Through Patient-Oriented Research and Mentorship
Intimate partner violence (IPV) is a serious public health problem that results in significant health and economic burdens including mortality, morbidity, and poor treatment outcomes.
- Conditions
- Alcohol Use Disorder, Posttraumatic Stress Disorder, Couples
- Trial name
- NCT05786157
- Testing
- Alcohol Administration
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Medical University of South Carolina
COVID-19, Coronavirus Infections
Functional Outcomes in COVID-19 Survivors and Use of a Digital Platform for Rehabilitation
COVID-19, an acute respiratory disease caused by coronavirus-2 (SARS-CoV-2), and in most cases, causes mild to moderate symptoms of fever, cough and dyspnea.
- Conditions
- COVID-19, Coronavirus Infections, Exercise Therapy
- Trial name
- NCT04695301
- Testing
- Rehabilitation protocol through a digital platform
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Hospital Israelita Albert Einstein
PTSD, Depression
Synchronized Transcranial Magnetic Stimulation for PTSD
The investigators propose a small, two-site, sham-controlled pilot study of synchronized Transcranial Magnetic Stimulation (sTMS) in patients with comorbid post-traumatic stress disorder (PTSD) and depression.
- Trial name
- sTMS (NCT02981381)
- Testing
- NEST-1, NEST-2
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Providence VA Medical Center
Adult ALL, Post-traumatic Stress Disorder
Effects of an EMDR Intervention on Traumatic and Obsessive Symptoms
The Eye Movement Desensitization and Reprocessing Protocol (EMDR) was first developed by Francine Shapiro in 1987 and can be adapted for online and in presence administration.
- Conditions
- Adult ALL, Post-traumatic Stress Disorder, Obsessive-Compulsive Disorder, Disgust
- Trial name
- MDL (NCT06110702)
- Testing
- EMDR
- Where
- Italy
- Volunteers
- 287 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Domestic Violence, Depression
Cortisol Evaluation in Abuse Survivors
This study looks at the biological effect of domestic violence and abuse (DVA) on women's mental health. The mechanisms through which DVA causes mental disorders are very poorly understood.
- Conditions
- Domestic Violence, Depression, Anxiety, Panic Disorder
- Trial name
- CEASE (NCT01632553)
- Where
- 2 sites in United Kingdom
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Bristol
Borderline Personality Disorder, Post-Traumatic Stress Disorders
Outcome of Crisis Intervention for Subjects With Borderline Personality Disorder or Post-Traumatic Stress Disorder
Dr. Laddis will test a hypothesis about the nature and the management of behavioral crises in patients with borderline personality disorder (BPD) or post-traumatic stress disorder (PTSD).
- Trial name
- NCT00269139
- Testing
- Crisis resolution
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Laddis, Andreas, M.D.
Adjustment Disorders, Mental Disorder
Transdiagnostic Behavior Therapy Vs TAU for Adjustment Disorder Following Traumatic Event Exposure
Adjustment Disorder (AjD) is the most common mental health condition diagnosed in Active Duty personnel, and is diagnosed following an extreme stress event such as traumatic loss of a comrade, serious accident or injury, or other…
- Trial name
- NCT06433271
- Testing
- Transdiagnostic Behavior Therapy (TBT), Treatment as Usual-Problem Solving Therapy (TAU-PST)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- The University of Texas Health Science Center, Houston
PTSD, Chronic Musculoskeletal Pain
Mission Reconnect-Veterans and Their Partners to Manage Pain and PTSD (MR)
This project is responsive to Rehabilitation Research and Development's (RR\&D) current special areas of interest for non-pharmacological activity-based interventions for chronic pain impacting pain reduction, function and…
- Trial name
- MR (NCT03593772)
- Testing
- Mission Reconnect
- Where
- 3 sites in United States
- Volunteers
- 730 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Testing the Efficacy of a Mindfulness- and Acceptance-Based Smartphone App for PTSD: A Randomized Controlled Trial
The purpose of the study is to test the feasibility and acceptability of a mindfulness- and acceptance-based smartphone app (MABSA) intervention for college student veterans with posttraumatic stress disorder (PTSD) symptoms.
- Trial name
- NCT04861311
- Testing
- Mindfulness/Acceptance-Based Smartphone App (MABSA) Intervention
- Volunteers
- 64 people
- Sponsor
- University of Nevada, Las Vegas
Menopause, Menopause Related Conditions
Hot Water Therapy for the Treatment of Menopause-related Hot Flashes
The purpose of this research is to determine whether hot water therapy (i.e. taking prolonged hot baths on multiple consecutive days) decreases hot flash symptoms and improves mood in women who are undergoing or who have…
- Conditions
- Menopause, Menopause Related Conditions, Menopause Syndrome
- Trial name
- NCT06192329
- Testing
- Hot water therapy, Warm water immersion
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Colorado, Colorado Springs
Posttraumatic Stress Disorder, Insomnia
Insomnia Treatment and Cardiometabolic Health in Older Adults With Posttraumatic Stress Disorder
This pilot pre-post trial will address a gap in knowledge related to addressing modifiable risk factors for cardiometabolic disease through treating residual insomnia, sleep difficulties that remain after successful treatment of…
- Conditions
- Posttraumatic Stress Disorder, Insomnia, Cardiovascular Diseases, Metabolic Disease
- Trial name
- NCT05516277
- Testing
- Behavioral Sleep Education Intervention
- Where
- United States
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Post Traumatic Stress Disorder
A Multi-site Expanded Access Program for MDMA-assisted Psychotherapy for Patients With Treatment-resistant PTSD
The goal of this expanded access protocol is to provide access to MDMA-assisted therapy for eligible patients with treatment-resistant PTSD who are not able to enroll in another MDMA-assisted therapy clinical trial.
- Trial name
- EAMP1 (NCT04438512)
- Testing
- Midomafetamine, Psychotherapy
- Where
- 2 sites in United States
- Sponsor
- Resilient Pharmaceuticals
Posttraumatic Stress Disorder
Telemental Health and Cognitive Processing Therapy for Female Veterans With Military-related PTSD
The immediate objective of this project is to evaluate the clinical effectiveness of a telemental health modality (video-teleconferencing) for providing an evidence-based group intervention to female rural veterans, Reservists…
- Trial name
- NCT02362477
- Testing
- Cognitive Processing Therapy in-person, Cognitive Processing Therapy through videoteleconference
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- VA Pacific Islands Health Care System
Post-traumatic Stress Disorder, Adjustment Disorders
Pivotal Trial of SAT-014 for Trauma and Stressor-Related Disorder Symptoms
The aim of this study is to evaluate the efficacy of SAt-014, a software as a medical device (SaMD), in alleviating symptoms of trauma and stressor-related disorders in patients with post-traumatic stress disorder (PTSD) or…
- Trial name
- NCT06734858
- Testing
- SAT014, Control
- Where
- 5 sites in South Korea
- Volunteers
- 110 people
- Sponsor
- S-Alpha Therapeutics, Inc.
Post-Traumatic Stress Disorder
Prolonged Exposure Therapy Versus Active Psychotherapy in Treating Post-Traumatic Stress Disorder in Adolescents
This study will compare the effectiveness of prolonged exposure therapy versus active psychotherapy in treating post-traumatic stress disorder (PTSD) in adolescents.
- Trial name
- NCT00183690
- Testing
- Prolonged Exposure Therapy, Active Psychotherapy
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- National Institute of Mental Health (NIMH)
Trauma, Psychological, Legal Education
Legal-Education Plus Trauma-informed Therapy to Improve Community Acceptance and Reintegration of Repentant Terrorists in Nigeria
Terrorism is an issue of global concern, and reintegrating repentant terrorists, including their families, has often proved challenging considering the damages done by the terrorist group.
- Trial name
- LETiT (NCT05397483)
- Testing
- Legal Education plus Trauma-informed Therapy (LETiT), Intervention As Usual (IAU)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Nottingham Trent University
Adjustment Disorders, Non-progressive Brain Injury
Does an Integrative Neuro-psychotherapy Program Foster the Adjustment in Depressed Stroke Patients? A Randomized Controlled Study.
This is an intervention study with patients after a non-progressive brain injury who suffer from depression. It will determine whether an integration of neuropsychological and psychotherapeutic techniques and an additional…
- Trial name
- NCT01039857
- Testing
- Neuropsychological Therapy, cognitive behavioral therapy, solution focused therapy, Integrative Neuro-Psychotherapy
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- University of Bern
Mental Disorders, Psychological Trauma
Hospital Cohort Survey of Public Health Post-attack of July 14, 2016
The terrorist attack on the ram truck, which occurred on 14 July 2016 on the Promenade des Anglais in Nice, involved a significant number of casualties in the civilian population: 86 dead including 10 children and adolescents…
- Trial name
- ECHOS (NCT03353805)
- Testing
- questionnaire
- Where
- France
- Volunteers
- 804 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Post Traumatic Stress Disorder, Obstructive Sleep Apnea
OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit
Substance use disorder (SUD) and posttraumatic stress disorder (PTSD) frequently co-occur and having both disorders is associated with greater psychological and functional impairment than having either disorder alone.
- Conditions
- Post Traumatic Stress Disorder, Obstructive Sleep Apnea, Substance Use Disorder, Residential Treatment Program
- Trial name
- NCT05156112
- Testing
- Positive Airway Pressure Device
- Where
- United States
- Volunteers
- 194 people
- Sponsor
- VA Office of Research and Development
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