Clinical trials: Trauma and Stress-related Disorders
Mental Health Disorder, PTSD
Psychosocial and Economic Impacts of Narrative Exposure Therapy for Violence Survivors in Eastern DRC
The objective of the study is to evaluate the impact of Narrative Exposure Therapy (NET) delivered by local counselors, on the mental health and socio-economic empowerment of survivors of Sexual and Gender Based Violence (SGBV)…
- Conditions
- Mental Health Disorder, PTSD, Depression Anxiety Disorder, Gender-based Violence
- Trial name
- NCT04841031
- Testing
- NET Treatment, Alternative Intervention
- Where
- 2 sites in Democratic Republic of the Congo
- Volunteers
- 1,053 people
- Sponsor
- World Bank
Post Traumatic Stress Disorder, Depression
Acceptance and Commitment Group Therapy for Unaccompanied Minors
Unaccompanied minors (UM) are considered to be a highly vulnerable refugee subgroup. Research has indicated that UM experience traumatic events and consequently develop high levels of psychopathology.
- Conditions
- Post Traumatic Stress Disorder, Depression, Anxiety Disorders
- Trial name
- NCT05218031
- Testing
- Acceptance and Commitment Therapy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Cyprus
Alcohol Use Disorder, Anxiety Disorder/Anxiety State
Stress Reactivity as a Determinant in Co-occurring Alcohol Use and Anxiety Disorder: Diagnosis and Alcohol Use Outcomes
Alcohol dependence is among the most common and costly public health problems affecting the nation. Among individuals with alcohol use disorder (AUD), those with (vs.
- Conditions
- Alcohol Use Disorder, Anxiety Disorder/Anxiety State, Stress Disorder, Hypothalamic Pituitary Adrenal
- Trial name
- NCT03056872
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Domestic Violence, Depression
Cortisol Evaluation in Abuse Survivors
This study looks at the biological effect of domestic violence and abuse (DVA) on women's mental health. The mechanisms through which DVA causes mental disorders are very poorly understood.
- Conditions
- Domestic Violence, Depression, Anxiety, Panic Disorder
- Trial name
- CEASE (NCT01632553)
- Where
- 2 sites in United Kingdom
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Bristol
Critical Illness, Stress Disorders, Traumatic, Acute
Intensiva 2.0: Improve the Communication Towards Families of Critically Ill Patients
The admission of a loved one in an ICU is a hard experience for family members. They frequently feel fear and grief, develop anxiety and depression symptoms, or even show some behaviors as this event was a real traumatic one…
- Conditions
- Critical Illness, Stress Disorders, Traumatic, Acute, Stress Disorders, Post-Traumatic
- Trial name
- Intensiva2 (NCT03438175)
- Testing
- Enhanced communication by brochure, website and posters
- Where
- Italy
- Volunteers
- 2,100 people
- Sponsor
- University of Milan
Nightmares Associated With Trauma and Stress
Exposure, Relaxation, & Rescripting Therapy-Child
Untreated trauma-related nightmares and sleep-related disorders are associated with chronic health problems, burdening both the suffering individual and the health-care system.
- Trial name
- ERRT-C (NCT01776229)
- Testing
- Exposure, Relaxation, & Rescripting Therapy-Child
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Tulsa
Posttraumatic Stress Disorder
A Multi-Site Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD (MAPP2)
The goal of this clinical trial is to learn if MDMA-assisted therapy is safe and effective in people with at least moderate PTSD.
- Trial name
- NCT04077437
- Testing
- Therapy, Midomafetamine
- Where
- 14 sites in United States, Israel
- Volunteers
- 121 people
- Sponsor
- Resilient Pharmaceuticals
PTSD
Reflective Function as a Mediator of Interpersonal Psychotherapy (IPT)
Our recent randomized controlled trial of psychotherapies for posttraumatic stress disorder (PTSD) showed that Interpersonal Psychotherapy (IPT) benefitted patients.
- Trial name
- NCT02645929
- Testing
- Interpersonal Psychotherapy (IPT)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- New York State Psychiatric Institute
Post-Traumatic Stress Disorder
Effectiveness of Propranolol For Treating People With Post-Traumatic Stress Disorder
This study will evaluate the effectiveness of propranolol in reducing symptoms of distress in people with post-traumatic stress disorder.
- Trial name
- NCT00648375
- Testing
- Propanolol, Cognitive therapy workbook
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Weill Medical College of Cornell University
Nightmares, Insomnia
Treating Insomnia & Nightmares After Trauma: Impact on Symptoms & Quality of Life
Exposure to trauma, especially when it manifests as Posttraumatic Stress Disorder (PTSD), results in numerous negative consequences for patients, families, and society.
- Conditions
- Nightmares, Insomnia, Posttraumatic Stress Disorder
- Trial name
- NCT01009112
- Testing
- PTSD + IRT/CBT-I, PTSD + Supportive Care Therapy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of California, San Diego
Insomnia, Nightmares
Initial Study of Insomnia/Nightmare Group Treatment for Posttraumatic Stress Disorder (PTSD)
Many combat Veterans suffer from posttraumatic stress disorder (PTSD), an anxiety disorder that develops after an extremely stressful event or events. PTSD is associated with problems falling asleep or staying asleep.
- Conditions
- Insomnia, Nightmares, Posttraumatic Stress Disorder
- Trial name
- NCT01314612
- Testing
- Cognitive-Behavioral Insomnia and Nightmare Group
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Michael E. DeBakey VA Medical Center
Post Traumatic Stress Disorder (PTSD)
A Clinical Trial for Post Traumatic Stress Disorder
he purpose of this study is to test whether a medication, called mifepristone (commonly known as the ³Morning-After-Pill²), can help to prevent emotional problems after someone has survived a traumatic experience.
- Trial name
- MATTER (NCT00554177)
- Testing
- Medicane (mifepristone)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Antonia New
Parents, Stress
Single Session Consultation for Parents
Single-Session Consultation (SSC) is a rapidly provided, low-intensity, goal-directed counseling service used for treatment of diverse mental health problems.
- Trial name
- SSC (NCT05048277)
- Testing
- Single Session Consultation
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- New York University
Postintensive Care Syndrome, Anxiety Disorder
Is Invasive ICU-treatment Associated With Mental Illness?
Understanding long-term complications after intensive care is important to be able to offer prophylactic and therapeutic measures to post-intensive care unit (ICU) patients.
- Conditions
- Postintensive Care Syndrome, Anxiety Disorder, Depression, PTSD
- Trial name
- NCT05137977
- Testing
- Intensive Care
- Volunteers
- 1,048,576 people
- Sponsor
- Uppsala University
Post Traumatic Stress Disorder
Quetiapine Augmentation of PE Therapy for the Treatment of Co-occurring PTSD and Mild Traumatic Brain Injury
A pilot study to evaluate feasibility for a full-scale merit application. Specifically, for veterans considering prolonged exposure (PE) therapy, following the model established by Foa et al, we need to establish safety, and…
- Trial name
- NCT04280965
- Testing
- Quetiapine Fumarate, Standard of care meducations
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Burnout, Secondary Trauma
PATH to Reducing Burnout Among Peers Who Deliver Overdose Prevention Services (R33 Phase Clinical Trial)
The investigators propose to test the effectiveness of PATH (Peer Advanced Training for total Health) as an educational workforce intervention for improving peer recovery support specialists' (PRSS) overdose prevention (OP)…
- Conditions
- Burnout, Secondary Trauma, Compassion Fatigue, Opioid Use Disorder
- Trial name
- NCT07886944
- Testing
- PATH (Peer Advanced Training for total Health)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Chestnut Health Systems
Posttraumatic Stress Disorder
Riluzole Effects on Hippocampus Biomarkers
To examine the clinical efficacy of the anti-glutamatergic medication riluzole in posttraumatic stress disorder (PTSD), and its effect on hippocampus biomarkers that our laboratory previously has identified using MRS.
- Trial name
- NCT04630444
- Testing
- Riluzole
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mclean Hospital
Anxiety, PTSD
Chaplain Family Project Trial
Our research team has designed a chaplain delivered intervention focused on surrogate decision makers for hospitalized adults in the ICU.
- Conditions
- Anxiety, PTSD, Depression, Communication
- Trial name
- CFP-RCT (NCT03702634)
- Testing
- Spiritual Care Assessment and Intervention (SCAI) framework
- Where
- 2 sites in United States
- Volunteers
- 192 people
- Sponsor
- Indiana University
Post-traumatic Stress Disorder
The Use of Noninvasive Brain Stimulation in Post-traumatic Stress Disorder
The purpose of this trial is to study the effect of noninvasive brain stimulation in adults with post-traumatic stress disorder.
- Trial name
- NCT02542709
- Testing
- Active repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Laval University
Posttraumatic Stress Disorder
MDMA-Assisted Psychotherapy in People With Posttraumatic Stress Disorder
The goal of this clinical trial is to compare MDMA-assisted therapy to placebo with therapy in people with chronic, treatment-resistant posttraumatic stress disorder (PTSD).
- Trial name
- NCT00090064
- Testing
- Midomafetamine HCl, Therapy
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Resilient Pharmaceuticals
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