Clinical trials: Trauma and Stress-related Disorders
Posttraumatic Stress Disorder, Borderline Personality Disorder
STAIR for Trauma and Emotion Dysregulation
This study will examine the impact of Skills Training in Affective and Interpersonal Regulation (STAIR) group, using self-report measures, on Posttraumatic Stress Disorder (PTSD), emotional dysregulation, borderline personality…
- Conditions
- Posttraumatic Stress Disorder, Borderline Personality Disorder, Emotion Regulation
- Trial name
- NCT05397613
- Testing
- STAIR
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Stanford University
Posttraumatic Stress Disorder, Acute Stress Disorder
Prevention of Intrusive Memories and Posttraumatic Stress Symptoms After Emergency Cesarean Section
This pilot study aims to investigate the effects of a brief computerized intervention (the computer game "Tetris") on intrusive memories and other posttraumatic stress symptoms following an emergency cesarean section.
- Trial name
- NCT02502513
- Testing
- Brief computerized intervention
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Posttraumatic Stress Disorder
Prevention of Posttraumatic Stress Disorder (PTSD) With Diazepam
PTSD is a pervasive and frequent disorder. Early psychological treatment - but not pharmacology - effectively prevent PTSD. Current pharmacological studies did not include treatment given immediately after trauma exposure.
- Trial name
- NCT01221883
- Testing
- Diazepam
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Hadassah Medical Organization
Treatment-resistant PTSD
REVERSE: Improving Treatment-resistant Post Traumatic Stress Disorder (PTSD) with Glucocorticoid Receptor (GR) Antagonism
Rationale: Post-traumatic stress disorder (PTSD) is a psychiatric disorder that can develop in people who have experienced or witnessed a traumatic event.
- Trial name
- REVERSE (NCT06689254)
- Testing
- Mifepristone 1200 mg daily
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Christiaan Vinkers
Intimate Partner Violence, Depression
MOSAIC (MOthers' AdvocateS In the Community) for Pregnant Women and Mothers of Children Under 5 With Experience of Intimate Partner Violence
The purpose of this R34 exploratory research proposal is to conduct formative work for a larger randomized controlled trial (RCT) evaluating the effectiveness of the "Mother AdvocateS In the Community (MOSAIC) Plus" intervention…
- Conditions
- Intimate Partner Violence, Depression, Post Traumatic Stress Disorder
- Trial name
- MOSAIC Plus (NCT05106361)
- Testing
- MOSAIC Plus, MOSAIC
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Michigan State University
Posttraumatic Stress Disorder
Implementation of Evidence-based Psychotherapy for PTSD
Approximately 9% of Canadians will have Posttraumatic Stress Disorder (PTSD) in their lifetime. In the military veteran population, the lifetime prevalence of PTSD has been estimated to be as high as 20%.
- Trial name
- NCT01861769
- Testing
- Technology-enhanced Teleconsultation, Standard Teleconsultation
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Toronto Metropolitan University
Adults, Acute Stress Reaction
Impact of MetaCalm on Stress of Healthy People With Acute Stress
This Open-Label, Non-Randomized Clinical Study involving 280 participants who will undergo a total participation of 6 hours.
- Trial name
- NCT07507669
- Testing
- 2 chewable tablets of MetaCalm, 4 chewable tablets of MetaCalm
- Where
- Italy
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Metagenics, Inc.
PTSD
Primary Care-Based Mindfulness Intervention for Veterans With PTSD
Primary care patients typically do not receive adequate PTSD treatment because of their reluctance to engage in empirically-supported treatments offered in specialty care settings.
- Trial name
- NCT02399696
- Testing
- Primary Care-Brief Mindfulness Program, Primary Care-Treatment as Usual
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Syracuse VA Medical Center
Mild Traumatic Brain Injury, Post Traumatic Stress Disorder
Neuromodulation and Neurorehabilitation for mTBI
This study will determine (i) the magnitude of immediate and sustained effects of a current clinical standard interactive computer attention processing training (APT) when combined with intermittent theta burst stimulation…
- Trial name
- NCT03819608
- Testing
- real iTBS, real APT
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Northwestern University
PTSD
Evaluating The Efficacy Of Combined Cognitive Processing Therapy and Stellate Ganglion Blocks for PTSD
The purpose of this study is to understand if we can improve the treatment for posttraumatic stress disorder (PTSD). We are looking into whether the combination of Stellate Ganglion Block (SGB) treatment and Cognitive Processing…
- Trial name
- NCT06570213
- Testing
- Cognitive Processing Therapy, Stellate Ganglion Block
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- Rush University Medical Center
Stress Disorders, Post-Traumatic
Novel Therapeutics in Posttraumatic Stress Disorder (PTSD): A Randomized Clinical Trial of Mifepristone
Posttraumatic stress disorder (PTSD) is a common and disabling psychiatric disorder for Veterans. Left untreated or under-treated, it can become a chronic condition associated with significant distress, depression, aggression…
- Trial name
- NCT01739335
- Testing
- Mifepristone Oral Tablet [Korlym]
- Where
- 5 sites in United States
- Volunteers
- 81 people
- Sponsor
- VA Office of Research and Development
Post Traumatic Stress Disorder, Traumatic Brain Injury
TMS-fNIRS Personalized Dosing
The intent of this study is to establish technical feasibility in a clinical population (PTSD, with or without mild TBI) of personalized TMS-fNIRS technology.
- Trial name
- NCT05916417
- Testing
- TMS-fNIRS over the dl-PFC
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Florida State University
Sexual Assault and Rape, Suicidal Thoughts
BEAR for Women Who Have Experienced Sexual Assault and Have Suicidal Thoughts
The goal of this clinical study is to learn if the BEAR intervention effects outcome in women who have experienced sexual assault (broadly defined) and who have suicidal thinking.
- Trial name
- BEAR-SI (NCT07902050)
- Testing
- BEAR Therapeutic Group
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Stanford University
PTSD, Pain, Chronic
Feasibility of Remote Tai Chi
In the proposed trial, the investigators plan to refine interventions, then conduct a small randomized trial to provide critical information to inform a future large-scale randomized efficacy trial of Tai Chi for Post Traumatic…
- Trial name
- NCT05693805
- Testing
- Tai Chi, Wellness program
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Boston University
Post-Traumatic Stress Disorder
Assessing PTSD After Earthquake in Turkey
Assessing the prevalence and natural course of PTSD after the 1999 Turkish earthquake
- Trial name
- NCT00269451
- Sponsor
- Sheba Medical Center
HIV, Stress Disorder
CBSM Intervention Via mHealth to Ameliorate HIV-related Fatigue
The purpose of this study is to create a smartphone, tablet and web-based application to help people deal with stress. Stress often increases fatigue in people with HIV infection, so successfully dealing with stress could help…
- Conditions
- HIV, Stress Disorder, Human Immunodeficiency Virus, Fatigue
- Trial name
- NCT03149094
- Testing
- CBSM-SMI, CBSM-SMI control
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical University of South Carolina
Stress Disorders, Post-Traumatic
Acupuncture for the Treatment of Post-Traumatic Stress Disorder (PTSD)
The purpose of this study is to evaluate acupuncture as a treatment for Post-Traumatic Stress Disorder (PTSD) and to correlate the diagnosis of PTSD with Traditional Chinese Medicine (TCM) diagnostic patterns.
- Trial name
- NCT00055354
- Testing
- Acupuncture, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Moral Injury
Thriving in the Midst of Moral Pain: The Acceptability and Feasibility of Acceptance and Commitment Therapy for Moral Injury (ACT-MI) Among Warzone Veterans
The need for moral injury interventions is increasingly being recognized as a domain in Veteran care that must be addressed. Consequences of exposure to morally injurious events include risk for suicide, substance abuse, and…
- Trial name
- NCT03760731
- Testing
- Acceptance and Commitment Therapy for Moral Injury (ACT-MI), Present Centered Therapy for Moral Injury (PCT-MI)
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- VA Office of Research and Development
Substance Use Disorders, Posttraumatic Stress Symptom
Safe & Sound Protocol in Adults With Trauma and SUD
This study will explore whether the use of the Safe and Sound Protocol (SSP) app is an effective adjunct to treatment as usual (TAU) in individuals with co-occurring substance use disorders and trauma.
- Conditions
- Substance Use Disorders, Posttraumatic Stress Symptom, Anxiety
- Trial name
- NCT07219056
- Testing
- Safe and Sound Protocol
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Caron Treatment Centers
PTSD, Post Traumatic Stress Disorder
Feasibility of a Digital Therapeutic for Adults With Posttraumatic Stress Disorder (PTSD)
This study is exploring the efficacy of a digital therapeutic app in reducing symptoms of posttraumatic stress disorder (PTSD) in adults.
- Trial name
- NCT06868446
- Testing
- OTX-601 Digital Therapeutic - Version 1, OTX-601 Digital Therapeutic - Version 2, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Oui Therapeutics, Inc.
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