Clinical trials: Trauma and Stress-related Disorders
Aggressive Behavior, Post-Traumatic Stress Disorder
Treatment of Aggressive Behavior and Post-Traumatic Stress Disorder
Street children and children of vulnerable families in conflict or former conflict regions are often exposed to multiple traumatic events and situations in which they are forced to engage in violent behavior.
- Trial name
- NCT01519193
- Testing
- Narrative Exposure Therapy for violent offenders (NETvo)
- Where
- Burundi
- Volunteers
- 42 people
- Sponsor
- University of Konstanz
Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD)
Pregnenolone to Target Concurrent PTSD and Stress Induced Alcohol Use in Veterans: A Dose Finding Study
The purpose of this research study is to find out how Zulresso®/brexanolone influences Posttraumatic Stress Disorder (PTSD) symptoms and alcohol use.
- Trial name
- NCT06580444
- Testing
- Brexanolone
- Volunteers
- 40 people
- Sponsor
- Pharmacotherapies for Alcohol and Substance Use Disorders Alliance
Depression, Stress Disorders, Post-Traumatic
Effectiveness and Implementation of eScreening in Post 9/11 Transition Programs
Electronic screening is effective for timely detection of, and intervention for, suicidal ideation and other mental health symptoms.
- Conditions
- Depression, Stress Disorders, Post-Traumatic, Suicide
- Trial name
- NCT04506164
- Testing
- eScreening, Screening As Usual
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
PTSD, Addiction
The Course and Outcome of Integreated Trauma and Addiction Treatment Between PTSD and CPTSD
In the ICD-11 post-traumatic stress disorder (PTSD) and complex PTSD (CPTSD) are distinguished. CPTSD is associated with early childhood traumatization and more severe symptom patterns.
- Trial name
- NCT06588309
- Testing
- Eye movement desensitization and reprocessing (EMDR), CRA
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- IrisZorg
PTSD
Safety and Efficacy of 50 mg NYX-783 QD vs. Placebo in PTSD
A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of 50 mg NYX-783 Once Daily Compared to Placebo in Participants with Post-Traumatic Stress Disorder (PTSD)
- Trial name
- NCT05181995
- Testing
- NYX-783
- Where
- 37 sites in United States
- Volunteers
- 121 people
- Sponsor
- Aptinyx
Post-traumatic Stress Disorder, Leadership
Implementering PTSD Treatment
The project will develop knowledge on how managers can lead the implementation of practices that have proven to be effective for post-traumatic stress disorders (PTSD) in adult specialized mental health services.
- Conditions
- Post-traumatic Stress Disorder, Leadership, Implementation
- Trial name
- ITV (NCT04735328)
- Testing
- LOCI, CT-PTSD, EMDR
- Where
- Norway
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Norwegian Center for Violence and Traumatic Stress Studies
Stress, Stress Disorder
The Professional Peer Resilience Initiative
The Professional Peer Resilience Initiative (PPRI) study is an observational study aimed at understanding how symptoms of traumatic stress and resilience evolve over time in the University of Minnesota (UMN) healthcare workforce…
- Conditions
- Stress, Stress Disorder, Stress, Psychological, Trauma, Psychological
- Trial name
- PPRI (NCT04396600)
- Testing
- MinnRAP Peer Support Program
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Posttraumatic Stress Disorder
Combined Mirtazapine and SSRI Treatment of PTSD: A Placebo-Controlled Trial
The overall goal of this study is to examine the efficacy of the combination of mirtazapine and sertraline in the treatment of posttraumatic stress disorder (PTSD).
- Trial name
- NCT01178671
- Testing
- Mirtazapine, Sertraline, Sugar pill
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Research Foundation for Mental Hygiene, Inc.
Trauma, PTSD
Key Dimensions of PTSD and ED
This study will test whether endothelial dysfunction could be the early subclinical mechanism by which posttraumatic stress disorder (PTSD) increases cardiovascular disease (CVD) risk, and whether posttraumatic fear-a key…
- Conditions
- Trauma, PTSD, Endothelial Dysfunction
- Trial name
- NCT03778307
- Testing
- Psychophysiological fear conditioning and extinction task, Eyetracking task
- Where
- United States
- Volunteers
- 168 people
- Sponsor
- University of California, Los Angeles
PTSD, Depressive Symptoms
Studying the Effectiveness and Implementation of Sudarshan Kriya Yoga for Canadian Veterans With PTSD
We plan to study the reach, effectiveness, adoption, implementation, and maintenance of the virtually-delivered Sudarshan Kriya Yoga (v-SKY) intervention.
- Conditions
- PTSD, Depressive Symptoms, Anxiety, Pain
- Trial name
- NCT05235828
- Testing
- Sudarshan Kriya Yoga (SKY)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Mount Sinai Hospital, Canada
Stress, Stress Disorder
Stress and Anxiety Affect Residents' Performance
Being an anesthesiologist implies huge dedication and both physical and psychological efforts. None has ever studied the impact of a working day on anxiety, perceived stress levels, physiological data, and executive functions.
- Conditions
- Stress, Stress Disorder, Work Related Stress
- Trial name
- NCT06200792
- Testing
- eSense device
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Padova
Stress Disorders, Post-Traumatic, Opioid Use Disorder
MDMA for Co-occurring PTSD and OUD After Childbirth
This is an open-label study of the use of MDMA Assisted Therapy for postpartum people with co-occurring Post Traumatic Stress Disorder (PTSD) and Opioid Use Disorder (OUD).
- Trial name
- NCT05219175
- Testing
- MDMA Assisted Therapy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of New Mexico
Trauma, Psychological
Systematic Case Series Investigating Eye Movement Desensitization Reprocessing (EMDR) Efficacy With Childhood Sexual Abuse Survivors
This study investigates the effectiveness of EMDR for survivors of childhood sexual abuse. All participants will undertake a standard course of EMDR via the National Heath Service program, alongside a number of questionnaires and…
- Trial name
- EMDR (NCT03966963)
- Testing
- Eye Movement Desensitization Reprocessing (EMDR)
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Salford
Posttraumatic Stress Disorder
Neuroeconomics of Social Behavior Following Trauma Exposure
This study will use a neuroeconomic paradigm with state-of-the-art imaging protocols to probe abnormal social reward processing underlying social withdrawal in symptomatic trauma-exposed women.
- Trial name
- NCT03383536
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Mental Health, Stress Disorders, Post-Traumatic
Integrating Clinical Practice Guidelines for Smoking Cessation Into Mental Health Care for Veterans With Posttraumatic Stress Disorder
The primary study objective is to conduct a prospective, randomized controlled clinical trial that compares the effectiveness of two approaches for delivering smoking cessation treatment for veterans with posttraumatic stress…
- Conditions
- Mental Health, Stress Disorders, Post-Traumatic, Substance-Related Disorders, Tobacco Use Disorder
- Trial name
- NCT00118534
- Testing
- Integrated Care for Smoking Cessation in PTSD patients, Standard of Care
- Where
- 11 sites in United States
- Volunteers
- 943 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Stress Disorders, Post-Traumatic
Image-guided, Robotically Delivered Transcranial Magnetic Stimulation Treatment for Combat-Related Post-Traumatic Stress Disorder
Mounting amounts of evidence suggests that non-invasive stimulation of the dorsolateral prefrontal cortex (DLPFC) using repetitive transcranial magnetic stimulation (rTMS) maybe a safe and effective treatment modality for…
- Trial name
- NCT02853032
- Testing
- Active repetitive transcranial magnetic stimulation, robotic arm
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Post Traumatic Stress Disorder (PTSD), Anxiety
COVID-Impact "Psychological IMPACT of Covid-19 on AP-HP Staff"
The epidemic of coronavirus induces a major influx of patients implying a rapid modification of the organizations, a work overload and a significant stress for the care teams and supports of the hospitals of the Assistance…
- Conditions
- Post Traumatic Stress Disorder (PTSD), Anxiety, Depression, Epidemic Disease
- Trial name
- Covid-Impact (NCT04558437)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 20,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Posttraumatic Stress Disorder
Clinical Trial to Preliminarily Assess the Safety and Feasibility of SAT-014, a Software for Alleviating Symptoms of Trauma and Stress-related Disorders
Failure to adapt to stress leads to functional impairments in various areas, including social, occupational, educational, and other significant domains, necessitating therapeutic intervention.
- Trial name
- NCT06439407
- Testing
- SAT-014(Software as Medical Device)
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- S-Alpha Therapeutics, Inc.
Stress Disorders, Post-Traumatic
A Study of Flexible Dose Brexpiprazole as Monotherapy or Combination Therapy in the Treatment of Adults With Post-traumatic Stress Disorder (PTSD)
To evaluate the safety, efficacy and tolerability of brexpiprazole (with placebo) as monotherapy or combination therapy with Zoloft (sertraline) in adults with PTSD.
- Trial name
- NCT03033069
- Testing
- Brexpiprazole, Sertraline
- Where
- 54 sites in United States
- Volunteers
- 336 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
PTSD, Chronic Pain
Feasibility and Efficacy of A Yoga Intervention for Comorbid Chronic Pain and PTSD
The goal of this pilot quasi-randomized study is test the feasibility, acceptability, and initial efficacy of Yoga for Warriors treatment program for comorbid chronic pain and PTSD, conducted virtually through the Richmond…
- Trial name
- NCT06123065
- Testing
- Yoga
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
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