Clinical trials: Trauma and Stressor Related Disorder
Stress Disorders, Post-Traumatic
Comparing Effects of a Holistic Yoga Program and a Wellness Program on PTSD Symptoms
Given the limited effectiveness of current treatments and the burden PTSD places on Veterans, civilians and clinicians, this research aims to compare the effects of a standardized, traditional, holistic yoga intervention…
- Trial name
- RELIEVE (NCT02234622)
- Testing
- Holistic Yoga Program, Wellness Lifestyle Program
- Where
- United States
- Volunteers
- 212 people
- Sponsor
- VA Office of Research and Development
Cardiac Arrest, Post Traumatic Stress Syndrome
Family-Authored ICU Diaries to Reduce Fear in Patients Experiencing a Cardiac Arrest (FAID Fear)
The present study will: Aim 1: Enroll 15 family members of CA patients to (a) pilot recruitment procedures, (b) estimate retention, and (c) assess acceptability of study procedures.
- Trial name
- FAID Fear (NCT05144477)
- Testing
- FAID Fear Intervention
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Columbia University
Burn-Out Syndrome, Work-Related Stress Disorder
A Mindfulness Based Cognitive Therapy (MBCT) Resiliency Program for Critical Care Nurses
Developed over 10 years ago, Mindfulness Based Cognitive Therapy (MBCT) synergistically combines mindfulness training and cognitive behavioral therapy and can increase resiliency.
- Trial name
- NCT03132220
- Testing
- Mindfulness-Based Cognitive Therapy, Book Club Active Control Intervention
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Acute Pain, Wound Care
RCT: Fentanyl Plus Ketamine Versus Fentanyl Alone for Acute Burn Pain
The Ketamine for Acute Pain in Burns study is a randomized, double-blind, parallel group trial (RCT) with active control (usual care) contrasting the efficacy and safety of "Ketamine Plus Opiate-based usual care" (O+K) with the…
- Conditions
- Acute Pain, Wound Care, Posttraumatic Stress Disorder
- Trial name
- NCT03305055
- Testing
- ketamine, Fentanyl
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Johns Hopkins University
Depression, Anxiety
Self-Defense Training in Women With Trauma
Previous research has shown that self-defense training can lead to gains in women's assertiveness, self-esteem, self-efficacy, and physical competence, and decreases in anxiety, helplessness, fear, and avoidant behaviors.
- Conditions
- Depression, Anxiety, Stress Disorders, Post-Traumatic
- Trial name
- NCT01380379
- Testing
- Life skills and self-defense training
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Stanford University
Post-Traumatic Stress Disorder
Neuromodulation for Post-Traumatic Stress Disorder
The investigators propose to use a clinical trial to test Trigeminal Nerve Stimulation (TNS) to examine the efficacy of TNS as a new treatment for Post Traumatic Stress Disorder (PTSD) in veterans.
- Trial name
- NCT02377089
- Testing
- Trigeminal Nerve Stimulation
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of California, Los Angeles
Stress Disorders, Post-Traumatic
Pharmacologic Treatment of PTSD in Sexually Abused Children
This study will evaluate the benefit of adding sertraline (Zoloft®) to Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) for sexually abused children who have Posttraumatic Stress Disorder (PTSD).
- Trial name
- NCT00078767
- Testing
- Trauma-Focused Cognitive Behavioral Therapy, Sertraline Pill
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
PTSD, Sleep Disorders
Cooperative Studies Program #563 - Prazosin and Combat Trauma PTSD
Background: Posttraumatic stress disorder (PTSD) is a debilitating and disabling mental disorder that afflicts at least 25% of Veterans who have suffered life-threatening war zone trauma.
- Trial name
- PACT (NCT00532493)
- Testing
- prazosin
- Where
- 15 sites in United States
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
PTSD, Panic Attacks
Exposure Therapy For Veterans With PTSD And Panic Attacks
To evaluate the feasibility, acceptability and effectiveness of Multiple Channel Exposure Therapy-Veterans (MCET-V) as a treatment for returning service members with comorbid PTSD and panic disorder (PD).
- Trial name
- NCT01033136
- Testing
- Multiple Channel Exposure Therapy - Veterans, Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- VA Office of Research and Development
Post-traumatic Stress Disorder
Primary Care Brief Mindfulness Training for Veterans With PTSD
The proposed study supports a line of research that seeks to improve the health of military veterans with post-traumatic stress disorder (PTSD) by teaching them mindfulness skills.
- Trial name
- NCT03352011
- Testing
- Primary Care Brief Mindfulness Training, PTSD Psychoeducational Class
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Syracuse VA Medical Center
Alcoholism, Alcohol Dependence
The Effect of NK1R Antagonism on Alcohol Craving and PTSD Symptoms in Alcohol Dependent Patients With PTSD
Objective: Alcoholism is highly co-morbid with post traumatic stress disorder (PTSD). Since stress and negative affective states are major relapse triggering factors for alcohol use, the negative symptoms associated with PTSD are…
- Conditions
- Alcoholism, Alcohol Dependence, Posttraumatic Stress Disorder
- Trial name
- NCT00896038
- Testing
- Aprepitant
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Posttraumatic Stress Disorder
Improving Psychosocial Functioning in Older Veterans With PTSD
The purpose of this project is to develop an intervention to improve psychosocial functioning and quality of life for older Veterans with partial or full PTSD.
- Trial name
- NCT02803125
- Testing
- Psychosocial intervention, Support group control
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
PTSD, TBI (Traumatic Brain Injury)
Top-Down Executive Control in Traumatic Brain Injury (TBI), PTSD and Combined
This research investigates processes involved with one being able to focus on relevant information and ignore non-relevant information in veterans with PTSD and those with a history of traumatic brain injury.
- Trial name
- NCT01072006
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Psychiatric Disorder, Mental Health Disorder
Attitudes Towards Receiving Mental Health Care Using Telehealth During the Coronavirus Disease 2019 (COVID-19) Pandemic
The purpose of this study is to collect patients' experiences and feedback to better understand and improve mental health care using telehealth services.
- Conditions
- Psychiatric Disorder, Mental Health Disorder, Stress, Adjustment Disorders
- Trial name
- NCT04693052
- Testing
- No interventions
- Where
- United States
- Volunteers
- 605 people
- Sponsor
- Northwestern University
Posttraumatic Stress Disorder
The Effect of Oxytocin on Fear Memory Consolidation Novel Intervention to Prevent Posttraumatic Stress Disorder (PTSD)
The purpose of the study is to learn how differences in learning under mildly-stressful circumstances may be changed by taking oxytocin. Oxytocin is a hormone made naturally in the body.
- Trial name
- NCT01466127
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pain, Stress Disorders, Post-Traumatic
Evaluating an eHealth Solution for Screening in Pediatric Care
This study will evaluate the predictive validity of a game-based screening system based on child self-report measures. The core study hypotheses are that (1) in-game assessments will predict problematic recovery (child pain and…
- Trial name
- NCT04506294
- Testing
- eScreen system
- Where
- 2 sites in United States
- Volunteers
- 320 people
- Sponsor
- Children's Hospital of Philadelphia
Smoking Cessation
Supplemental Nicotine Administration for Smoking Cessation in Posttraumatic Stress Disorder (PTSD)
The investigators propose to evaluate the relationship between PTSD, mood, craving and withdrawal symptoms and factors associated with relapse in the context of a randomized clinical smoking cessation trial.
- Trial name
- NCT01055886
- Testing
- nicotine patch
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Duke University
Posttraumatic Stress Disorder
MDMA-Assisted Psychotherapy in People With Posttraumatic Stress Disorder
The goal of this clinical trial is to compare MDMA-assisted therapy to placebo with therapy in people with chronic, treatment-resistant posttraumatic stress disorder (PTSD).
- Trial name
- NCT00090064
- Testing
- Midomafetamine HCl, Therapy
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Resilient Pharmaceuticals
Post-Traumatic Stress Disorder, Substance Use Disorders
Effectiveness of Peer-Delivered Trauma-Specific Treatment
Patient-Centered Trauma Treatment, i.e., treatment delivered by peers with lived-experience, has the potential to increase access to trauma treatment in underserved communities.
- Trial name
- NCT02081417
- Testing
- Seeking Safety
- Where
- United States
- Volunteers
- 291 people
- Sponsor
- University of New Mexico
Combat Disorders, Posttraumatic Stress Disorder
Exposure Therapy for Chronic PTSD: Efficacy and Mechanisms
The goals of the proposed research are to produce preliminary evidence of PE with OEF/OIF veterans with PTSD and to examine cognitive, psychophysiological, and neuroendocrine mechanisms of change in PTSD treatment.
- Trial name
- NCT00475241
- Testing
- Prolonged Exposure therapy for PTSD, Present centered therapy for PTSD
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development