Clinical trials: Trauma and Stressor Related Disorders
Posttraumatic Stress Disorder
Stepped Care for Children After Trauma: Optimizing Treatment
Children who are exposed to traumatic events are at risk for developing PTSD and other mental health problems. Although effective treatments for childhood PTSD exist, service delivery approaches that are more accessible…
- Trial name
- NCT02537678
- Testing
- Stepped Care TF-CBT, Standard TF-CBT
- Where
- 6 sites in United States
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Suicide and Depression
Characterizing Inflammatory Profiles and Suicidal Behavior in Adolescents
Despite increasing suicide rates in adolescents, there remains a paucity of approaches to use to prevent re-attempts. Any hope for breaking the code to prevent youth suicide lies in understanding biological factors that play a…
- Trial name
- NCT04783506
- Testing
- Observational Study
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Posttraumatic Stress Disorder
MGH Trauma-related Nightmares SDI Study
Interested individuals will first complete a telephone screening followed by a series of structured clinical interviews to diagnose PTSD and comorbid psychiatric disorders, confirm initial inclusion criteria, rule out exclusion…
- Trial name
- NM (NCT05195684)
- Testing
- imaginal probe
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
PTSD
A Trial Comparing Interpersonal Therapy to Exposure Therapy for PTSD Due to Military Sexual Trauma (MST) in Male and Female Military Personnel
The purpose of this study is to compare two kinds of therapy for Posttraumatic Stress Disorder (PTSD): exposure therapy (ET) and Interpersonal Psychotherapy (IPT).
- Trial name
- NCT03803332
- Testing
- Exposure Therapy, Interpersonal Psychotherapy
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- Weill Medical College of Cornell University
Posttraumatic Stress Disorder
Implementing a Skills Training Evidence-Based Treatment for Posttraumatic Stress Disorder in Primary Care
A majority of residents in low income communities have been exposed to a potentially traumatic event, and up to half (30-50%) of trauma-exposed residents in safety net clinical settings meet criteria for posttraumatic stress…
- Trial name
- I-STEP (NCT04937504)
- Testing
- STAIR-PC Group, WebSTAIR Group
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Boston Medical Center
Anxiety Disorders, Major Depression
CBT vs RTW Intervention for Patients With Common Subclinical Mental Illness in Primary Care
Background: Common mental illness, such as anxiety disorders and depression, is the main cause for sick leave in Sweden. Cognitive behavior therapy (CBT) has been shown to be effective in alleviating target symptoms of these…
- Conditions
- Anxiety Disorders, Major Depression, Stress Disorders, Primary Insomnia
- Trial name
- NCT01667809
- Testing
- Cognitive behavior therapy, Return to work
- Where
- Sweden
- Volunteers
- 5 people
- Sponsor
- Karolinska Institutet
Psychological Distress, Trauma, Psychological
Feasibility Study of a Group Intervention for Youth Wellbeing
Psychological distress, anxiety and depression are common in adolescence, and even more so following traumatic events. On Friday 15 March 2019, two mosques in Ōtautahi, Christchurch were targeted in an act of terrorism, resulting…
- Conditions
- Psychological Distress, Trauma, Psychological, Emotional Problem
- Trial name
- NCT05030909
- Testing
- transdiagnostic group treatment
- Where
- New Zealand
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Otago
Post Traumatic Stress Disorder, Childbirth Experience
"Connected Caesarean Section": Creating a Virtual Link Between Mothers and Their Infants to Improve Maternal Childbirth Experience: A Pilot Trial
One third of mothers rate their childbirth as traumatic. The prevalence of childbirth-related posttraumatic stress disorder (CB-PTSD) is of 4.7% and the prevalence of childbirth-related posttraumatic stress symptoms (CB-PTSS) of…
- Trial name
- e-motion-pilot (NCT05319665)
- Testing
- Head-mounted display
- Where
- Switzerland
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Depression, Post-traumatic Stress Disorder
Phase I: At-Home Support for Rural Women Using Group Video Calling
This randomized phase I trial studies at-home group video calling sessions in quality of life in rural patients with breast cancer.
- Conditions
- Depression, Post-traumatic Stress Disorder, Recurrent Breast Cancer, Stage IA Breast Cancer
- Trial name
- NCT01672684
- Testing
- support group therapy, educational intervention
- Where
- 2 sites in United States
- Volunteers
- 34 people
- Sponsor
- Stanford University
Post-Traumatic Stress Disorder, Chronic, Depressed Mood
An Interrupted Time-Series Pilot Trial of LGBTQ-Affirming Cognitive Processing Therapy for Interpersonal and Developmental Trauma
The researchers are testing a single-group cognitive-behavioral intervention for treating traumatic stress related to interpersonal and developmental trauma in LGBTQ adults.
- Conditions
- Post-Traumatic Stress Disorder, Chronic, Depressed Mood, Depressive and Anxiety Disorders, Anxiety
- Trial name
- NCT07863817
- Testing
- Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Alabama at Birmingham
Chronic Pain, Post-traumatic Stress Disorder
Treatment of Post-Traumatic Stress Disorder (PTSD) and Chronic Pain After Traumatic Orthopedic Injury
The purpose of this study is to examine the efficacy of multiple treatment options in addressing the co-morbidity between pain and PTSD symptoms.
- Trial name
- NCT00957164
- Testing
- Brief Prolonged Exposure Protocol, Chronic Pain Management Treatment, Self-Care
- Where
- 4 sites in United States
- Volunteers
- 51 people
- Sponsor
- The University of Texas at Arlington
Stress Disorders
Strength and Awareness in Action
The aims of this research study are to 1) assess the acceptability and feasibility of conducting a yoga-based intervention for Veterans receiving care at a Veterans Affairs Medical Center, and 2) obtain preliminary data regarding…
- Trial name
- NCT01717547
- Testing
- Yoga-based treatment
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- VA Eastern Colorado Health Care System
Posttraumatic Stress Disorder (PTSD)
Psilocybin-Assisted Psychotherapy for Veterans With PTSD
This study will evaluate the feasibility, safety and preliminary efficacy of psilocybin-assisted psychotherapy in military veterans with treatment-refractory posttraumatic stress disorder (PTSD).
- Trial name
- PsiVet (NCT07792538)
- Testing
- Psilocybin-assisted Psychotherapy
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- ARQ National Psychotrauma Centre
Depression, Major Depressive Disorder
The Treatment of Depression With Yoga and Walking
This randomized controlled trial is designed to test the Vagal-gamma amino-butyric acid (GABA) Hypothesis that one of the mechanisms by which yoga-based practices improve mood and decrease anxiety is by correcting an autonomic…
- Conditions
- Depression, Major Depressive Disorder, PTSD, Anxiety
- Trial name
- NCT02907476
- Testing
- Iyengar Yoga, Walking
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Boston University
Depression, Post-traumatic Stress Disorder
Trigeminal Nerve Stimulation for Post Traumatic Stress Disorder (PTSD) and Depression
This is a 20-subject, dose finding study to examine the use of external trigeminal nerve stimulation (TNS) as an adjunctive treatment for adults with major depressive disorder (MDD) co- occurring with posttraumatic stress…
- Trial name
- NCT01335217
- Testing
- Transcutaneous Electrical Nerve Stimulator (TENS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Sedation, Mechanical Ventilation
Sedation and Psychopharmacology in Critical Care
Certain methods of sedation increase the duration of respiratory failure. Two strategies, a nursing- implemented sedation algorithm and daily interruption of sedatives, decrease length of mechanical ventilation compared to…
- Conditions
- Sedation, Mechanical Ventilation, Depression, Post-traumatic Stress Disorder
- Trial name
- NCT00205517
- Testing
- Daily interruption of sedation versus sedation algorithm
- Volunteers
- 75 people
- Sponsor
- Virginia Commonwealth University
PTSD
Mobile Acoustic Startle Reflex-monitoring System (MARS)
This is a pilot study of 55 adult male veterans with PTSD. The study will test a new mobile application "app" that can be run on an iPhone10.
- Trial name
- NCT04113850
- Testing
- Mobile Acoustic startle Reflex monitoring System (MARS)
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Johns Hopkins University
Posttraumatic Stress Disorder
Thermal Clinic Treatment in Gulf War Illness
Although thermal therapy has been utilized in the rehabilitation of war veterans since the Roman Empire, no investigations actually exist about the use of thermal therapy in GWI, This due to the fact that nobody knows that the…
- Trial name
- TCTGWI (NCT02293291)
- Testing
- Lithium Water
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- American Society Of Thermalism And Climatology Inc
PTSD - Post Traumatic Stress Disorder
Evaluating Evidenced Based Options for PTSD Treatment
This study will look at: How practical it is to offer another round of proven therapy. How effective different therapy options are for people who didn't respond to the first treatment.
- Trial name
- NCT06733376
- Testing
- Cognitive Processing Therapy, Prolonged Exposure, Skills Training for Affective and Interpersonal Regulation
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Rush University Medical Center
Post Traumatic Stress Disorder
eTMS for Veterans and First Responders With PTSD
A battery of physiological and behavioral data will be collected before and after application of eTMS. Participants will be veterans or first responders diagnosed with PTSD.
- Trial name
- NCT06294106
- Testing
- Electroencephalogram personalized Transcranial Magnetic Stimulation (eTMS)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Virginia Polytechnic Institute and State University