Clinical trials: Trauma-related Wound
Bone Fracture, Fresh Fracture
Sustained Acoustic Medicine (SAM) for Symptomatic Treatment of Pain Related to Bone Fracture
The purpose of this study is to assess the ability of long-duration low-intensity therapeutic ultrasound (LITUS) to alleviate bone-fracture related pain over a 12-week period.
- Trial name
- NCT05883241
- Testing
- Sustained Acoustic Device with 2.5% Diclofenac Patch, 2.5% Diclofenac Patches
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- ZetrOZ, Inc.
Bereavement
Family-authored Digital ICU Diary Intervention to Support Bereaved Family Members in Intensive Care Unit: A Pilot Mixed Methods Study
Objectives: To assess the feasibility, acceptability and appropriateness of a family-authored digital ICU diary intervention for bereaved family members in Hong Kong ICUs, and to explore family members' experiences of writing…
- Trial name
- ICU-Diary-HK (NCT07788768)
- Testing
- Family-authored Digital ICU Diary Intervention, Standard Care
- Volunteers
- 40 people
- Sponsor
- The University of Hong Kong
Traumatic Brain Injury
Improving Sleep, Sleep-related Outcomes, and Biomarkers in Veterans
The primary purpose of this project is to determine the effect of morning bright light therapy (MBLT) on sleep in Veterans with traumatic brain injury (TBI).
- Trial name
- NCT03968874
- Testing
- Light box therapy, Negative Ion Generator
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Portland VA Medical Center
Concussion, Mild, Sleep
Impact of Concussion History on Sleep and Physical Performance in Contact Sports Athletes
This study investigates the correlation between a history of concussions and its effects on both sleep patterns and physical performance among athletes engaged in contact sports.
- Conditions
- Concussion, Mild, Sleep, Physical Performance
- Trial name
- NCT06328023
- Testing
- SCOAT 6 to find association
- Where
- Pakistan
- Volunteers
- 115 people
- Sponsor
- Riphah International University
Opioid Use Disorder, Posttraumatic Stress Disorder (PTSD)
Integrated Treatment for Opioid Use Disorder and PTSD
This study will test a therapy intervention, HOPE, for individuals with opioid use disorder and posttraumatic stress disorder. Interested individuals will need to be taking medications for opioid use disorder (e.g., suboxone…
- Trial name
- NCT06641115
- Testing
- HOPE Therapy
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Medical University of South Carolina
Post-Traumatic Stress Disorder
Visual Dysfunction in Mild Traumatic Brain Injury (MTBI): A Comparison Group Study
In an on-going study of visual characteristics of personnel diagnosed with a mild traumatic brain injury (MTBI) related to their service in Iraq and Afghanistan we found a high rate of binocular vision problems (such as…
- Trial name
- VDMTBI (NCT00671450)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- US Department of Veterans Affairs
Psychological Trauma, Trauma and Stress Related Disorders
Trauma-Focused Intervention With Women Experiencing Homelessness
Homelessness and associated traumas disproportionately affect women. The biopsychosocial health consequences of untreated trauma are profound.
- Conditions
- Psychological Trauma, Trauma and Stress Related Disorders, Substance-Related Disorders, Substance Use
- Trial name
- NCT05873517
- Testing
- Immediate Narrative Exposure Therapy (NET)+, Waitlist + NET+
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Post Traumatic Stress Disorder, Anxiety
The Effects of the Safe and Sound Protocol on PTSD Symptoms and Anxiety
The Safe and Sound Protocol (SSP) is a passive acoustic intervention that is designed as a "neural exercise" to promote efficient regulation of autonomic state.
- Trial name
- NCT04999852
- Testing
- Safe and Sound Protocol, Psychotherapy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Indiana University
Musculoskeletal Injury, Musculoskeletal Strain
Multi-axis Assessment of Injured Workers
The percentage of loss time claims receiving Loss of Earnings benefits at 3 months has continued to rise amongst injured workers in Ontario despite the Workplace Safety and Insurance Board (WSIB) approach of "Better at Work".
- Conditions
- Musculoskeletal Injury, Musculoskeletal Strain, Low Back Pain, Neck Pain
- Trial name
- NCT06016647
- Testing
- Musculoskeletal-specific WSIB programs of care
- Where
- Canada
- Volunteers
- 350 people
- Sponsor
- Dave Walton
Drug-induced Disorder of Liver, Adverse Reaction to Drug
Cells of Monocytic Origin as Surrogate Markers for Individual Drug Effects and Hepatotoxicity
Drug metabolism in the liver is subject to large fluctuations (differences between women and men, people of different ethnic backgrounds, children and adults).
- Trial name
- NCT02353455
- Testing
- Blood sampling
- Where
- 5 sites in Australia, Germany and 3 more
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Andreas Benesic, MD
Posttraumatic Stress Disorder, Rumination - Thoughts
Evaluation of a Rumination Intervention for Individuals With PTSD: A Case Series
After a traumatic event, it is common for thoughts to run through our minds over and over again. Typically, these include unanswerable questions like "why did this happen to me?", "what if I had done something differently?"…
- Trial name
- NCT05625126
- Testing
- Rumination Intervention for individuals with PTSD
- Where
- 2 sites in United Kingdom
- Volunteers
- 16 people
- Sponsor
- University of Oxford
Surgical Site Infection, Pancreaticoduodenectomy
Association of Cephalosporin Resistance and Surgical Site Infections in Patients Undergoing Pancreaticoduodenectomy
Preoperative biliary drainage predisposes the bile to be contaminated with bacteria of the duodenum. These bacteria colonizing the bile are a potential source for surgical site infections after pancreaticoduodenectomy and many…
- Conditions
- Surgical Site Infection, Pancreaticoduodenectomy, Biliary Tract Infection Bacterial
- Trial name
- NCT05581017
- Testing
- Preoperative biliary drainage
- Where
- Finland
- Volunteers
- 376 people
- Sponsor
- Helsinki University Central Hospital
Hip Fracture, Anemia
IV Iron in Association With Tranexamic Acid for Hip Fracture
It is a prospective randomized controlled study aiming to test if tranexamic acid combined to intravenous iron before and after surgery for hip fracture in elderly can decrease peri-operative red cell transfusion.
- Trial name
- NCT02428868
- Testing
- tranexamic acid (Exacyl®), intravenous iron (Ferroven®), Saline
- Where
- Tunisia
- Volunteers
- 150 people
- Sponsor
- Institut Kassab d'Orthopédie
Post Traumatic Stress Disorder, Offensive Aggression
Exploring the Psycho-traumatic Impact of a Violent Act Commited at the Bordeaux-Gradignan Penitentiary Center
The study will seek to explore the possibility of developing post-traumatic stress disorder following a violent offense commited, among the population of prisoners of the Bordeaux-Gradignan penitentiary center.
- Conditions
- Post Traumatic Stress Disorder, Offensive Aggression, Violent Behavior
- Trial name
- IPTAVC (NCT05026450)
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Centre Hospitalier Charles Perrens, Bordeaux
PTSD, Exercise Intensity
Using Exercise to Enhance Fear Extinction Learning
The goal of the current project is to establish the efficacy and mechanisms of exercise-enhanced fear extinction retrieval and generalization in posttraumatic stress disorder (PTSD).
- Conditions
- PTSD, Exercise Intensity, Fear Extinction, Fear Conditioning
- Trial name
- NCT07548125
- Testing
- Exercise
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Josh Cisler
Transfusion-related Acute Lung Injury, Chronic Liver Disease
Predicting Lung Injury From Transfusion in Patients With Liver Disease
A certain molecule floating in the blood may represent a risk of lung injury after a transfusion. We are determining whether detection of this molecule on a simple blood clotting test will predict the development of lung injury…
- Conditions
- Transfusion-related Acute Lung Injury, Chronic Liver Disease, Gastrointestinal Bleeding
- Trial name
- NCT01756690
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- University of Colorado, Denver
PTSD
Immunological Changes Through Narrative Treatment of Post-Traumatic Stress Disorder (PTSD) in Torture Victims
Posttraumatic stress disorder (PTSD) is associated with poor health, high health care utilization, and an increased risk for a variety of somatic, inflammatory and autoimmune diseases.
- Trial name
- NCT01206790
- Testing
- NET
- Where
- Germany
- Volunteers
- 47 people
- Sponsor
- University of Konstanz
Chronic Pain, Post-traumatic Stress Disorder
The Norwegian Addiction, Pain and Trauma Study
In populations with substance use disorders (SUD), there is a high prevalence of chronic pain with various underlying causes. Chronic pain can complicate the treatment of SUD and lead to poorer treatment outcomes.
- Conditions
- Chronic Pain, Post-traumatic Stress Disorder, Substance Use Disorders
- Trial name
- NOR-APT (NCT04908410)
- Where
- 4 sites in Norway
- Volunteers
- 1,650 people
- Sponsor
- University Hospital, Akershus
Posttraumatic Stress Disorder (PTSD), Alcohol Use Disorder (AUD)
NAC for Treating Comorbid PTSD and SUD
As a result of sustained operations in Afghanistan and Iraq, there are an increasing number of U.S. military Veterans with substance use disorders and comorbid posttraumatic stress disorder (PTSD).
- Conditions
- Posttraumatic Stress Disorder (PTSD), Alcohol Use Disorder (AUD), Substance Use Disorder (SUD)
- Trial name
- DoD-NAC (NCT02911285)
- Testing
- N-acetylcysteine, Cognitive behavioral therapy
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Medical University of South Carolina
PTSD, Depression
Online and Shared Decision-Making Interventions to Engage Service Men and Women in Post-Deployment Mental Health Care
OEF/OIF/OND war Veterans have unique post-deployment care needs that the VA is striving to understand and address. Unfortunately, there is a significant disparity in utilization of mental health (MH) care and VA access as most…
- Conditions
- PTSD, Depression, Substance Use Disorder, Traumatic Brain Injury
- Trial name
- eSDM (NCT03539068)
- Testing
- WEB-ED+ Treatment Arm
- Where
- United States
- Volunteers
- 1,312 people
- Sponsor
- VA Office of Research and Development
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