Clinical trials: Traumatic Bleeding
Iliofemoral Artery Injury, Shock
Posterior Tibial Artery Bypass for Iliofemoral Artery Injury Associated With Massive Blood Loss and Shock
Traumatic disruption of iliofemoral arterial segment is often associated with multiple injuries, massive hemorrhage, state of shock, and loss of blood supply to the ipsilateral lower extremity, as well as with high mortality.
- Trial name
- NCT00900848
- Volunteers
- 8 people
- Sponsor
- The Second Hospital of Qinhuangdao
Consciousness Disorders, Persistent Vegetative State
Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)
After a severe brain injury some patients survive but cannot communicate, and deciding early which of them are likely to recover consciousness remains one of the hardest problems in neurocritical care.
- Conditions
- Consciousness Disorders, Persistent Vegetative State, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- CyDoC-MAP (NCT07736820)
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Nicosia General Hospital
Hemothorax, Hemopneumothorax; Traumatic
Prospective Evaluation of 14F Thal Tube vs 28 French Chest Tube for Hemothorax and Use of Maximum Barrier Precautions
Traumatic hemothorax and hemopneumothorax are common diagnoses which are typically treated by placement of a chest tube. 28-32 Fr chest tubes have previously been shown equivalent to 36-40 Fr chest tubes for the non-emergent…
- Conditions
- Hemothorax, Hemopneumothorax; Traumatic, Empyema, Chest Tube Size
- Trial name
- NCT03167723
- Testing
- Chest tube placement
- Where
- United States
- Volunteers
- 193 people
- Sponsor
- Wake Forest University Health Sciences
Subdural Hematoma
Embolization of Middle Meningeal Artery for Subdural Hematoma in Canada (EMMA Can)
EMMA-Can is a prospective cohort study to assess the safety and effectiveness of MMA-embolization for the treatment of CSDH. Hypothesis- EMMA reduces the recurrence rate of CSDH with or without concomitant surgical evacuation.
- Trial name
- EMMA-Can (NCT04923984)
- Testing
- Embolization of the middle meningeal artery
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- University of Manitoba
Traumatic Brain Injury, Subarachnoid Hemorrhage
Normothermia in Patients With Acute Cerebral Damage
The purpose of our study is to verify wherever normothermia (achieved with diclofenac administration) may improve intracranial pressure control and may limit secondary cerebral damage thus positively influencing outcome in…
- Trial name
- NCT00491192
- Testing
- Diclofenac
- Where
- Italy
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Hematoma, Subdural, Chronic, Brain Diseases
The Onyx™ Trial For The Embolization Of The Middle Meningeal Artery For Chronic Subdural Hematoma
Middle meningeal artery (MMA) embolization via a minimally invasive endovascular approach might increase the likelihood of resolution and might prevent reaccumulation of Chronic Subdural Hematoma (CSDH).
- Conditions
- Hematoma, Subdural, Chronic, Brain Diseases, Central Nervous System Diseases, Wounds and Injuries
- Trial name
- OTEMACS (NCT04742920)
- Testing
- Middle Meningeal Artery Embolization, Standard Management
- Where
- 6 sites in France
- Volunteers
- 247 people
- Sponsor
- University Hospital, Montpellier
Chronic Subdural Hematoma
Association Between Dietary Factors and Chronic Subdural Hematoma (DISH)
A prospective, multicenter, case control trial is designed to compare difference in dietary and nutritional factors in patients with and without chronic subdural hematoma.
- Trial name
- DISH (NCT05599217)
- Testing
- Dietary and nutritional questionnaire, Neurological function, cognitive function, and life quality assessment, Peripheral blood test
- Where
- 4 sites in China
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Traumatic Brain Injury (TBI), Intracerebral Hemorrhage
Hemodynamic ABI Monitor
The goal of this observational study is to explore the relationship of heart function with the course and outcomes after traumatic brain injuries and nontraumatic intracerebral hemorrhage.
- Trial name
- NCT06725108
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Chicago
Subdural Hematoma, Chronic
Endovascular vs Conservative Treatment in Patients With Chronic Subdural Hematomas and Mild Symptoms
Embotrial-1 is an Italian multicenter prospective randomized clinical trial with open-label treatment and blinded outcome assessment (PROBE) to assess the superiority of MMA embolization compared to conservative treatment.
- Trial name
- NCT06274580
- Testing
- embolization of the middle meningeal artery
- Volunteers
- 300 people
- Sponsor
- Ospedale Policlinico San Martino
Traumatic Brain Injury, Subarachnoid Hemorrhage
Hyperpolarized 13C-pyruvate Metabolic MRI With Traumatic Brain Injury
The purpose of this study is to examine the safety and feasibility of using hyperpolarized metabolic MRI to study early brain metabolism changes in subjects presenting with head injury and suspected non-penetrating traumatic…
- Trial name
- NCT06103201
- Testing
- Hyperpolarized 13C-Pyruvate
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Trauma, Brain, Subarachnoid Hemorrhage
Non-invasive ONSD-based Neuromonitoring in a Neurointensive Care Setting
Intensive care patients with established invasive intracranial neuromonitoring due to neurotrauma are subjected to a repeated non-invasive sonographic recording of the optic-nerve-sheath-diameter (ONSD).
- Conditions
- Trauma, Brain, Subarachnoid Hemorrhage, Intracranial Hypertension
- Trial name
- ONSDDynamics (NCT05818371)
- Testing
- Sonographic determination of the optic nerve sheath diameter
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Tuebingen
Brain Injuries, Traumatic, Biomarkers
Detecting Traumatic Intracranial Hemorrhage With Microwaves and Biomarkers
This study will evaluate if traumatic intracranial hemorrhage can be safely ruled out by using a microwave scanner (MD100) in conjunction with a combination of different brain biomarkers analyzed in serum.
- Conditions
- Brain Injuries, Traumatic, Biomarkers, Microwave Imaging
- Trial name
- MBI01 (NCT04666766)
- Testing
- Microwave scanning of the head
- Where
- Sweden
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Region Skane
Minor Head Injury, Intracranial Bleeding
Risk Factors of Minor Head Injury
Introduction and Aims: The objective of this prospective study is to evaluate the risk factors of minor head injury in all consecutive patients of one year.
- Conditions
- Minor Head Injury, Intracranial Bleeding, Traumatic Brain Injury
- Trial name
- NCT00451789
- Where
- Austria
- Volunteers
- 12,500 people
- Sponsor
- Medical University of Vienna
Oral Nimodipine, Milrinone
Management of Cerebral Vascular Spasm in Posttraumatic Subarachnoid Hemorrhage Using Combination Therapy
To evaluate the efficacy and safety of oral Nimodipine and IV milrinone combination therapy for management of cerebral spasm after aneurysmal subarachnoid hemorrhage.
- Conditions
- Oral Nimodipine, Milrinone, Vascular Spasm After Traumatic Subarachnoidhaemorrhage
- Trial name
- NCT05131867
- Testing
- nimodipine, Oral Nimodipine and milrinone
- Where
- 2 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Zagazig University
Subdural Hematoma
The Use of Tranexamic Acid in the Treatment of Symptomatic Subdural Hematoma
Subdural hematoma (SDH) is a common condition experienced after head injury. Blood collects on the surface of the brain, causing headaches which can progress to confusion, weakness, or even coma.
- Trial name
- TRACE (NCT05713630)
- Testing
- Tranexamic acid (TXA)
- Where
- Canada
- Volunteers
- 130 people
- Sponsor
- Unity Health Toronto
Chronic Subdural Hematoma
Adjuvant Tranexamic Acid (TXA) Versus Surgery Alone for Adult Patients With Chronic Subdural Hematoma (CSDH)
This study is an open label randomized controlled trial. Patients with a symptomatic Chronic Subdural Hematoma (CSDH) confirmed on radiological imaging, planned for surgery, age over 18, free from other intracranial pathologies…
- Trial name
- RATATA (NCT07245264)
- Testing
- Tranexamic Acid (Cyklokapron)
- Where
- India
- Volunteers
- 274 people
- Sponsor
- St. Olavs Hospital
Chronic Subdural Hematoma
Middle Meningeal Artery Embolization for the Treatment of Subdural Hematomas With TRUFILL® n-BCA
This is a prospective, multi-center, open-label, randomized controlled study in which subjects can receive standard of care (SOC) alone or SOC and TRUFILL n-BCA MMA embolization for the treatment of chronic subdural hematomas…
- Trial name
- MEMBRANE (NCT04816591)
- Testing
- Experimental: Interventional Cohort: TRUFILL n-Butyl Cyanoacrylate (n-BCA) Liquid Embolic System, Standard of Care Surgery, Experimental: Interventional Cohort: TRUFILL n-BCA Liquid Embolic System
- Where
- 33 sites in United States, China
- Volunteers
- 376 people
- Sponsor
- Cerenovus, Part of DePuy Synthes Products, Inc.
Chronic Subdural Hematoma
Low Intracranial Pressure Treatment Strategies for Chronic Subdural Hematoma Patients
The proportion of the elderly population is increasing rapidly. Chronic subdural hematoma has become the most common cause of surgery in neurosurgery for elderly patients. The standard treatment for cSDH is mostly surgery.
- Trial name
- CSDH-LP (NCT04607447)
- Testing
- low intracranial pressure strategy treatment, Atorvastatin plus Dexamethasone
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Huashan Hospital
TBI (Traumatic Brain Injury), Brain Edema
Teen Online Problem Solving (TOPS) - An Online Intervention Following TBI
The purpose of this study is to learn if using the World Wide Web to train teens and their families in problem-solving, communication skills, and stress management strategies can help them to cope better following traumatic brain…
- Conditions
- TBI (Traumatic Brain Injury), Brain Edema, Craniocerebral Trauma, Hematoma
- Trial name
- TOPS (NCT00409058)
- Testing
- Teen Online Problem Solving
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Hemorrhagic Shock
Safety and Efficacy of PolyHeme(R) in Hemorrhagic Shock Following Traumatic Injuries Beginning in the Pre-Hospital Setting
This study is designed to assess the survival benefit of administering PolyHeme to severely injured trauma patients in hemorrhagic shock beginning in the prehospital setting, where blood is not available, and continuing…
- Trial name
- NCT00076648
- Testing
- Poly SFH-P Injection
- Where
- 32 sites in United States
- Sponsor
- Northfield Laboratories