Clinical trials: Traumatic Brain Injury, Mild
Concussion, Traumatic Brain Injury
Advanced MRI Applications for Mild Traumatic Brain Injury-Phase 2
This is an open-label, non-randomized, prospective, multi-site, parallel group (segment), hypothesis-generating study designed to collect data that will aid in future scientific and engineering exploration of correlations between…
- Trial name
- mTBI-phase2 (NCT02556177)
- Testing
- MRI
- Where
- 7 sites in United States
- Volunteers
- 477 people, healthy volunteers welcome
- Sponsor
- GE Healthcare
Concussion, Mild
Novel Protection Against Potential Brain, Hearing and Vision Injury During Blast Wave Exposure
The purpose of the study is to monitor changes in brain structure and function between the pre-training and post-training, in a population of tactical team members wearing the Device and compared to a similar population not…
- Trial name
- BLAST (NCT03017924)
- Testing
- Q collar
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Concussion, mTBI
Neurofeedback Impact on Veterans With mTBI
This study will evaluate neurofeedback (NFB) training as a low risk, non-invasive, effective treatment for Veterans diagnosed with mild traumatic brain injury (mTBI) and experiencing chronic post-concussive symptoms (PCSs).
- Conditions
- Concussion, mTBI, Post-Concussive Symptoms, Chronic Headache
- Trial name
- NFBVETmTBI (NCT04195685)
- Testing
- Neurofeedback (NFB)
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- VA Office of Research and Development
Chronic Musculoskeletal Pain, Posttraumatic Stress Disorder (PTSD)
Neurobiological and Psychological Benefits of Exercise in Chronic Pain and PTSD
The wars in Iraq and Afghanistan are creating a new generation of Veterans, including an increasing number of women Veterans, who present with comorbid PTSD and chronic pain conditions from recent deployment-related physical…
- Conditions
- Chronic Musculoskeletal Pain, Posttraumatic Stress Disorder (PTSD), Mild or Moderate Traumatic Brain Injury
- Trial name
- EXCPPTSD (NCT03283163)
- Testing
- Exercise Testing and Training
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Brain Injuries, Traumatic
Noninvasive Neuromodulation for Treatment of Symptoms Due to Mild or Moderate Traumatic Brain Injury
The investigators hypothesis is that electrical stimulation to the tongue that directly stimulates two cranial nerve nuclei (Trigeminal and Facial Nerve Nuclei), will excite neural impulses to the brainstem and cerebellum.
- Trial name
- NCT02158494
- Testing
- Balance and Gait Training using neurostimulation modulation.
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Wisconsin, Madison
Mild Cognitive Impairment, Alzheimer's Disease
Behavioral and Neuroimaging Changes After Cognitive Rehab in Traumatic Brain Injuries (TBI) and Mild Cognitive Impairment (MCI)
Memory deficits are common after traumatic brain injuries (TBI) and are characteristic of various forms of dementia, such as Alzheimer's disease and its common precursor mild cognitive impairment (MCI).
- Conditions
- Mild Cognitive Impairment, Alzheimer's Disease, Traumatic Brain Injury
- Trial name
- NCT00714571
- Testing
- Mnemonic strategy training (MST), Repeated exposure (XP), Subtracting Cues training
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
Mild Hypothermia and Supplemental Magnesium Sulfate Infusion in Severe Traumatic Brain Injury (TBI) Subjects
The investigators hypothesize that hypothermia (body cooling) and additional magnesium sulfate will improve the outcome of severe Traumatic Brain Injury (TBI) patients.
- Trial name
- NCT01333488
- Testing
- Arctic Sun, Magnesium Sulfate
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- United States Department of Defense
Concussion, Mild Traumatic Brain Injury
Clinical Trial of a Rehabilitation Game - SuperBetter
Today's hospitals need innovative solutions to help patients transition from our care to self-management at home. The vast majority of the patients seen in Dodd Rehabilitation Hospital and associated clinics leave our care with…
- Conditions
- Concussion, Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury
- Trial name
- SuperBetter (NCT01398566)
- Testing
- SuperBetter play
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Ohio State University
Concussion, Mild, Convergence Insufficiency
Spectacles Lens in Concussed Kids
We will be looking at 3 treatment arms in the form of different type of glasses to see if one is superior to helping kids have sustained a concussion and are symptomatic.
- Conditions
- Concussion, Mild, Convergence Insufficiency, Accommodation; Insufficiency
- Trial name
- SLICK (NCT03123822)
- Testing
- Glasses
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Traumatic Brain Injury
Effect of Namenda on Short Term Memory and Attention in Patients With Mild to Moderate Traumatic Brain Injury
The purpose of this study is to determine whether memantine (Namenda) improves memory and attention in patients with mild to moderate traumatic brain injury.
- Trial name
- NCT00462228
- Testing
- Memantine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Missouri-Columbia
Traumatic Brain Injury
Study to Evaluate the Safety, Tolerability, and Efficacy of Armodafinil as Treatment for Patients With Excessive Sleepiness Associated With Mild or Moderate Closed Traumatic Brain Injury
The primary objective of this study is to evaluate the safety and tolerability of long-term (12 months) armodafinil treatment in patients with excessive sleepiness associated with mild or moderate closed traumatic brain injury…
- Trial name
- NCT00983437
- Testing
- Armodafinil
- Where
- 61 sites in United States
- Volunteers
- 49 people
- Sponsor
- Cephalon, Inc.
Traumatic Brain Injury
Advanced MRI Applications for Mild Traumatic Brain Injury - UCSF
This hypothesis-generating feasibility study compares mTBI Patients and Controls using advanced MRI Applications.
- Trial name
- TBI-2 (NCT02141360)
- Testing
- MRI Diagnostic
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- GE Healthcare
Persistent Post Traumatic Headache, Mild Traumatic Brain Injury
Remotely Supervised tDCS for Persistent Post-traumatic Headache
This pilot study is designed to provide preliminary data for a large scale, randomized clinical trial to evaluate the efficacy of remotely administrated at home transcranial Direct Current Stimulation (tDCS) with real-time…
- Trial name
- tDCS for PTH (NCT04012853)
- Testing
- transcranial direct current stimulation
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- VA Office of Research and Development
Vestibular Diseases, Labyrinth Diseases
Evaluation of a Sensory Enrichment Multimodal Device (SEMD) on Physical Therapy Patients With Disequilibrium
Purpose of this study is to determine the efficiency and safety of a Sensory Enrichment Multimodal Device (SEMD) when applied in conjunction with usual care vestibular-balance physical therapy for rehabilitation of patients who…
- Conditions
- Vestibular Diseases, Labyrinth Diseases, Ear Diseases, Otorhinolaryngologic Diseases
- Trial name
- SEMD (NCT01483937)
- Testing
- Usual care physical therapy plus SEMD, Usual care physical therapy only
- Where
- 4 sites in United States
- Volunteers
- 32 people
- Sponsor
- Karen L Atkins
Stress Disorders, Post-Traumatic, Concussion, Mild
Meditation in Veterans With PTSD and Mild TBI
The goal of this study is to learn more about how Inner Resources for Veterans (IRV), a mindfulness and mantra therapy, helps Veterans with Post Traumatic Stress Disorder (PTSD) and mild traumatic brain injury (mTBI).
- Trial name
- NCT02280304
- Testing
- Inner Resources for Veterans (IRV), Essential Skills therapy
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- VA Office of Research and Development
Concussion, Mild Traumatic Brain Injury
DHA For The Treatment of Pediatric Concussion Related to Sports Injury
In recent years, media attention has focused on the long-term sequelae of repeated concussive episodes in professional athletes.
- Trial name
- NCT01903525
- Testing
- Docosahexaenoic acid (DHA)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Texas Southwestern Medical Center
Traumatic Brain Injury
Adjunctive Pregnenolone in Veterans With Mild TBI
Mild traumatic brain injury (TBI) is common among veterans who have served in OEF/OIF (Operation Enduring Freedom in Afghanistan/Operation Iraqi Freedom) and other theatres.
- Trial name
- NCT00623506
- Testing
- Pregnenolone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Durham VA Medical Center
Mild Traumatic Brain Injury
Disparity Driven Vergence in Mild Traumatic Brain Injury (mTBI)
This study aims to determine the validity and safety of disparity driven vergence using a portable goggle system (I-PAS) using a pseudorandom ternary sequence of frequencies for testing.
- Trial name
- NCT03529799
- Testing
- I-PAS Goggles
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Miami
Concussion Post Syndrome, Headaches Posttraumatic
Pediatric Concussion Outcomes
This is a randomized, placebo-controlled, double-blinded trial in which subjects with a post concussive headache meeting inclusion criterion will be assigned to one of two treatment groups: placebo or nortriptyline.
- Conditions
- Concussion Post Syndrome, Headaches Posttraumatic, Mild Traumatic Brain Injury
- Trial name
- PeCon (NCT04226365)
- Testing
- Nortriptyline
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Lancaster General Hospital
Mild Traumatic Brain Injury, Distress-based Psychopathology
One-Day Life Skills Workshop for Veterans With TBI, Pain and Psychopathology
Traumatic brain injury (TBI) is the signature wound of Veterans returning from the recent operations in Iraq and Afghanistan (i.e OIF/OEF/OND), with up to 20 percent experiencing persistent post-concussive symptoms.
- Conditions
- Mild Traumatic Brain Injury, Distress-based Psychopathology, Chronic Pain
- Trial name
- NCT02844946
- Testing
- Acceptance and Commitment Therapy
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- VA Office of Research and Development