Clinical trials: Traumatic Brain Injury
Traumatic Brain Injury
PC-Based Cognitive Rehabilitation for Traumatic Brain Injury (TBI)
The investigators evaluated whether it was possible to improve the measurement of memory, attention, and executive function in patients who have suffered traumatic brain injury through the use of computer-based testing.
- Trial name
- NCT00927576
- Testing
- Digit span testing, Spatial span testing, Finger tapping
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Traumatic Brain Injury, Coma
The Efficacy of Familiar Voice Stimulation During Coma Recovery
The purpose of the study is to determine whether familiar vocal stimulation, provided during coma recovery, improves outcomes for persons who are unconscious after severe TBI.
- Conditions
- Traumatic Brain Injury, Coma, Vegetative State, Minimally Conscious State
- Trial name
- FAST (NCT00557076)
- Testing
- Familiar Auditory Sensory Training
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Hopelessness
Window to Hope-Evaluating a Psychological Treatment for Hopelessness Among Veterans With Traumatic Brain Injury
The purpose of this project is to provide further evidence regarding a groundbreaking psychological treatment for suicide prevention in individuals with moderate to severe traumatic brain injury (TBI), Window to Hope (WtoH).
- Conditions
- Traumatic Brain Injury, Hopelessness, Suicide
- Trial name
- WtoH (NCT01691378)
- Testing
- Window to Hope, Waitlist Control
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Lisa Brenner
Brain Injuries, Traumatic
Beta Blockade in in Traumatic Brain Injury
The purpose of this study is test the effect of beta-adrenergic blockade on mortality in patients with traumatic brain injury with the hypothesis being that the addition of beta blockade to the treatment regime of this patient…
- Trial name
- NCT02957331
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Tennessee
Brain Contusion
A Study to Evaluate the Efficacy and Safety of BIIB093 in Participants With Brain Contusion
The primary objective is to determine if BIIB093 reduces brain contusion expansion by Hour 96 when compared to placebo. The secondary objectives are to evaluate the effects of BIIB093 on acute neurologic status, functional…
- Trial name
- ASTRAL (NCT03954041)
- Testing
- BIIB093
- Where
- 63 sites in United States, France and 5 more
- Volunteers
- 92 people
- Sponsor
- Remedy Pharmaceuticals, Inc.
Traumatic Brain Injury
Noninvasive Modulation of Motivational Brain Regions in Healthy Volunteers
21 healthy control participants will be recruited. On Day 1 they will complete reward-guided decision making tasks and questionnaires followed by a functional magnetic resonance imaging (fMRI) scan.
- Trial name
- NCT04972786
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Brain Injury
Traumatic Brain Injury (TBI) Screening Instruments
Goal: The ultimate goal of this research program is to improve the health and quality of life for wounded warriors from Operations Enduring Freedom and Iraqi Freedom (OEF/OIF) through screening, risk assessment, and outcome…
- Trial name
- NCT00875329
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Chronic Subdural Hematoma
Middle Meningeal Artery Embolization for the Treatment of Subdural Hematomas With TRUFILL® n-BCA
This is a prospective, multi-center, open-label, randomized controlled study in which subjects can receive standard of care (SOC) alone or SOC and TRUFILL n-BCA MMA embolization for the treatment of chronic subdural hematomas…
- Trial name
- MEMBRANE (NCT04816591)
- Testing
- Experimental: Interventional Cohort: TRUFILL n-Butyl Cyanoacrylate (n-BCA) Liquid Embolic System, Standard of Care Surgery, Experimental: Interventional Cohort: TRUFILL n-BCA Liquid Embolic System
- Where
- 33 sites in United States, China
- Volunteers
- 376 people
- Sponsor
- Cerenovus, Part of DePuy Synthes Products, Inc.
Traumatic Brain Injury
Pilot and Feasibility of MEMI for Chronic Traumatic Brain Injury
This is a pilot and feasibility study for a mobile phone-delivered intervention for memory, called MEMI (memory ecological momentary intervention), that was designed to support adults with chronic traumatic brain injury with…
- Trial name
- NCT06375421
- Testing
- MEMI (Memory Ecological Momentary Intervention) Spaced Retrieval, Blocked Retrieval
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Concussion Injury of Cerebrum, Cranial Osteopathic Medicine
Cranial Osteopathic Manipulative Medicine as an Adjunct Treatment for Concussion
Patients who have concussions exhibit an array of symptoms, also known as post-concussive symptoms, including headaches, feeling slowed down or foggy and difficulty with concentration.
- Trial name
- NCT03225599
- Testing
- Cranial Osteopathic Manipulative Medicine
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Northwell Health
TBI (Traumatic Brain Injury), Brain Injuries
Brain Markers of Improvements in Cognitive Functioning
Some of the most common, persistent, and disabling consequences of traumatic brain injury affect an individual's ability to achieve personal goals.
- Conditions
- TBI (Traumatic Brain Injury), Brain Injuries, Stress, Attention Deficit
- Trial name
- NCT03490110
- Testing
- State regulation skill training, Treatment-as-usual
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- VA Office of Research and Development
Alcohol Use Disorder, Mild Traumatic Brain Injury
Pilot rTMS for AUD+mTBI
This is a pilot randomized controlled trial (RCT) for Veteran participants with alcohol use disorder co-occurring with mild traumatic brain injury and/or post-traumatic stress disorder.
- Conditions
- Alcohol Use Disorder, Mild Traumatic Brain Injury, Post-traumatic Stress Disorder
- Trial name
- TMS_AUD+mTBI (NCT03995173)
- Testing
- repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- VA Office of Research and Development
Chronic Pain, Traumatic Brain Injury
Establishing Efficacy of a Functional-Restoration Based CAM Pain Management Program in Post-9/11 Veterans
This is a research study of an interdisciplinary pain management program for U.S. military veterans who served during the post-9/11 combat eras (e.g., Operations Iraqi Freedom [OIF], Enduring Freedom [OEF], New Dawn [OND])…
- Conditions
- Chronic Pain, Traumatic Brain Injury, Posttraumatic Stress Disorder, Depression
- Trial name
- NCT02657317
- Testing
- FORT-A, VA Treatment as Usual
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Caregivers
Improving Outcomes for Care Partners of Persons With Traumatic Brain Injury
Care partners of persons with traumatic brain injury (TBI) are often faced with considerable physical and emotional stress resulting from their caregiver role.
- Trial name
- NCT04570930
- Testing
- Just-in-time adaptive intervention (JITAI), Control
- Where
- 2 sites in United States
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Traumatic Brain Injury
Effects of LEDs on Memory in TBI Patients
The purpose of the study is to investigate whether transcranial, high-intensity LED placed on the scalp can improve working memory in people who have sustained a concussion with lingering effects or a mild brain injury.
- Trial name
- LED (NCT01598532)
- Testing
- MedX Health Phototherapy (light therapy)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Spaulding Rehabilitation Hospital
Nervous System Disorders
Dysport® Adult Upper Limb Spasticity
The purpose of this research study is to assess the efficacy of Dysport compared to placebo in improving muscle tone in hemiparetic subjects with upper limb spasticity due to stroke or traumatic brain injury.
- Trial name
- NCT01313299
- Testing
- Botulinum toxin type A
- Where
- 40 sites in United States, Belgium and 7 more
- Volunteers
- 243 people
- Sponsor
- Ipsen
Brain Injuries, Traumatic, Transitional Care
Enhancing the Transition From Hospital to Home for Patients With Traumatic Brain Injury and Families
Despite high risks of readmission and complex medical needs, there are no transitional care standards in the U.S. for patients with moderate-to-severe traumatic brain injury (TBI) discharged home from acute hospital care without…
- Conditions
- Brain Injuries, Traumatic, Transitional Care, Family Members, Patients
- Trial name
- R03 (NCT04584554)
- Testing
- BETTER Transitional Care Intervention
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Duke University
Brain Injury, Concussion
Sub-Threshold Exercise Treatment for Adolescents With Sports Related Concussion
Adolescents with concussion will be randomly assigned to a treatment group where they will receive sub-threshold exercise, or assigned to a placebo group where they will receive structured stretching exercises.
- Trial name
- NCT02710123
- Testing
- Sub-Threshold exercise prescription, Structured stretching prescription
- Where
- United States
- Volunteers
- 113 people
- Sponsor
- University at Buffalo
Traumatic Brain Injury
Translational Research Examining Acupuncture Treatment in Traumatic Brain Injury
The purpose of this study is to examine the effects of acupuncture on cerebral blood flow (CBF) and blood biomarkers during the acute 10-day window following traumatic brain injury, to determine if those changes correlate with…
- Trial name
- TREAT-TBI (NCT02623218)
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- AOMA Graduate School of Integrative Medicine
Traumatic Brain Injury, Attention Deficit Disorder
Treatment of Traumatic Brain Injury (TBI)-Related Attention Deficits
The purpose of this research study is to evaluate whether Vyvanse, a psychostimulant, can help with attention deficits due to traumatic brain injury (TBI).
- Trial name
- NCT01000064
- Testing
- Vyvanse, fMRI
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Vanderbilt University