Clinical trials: Traumatic Brain Injury, completed
Mild Traumatic Brain Injury
High-Definition Transcranial Direct Current Stimulation (HD-tDCS) for Sensory Deficits in Complex Traumatic Brain Injury
Aim 1: To use magnetoencephalography (MEG) and magnetic resonance imaging (MRI) in Veterans and civilians with mild traumatic brain injury (mTBI) and sensory postconcussive symptoms (PCS) to demonstrate the mechanism of…
- Trial name
- NAVIGATE-TBI (NCT03799458)
- Testing
- Active High-definition transcranial direct current stimulation (HD-tDCS)
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Traumatic Brain Injury
Comparison of C-Reactive Protein Levels in Traumatic Brain Injury Patients Undergoing Craniotomy With and Without Dexmedetomidine
Traumatic Brain Injury (TBI) is a major cause of morbidity and mortality and is often associated with a systemic inflammatory response after surgery. C-reactive protein (CRP) is a commonly used biomarker to assess inflammation.
- Trial name
- DEX-CRP (NCT07406555)
- Testing
- Dexmedetomidine, Sufentanyl
- Where
- Indonesia
- Volunteers
- 25 people
- Sponsor
- Universitas Jenderal Soedirman
Blepharoptosis, Ptosis, Eyelid
Clinical Trial to Improve the Magnetic Levator Prosthesis
Blepharoptosis (incomplete opening of the eyelids) occurs because of a disruption in the normal agonist-antagonist neuro-muscular complex balance. An external device could restore eyelid movement.
- Conditions
- Blepharoptosis, Ptosis, Eyelid, Myasthenia Gravis, Stroke
- Trial name
- NCT03818204
- Testing
- Magnetic Levator Prosthesis (MLP)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Dementia, Stroke
Music Therapy on Cognition in Neurorehabilitation
Music therapy has received more attention with its surging application in neuro-rehabilitation overseas. Given the dearth of music therapy and cognitive rehabilitation research conducted in Malaysia, this pilot study intended to…
- Conditions
- Dementia, Stroke, Traumatic Brain Injury
- Trial name
- NCT06156735
- Testing
- Passive Music Therapy (P), Active Music Therapy (A), Standard Care Control Condition (C)
- Where
- Malaysia
- Volunteers
- 30 people
- Sponsor
- University of Malaya
Concussion, Mild
Multimodal Approach to Testing the Acute Effects of Mild Traumatic Brain Injury (mTBI)
The objective of the study is to determine the relative roles for various testing modalities in the diagnosis and prognosis of mild traumatic brain injury.
- Trial name
- NCT02069613
- Where
- 3 sites in United States
- Volunteers
- 44 people
- Sponsor
- Huntington Medical Research Institutes
Traumatic Brain Injury, Child Development
Heart Rate Variability in Children With Traumatic Brain Injury
Using a prospective cohort of children admitted to the PICU, the investigators will determine HRV monitoring is feasible, if a decreased HRV in the 7 days following moderate or severe TBI in children is associated with a worse…
- Trial name
- HRV-TBI (NCT03701620)
- Testing
- HRV monitoring
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- St. Justine's Hospital
Traumatic Brain Injury
Effects of Neurofeedback in Cognitive Deficit in Patients With TBI
Background: Cognitive impairment is common in patients with traumatic brain injury (TBI) at all levels of severity. Such impairments may affect their ability to return to work and thus increase healthcare costs and the associated…
- Trial name
- NCT03515317
- Testing
- LoRETA Z-score NF, theta/beta NF
- Where
- 4 sites in Taiwan
- Volunteers
- 74 people
- Sponsor
- Taipei Medical University
Traumatic Brain Injury (TBI), Hazardous and Harmful Alcohol Use
Topiramate Treatment of Hazardous and Harmful Alcohol Use in Veterans With TBI
The goal of the proposed project is to improve the treatment of veterans with co-occurring traumatic brain injury (TBI) and hazardous or harmful alcohol use.
- Trial name
- VAT (NCT01750268)
- Testing
- Medical Management Counseling, Topiramate
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, San Francisco
Traumatic Brain Injury
Physical Work Capacity After Traumatic Brain Injury
The purpose of this study is to determine whether body weight supported treadmill training is more effective than traditional physical therapy at restoring gait in persons recovering from traumatic brain injury.
- Trial name
- NCT00653640
- Testing
- body weight supported treadmill training, traditional physical therapy
- Where
- 2 sites in United States
- Volunteers
- 88 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Spinal Cord Injury
Cardiovascular, Cerebrovascular, and Cognitive Function in Spinal Cord Injury
Increased life expectancy in individuals with spinal cord injury (SCI) present clinicians with the challenge of managing the secondary complications of SCI with the chronic diseases common in an aging population.
- Trial name
- NCT02122991
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Traumatic Brain Injury, Subarachnoid Hemorrhage
Assess Safety and Efficacy of Levetiracetam(LEV;Keppra)for Seizure Prevention
To show that the use of intravenous levetiracetam(LEV;Keppra)for seizure prevention in patients in the Neuroscience Intensive Care Unit will result in fewer side effects compared to the current standard of care anticonvulsant and…
- Trial name
- Keppra (NCT00618436)
- Testing
- Levetiracetam, Phenytoin
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Cincinnati
Traumatic Brain Injury, Parkinson's Disease
Imaging Biomarkers of Delayed Sequelae in Trauma Brain Injury
The purpose of this study is to learn if a new brain imaging technology called DaTscan can detect subtle changes in the brain that are similar to those seen in early Parkinson's disease (PD).
- Trial name
- NCT01516281
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Mild Traumatic Brain Injury, Posttraumatic Stress Disorders
Multifamily Group to Reduce Marital Conflict and Disability in Veterans With mTBI
This project addresses the rehabilitation and mental health needs of married combat Veterans post-deployed from Iraq or Afghanistan with a mild traumatic brain injury (mTBI) and/or significant posttraumatic stress (PTS) or…
- Conditions
- Mild Traumatic Brain Injury, Posttraumatic Stress Disorders, Depression
- Trial name
- MFG-mTBI (NCT02057081)
- Testing
- Multifamily Group for mTBI for Couples, Group Health Education (GHE)
- Where
- 3 sites in United States
- Volunteers
- 249 people
- Sponsor
- VA Office of Research and Development
Concussion
Pathology in the Brain After mTBI - A Multimodal MRI Study
The purpose is to use Diffusion Kurtosis Imaging (DKI), Diffusion Tensor Imaging (DTI) and resting state functional MRI to examine tissue damage in the brains of people who have had a concussion, both acute and 3 months after the…
- Trial name
- NCT01936792
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Traumatic Brain Injury
Transforming Research and Clinical Knowledge in Traumatic Brain Injury
The overall goal of Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) study is to determine the relationships among the clinical, neuroimaging, cognitive, genetic and proteomic biomarker…
- Trial name
- TRACK-TBI (NCT02119182)
- Testing
- In-Person Outcome Assessment, Phone Outcome Assessment, 3T Magnetic Resonance Imaging (MRI)
- Where
- 23 sites in United States
- Volunteers
- 2,996 people
- Sponsor
- University of California, San Francisco
Traumatic Brain Injury
Myocardial Dysfunction at Early Phase of Traumatic Brain Injury : Evaluation by Two Dimensional and Speckle Tracking Transthoracic Echocardiography
Traumatic brain injury (TBI) is a frequent pathology leading to major morbidity and mortality in young people. Cerebral flood flow maintenance is a major goal directed therapy to improve the prognosis of the patient.
- Trial name
- Echo-TC (NCT02380482)
- Testing
- Transthoracic echocardiography on TBI patients, Transthoracic echocardiography on control patients
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Grenoble
Acute Respiratory Distress Syndrome, Acute Lung Injury
Non-invasive Vagal Neurostimulation (nVNS) for Traumatic Brain Injury (TBI)-Induced Acute Respiratory Distress
This is a prospective, randomized, two-arm, controlled 30-day investigational pilot trial using the gammaCore Sapphire S non-invasive vagus nerve stimulation (nVNS) device + standard of care (SOC) in newly-hospitalized patients…
- Conditions
- Acute Respiratory Distress Syndrome, Acute Lung Injury, Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Traumatic Brain Injury
- Trial name
- NCT04935697
- Testing
- nVNS, SOC
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Traumatic Brain Injury (TBI), Post Traumatic Stress Disorder (PTSD)
Effectiveness of a Driving Intervention on Safe Community Mobility for Returning Combat Veterans
The main objective of this study is to discern if an Occupational Therapy Driving Intervention (OT-DI) improves fitness to drive abilities of Combat Veterans and also investigate if results leads to reduced driving errors on the…
- Trial name
- NCT02765672
- Testing
- Driving Behavior Interview, Clinical Driving Assessment, Propensity for Angry Driving Scale
- Where
- 2 sites in United States
- Volunteers
- 58 people
- Sponsor
- University of Florida
Statistical Analysis of Traumatic Brain Injury Victims
Morbidity and Mortality in Solo Adult Traumatic Brain Injury Patients in Minia University Hospital
Tracking post-traumatic brain injury sequale
- Trial name
- NCT05075239
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Minia University
Trumatic Brain Injury
Impact of Sensory Stimulation Techniques on Consciousness Levels
Traumatic brain injury is a leading cause of long-term disability, necessitating innovative rehabilitation methods. This study evaluates the effectiveness of integrating nursing techniques with arousal enhancement protocol to…
- Trial name
- NCT06664463
- Testing
- Arousal enhancment protocol, Routine Care
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University