Clinical trials: Traumatic Brain Injury (TBI)
PTSD - Post Traumatic Stress Disorder, TBI-Traumatic Brain Injury
Adaptation of the STAIR-NT for First Responders
This study is a randomized controlled pilot examining the implementation of an adapted intervention, Skills Training in Affective and Interpersonal Regulation-Narrative Therapy (STAIR-NT), among a first responder population with…
- Trial name
- NCT07212140
- Testing
- Adapted STAIR-NT
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Florida State University
TBI (Traumatic Brain Injury), ICP (Intracranial Pressure) Increase
Comparison of Hyperosmolar Agent in Reduction of Increased Intracranial Pressure in Patients With Traumatic Brain Injury Using Ultrasonography
The aim of this study to compare the efficacy of hypertonic saline and mannitol in reducing intracranial pressure, as assessed by serial optic nerve sheath diameter (ONSD) ultrasound measurements, in patients with traumatic brain…
- Conditions
- TBI (Traumatic Brain Injury), ICP (Intracranial Pressure) Increase, Optic Nerve Sheath Diameter Measurement
- Trial name
- MHTS-ONSD (NCT07786324)
- Testing
- Mannitol (20%), Hypertonic Saline ( 3% Sodium Chloride Saline)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
TBI Traumatic Brain Injury
Feasibility of SUPPORT-TBI
Many people who have had a traumatic brain injury (TBI) struggle to stay connected with others. They often lose friendships, become isolated, and have strained family relationships.
- Trial name
- NCT07625098
- Testing
- SUPPORT-TBI
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington University School of Medicine
TBI (Traumatic Brain Injury)
ENGAGE-TBI Feasibility Study
This study will first evaluate the feasibility of delivering the ENGAGE-TBI intervention in a community setting with adults with TBI.
- Trial name
- NCT07549997
- Testing
- Social intervention study for TBI survivors
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Moderate Traumatic Brain Injury (TBI), Severe Traumatic Brain Injury
Valproic AcId for Traumatic BRAin INjury Trial
The long-term goal of the clinical trial is to develop effective, safe, and easily administered life-saving treatments for patients with moderate to severe traumatic brain injury (TBI).
- Trial name
- VIBRANT (NCT07166393)
- Testing
- Valproic Acid (VPA), Standard of care treatment + normal saline
- Where
- 8 sites in United States
- Volunteers
- 432 people
- Sponsor
- Northwestern University
Traumatic Brain Injury, TBI (Traumatic Brain Injury)
Paired VNS For TBI Rehabilitation
This study is evaluating whether pairing vagus nerve stimulation (VNS) with structured upper limb rehabilitation therapy can improve arm and hand function in individuals with chronic moderate to severe traumatic brain injury…
- Trial name
- VNS for TBI (NCT07719829)
- Testing
- VNS for TBI group
- Volunteers
- 20 people
- Sponsor
- Stony Brook University
Traumatic Brain Injury, Concussion, Intermediate
Intervention to Change Affect Recognition and Empathy
Determine the feasibility, practicality, and early efficacy of a TeleRehab program (ICARE) to improve outcomes for persons with traumatic brain injury (TBI) in recognizing and responding to others' emotions alongside their care…
- Conditions
- Traumatic Brain Injury, Concussion, Intermediate, Concussion, Severe, Concussion With LOC 31 to 59 Minutes
- Trial name
- ICARE (NCT05636020)
- Testing
- ICARE Treatment
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Indiana University
Traumatic Brain Injury (TBI), Posttraumatic Stress Disorder (PTSD)
Cognitive Rehabilitation for Treatment of Anger in Veterans With TBI and PTSD
This randomized clinical trial will enroll 100 Veteran-family/friend dyads to test the efficacy of CALM in treating anger in TBI and PTSD.
- Trial name
- CALM (NCT07227987)
- Testing
- CALM (Cognitive Apps for Life Management), Psychoeducation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Duke University
Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients
Comparing Approaches to Helping People With Chronic Traumatic Brain Injury Manage Their Health Care
The goal of this double-masked, randomized control trial is to learn about the potential benefits of two different strategies at helping people with traumatic brain injury who see a brain injury physician be more engaged in their…
- Conditions
- Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients, TBI
- Trial name
- 2BeHealthy (NCT07483528)
- Testing
- Patient Priorities Care (PPC), Resource Education
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- Indiana University
TBI (Traumatic Brain Injury)
Evaluation of Decision-Making Fatigue After Traumatic Brain Injury
This is a preliminary, prospective, cohort study to investigate the feasibility of using the COGED and Restless Bandit tasks after a mild to moderate traumatic brain injury as well as in healthy controls.
- Trial name
- EDIFY (NCT07103200)
- Testing
- COGED, Restless Bandit
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
TBI Traumatic Brain Injury
Efficacy of Early Continuous Infusion of HSS on the Neurological Outcome at 6 Months in TBI Patients.
The purpose of this study is to demonstrate the efficacy of early continuous intravenous infusion of hypertonic saline solution (HSS) to improve survival and independence in daily life activities (at 6 months) of patients with…
- Trial name
- COSMOS-TBI (NCT07319208)
- Testing
- Hypertonic saline solution
- Where
- 23 sites in France
- Volunteers
- 760 people
- Sponsor
- Nantes University Hospital
Chronic Traumatic Brain Injury, TBI (Traumatic Brain Injury)
Cognitive Network Restoration Therapy for Moderate to Severe Traumatic Brain Injury: A Feasibility Study
The purpose of this feasibility clinical investigation is to evaluate the safety and usability of central thalamic deep brain stimulation (CT-DBS) for use in patients with chronic moderate to severe traumatic brain injury (TBI)…
- Trial name
- NCT07730099
- Testing
- Deep brain stimulation
- Volunteers
- 40 people
- Sponsor
- ReEmerge, Inc.
Traumatic Brain Injury, TBI (Traumatic Brain Injury)
Cervical Transcutaneous SCS for TBI
The goal of this study is to test the effects of non-invasive electrical stimulation of the spinal cord (called transcutaneous spinal cord stimulation, or tSCS) on arm and hand movement in people with motor impairments after a…
- Trial name
- NCT07147816
- Testing
- Transcutaneous electrical stimulation of the cervical spinal cord (tSCS)
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Roberto de Freitas
Traumatic Brain Injury, Traumatic Brain Injury | Patient
A Pilot Study of Home-Based Rhythmic Auditory Stimulation to Evaluate Mobility, Balance, and Patient-Reported Outcomes After Traumatic Brain Injury
The goal of this study is to learn whether a home-based rhythmic auditory stimulation (RAS) program using the MR-001 device can help improve walking, balance, and other health outcomes in adults with moderate to severe traumatic…
- Conditions
- Traumatic Brain Injury, Traumatic Brain Injury | Patient, TBI, TBI-Traumatic Brain Injury
- Trial name
- BEAT TBI (NCT07702513)
- Testing
- Home-Based Rhythmic Auditory Stimulation
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Craig Hospital
TBI (Traumatic Brain Injury), Cognitive Symptoms
Cognitive Rehabilitation for Victims of War and Related Traumas With Traumatic Brain Injury and Cognitive Impairment
Researchers at Massachusetts General Hospital are looking to see if a program created to help improve thinking and memory can work for people affected by trauma, including asylum seekers and refugees, survivors of intimate…
- Trial name
- NCT06839079
- Testing
- A Trauma-informed, Paraprofessional Delivered Virtual Cognitive Rehabilitation Program
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
PTSD - Post Traumatic Stress Disorder, Insomnia
Suvorexant 3 - PE-PC
The goal of this clinical trial is to learn if combining suvorexant (a sleep medication) with a shorter form of prolonged exposure therapy called PE-PC works to treat PTSD symptoms and improve sleep in Veterans and military…
- Conditions
- PTSD - Post Traumatic Stress Disorder, Insomnia, TBI (Traumatic Brain Injury)
- Trial name
- NCT07686731
- Testing
- Suvorexant, Prolonged Exposure Therapy for Primary Care (PE-PC)
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- Northern California Institute of Research and Education
TBI (Traumatic Brain Injury), Implementation Research
Emergency Department Implementation of the i-STAT Alinity Traumatic Brain Injury Whole Blood Test
The objective of this study is to identify determinants for implementing the i-STAT Alinity whole blood traumatic brain injury (TBI) test for its Food and Drug Administration (FDA)-indicated use and to evaluate other potential…
- Trial name
- EDI (NCT07373509)
- Testing
- i-STAT Alinity TBI test
- Where
- United States
- Volunteers
- 340 people
- Sponsor
- Shawn Eagle
Traumatic Brain Injury With Loss of Consciousness, Brain Injury Traumatic Severe
Cerebral Autoregulation, Brain Perfusion, and Neurocognitive Outcomes After Traumatic Brain Injury
Cognitive impairment after moderate to severe traumatic brain injury (msTBI) not only significantly affects the quality of life in individuals with msTBI, but also increases the possibility of late-life dementia.
- Conditions
- Traumatic Brain Injury With Loss of Consciousness, Brain Injury Traumatic Severe, Brain Injury Traumatic Moderate, TBI (Traumatic Brain Injury)
- Trial name
- CAPCOG-TBI (NCT06480838)
- Where
- 3 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of Texas Southwestern Medical Center
TBI Traumatic Brain Injury
Noninvasive Brain Stimulation to Enhance Cognition at Home Following a TBI.
The purpose of this study is to examine the feasibility and preliminary efficacy of using transcutaneous vagus nerve stimulation (tVNS) at home, to enhance cognitive recovery in patients with mild-moderate traumatic brain injury…
- Trial name
- NCT07428980
- Testing
- Transcutaneous Vagus Nerve Stimulation (tVNS)
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Shirley Ryan AbilityLab
Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness
fNIRS for Disorders of Consciousness
The goal of this observational study is to learn whether functional near-infrared spectroscopy (fNIRS) can measure brain activity in healthy adults and in people with disorders of consciousness (DoC) in the neuro-intensive care…
- Conditions
- Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness, Coma, Minimally Conscious State
- Trial name
- NCT07485361
- Testing
- Functional Near-Infrared Spectroscopy Monitoring
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles