Clinical trials: Traumatic Brain Injury (TBI)
Traumatic Brain Injury
Evaluation, Pathogenesis, and Outcome of Subjects With or Suspected Traumatic Brain Injury
Background: Traumatic brain injury may have a range of effects, from severe and permanent disability to more subtle functional and cognitive deficits that often go undetected during initial treatment.
- Trial name
- NCT01132937
- Where
- United States
- Volunteers
- 886 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Brain Injuries, Traumatic
Acute Intermittent Hypoxia in Traumatic Brain Injury
This study is designed to answer questions related to safety and preliminary efficacy of Acute Intermittent Hypoxia (AIH) in Traumatic Brain Injury (TBI) survivors.
- Trial name
- AIH (NCT04890639)
- Testing
- Acute Intermittent Hypoxia
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Shirley Ryan AbilityLab
Brain Injuries, Traumatic
Outcomes of Traumatic Brain Injury and External Validation of CRASH Prognostic Model
As per World Health Organization (WHO) 2015 report, road injury is the tenth cause of mortality in the world. 90% of these occur in Low and Middle-Income countries (LMICs) Amongst Injuries, Traumatic Brain Injuries is the leading…
- Trial name
- NCT03932500
- Where
- India
- Volunteers
- 500 people
- Sponsor
- Seth Gordhandas Sunderdas Medical College
Brain Concussion, Dizziness
Effectiveness of Early Physical Therapy Intervention for Patients With Dizziness After a Sports-Related Concussion
Therefore, the purpose of this pilot study is to determine the feasibility of conducting a randomized clinical trial (RCT) on physical therapist treatment for dizziness after sports-related concussion.
- Trial name
- NCT02299128
- Testing
- Physical Therapy Treatment
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Walsh University
Traumatic Brain Injury (TBI)
A First in Human Study of the Safety, Tolerability and Pharmacokinetics of PRV-002 in Healthy Volunteers
The purpose of this study is to assess the safety, tolerability, and pharmacokinetics of different dose levels of PRV-002 in Health Volunteers
- Trial name
- NCT05033444
- Testing
- PRV-002
- Where
- Australia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Odyssey Group International, Inc.
Insomnia Chronic, Mild Traumatic Brain Injury
Internet-guided Cognitive Behavioral Therapy for Insomnia in Military Service Members With History of TBI
This study aims to validate an established internet-guided cognitive behavioral therapy for insomnia (CBT-I) as an alternative program to traditional in-person therapy that may increase treatment availability and utilization…
- Trial name
- NCT04377009
- Testing
- Sleep Healthy Using the Internet (SHUTi), Education Control Program
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Mild Traumatic Brain Injury, Photophobia
Pilot Study of Neurofeedback for Photosensitivity in Mild Traumatic Brain Injury
The goal of this study is to complete a pilot study testing the feasibility and acceptability of low-intensity pulse-based transcranial stimulation (LIP-tES) neurofeedback intervention for reducing photosensitivity symptoms in…
- Trial name
- NCT06109909
- Testing
- Micro Current Neurofeedback Device using Low-Frequency Pulse-Based Transcranial Electrical Stimulation
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Coping Skills
Telemedicine Brain Injury Coping Skills (BICS-T) Support Group for Brain Injury Survivors and Their Caregivers
Brain Injury can be devastating for both patients and family members and can result in chronic difficulties in vocational, social, financial, as well as physical functioning.
- Trial name
- BICS-T I (NCT04371211)
- Testing
- Telemedicine Brain Injury Coping Skills
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Rehabilitation Hospital of Indiana
Stroke, Traumatic Brain Injury
Informal Caregivers ANSWERS-VA
The purpose of this study is to determine the effectiveness of the ANSWERS- VA intervention (Acquiring New Skills While Enhancing Remaining Strengths for Veterans) while also determining it's cost effectiveness in the stroke and…
- Trial name
- NCT02398409
- Testing
- ANSWERS - Acquiring New Skills While Enhancing Remaining Strengths, Control
- Where
- 2 sites in United States
- Volunteers
- 143 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
IRB-HSR# 14299: The Use of the Intrathoracic Pressure Regulator (ITPR) to Improve Cerebral Perfusion Pressure in Patients With Altered Intracranial Elastance
Patients who have a functioning intracranial pressure-monitoring device (either a subarachnoid bolt, or an intraventricular catheter) in place, and are either sedated, intubated, and mechanically ventilated (i.e.
- Trial name
- NCT01205607
- Testing
- ITPR -5 mm Hg then -9 mm Hg, ITPR -9 & then -5mm Hg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Virginia
Traumatic Brain Injury
Intervention to Promote Survivor Resilience and Adjustment: Efficacy and Sustainability
The aims of this traumatic brain injury (TBI) study are: 1. to evaluate the short and long-term efficacy of two structured outpatient intervention programs, Resilience and Adjustment Intervention (RAI) vs.
- Trial name
- NCT03421964
- Testing
- Resilience/Adjustment Counseling, Resilience/Adjustment Counseling with Booster Sessions
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- Virginia Commonwealth University
Mild Traumatic Brain Injury
A Study of Biomarkers of Mild Traumatic BRAIN Injury
Patients with mild traumatic brain injury (mTBI) represent a burden of patients admitted to the emergency department. According to the guidelines, a cerebral CT scan is indicated after mTBI according to the specific conditions.
- Trial name
- BRAINI (NCT04032509)
- Testing
- 2 x 5 mL blood sample
- Where
- 16 sites in France, Spain
- Volunteers
- 1,501 people
- Sponsor
- University Hospital, Grenoble
Central Auditory Processing Disorder, Traumatic Brain Injury
Central Auditory Processing Disorders Associated With Blast Exposure
The incidence of central auditory dysfunction in war fighters who are exposed to high-explosive blasts while serving in combat have not been clearly determined.
- Conditions
- Central Auditory Processing Disorder, Traumatic Brain Injury, Hearing Loss
- Trial name
- NCT00554801
- Testing
- Audiological testing
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cognitive Function 1, Social
Social Cognition Assessment in Young Adults
The primary objective of this study is to determine the efficacy and feasibility of a battery of neuropsychological measures evaluating social cognition and behavior in young adults diagnosed with schizophrenia, autism spectrum…
- Trial name
- NCT02922400
- Testing
- Social Cognition Assessment and Training
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Concussion, Brain
Developing a Tool to Support Shared Decision Making Post-Concussion Between Adolescents, Parents and Clinicians
Investigators will conduct a pilot efficacy test of a decision aid about contact sport participation post-concussion.
- Trial name
- NCT04777864
- Testing
- Decision Aid
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Traumatic Brain Injury (TBI) Patients
Efficacy of Propranolol in Traumatic Brain Injury Patients Admitted to the ICU: A Prospective, Randomized, Triple-Blind Study
Beta-blockers have shown promise as a treatment to improve patient prognosis following traumatic brain injury (TBI), although the exact mechanism by which they might confer this benefit remains unknown.
- Trial name
- ProP-TBI ICU (NCT07899164)
- Where
- 6 sites in Spain
- Volunteers
- 536 people
- Sponsor
- Fundació d'investigació Sanitària de les Illes Balears
Chronic Troublesome Sialorrhea, Parkinson's Disease
Clinical Study to Investigate the Efficacy and Safety of Two Dose Levels of NT 201 Versus Placebo in Treating Chronic Troublesome Sialorrhea in Various Neurological Conditions
The objective of this study is to investigate the efficacy and safety of two different dose levels of NT 201 (75 U or 100 U per cycle), compared with placebo, in reducing the salivary flow rate, and the severity and frequency of…
- Conditions
- Chronic Troublesome Sialorrhea, Parkinson's Disease, Post-stroke, Traumatic Brain Injury
- Trial name
- SIAXI (NCT02091739)
- Testing
- IncobotulinumtoxinA (100 Units), IncobotulinumtoxinA (75 Units)
- Where
- 31 sites in Germany, Poland
- Volunteers
- 184 people
- Sponsor
- Merz Pharmaceuticals GmbH
Intracranial Hypertension, Acute Brain Injury
Non-Invasive Triage for Intracranial Hypertension in Prehospital Care
This study tests whether two non-invasive tools can help paramedics detect dangerously high pressure inside the skull in patients with a sudden brain injury, such as stroke or head trauma, before they reach the hospital.
- Conditions
- Intracranial Hypertension, Acute Brain Injury, Stroke, Traumatic Brain Injury
- Trial name
- B4C-APH (NCT07747636)
- Testing
- Brain4care non-invasive intracranial pressure monitor, Optic nerve sheath diameter ultrasound
- Volunteers
- 180 people
- Sponsor
- Juliana Caldas
Traumatic Brain Injury, Intracranial Hypertension
A Non-invasive Intracranial Pressure (nICP) Monitoring System
Researchers have developed a probe that contains infrared light sources that can illuminate the deep brain tissue of the frontal lobe.
- Trial name
- NCT05632302
- Testing
- nICP
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Crainio Ltda
Migraine, Traumatic Brain Injury
Efficacy of Xeomin for Migraines in Patients With Traumatic Brain Injuries vs. Anomalous Health Incidents
This cohort study aims to compare the efficacy of Xeomin injections for migraine management in patients with a history of Traumatic Brain Injury (TBI) versus those with a history of Anomalous Health Incidents (AHI).
- Conditions
- Migraine, Traumatic Brain Injury, Anomalous Health Incidents
- Trial name
- NCT07267819
- Testing
- Xeomin (incobotulinumtoxinA)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Uniformed Services University of the Health Sciences
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