Clinical trials: Traumatic Brain Injury (TBI)
Concussion, Brain
Role of Rehabilitation in Concussion Management: A Randomized Controlled Trial
Approximately 420 professional and amateur athletes will participate in rehabilitation during recovery after sports-related concussion. Participants will be cluster randomized, by study site, to a specific study arm.
- Trial name
- NCT02988596
- Testing
- Multidimensional Active Rehabilitation, Enhanced Graded Exertion
- Where
- 11 sites in United States, Canada and 1 more
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Iatrogenic Withdrawal Symptomes
Iatrogenic Withdrawal Symptoms in Severe Traumatic Brain Injury
Iatrogenic withdrawal symptomes has been associated with prolonged mechanical ventilation and the and the derived symptoms such as fever and agitation has been shown to cause significantly prolonged ICU and hospital length of…
- Trial name
- NCT04320927
- Where
- Denmark
- Volunteers
- 215 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Brain Injuries, Traumatic Brain Injury
Digital Gaming for Persons With Traumatic Brain Injury
The purpose of this feasibility study is to determine whether digital games are effective and acceptable in the treatment for patients with traumatic brain injury.
- Conditions
- Brain Injuries, Traumatic Brain Injury, TBI (Traumatic Brain Injury), Injury, Brain, Traumatic
- Trial name
- PLAY (NCT02425527)
- Testing
- The rehabilitation gaming, The entertaining gaming
- Where
- Finland
- Volunteers
- 90 people
- Sponsor
- University of Turku
Stroke, Traumatic Brain Injury
Comparison of Gait Metrics in Patients With Stroke, Traumatic Brain Injury, and Multiple Sclerosis
People with neurological conditions often have difficulty walking, including problems such as foot drop. Functional electrical stimulation (FES) is a treatment that uses electrical signals to activate muscles and support walking.
- Conditions
- Stroke, Traumatic Brain Injury, Multiple Sclerosis
- Trial name
- NCT07492602
- Testing
- Functional Electrical Stimulation, Normal care
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Concussion
Cervicovestibular Physiotherapy and Aerobic Exercise in Concussion
Sport concussions are among the most commonly occurring injuries in sport and recreation and pose significant public health implications for Canadians.
- Trial name
- NCT02988323
- Testing
- Cervicovestibular Physio (CV PT), Low-Level Aerobic Exercise (LLAE), Combination (LLAE and CV PT)
- Volunteers
- 96 people
- Sponsor
- Sport Injury Prevention Research Centre
Traumatic Brain Injury, Post-traumatic Stress Disorder
Improving Sleep in Veterans With the Polytrauma Clinical Triad
The "polytrauma clinical triad" (PCT), a highly disabling constellation of factors, is defined by the coexistence of traumatic brain injury, post-traumatic stress disorder, and chronic pain.
- Conditions
- Traumatic Brain Injury, Post-traumatic Stress Disorder, Chronic Pain
- Trial name
- LIONv2 (NCT06477796)
- Testing
- Morning Bright Light Therapy, Negative Ion Generator
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- VA Office of Research and Development
Brain Injuries, Traumatic, Cerebrovascular Circulation
CPPopt Guided Therapy: Assessment of Target Effectiveness
Despite improvements in management, mortality in severe traumatic brain injury (TBI) remains 25% and only 40% of patients survive without major handicap.
- Conditions
- Brain Injuries, Traumatic, Cerebrovascular Circulation, Homeostasis
- Trial name
- COGITATE (NCT02982122)
- Testing
- For both groups, CPP targets will be achieved first by ICP control if this is raised and then by ABP support by titration (up or down) of vasopressors and fluids according to local protocols.
- Where
- 2 sites in Belgium, United Kingdom
- Volunteers
- 60 people
- Sponsor
- Maastricht University Medical Center
Traumatic Brain Injury, Cerebral Hemorrhage
TCD Detection of Ophthalmic Artery Blood Flow Velocity Prediction Feasibility Study of Intracranial Pressure
Increased intracranial pressure is a cause of disease progression in patients with brain disease, a common cause of poor prognosis.
- Conditions
- Traumatic Brain Injury, Cerebral Hemorrhage, Increased Intracranial Pressure
- Trial name
- NCT02240394
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Minor/Mild Traumatic Brain Injury
S100 Protein in Minor/Mild Traumatic Brain Injury
Traumatic brain injury (TBI) is a Public Health problem, because of the numbers of events (more than 200,000 per year in France).
- Trial name
- S100 (NCT00822445)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Depression, Brain Injuries, Traumatic
Buspirone and Melatonin for Depression Following Traumatic Brain Injury
Traumatic brain injuries (TBIs) are common. Post-TBI depression is associated with anxiety, aggression, fatigue, distractibility, anger, irritability, and rumination.
- Trial name
- NCT04400266
- Testing
- Buspirone, Mealatonin
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Traumatic Brain Injury, Posttraumatic Stress Disorder
Cognitively Augmented Behavioral Activation for Veterans With Comorbid TBI/PTSD
The primary objective of this study is to evaluate the efficacy of Cognitively Augmented Behavioral Activation (CABA), a new hybrid treatment for Veterans diagnosed with comorbid mild Traumatic Brain Injury (mTBI) and…
- Trial name
- CABA (NCT02391402)
- Testing
- Cognitively Augmented Behavioral Activation, Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 73 people
- Sponsor
- VA Office of Research and Development
Dysexecutive Syndrome
Modulation and Assessment of Mental Flexibility in Dysexecutive Brain Patients
This project aims to (1) define and characterize brain networks of cognitive flexibility amongst patients with frontal lesions; (2) quantify the effects of ecological cognitive trainings and brain stimulation on behavioral…
- Trial name
- MODEX (NCT04253522)
- Testing
- Cognitive training
- Where
- France
- Volunteers
- 16 people
- Sponsor
- University Hospital, Toulouse
Mild Traumatic Brain Injury
Combining Attention and Metacognitive Training to Improve Goal Directed Behavior in Veterans With TBI
Veterans with mild traumatic brain injury continue to deal with symptoms that interfere with their ability to engage in productive activities.
- Trial name
- NCT04044456
- Testing
- Goal Management Training, Attention Training, Brain Health Workshop
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
Co-ultra PEALut Enhances Neuronal Recovery Following Moderate Traumatic Brain Injury
Traumatic brain injury (TBI) typically provokes secondary injury mechanisms, including the dynamic interplay between the ischemic, inflammatory, and cytotoxic processes.
- Trial name
- GLIA13 (NCT03818451)
- Testing
- Co-ultraPEALut (Glialia)
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Messina
Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders
Integrating Metabolism, Connectivity, and Mesoscale Imaging at Ultra-high Field to Decipher Mechanisms of Resilience and Neurodegeneration in Neurological Diseases and Healthy Aging
The MESO7 study is a prospective observational research project designed to investigate the mechanisms of resilience and neurodegeneration in neurological diseases and healthy aging.
- Conditions
- Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD), Alzheimer Disease
- Trial name
- MESO7 (NCT07202494)
- Testing
- Imaging Techniques (MRI 3T & 7T, Functional, Structural, and Metabolic Imaging)
- Where
- France
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Tbi, Intracranial Edema
Comparative Effectiveness of Family Problem-Solving Therapy (F-PST) for Adolescent TBI
Traumatic brain injury (TBI) is the most common cause of acquired disability in youth and a source of significant morbidity and family burden.
- Conditions
- Tbi, Intracranial Edema, Brain Edema, Craniocerebral Trauma
- Trial name
- NCT02368366
- Testing
- Therapist Guided Face to Face Family Problem Solving, Therapist Guided Online Family Problem Solving, Self-Guided Online Family Problem Solving
- Where
- 5 sites in United States
- Volunteers
- 151 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Autonomic Nervous System Disease, Concussive Injury
Randomized Controlled Trial of Treatment to Optimize Heart Rate Variability for Persistent Post-Concussion Symptoms
Many combat veterans (c-Vs), service members (SMs) and civilians with mild traumatic brain injury (mTBI, also termed concussion) suffer from persistent post-concussion symptoms (PPCS) that degrade physical and cognitive…
- Conditions
- Autonomic Nervous System Disease, Concussive Injury, Mild Traumatic Brain Injury, Post Traumatic Stress Disorder
- Trial name
- NCT07071350
- Testing
- HRV Coherence Ratio, NSI, Pittsburgh Sleep Quality Index (PSQI)
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Virginia Commonwealth University
Traumatic Brain Injury (TBI)
Functional Recovery Effect of Bloodletting Puncture at Jing-well Points on Acute Brain Injury Patients
Traumatic brain injury (Traumatic brain injury, TBI) can be derived from various forms of injury, including blunt trauma, penetrating or acceleration/deceleration force caused by head injury.There are some study data show that…
- Trial name
- NCT04930146
- Testing
- acupuncture and bloodletting
- Where
- Taiwan
- Volunteers
- 72 people
- Sponsor
- Chang Gung Memorial Hospital
Brain Injuries, Acquired Brain Injury
Human-Animal Interaction to Promote Recovery Following Pediatric Brain Injury
This study evaluates the addition of therapy dogs in inpatient physical and occupational therapy. Data will be collected across 10 PT and 10 OT sessions, half of which will incorporate a therapy dog.
- Conditions
- Brain Injuries, Acquired Brain Injury, Traumatic Brain Injury
- Trial name
- AAT (NCT04016961)
- Testing
- AAT - Dog, TAU - No Dog
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Concussion, Mild
Impact of Instability Training on Vestibular Dysfunction in Postconcussion Combat Athletes
We are conducting RCT study on concussion on combat sports athlete and there is high incidence of on concussion in this sports and we will find the association between concussion and vestibular impairment and then we will apply…
- Trial name
- NCT07729761
- Testing
- Traditional Physical therapy, Instability training
- Where
- Pakistan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Riphah International University