Clinical trials: Traumatic Brain Injury (TBI)
Cognition Disorder, Functional Brain Imaging
fMRI and NIRS Imaging for Traumatic Brain Injury
Background: The amount of blood flowing in brain areas goes up when those areas are being used for activities, such as movement or seeing.
- Trial name
- NCT01668758
- Volunteers
- healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Mild Traumatic Brain Injury, Cognitive Impairment
The Effect of Cognitive Rehabilitation Therapy in Improving Cognitive Function of Attention Following Mild Traumatic Brain Injury
This research is a randomised controlled study. The study hypothesis is cognitive rehabilitation for attention deficits following mild traumatic brain injury will improve patient's cognitive outcome, measured by…
- Trial name
- NCT03237676
- Testing
- Structured cognitive rehabilitation therapy, Patient-centred cognitive therapy
- Where
- Malaysia
- Volunteers
- 90 people
- Sponsor
- University of Malaya
Traumatic Brain Injury
Effect of Intermittent Oro-esophageal Tube Feeding on Severe Traumatic Brain Injury Patients With Tracheostomy
This was a multicenter randomized controlled study of 98 severe Traumatic Brain Injury patients with tracheostomy. Patients enrolled were divided randomly into the observation group with Intermittent Oro-esophageal Tube Feeding…
- Trial name
- STBI (NCT06199778)
- Testing
- Rehabilitation therapy, Intermittent Oro-esophageal Tube Feeding, Nasogastric tube feeding
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Zeng Changhao
Traumatic Brain Injury, Concussion, Mild
fMRI-neuronavigated rTMS Treatment for Symptoms of Depression Associated With Concussive TBI in the Military Population
This study aims to investigate the efficacy and tolerability of fMRI-targeted repetitive transcranial magnetic stimulation (rTMS) in the treatment of depressive symptoms in service members with a history of concussive traumatic…
- Conditions
- Traumatic Brain Injury, Concussion, Mild, Depressive Symptoms
- Trial name
- NCT03523507
- Testing
- Active: rTMS
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Traumatic Brain Injury, Mild Cognitive Impairment
Speed of Processing Training to Improve Cognition in Traumatic Brain Injury and Mild Cognitive Impairment
The purpose of this research study is to investigate the effectiveness of a technique designed to improve processing speed (i.e. the amount of time it takes to process information) in a Traumatic Brain Injury (TBI) population.
- Trial name
- NCT02020564
- Testing
- Speed of Processing Training
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Kessler Foundation
Traumatic Brain Injury, Insomnia
CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms
This study is a prospective two-arm, single blind randomized controlled trial design to compare the clinical effectiveness of telemedicine-delivered, 6-session, standardized cognitive behavioral therapy for insomnia (CBT-I) and…
- Conditions
- Traumatic Brain Injury, Insomnia, Depression, Post-traumatic Stress
- Trial name
- NCT05663034
- Testing
- Mindfulness-based treatment for insomnia (MBTI), Cognitive behavioral therapy for insomnia (CBT-I)
- Where
- 5 sites in United States
- Volunteers
- 360 people
- Sponsor
- Johns Hopkins University
Traumatic Brain Injury
Prediction of Neurological Outcome of Children After a Traumatic Brain Injury Based on an Integrated Predictive Model
This study aims to develop a integrated predictive model based on serum biomarkers, HRV, and an innovative computerized classifier output, to predict the patient long term neurological outcome after a moderate or severe TBI in…
- Trial name
- NCT04157634
- Testing
- Prognostication model
- Volunteers
- 70 people
- Sponsor
- St. Justine's Hospital
Neurologic Injury, Traumatic Brain Injury
Enteral Glutamine in Neurologically-injured Patients
Nutrition is an important part of the recovery process after having a head injury so that subjects can gain strength and fight off infection.
- Trial name
- NCT00204971
- Testing
- Enteral glutamine powder
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- University of Wisconsin, Madison
All Adult Patients Admitted to theHMPIT ICU for Management of Head Trauma
Quality of Life in Traumatic Brain Injury Patients
The aim of this study is to describe the quality of life of CT patients in our study, at least 6 months after the occurrence of the trauma. This assessment is related to the patient's degree of sequelae, using the GOSE scale.
- Trial name
- NCT05993312
- Testing
- quality of life
- Where
- 2 sites in Tunisia
- Volunteers
- 100 people
- Sponsor
- General Administration of Military Health, Tunisia
Traumatic Brain Injury, Venous Thromboembolism
Evaluation of the SCALED (SCaling AcceptabLE cDs)
This project will adapt a currently deployed Clinical Decision Support (CDS) system to deliver a VTE prevention guideline for adult patients with traumatic brain injury (TBI).
- Trial name
- NCT05628207
- Testing
- Observational, Observational-control
- Where
- United States
- Volunteers
- 15,000 people
- Sponsor
- University of Minnesota
Intracranial Hypertension
Non-invasive Intracranial Pressure (ICP) Monitoring in Pediatric Patients
The purpose of this study is to prospectively evaluate the accuracy and safety of non-invasive intracranial pressure (ICP) measurements using the HeadSense-1000 (HS-1000) device compared to the current invasive external…
- Trial name
- NCT02695264
- Testing
- HS-1000 recording
- Where
- United States
- Sponsor
- HeadSense Medical
Concussion
Concussion Texting Study
This will be a prospective study of the implementation of a real-time assessment and intervention of a text messaging tool in mild traumatic brain injury (mTBI) patients post-discharge from the emergency department.
- Trial name
- texting (NCT03099733)
- Testing
- text message
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wake Forest University Health Sciences
Traumatic Brain Injury
Crainio Non-invasive ICP Monitor for TBI
The clinical investigation aims to advance the Crainio device, designed for non-invasive intracranial pressure (ICP) monitoring.
- Trial name
- NCT06453733
- Testing
- Crainio
- Where
- United Kingdom
- Volunteers
- 54 people
- Sponsor
- Crainio Ltda
Traumatic Brain Injury, Stroke
The Effect of Cognitive Reserve on Outcome After Stroke or Traumatic Brain Injury
A long-term follow-up study of patients who acquired a stroke or traumatic brain injury (TBI) 5-15 years ago. Primary objective is to describe the interaction between measures of cognitive reserve and neuropsychological…
- Trial name
- NCT05407948
- Where
- Sweden
- Volunteers
- 87 people
- Sponsor
- Natascha Ekdahl
Traumatic Brain Injury
Prevalence, Severity, Risk Factors, and Prognostic Value of Hyponatremia in Patients With Traumatic Brain Injury
Hyponatremia (HN) is the most common electrolytic disorder in the traumatic brain injury (TBI) population, found in 17 to 51% of patients according to the series.
- Trial name
- WATERWAR (NCT05301049)
- Where
- France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Montpellier
Traumatic Brain Injury
Could Early Atorvastatin Offer Anti Inflammatory Effects Upon Brain in Traumatic Head Injury?
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, known as statins, are widely used to reduce levels of low-density lipoprotein-cholesterol.
- Trial name
- NCT04718155
- Testing
- Atorvastatin
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Concussion, Mild, Concussion, Severe
Ketone Supplementation in Adolescents Post-Concussion
Adolescent brains undergo rapid and significant changes in structural architecture and functional organization during development.
- Conditions
- Concussion, Mild, Concussion, Severe, Concussion, Brain, Concussive Injury
- Trial name
- NCT04079907
- Testing
- Ketone
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Traumatic Brain Injury (TBI), Agitated Behaviour
Modified Environment for Agitation in Patients With TBI
This study examines the effect of an intervention consisting of dynamic circadian light and sound therapy, as well as systematic information on sleep pattern, agitated behavior and functioning level.
- Trial name
- ABS (NCT02524067)
- Testing
- Multifactorial circadian concept
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Traumatic Brain Injury, Healthy
Measuring Blood Flow in the Brain
This study will test a method of measuring brain blood flow called near infrared spectroscopy (NIRS). It will determine whether NIRS gives the same results as the more commonly used technique, functional magnetic resonance…
- Trial name
- NCT00466934
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Traumatic Brain Injury, Hemorrhage
Fibrinogen Concentrate in Isolated Traumatic Brain Injury
Fibrinogen is a unique precursor of fibrin and cannot be compensated for by other coagulation factors. If plasma fibrinogen concentrations are insufficient, hemostatic clots cannot be formed with the appropriate firmness.
- Trial name
- NCT03304899
- Testing
- RiaSTAP Injectable Product
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Leila Dehghani
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