Clinical trials: Traumatic Brain Injury (TBI)
Traumatic Brain Injury
Effect of Oral Enteral Nutrition on Severe Traumatic Brain Injury
This was a multicenter randomized controlled study of 98 severe Traumatic Brain Injury patients with tracheostomy. Patients enrolled were divided randomly into the observation group with Intermittent Oro-esophageal Tube Feeding…
- Trial name
- NCT06304012
- Testing
- Nasogastric tube feeding, Intermittent Oro-esophageal Tube Feeding, Rehabilitation therapy
- Where
- Taiwan
- Volunteers
- 104 people
- Sponsor
- Muhammad
Spinal Cord Injury
A Longitudinal Examination of Aging With a Spinal Cord Injury: Cardiovascular, Cerebrovascular and Cognitive Consequences
The general population is aging, today 12% of the United States population is older than 65 and it is estimated that by 2020 the number of people in the United States older than 65 will outnumber children younger than 5.
- Trial name
- NCT03023163
- Testing
- Longitudinal
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Traumatic Brain Injury (TBI) Patients, Post Concussive Symptoms
Hyperbaric Oxygen Therapy for Veterans With TBI and PCS: A Biomarker Study
The goal of this study is to examine changes in blood biomarkers following hyperbaric oxygen therapy (HBOT) in military veterans with traumatic brain injury and persistent post-concussive symptoms.
- Conditions
- Traumatic Brain Injury (TBI) Patients, Post Concussive Symptoms, PTSD
- Trial name
- NCT07849465
- Testing
- Hyperbaric Oxygen Therapy (HBOT)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Summit Hyperbarics and Wellness
Stroke, Traumatic Brain Injury
Daily Light Exposure for Sleep Disturbance, Fatigue, and Functional Outcomes in Acute Brain Injury
The purpose of this study is to assess the safety and efficacy of daily morning exposure to colored light in patients receiving acute inpatient rehabilitation services for stroke, traumatic brain injury, or non-traumatic brain…
- Conditions
- Stroke, Traumatic Brain Injury, Non-traumatic Brain Injury
- Trial name
- NCT03125967
- Testing
- Philips GoLite Blu HF3429/60, Philips LivingColor Aura 70998/60/48
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- St. Luke's Rehabilitation Institute
TBI (Traumatic Brain Injury)
The Effect of Melatonin Administration on Sedation Level as Adjuvant to Propofol
This study assess the effect of administration of exogenous melatonin as adjuvant to propofol on the level of sedation and consequently the rate of propofol infusion.
- Trial name
- NCT04034771
- Testing
- Melatonin 10 MG Oral Tablet, Propofol
- Where
- Egypt
- Volunteers
- 38 people
- Sponsor
- Cairo University
Intracranial Hypertension
Mannitol Versus Hypertonic Saline Solution in the Treatment of Elevated Intracranial Pressure
The purpose of this study is to determine whether mannitol is as effective as hypertonic saline solution in the treatment of elevated intracranial pressure in patients with brain injury.
- Trial name
- NCT00447018
- Testing
- 20% mannitol, 7.45% hypertonic saline solution
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Grenoble
Post-Traumatic Stress Disorders, Brain Injuries
Identifying Biomarkers That Distinguish PTSD and mTBI Using Advanced Magnetic Resonance Spectroscopy
The purpose of this study is to develop a new test to help diagnose mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) in soldiers.
- Trial name
- NCT02927288
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Persistent Post-concussive Symptoms, Convergence Insufficiency
Persistent Post-Concussion Symptoms With Convergence Insufficiency
Our successful R01 discovered 1) the neural mechanistic difference between typically occurring convergence insufficiency (TYP-CI) and binocularly normal controls and 2) the underlying mechanism of office-based vergence and…
- Conditions
- Persistent Post-concussive Symptoms, Convergence Insufficiency, Mild Traumatic Brain Injury, Concussion, Mild
- Trial name
- PPCS-CI (NCT05262361)
- Testing
- Office-based Vergence and Accommodative Therapy
- Where
- 2 sites in United States
- Volunteers
- 112 people
- Sponsor
- New Jersey Institute of Technology
Traumatic Brain Injury
SMS Messaging to Reduce Depression and Anxiety Following TBI
This investigation addresses emotional health in community dwelling persons with traumatic brain injury (TBI). It is designed to test the efficacy of a novel behavioral treatment for depression and anxiety symptoms.
- Trial name
- NCT02061553
- Testing
- Motivation, Intention, BA-Tech
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- Albert Einstein Healthcare Network
Trauma, Brain
(POCUS) As an Early Screening Tool for Diagnosing Skull Fractures in Children
This study aims to evaluate the accuracy of POCUS as a screening tool for early diagnosis of skull fractures in children with mild closed head injuries admitted to the emergency department.
- Trial name
- NCT05726201
- Testing
- ultrasound
- Where
- Egypt
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Assiut University
Paroxysmal Sympathetic Hyperactivity
Effects of Early Musical Intervention on Prevalence and Severity of Paroxysmal Sympathetic Hyperactivity After Severe Traumatic Brain Injury
Paroxysmal sympathetic hyperactivity (PSH) is a frequent symptom after traumatic brain injury and concerns up to 30% of severely brain-injured patients.
- Trial name
- MUSIC-TCNV (NCT02783105)
- Testing
- Musical intervention, Control
- Where
- France
- Volunteers
- 11 people
- Sponsor
- University Hospital, Strasbourg, France
Head Injury, Sport Injury
Dynamic Vision Testing and Concussion Management
The purpose of this study is to determine the value of including dynamic vision testing into California State University, Northridge (CSUN) Athletics' established concussion protocol.
- Conditions
- Head Injury, Sport Injury, Concussion, Brain
- Trial name
- NCT04837066
- Testing
- Dynamic Vision Testing (Bertec Vision Advantage System) and Balance Error Scoring System
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- California State University, Northridge
Traumatic Brain Injury, Walking Impairment
Treadmill Training at Constant or Different Speeds for People With Traumatic Brain Injury
Background: Many people who have had a traumatic brain injury have difficulty walking. Training on a treadmill is often used to help people with walking difficulties.
- Conditions
- Traumatic Brain Injury, Walking Impairment, Gait Training
- Trial name
- NCT01419522
- Testing
- Gait Training Method
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Concussion, Brain
One Team: Changing the Culture of Youth Sport With Pregame Safety Huddles
Randomized controlled trial of a behavioral intervention (Pre-Game Safety Huddles) designed to study the impact of huddles on concussion safety in youth sport, primarily regarding intention to report concussive symptoms.
- Trial name
- NCT04099329
- Testing
- Pre-game Safety Huddles
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Seattle Children's Hospital
Traumatic Brain Injury, Anxiety
Sleep Quality, Heart Rate Variability and Anxiety Following Brain Injury
The investigators predict that decreased heart rate variability and poor sleep quality will be significantly correlated with higher self-reported anxiety following brain injury.
- Trial name
- NCT04652895
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Shirley Ryan AbilityLab
Brain Injuries, Traumatic, Repetitive Transcranial Magnetic Stimulation
Efficacy of Repetitive Transcranial Magnetic Stimulation for Improvement of Memory in Older Adults With TBI
The proposed study will evaluate the safety, durability and efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) as a promising non-invasive therapeutic treatment for improving memory in older adults with mild or…
- Conditions
- Brain Injuries, Traumatic, Repetitive Transcranial Magnetic Stimulation, Memory Deficits, Aging
- Trial name
- NCT03727737
- Testing
- Repetitive Transcranial magnetic Stimulation
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Palo Alto Veterans Institute for Research
Traumatic Brain Injury With Persistent Cognitive Deficits
An Extension Study Evaluating the Efficacy and Safety of Rivastigmine in Patients With Traumatic Brain Injury (TBI) With Persistent Cognitive Deficits
Patients who completed the 12-week double blind protocol may enter this 26-week, open-label extension. This extension will give patients who complete the study an opportunity to receive treatment with open-label rivastigmine 3-12…
- Trial name
- NCT00219245
- Testing
- Rivastigmine
- Volunteers
- 157 people
- Sponsor
- Novartis
Traumatic Brain Injury, Severe Traumatic Brain Injury
Feasibility and Safety of Targeting Neutral vs Liberal Fluid Balance in Traumatic Brain Injured Patients- LIMIT-TBI Trial
The LIMIT-TBI trial is a multicenter, international, randomized, phase II clinical trial designed to evaluate the feasibility and safety of targeting a neutral fluid balance compared to standard care in critically ill adult…
- Conditions
- Traumatic Brain Injury, Severe Traumatic Brain Injury, Acute Brain Injury, Neurocritical Care
- Trial name
- LIMIT-TBI (NCT07625995)
- Testing
- Neutral Fluid Balance Strategy
- Where
- 3 sites in Belgium, Italy
- Volunteers
- 88 people
- Sponsor
- Erasme University Hospital
Brain Injuries, Traumatic
Neuroactive Steroids and Traumatic Brain Injury (TBI) in OEF/OIF Veterans
Purpose: Mild traumatic brain injury (TBI) is extremely common among Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) era Veterans.
- Trial name
- NCT01336413
- Testing
- Pregnenolone
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Trauma, Head
Complement Inhibition: Attacking the Overshooting Inflammation @Fter Traumatic Brain Injury
Severe Traumatic Brain Injury (s-TBI) is a major cause of death and disability across all ages. Besides the primary impact, the pathophysiologic process of major secondary brain damage consists of a neuroinflammation response…
- Trial name
- CIAO@TBI (NCT04489160)
- Testing
- C1 Inhibitor, Human
- Where
- 3 sites in Netherlands
- Volunteers
- 106 people
- Sponsor
- Leiden University Medical Center
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