Clinical trials: Traumatic Brain Injury (TBI)
Traumatic Brain Injury, Degeneration
Offsetting Hippocampal Degeneration in m-sTBI
The goal of this study is to establish the feasibility of an intervention designed to improve memory in patients who have experienced a moderate or severe traumatic brain injury (m-sTBI) and to examine its effect on brain…
- Conditions
- Traumatic Brain Injury, Degeneration, Memory; Loss, Mild, Following Organic Brain Damage
- Trial name
- m-sTBI (NCT03727334)
- Testing
- Online Spatial Navigation Training
- Where
- 2 sites in Canada
- Volunteers
- 25 people
- Sponsor
- University of British Columbia
Mild Traumatic Brain Injury
A Study of Biomarkers of Mild Traumatic BRAIN Injury
Patients with mild traumatic brain injury (mTBI) represent a burden of patients admitted to the emergency department. According to the guidelines, a cerebral CT scan is indicated after mTBI according to the specific conditions.
- Trial name
- BRAINI (NCT04032509)
- Testing
- 2 x 5 mL blood sample
- Where
- 16 sites in France, Spain
- Volunteers
- 1,501 people
- Sponsor
- University Hospital, Grenoble
Traumatic Brain Injury, Rehabilitation
Improving Health Outcomes With Resource Facilitation
The purpose of this research is to test a service the investigators of the study believe may increase quality of life after brain injury and reduce the level of disability that might be associated with that injury.
- Conditions
- Traumatic Brain Injury, Rehabilitation, Intervention
- Trial name
- ACL (NCT04462549)
- Testing
- Resource Facilitation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Rehabilitation Hospital of Indiana
Traumatic Brain Injury
Evaluation the Effects of French Maritime Pine Bark Extract on the Clinical Status in Traumatic Brain Injury Patients
Introduction: Traumatic brain injury (TBI) is one of the major health and socioeconomic problems in the world. Immune-enhancing enteral formula has been proven to significantly reduce infection rate in TBI patient.
- Trial name
- NCT03777683
- Testing
- Dietary Supplement (OLIGOPIN)
- Where
- Iran
- Volunteers
- 67 people
- Sponsor
- Mashhad University of Medical Sciences
Traumatic Brain Injury
An Exploration of Sleep Disturbance and Outcomes in TBI (SLEEP-TBI)
This study aims to look at how sleep disturbance affects people who have had a traumatic brain injury. Sleep disturbance can include waking frequently in the night, difficulty falling asleep, excessive sleepiness or changes to…
- Trial name
- SLEEP-TBI (NCT07120373)
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- University of Nottingham
Traumatic Brain Injury
Heart Rate Variability Biofeedback Following Traumatic Brain Injury
Individuals with mild traumatic brain injury will be randomly assigned to an active heart rate variability biofeedback condition and a sham condition.
- Trial name
- NCT05913505
- Testing
- OSC+, OSC-
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Brigham Young University
Brain Concussion, Traumatic Brain Injury
DANA Compared to MACE in Evaluation of Suspected Acute Concussion
The purpose of this study is to compare the sensitivity of the DANA Rapid exam with the MACE cognitive score. The primary hypothesis is that the DANA Rapid exam will be more sensitive for detecting impaired cognitive performance…
- Trial name
- NCT01728129
- Testing
- DANA Rapid, MACE
- Where
- Afghanistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Traumatic Brain Injury
Combinatory Rehabilitation Used for Substantially Helping Individuals With Traumatic Brain Injury
New learning and memory impairment (NLMI) is a common and devastating manifestation of TBI associated with substantial life burdens. Persons with moderate to severe TBI have shown improvement in NLM for prose material (e.g.
- Trial name
- CRUSH-IT (NCT05716048)
- Testing
- KF-mSMT Plus Aerobic Exercise Training, KF-mSMT Plus Stretching Exercise Training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Kessler Foundation
Traumatic Brain Injury
Detection of Hemodynamic Changes in TBI Population With Functional Near Infrared Spectroscopy
The goal of this project is to develop a test to assess frontal lobe function using a rapid, inexpensive, objective, and standardized method, without the need for expertise in cognitive test administration.
- Trial name
- NCT01797549
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Brain Injuries, Traumatic, Spinal Cord Trauma
Characterization of Human Autoantibody Titers After Central Nervous System Insult
The aim of the study is to quantitate Central Nervous System (CNS) autoantibody development in human blood using ELISA after human brain injury, spinal cord injury, and intra-axial brain surgeries.
- Conditions
- Brain Injuries, Traumatic, Spinal Cord Trauma, Intracranial Neoplasm
- Trial name
- CHAT CNS (NCT03089749)
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Utah
Concussion, mTBI
Neurofeedback Impact on Veterans With mTBI
This study will evaluate neurofeedback (NFB) training as a low risk, non-invasive, effective treatment for Veterans diagnosed with mild traumatic brain injury (mTBI) and experiencing chronic post-concussive symptoms (PCSs).
- Conditions
- Concussion, mTBI, Post-Concussive Symptoms, Chronic Headache
- Trial name
- NFBVETmTBI (NCT04195685)
- Testing
- Neurofeedback (NFB)
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
Predict Severe Traumatic Brain Injury
Severe traumatic brain injury (TBI) is associated with a 20-30% mortality rate and significant disability among most survivors. The Centers for Disease Control and Prevention (CDC) estimate that 2% of the U.S.
- Trial name
- NCT06966713
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Chicago
Diffuse Brain Injury
Trial Estimating the Efficiency of the Light Therapy in Brain Trauma Sequel Fatigue
After a brain injury (BI) , patients complain in particular about sequel fatigue. This symptom affects about 50 % of the patients; it is severe, with a repercussion on quality of life, reeducation and occupational reintegration…
- Trial name
- phototrauma (NCT02420275)
- Testing
- "Luminette",Lucimed Belgium
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Traumatic Brain Injury
A Health and Wellness Lifestyle Program to Support Community-Dwelling Persons With Traumatic Brain Injury
To evaluate the efficacy of an adapted telehealth-based, health and wellness lifestyle program on promoting healthy lifestyle behaviors and improving health outcomes.
- Trial name
- POWERS-TBI (NCT04288258)
- Testing
- Telehealth-Based Health and Wellness Program (POWERS-TBI)
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Alabama at Birmingham
Brain Concussion, mTBI - Mild Traumatic Brain Injury
Screening Instruments for Measuring Visual Symptoms in Victims of Concussion
Visual dysfunction after mild traumatic brain injury (mTBI) is common but often remain undiscovered during longer periods of time. No valid, reliable and easy-to-use screening instrument for uncovering visual dysfunction exists.
- Trial name
- VisCom (NCT05862571)
- Where
- Denmark
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Traumatic Brain Injury, Cervical Spinal Cord Injury
Restorative Neuromodulation for Upper Extremity Functions
The objective of this research study is to find the efficacy of trans-spinal electrical stimulation, a non-invasive neurostimulation method to modulate the functions of spinal cord neurocircuits, on improving upper-extremity…
- Trial name
- NCT04183998
- Testing
- Trans-spinal Electrical Stimulation (tsES)
- Where
- Hong Kong
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Adult, Traumatic Brain Injury
Effects of Rapid-Resisted Exercise and Bright Light Therapy on Ambulatory Adults With Traumatic Brain Injury
Background: Traumatic brain injury may have a range of effects, from severe and permanent disability to more subtle functional and cognitive deficits that often go undetected during initial treatment.
- Conditions
- Adult, Traumatic Brain Injury, fMRI
- Trial name
- NCT01175993
- Testing
- Elliptical exercise
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Acute Brain Injury, Traumatic Brain Injury
Effect of Central Venous Catheterization on Brain Pressure in Acute Brain Injury Patients
Acute brain injury (ABI) is a serious condition that can cause a dangerous increase in pressure inside the skull (called intracranial pressure, or ICP), which can harm the brain.
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Intracerebral Hemorrhage, Aneurysmal Subarachnoid Hemorrhage (aSAH)
- Trial name
- CVC-ICP (NCT07704528)
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Beijing Tiantan Hospital
Sleep Disorder, Traumatic Brain Injury
Pilot Study of BCAA on Sleep
Individuals will be recruited from the VA Portland Health Care System and the community affiliated with Oregon Health \& Science University. Traumatic brain injury status will be assessed as a contributing factor.
- Trial name
- NCT03990909
- Testing
- Branched Chain Amino Acids, Rice Protein, Microcrystalline Cellulose
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Portland VA Medical Center
Traumatic Brain Injury
Aerosolized Endotracheal Lidocaine to Avoid Intracranial Pressure Spikes in Patients With Severe Traumatic Brain Injury
The purpose of this study is to evaluate the effectiveness of nebulized lidocaine before Endotracheal suctioning (ETS) compared to instilled lidocaine and the effectiveness of aerosolized lidocaine versus instilled normal saline…
- Trial name
- NCT05058677
- Testing
- aerosolized 2% lidocaine (20mg/ml), instilled 0.9% sodium chloride (NS), instilled 2% lidocaine solution
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Health Science Center, Houston
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