Clinical trials: Traumatic Head Injury
Concussion, Mild
Interdisciplinary Interventions After mTBI
The investigators aim to investigate the impact of interdisciplinary and individually tailored programs for mTBI (concussion) on quality of life and work capacity, both at the conclusion of the program and after 1 and 3 years.
- Trial name
- NCT06815692
- Testing
- Psychoeducation, Physiotherapy, Treatment of tinnitus and increased sound sensitivity
- Volunteers
- 140 people
- Sponsor
- Rune Skovgaard Rasmussen
Mild Traumatic Brain Injury, Post Traumatic Stress Disorder
Biological Signatures, Probiotic Among Those With mTBI and PTSD
Exaggerated inflammation in the body and brain is thought to play a role in the vulnerability to and aggravation and perpetuation of adverse consequences among those with co-occurring mild TBI (mTBI) and post-traumatic stress…
- Trial name
- NCT02723344
- Testing
- of Lactobacillus reuteri (L. reuteri; DSM 17938), Sunflower and medium chain triglyceride oils
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- VA Office of Research and Development
Brain Concussion
Examination of Balance, Vestibular, and Ocular Functions and Activity Following Concussion
Previous research and position statements have outlined the necessity of balance and gait testing in the post-concussion evaluation of athletes.
- Trial name
- NCT02317107
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Traumatic Brain Injury
Diagnosis of Intracranial Hypertension Using TCCD, ONSD and ODH by Bedside Ultrasound
The goal of this observational study is to investigate several means of measuring intracranial pressure (ICP) non-invasively in patients who had head trauma and received implantation of invasive ICP monitor device.
- Trial name
- NCT07151287
- Testing
- TCCD, ONSD, ODH
- Volunteers
- 64 people
- Sponsor
- Xiangya Hospital of Central South University
Chronic Subdural Hematoma
Spinal CSF Leaks in Chronic Subdural Hematoma
Background: Chronic subdural hematoma (cSDH) is a type of intracranial bleeding, predominantly affecting the elderly and males, with an estimated incidence of 8/100.000.
- Trial name
- SPICE (NCT06323434)
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- University of Freiburg
Post Traumatic Stress Disorder, Traumatic Brain Injury
Therapeutic Horsemanship in Veterans
The project partnered with U.S. military veterans with a premier accredited therapeutic riding center for six weeks. The veterans interacted with horses by grooming and learning about them, as well as riding them for one hour per…
- Trial name
- NCT02891421
- Testing
- Therapeutic Horseback Riding, Standard Care
- Volunteers
- 38 people
- Sponsor
- University of Missouri-Columbia
Persistent Post Concussive Headache, Mild Traumatic Brain Injury
Pilot TMS in Mild TBI
Persistent post-concussive symptoms (PPCS) involve an array of physical, cognitive, and behavioral symptoms lasting more than a month after mild traumatic brain injury (mTBI).
- Trial name
- NCT06999304
- Testing
- Intermittent theta burst stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- HealthPartners Institute
Subdural Hematoma
MMA Embolization With NeoCast for Subacute and Chronic Subdural Hematoma
The purpose of this study is to evaluate the safety and efficacy of embolization of the middle meningeal artery (MMA) using the NeoCast Embolic System for treatment of symptomatic subacute or chronic subdural hematoma (SDH)…
- Trial name
- RADIANT (NCT07541404)
- Testing
- NeoCast Embolic System, Onyx LES, an FDA-Approved Commercial Liquid Embolic
- Where
- 2 sites in United States
- Volunteers
- 360 people
- Sponsor
- Arsenal Medical, Inc.
Chronic Subdural Hematoma
Tranexamic Acid in the Treatment of Residual Chronic Subdural Hematoma
Chronic subdural hematoma (CSDH) is a common disease after minor head trauma, especially in elderly patients. This medical condition is characterized by blood collection in the subdural space, which can result in severe…
- Trial name
- TRACE (NCT03280212)
- Testing
- Tranexamic Acid 500 MG
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
TBI (Traumatic Brain Injury)
Pharmacological Intervention in Depression After Traumatic Brain Injury
The purpose of this study is to determine if treatment with venlafaxine reduces symptoms of depression in persons with traumatic brain injury.
- Trial name
- NCT00205491
- Testing
- Venlafaxine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Virginia Commonwealth University
Brain Injuries, Traumatic
Evaluating the Effectiveness of Treatment for Metacognition in Moderate and Severe Traumatic Brain Injury
Metacognition, in-the-moment awareness of performance while engaging in cognitive tasks, is negatively affected by traumatic brain injury (TBI).
- Trial name
- NCT03169647
- Testing
- Listening-based intervention
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Kessler Foundation
Minor Head Injury
Outcome of Patients With Mild Head Injury and Presence of an Acute Traumatic Abnormality on CT Scan of Head
Background: Patients with mild blunt traumatic brain injury (TBI) are frequently transferred to Level 1 trauma centers (L1TC) if they have any positive finding of any acute intracranial injury identified on a CT scan of the head.
- Trial name
- NCT04143347
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Massachusetts General Hospital
Ventilator Associated Pneumonia, Morality
Endotracheal Tube Cuff Pressure Measurement
The effect of endotracheal cuff pressure measurement technique for preventing ventilatory associated pneumonia.
- Conditions
- Ventilator Associated Pneumonia, Morality, Trauma, Brain, Endotracheal Aspiration
- Trial name
- NCT04397952
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Bagcilar Training and Research Hospital
Head Injury, Sport Injury
Dynamic Vision Testing and Concussion Management Dream Team 65
The purpose of this study is to determine the value of including dynamic vision testing into California State University, Northridge (CSUN) Athletics' established concussion protocol.
- Conditions
- Head Injury, Sport Injury, Concussion, Brain
- Trial name
- NCT05326555
- Testing
- Dynamic Vision Testing (Bertec Vision Advantage System) and Balance Error Scoring System
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- California State University, Northridge
Stroke, Joint Replacement Surgery
SG Healthcare and Assistive Robotics Programme (SHARP) - Proof of Concept Study
Robots are commonly used in many settings to help with transportation needs, reduce human injuries, and assisting clinicians during surgeries.
- Conditions
- Stroke, Joint Replacement Surgery, Acquired Brain Injury, Spinal Cord Injuries
- Trial name
- SHARPCARE (NCT04315389)
- Testing
- (1) Mobile Assistant Balance Robot, (2) Transfer Assistive Cobot
- Where
- Singapore
- Volunteers
- 52 people
- Sponsor
- Tan Tock Seng Hospital
Traumatic Brain Injury
Respiratory Treatment of Patients With Moderate and Severe Traumatic Brain Injury
Intracranial pressure (ICP) in patients with traumatic brain injury (TBI) is influenced by several factors of which one is arterial CO2 tension.
- Trial name
- NCT01955785
- Testing
- pressure controlled ventilator, Pressure Regulated Volume Controlled Ventilator
- Where
- Norway
- Volunteers
- 11 people
- Sponsor
- Norwegian University of Science and Technology
Traumatic Brain Injury (TBI)
Targeted Evaluation, Action, & Monitoring of Traumatic Brain Injury
TEAM-TBI (Targeted Evaluation, Action, and Monitoring of Traumatic Brain Injury) is a research study that brings together TBI patients, advanced evaluation methods, and experts in a multi-faceted study to address the…
- Trial name
- TEAM-TBI (NCT02657135)
- Testing
- Cognitive/Neuropsychological Testing, Vestibular/Ocular-Motor Testing, Cervical (Neck) Evaluation
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- University of Pittsburgh
Traumatic Brain Injury
Transcranial Direct Current Stimulation (tDCS) and Motor Training for Traumatic Brain Injury (TBI) Survivors
The aim of this study is to compare the effect of transcranial direct current stimulation and functional upper extremity task training to functional upper extremity task training alone.
- Trial name
- NCT01749735
- Testing
- Transcranial Direct Current Stimulation, Armeo training
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Spaulding Rehabilitation Hospital
Traumatic Brain Injury
Rehabilitation Research and Training Center for Traumatic Brain Injury Interventions--Teen Online Problem Solving Study
This study will evaluate the effectiveness of an Internet-based psychosocial treatment in improving problem-solving, communication skills, stress management strategies, and coping among teens who have had a traumatic brain injury…
- Trial name
- RRTC--TOPS (NCT01042899)
- Testing
- Teen Online Problem Solving (TOPS), Teen Online Problem Solving--Teen Only (TOPS-TO), Internet Resources Comparison (IRC)
- Where
- 5 sites in United States
- Volunteers
- 153 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Intracranial Pressure, Intracranial Pressure Changes
CoMind Early Feasibility Study
The purpose of this research, which has been determined as non-significant risk by the central IRB overseeing the study, is to obtain information to help further develop a machine (a medical device) to measure the pressure around…
- Conditions
- Intracranial Pressure, Intracranial Pressure Changes, Traumatic Brain Injury, Intracerebral Hemorrhage
- Trial name
- CoMind EFS (NCT06368648)
- Where
- 17 sites in United States
- Volunteers
- 581 people
- Sponsor
- CoMind Technologies Limited
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