Clinical trials: Traumatic Head Injury
Traumatic Brain Injury
Anger Self-Management in Traumatic Brain Injury
The present study addresses problematic anger and irritability in community dwelling persons with traumatic brain injury (TBI). It is designed to test the worth of a novel treatment approach called Anger Self-Management Training…
- Trial name
- ASMT (NCT01745146)
- Testing
- ASMT, PRE
- Where
- 3 sites in United States
- Volunteers
- 90 people
- Sponsor
- Albert Einstein Healthcare Network
Traumatic Brain Injury
Effects of Hypothermia Upon Outcomes After Acute Traumatic Brain Injury
Induction of hypothermia to < 35˚C by < 2.5 hours after severe traumatic brain injury, reaching 33˚C by 4 hours after injury and maintained for 48 hours in patients aged 16-45 will result in an increased number of patients with…
- Trial name
- NABIS:HIIR (NCT00178711)
- Testing
- Hypothermia
- Where
- 5 sites in United States, Canada
- Volunteers
- 232 people
- Sponsor
- The University of Texas Health Science Center, Houston
Trauma, Brain, Brain Injuries
Intervention to Change Attributions That Are Negative (ICAN)
ICAN is the first treatment to target hostile attributions after TBI, making it a novel anger/ aggression management approach in this population. This is a randomized waitlist control trial.
- Conditions
- Trauma, Brain, Brain Injuries, Traumatic Brain Injury, Brain Injuries, Traumatic
- Trial name
- ICAN (NCT03648476)
- Testing
- ICAN
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Indiana University
Concussion, Mild, Post-Concussion Symptoms
Bright Light Therapy for Treatment of Sleep Problems Following Mild Traumatic Brain Injury
The purpose of the research study is to understand the effectiveness of a six-week course of light exposure on cognitive functioning, mood, activity, and sleep in people that have suffered a head injury leading to a concussion.
- Conditions
- Concussion, Mild, Post-Concussion Symptoms, Sleep Problems
- Trial name
- NCT02374918
- Testing
- mTBI wavelength-1 bright light, mTBI wavelength-2 bright light, HC wavelength-1 bright light
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Traumatic Brain Injury
Advanced MRI Applications for Mild Traumatic Brain Injury - UCSF
This hypothesis-generating feasibility study compares mTBI Patients and Controls using advanced MRI Applications.
- Trial name
- TBI-2 (NCT02141360)
- Testing
- MRI Diagnostic
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- GE Healthcare
Traumatic Brain Injury
VR-based EF Rehabilitation for Pediatric TBI
Childhood traumatic brain injury (TBI) poses significant impairment in children's executive functions (EFs) for moderate to severe injuries, yet interventions specifically designed for children's EF rehabilitation post-TBI and…
- Trial name
- NCT03611062
- Testing
- VR Executive Functions Training
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Massachusetts, Lowell
Concussion, Mild
Delivery of Digital Cognitive Behavioural Therapy Following Concussion
Concussion is common and patients can go on to suffer with a constellation of symptoms which impacts their functional outcome and quality of life.
- Trial name
- HEADON (NCT05069948)
- Testing
- HeadOn
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Edinburgh
Traumatic Brain Injury
Prehospital Tranexamic Acid Use for Traumatic Brain Injury
Primary aim: To determine the efficacy of two dosing regimens of TXA initiated in the prehospital setting in patients with moderate to severe TBI (GCS score ≤12).
- Trial name
- TXA (NCT01990768)
- Testing
- 1 gram Tranexamic Acid (TXA), 2 grams TXA, 0.9% Sodium Chloride injectable
- Where
- 12 sites in United States, Canada
- Volunteers
- 967 people
- Sponsor
- University of Washington
Chronic Subdural Hematoma
Dexamethasone Versus Burr Hole Craniostomy for Symptomatic Chronic Subdural Hematoma
Chronic subdural hematoma (cSDH) is condition where blood has slowly leaked out of small blood vessels surrounding the brain. Over time, the blood may cause a variety of symptoms including headache, confusion, limb weakness, and…
- Trial name
- DECS (NCT02111785)
- Testing
- Dexamethasone, Burr Hole Craniostomy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Virginia
Depression, Traumatic Brain Injury
Mindfulness-Based Cognitive Therapy Intervention to Treat Depression in Individuals With a Traumatic Brain Injury
The purpose of this study is to determine whether mindfulness-based cognitive therapy is effective in reducing depression symptoms in individuals who have experienced a traumatic brain injury.
- Trial name
- NCT00745940
- Testing
- MBCT for TBI
- Where
- 3 sites in Canada
- Volunteers
- 105 people
- Sponsor
- Lakehead University
Traumatic Brain Injury, Headaches Posttraumatic
Adjunct VR Pain Management in Acute Brain Injury
Severe and refractory pain after acute injury is a known-risk factor for chronic opioid use disorder. In this study, the investigators will use Virtual Reality (VR) immersion as a non-pharmacological adjunct to treat pain…
- Conditions
- Traumatic Brain Injury, Headaches Posttraumatic, Trauma, Pain, Acute
- Trial name
- NCT04356963
- Testing
- Virtual Reality Session (VR Blu), Tablet-based Session (Tablet Blu), Use of Virtual Reality Head Mounted Display without Content (VR Blank)
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Maryland, Baltimore
Traumatic Brain Injury
SmART-TBI: Supplementation With Amino Acid Rehabilitative Therapy in TBI
The most persistent and disabling postconcussive symptoms following mild traumatic brain injury (mTBI) are sleep disturbances and cognitive dysfunction, with few tractable interventions currently available.
- Trial name
- SmART-TBI (NCT04603443)
- Testing
- Branched Chain Amino Acids, Protein Control
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- VA Office of Research and Development
Concussion, Headache
Sphenopalatine Ganglion Block for Headache After Concussion
This clinical trial will enroll participants to evaluate the effects of SPG block on post-traumatic headache. The study hypothesizes that patients that receive a SPG block with lidocaine vs.
- Trial name
- NCT04650282
- Testing
- Lidocaine in SphenoCath device, Saline Solution in SphenoCath device
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Michigan
Traumatic Brain Injury, Post-Traumatic Stress Disorder
Executive Functioning in TBI From Rehabilitation to Social Reintegration: COMPASS
Interventional, controlled clinical trial with two arms, 110 Veterans with TBI and PTSD
- Trial name
- COMPASS (NCT01816061)
- Testing
- Experimental - COMPASS, Control - COMPASS
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Blepharoptosis, Ptosis, Eyelid
Clinical Trial to Improve the Magnetic Levator Prosthesis
Blepharoptosis (incomplete opening of the eyelids) occurs because of a disruption in the normal agonist-antagonist neuro-muscular complex balance. An external device could restore eyelid movement.
- Conditions
- Blepharoptosis, Ptosis, Eyelid, Myasthenia Gravis, Stroke
- Trial name
- NCT03818204
- Testing
- Magnetic Levator Prosthesis (MLP)
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Fatigue
Post-Traumatic Brain Injury (Post-TBI) Fatigue and Its Treatment
Randomized clinical trial of modafinil vs. placebo for treatment of fatigue after TBI.
- Trial name
- NCT00233090
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Traumatic Brain Injury, Post-traumatic Stress Disorder
Telerehabilitation for OIF/OEF Returnees With Combat-Related Traumatic Brain Injury
The scientific objective of this program is to meet the rehabilitation needs of combat wounded Veterans with mild to moderate Traumatic Brain Injury (TBI) via telerehabilitation and determine the effect of this modality of care…
- Trial name
- NCT00676182
- Testing
- Telerehabilitation
- Where
- 2 sites in United States
- Volunteers
- 81 people
- Sponsor
- VA Office of Research and Development
Primary Osteoarthritis, Post-traumatic Osteoarthritis of Hip Nos
Observational Study Evaluating Outcomes of Hip Arthroplasty Using Tornier Dual Mobility Acetabular Cup
The purpose of this study is to demonstrate the performance and reliability of Tornier "Dual Mobility Cup" used during primary total hip replacement or hip replacement revision surgery at least 24 months post-insertion.
- Conditions
- Primary Osteoarthritis, Post-traumatic Osteoarthritis of Hip Nos, Femur Head Necrosis, Femur Neck Fracture
- Trial name
- NCT02062450
- Testing
- Primary surgery with Dual Mobility Cup, Revision surgery with Dual Mobility Cup
- Volunteers
- 379 people
- Sponsor
- Stryker Trauma and Extremities
Traumatic Brain Injury, Vestibular Deficits
Traditional Balance vs Vibrotactile Feedback Training for Vestibular Rehabilitation
The goal of this clinical research study at RIC is to determine the value and benefit of the SK multimodal balance training system through independent clinical evaluations.
- Trial name
- NCT01672658
- Testing
- Sensory Kinetics Balance System, Traditional Vestibular Rehabilitation
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Shirley Ryan AbilityLab
Acquired Brain Injury
Integrated PRocess and StrategieS Training: I-PRESS Training
There is a pressing need to develop more effective interventions to remediate cognitive deficits in highly prevalent disabling conditions such as stroke, head injury and other forms of acquired brain injury (ABI).
- Trial name
- I-PRESS (NCT04882215)
- Testing
- GMT combined with WMU Training
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- NHS Greater Glasgow and Clyde