Clinical trials: Traumatic Head Injury
Traumatic Brain INjury
IL-1ra Dose-range Study for Moderate-to-severe TBI Patients
Traumatic brain injury (TBI) is a common condition with high degree of morbidity and mortality (Hyder et al., 2007). Current treatment paradigms for TBI focus on mitigating secondary injury and maintaining cerebral physiology…
- Trial name
- IL1ra (NCT02997371)
- Testing
- Anakinra Prefilled Syringe, Isotonic saline
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Adel Helmy
Acquired Brain Injury Including Stroke
Prescription Patterns of Antidepressants, Analgesics, and Antiepileptics Drugs in Adult With Acquired Brain Injury
Acquired brain injury (ABI), primarily caused by stroke and traumatic brain injury (TBI), leads to severe disabilities and requires complex pharmacological management during post-acute rehabilitation.
- Trial name
- PRES'SMR (NCT06983314)
- Testing
- Observation
- Where
- France
- Volunteers
- 201 people
- Sponsor
- University Hospital, Caen
Sports Injuries, Concussion, Brain
AIM CONTROL and SWECON - Handball The SWEdish CONcussion Study in Elite Handball
Handball is reported to be top 5 in Europe when it comes to sports injuries. There are few studies based on player reported data, and earlier Swedish data is mainly based on data from Insurance ´companies and mostly acute…
- Conditions
- Sports Injuries, Concussion, Brain, Exposure, Psychological
- Trial name
- NCT04109677
- Where
- Sweden
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Linkoeping University
Spasticity
Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Lower Limb Spasticity
Phase 2/3, randomized, double-blind, placebo-controlled, single-treatment, multicenter trial assessing the efficacy and safety of MYOBLOC for the treatment of lower limb spasticity, in adults followed by an open-label extension…
- Trial name
- NCT04099667
- Testing
- Phase 2; Low Dose MYOBLOC (15,000 Units), Phase 2; High Dose MYOBLOC (20,000 Units), Phase 3; MYOBLOC
- Where
- 9 sites in United States, Hungary and 1 more
- Volunteers
- 40 people
- Sponsor
- Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC
Cerebral Concussion
Concussion in French Amateur Rugby : Survey About the Management and Knowledge of Players
Rugby is a popular contact sport in France the majority of whom are amateur players. Concussion is one of the main risks given its potential severity and frequency (between 2.78 and 10 per 1,000 player hours).
- Trial name
- RUGBY-COM (NCT04760834)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
TBI, TBI Traumatic Brain Injury
fREMS for Mortality Prediction in TBI
This prospective observational study aims to develop and internally validate a new clinical score, the FOUR-Rapid Emergency Medicine Score (fREMS), for predicting in-hospital mortality in patients with traumatic brain injury…
- Trial name
- fREMS (NCT07816016)
- Where
- Iraq
- Volunteers
- 2,000 people
- Sponsor
- Al-Nahrain University
Tissue Adhesives, Laceration
Long-Term Outcome of Pediatric Traumatic Wound Repair: Suture Versus Tissue Adhesive
This project is an observational trial investigating wound cosmetic appearance after repair of traumatic skin lacerations in the head area of pediatric patients with two different approaches to skin closure: sutures versus tissue…
- Conditions
- Tissue Adhesives, Laceration, Sutures, Wounds and Injuries
- Trial name
- NCT03080467
- Where
- Switzerland
- Volunteers
- 386 people
- Sponsor
- University Children's Hospital, Zurich
Traumatic Brain Injury
Intervention to Promote Survivor Resilience and Adjustment: Efficacy and Sustainability
The aims of this traumatic brain injury (TBI) study are: 1. to evaluate the short and long-term efficacy of two structured outpatient intervention programs, Resilience and Adjustment Intervention (RAI) vs.
- Trial name
- NCT03421964
- Testing
- Resilience/Adjustment Counseling, Resilience/Adjustment Counseling with Booster Sessions
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- Virginia Commonwealth University
Stroke, Subarachnoid Hemorrhage
MUSic Therapy In Complex Specialist Neurorehabilitation
Aim: Investigate whether patients undergoing specialist rehabilitation after complex neurological injury show different functional outcomes if music therapy is included in their rehabilitation program compared to usual care.
- Conditions
- Stroke, Subarachnoid Hemorrhage, Traumatic Brain Injury, Tumor, Brain
- Trial name
- MUSICS (NCT05777499)
- Testing
- Music Therapy, Control Therapy
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University College, London
Traumatic Brain Injury
Improving Traumatic Brain Injury Rehab Care With Comm Health Services: a Research Project Within the TBI Model System
TBI rehabilitation care transitions refer to the processes of preparing patients, families, and community-based healthcare providers for the patient's passage from inpatient rehabilitation to the home and community or to another…
- Trial name
- NCT06188364
- Testing
- Standard of Care, Experimental
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Virginia Commonwealth University
Acupuncture, Mild Traumatic Brain Injury
Acupuncture for Mild Traumatic Brain Injury：A Functional Magnetic Resonance Imaging Study
The overall goal of this study is to examine if acupuncture intervention can reduce the post-concussion symptom (PCS), and affective and cognitive complaints among mild traumatic brain injury (TBI).
- Conditions
- Acupuncture, Mild Traumatic Brain Injury, MRI
- Trial name
- NCT02868671
- Testing
- acupuncture
- Where
- China
- Volunteers
- 66 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Anosmia, Occupational Therapy
Clinical Utility of Olfactory Rehabilitation: Treatment for Pacients With Neurosensorial Anosmia
The aim of our study was to compare the recovery of smell in people suffering posttraumatic olfactory impairment following a systematic olfactory rehabilitation performed by occupational therapists to natural recovery in a…
- Conditions
- Anosmia, Occupational Therapy, Brain Injuries, Traumatic
- Trial name
- NCT04957563
- Testing
- olfactory rehabilitation
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Cristina Gomez Calero
Traumatic Brain Injury, Chronic Traumatic Encephalopathy
Amyloid and Tauopathy PET Imaging in Acute and Chronic Traumatic Brain Injury
The potential long-term effects of Traumatic Brain Injury (TBI) are poorly understood. Repeated concussions have been associated with an elevated incidence of Alzheimer's disease (AD) along with a reduced age of onset.
- Conditions
- Traumatic Brain Injury, Chronic Traumatic Encephalopathy, Mild Cognitive Impairment
- Trial name
- NCT02266563
- Testing
- Amyvid PET Scan, T807 PET scan
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Samuel Gandy
Traumatic Brain Injury, Exercise
AI-driven Personalized Exercise Feedback Program on Exercise Adherence in Traumatic Brain Injury
This study aims to develop and evaluate an AI-driven Personalized Exercise Feedback Program (AI-PEF) to enhance exercise adherence and health outcomes in mTBI patients.
- Conditions
- Traumatic Brain Injury, Exercise, AI (Artificial Intelligence), Digital Health
- Trial name
- NCT06817564
- Testing
- AI-PEF, Theory-based digital exercise, Active Control
- Volunteers
- 125 people
- Sponsor
- National Defense Medical Center, Taiwan
mTBI - Mild Traumatic Brain Injury
MindRhythm Detection of Concussion and Recovery Study
This study is designed to observe HeadPulse data in concussed subjects that may have experienced a concussion via an injury down to the age of 4.
- Trial name
- DISCOVERY (NCT07190963)
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- MindRhythm, Inc.
Traumatic Brain Injury, Ischemic Stroke
Shared Decision Making to Improve Goals-of-Care Decisions for Families of Severe Acute Brain Injury Patients
Severe acute brain injury (SABI), including large artery acute ischemic stroke, intracerebral hemorrhage, and severe traumatic brain injury continue to be the leading cause of death and disability in adults in the U.S.
- Conditions
- Traumatic Brain Injury, Ischemic Stroke, Intracerebral Hemorrhage
- Trial name
- NCT03833375
- Testing
- Decision Aid
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- University of Massachusetts, Worcester
Traumatic Optic Neuropathy
The Neuroprotective Effect of PEG-GCSF in the Traumatic Optic Neuropathy
The clinical trial will be a phase 1, semi-experimental trial, which will be performed in Hualien Tzu Chi Hospital. Twenty patients will be recruited in this study starting from the 2nd year of the project to the 3rd year of the…
- Trial name
- NCT06168188
- Testing
- Neulasta® (pegfilgrastim)
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Brain Injury, Cognition
Comparing Telehealth to In-person a Combined Metacognitive Training in Veterans With mTBI/PTSD
Veterans with mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) commonly experience cognitive impairments including attention and executive function deficits that interfere with their ability to engage…
- Conditions
- Brain Injury, Cognition, PTSD, Intervention
- Trial name
- NCT05380050
- Testing
- Goal Management Training plus Attention Training, Brain Health Workshop and National Geographic Movies
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
Investigating How Sleep After Training Can Affect the Learning of a Motor Skill in Individuals With Brain Injury
Studies have shown that a period of sleep, even in the form of a daytime nap, after a period of training on a motor learning task can boost subsequent performance beyond that observed after an equal amount of time spent awake and…
- Trial name
- NCT04810442
- Testing
- Nap
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Kessler Foundation
Sars-CoV2, Severe Neurologic Injury
COVID-19 Brain Injury
A prospective cohort minimal risk study to determine the impact of the COVID-19 crisis on outcomes of neurologically injured ICU patients.
- Conditions
- Sars-CoV2, Severe Neurologic Injury, Ischemic Stroke, Hemorrhagic Stroke
- Trial name
- NCT04496076
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Pittsburgh
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