Clinical trials: Traumatic Head Injury
Traumatic Brain Injury
Assistive Soft Skills and Employment Training (ASSET) in TBI Injury
Pediatric traumatic brain injury (TBI) is often associated with difficulties in social functioning. Loss of social contacts and difficulties maintaining social connections is common after pediatric TBI, extending into adulthood.
- Trial name
- NCT05705817
- Testing
- Assistive Soft Skills and Employment Training (ASSET)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kessler Foundation
Cerebral Palsy, Stroke
Feasibility of the Portable YouGrabber System
The aim of the study is to determine the feasibility of the portable version of the YouGrabber® system in children with central motor disorders.
- Conditions
- Cerebral Palsy, Stroke, Traumatic Brain Injury, Meningomyelocele
- Trial name
- YouGrabber (NCT02368223)
- Testing
- YouGrabber
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- University Children's Hospital, Zurich
Traumatic Brain Injury, Post-traumatic Stress Disorder
Improving Sleep in Veterans With the Polytrauma Clinical Triad
The "polytrauma clinical triad" (PCT), a highly disabling constellation of factors, is defined by the coexistence of traumatic brain injury, post-traumatic stress disorder, and chronic pain.
- Conditions
- Traumatic Brain Injury, Post-traumatic Stress Disorder, Chronic Pain
- Trial name
- LIONv2 (NCT06477796)
- Testing
- Morning Bright Light Therapy, Negative Ion Generator
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- VA Office of Research and Development
Brain Injuries, Traumatic, Demyelinating Disorder
Exploring the Utility of [18F]3F4AP for Demyelination Imaging in Controls, Neurodegeneration and Traumatic Brian Injury
The overall objective is to obtain an initial assessment of the value of using [18F]3F4AP for imaging demyelinating diseases such as traumatic brain injury (TBI), neurodegenerative diseases such as mild cognitive impairment (MCI)…
- Conditions
- Brain Injuries, Traumatic, Demyelinating Disorder, Alzheimer Disease
- Trial name
- NCT04710550
- Testing
- F18-3F4AP
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Post-traumatic Stress Disorder, Traumatic Brain Injury
Multisite RCT of STEP-Home: A Transdiagnostic Skill-based Community Reintegration Workshop
In this proposal, the investigators extend their previous SPiRE feasibility and preliminary effectiveness study to examine STEP-Home efficacy in a RCT design.
- Conditions
- Post-traumatic Stress Disorder, Traumatic Brain Injury, Substance Related Disorders, Depression
- Trial name
- STEP-Home (NCT03868930)
- Testing
- STEP-Home, PCGT
- Where
- 2 sites in United States
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Brain Injuries
Multimodal Monitoring of Cerebral Autoregulation After Pediatric Brain Injury
Various methods have been studied to evaluate autoregulation. However, there is currently no universally accepted technique to assess integrity of the cerebral autoregulation neurovascular system.
- Conditions
- Traumatic Brain Injury, Brain Injuries, Brain Injury, Vascular
- Trial name
- NCT04242602
- Testing
- Transcranial Doppler
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury
BIOmarkers of TRAumatic Brain Injury Spain (BIOTRABIS)
Traumatic brain injury (TBI) is defined as a structural alteration of brain function caused by external causes, where mild traumatic brain injury (mTBI) represents approximately 80% of all TBI, and although its prognosis is…
- Trial name
- BIOTRABIS (NCT04641767)
- Where
- 9 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Universitario Virgen Macarena
Craniectomy, Trephined Syndrome
External Post-Operative Skull Prosthesis to Prevent Sunken Flap Syndrome in Craniectomy Patients
Patients that undergo decompressive craniectomy are at risk of delayed changes in brain function known as "Sunken Flap Syndrome" or "Syndrome of the Trephined." The goal of this clinical trial is to see if placing a prosthetic…
- Conditions
- Craniectomy, Trephined Syndrome, Traumatic Brain Injury (TBI) Patients, Ischemic Stroke
- Trial name
- ExO-Skull (NCT06899711)
- Testing
- External Cranial Prosthesis
- Where
- 2 sites in United States
- Volunteers
- 72 people
- Sponsor
- Johns Hopkins University
Brain Injuries, Traumatic
Safe@Home: A Self-Management Program for Individuals With TBI and Their Families
People who sustain moderate to severe traumatic brain injury (TBI) have an increased risk for unintentional injury and harm when resuming day to day activities in the home and community.
- Trial name
- NCT02893345
- Testing
- Safe@Home Intervention Group, Usual Care Group
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Shepherd Center, Atlanta GA
Brain Injury Traumatic Severe, Subarachnoid Hemorrhage
Mobilising Patients With Severe Brain Injury in Intensive Care
Introduction Patients with severe brain injury are often restricted to bed rest during the early period of brain injury which may lead to unwanted secondary complications.
- Conditions
- Brain Injury Traumatic Severe, Subarachnoid Hemorrhage, Intracranial Hematoma
- Trial name
- MAWERIC (NCT05038930)
- Testing
- Mobilisation using the Sara Combilizer
- Where
- Denmark
- Volunteers
- 22 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Brain Injury, Mechanical Ventilation
Regional Ventilation Evaluation During Neuro-injury Weaning Study
This study evaluates changes in regional lung ventilation using thoracic electrical impedance tomography (EIT) during the weaning process from mechanical ventilation in ICU patients with acute brain injury.
- Conditions
- Acute Brain Injury, Mechanical Ventilation, Prolonged Weaning, Traumatic Brain Injury
- Trial name
- ReVENtS (NCT07067671)
- Testing
- Internal Thoracic Impedance
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Insomnia Disorder, Mild Traumatic Brain Injury
Sleep MAPP in the Polytrauma/TBI System of Care
This pilot implementation trial will evaluate the Sleep Disorder Management Assistance for Providers and Patients (Sleep MAPP) Care Pathway in one Veterans Health Administration Polytrauma/TBI System of Care clinic.
- Trial name
- Sleep MAPP (NCT07886398)
- Testing
- Sleep MAPP Care Pathway
- Where
- 2 sites in United States
- Volunteers
- 900 people
- Sponsor
- VA Office of Research and Development
Ventilator Associated Pneumonia
Probiotics to Actively Counter Ventilator Associated Pneumonia (PROACT)
PROACT study aims to resolve uncertainties to influence actual practice guidelines or public health policing regarding VAP prevention in ICU by using probiotics administration.
- Trial name
- PROACT (NCT06092554)
- Testing
- LactoLevure
- Where
- 10 sites in Belgium, Italy
- Volunteers
- 213 people
- Sponsor
- University of Bari
Subdural Hematoma, Atrial Fibrillation
Anticoagulation Therapy Timing in Atrial Fibrillation After Acute and Chronic Subdural Hematoma
Subdural hematoma (SDH) is a common disorder that typically results from head trauma and has increased in prevalence in recent decades.
- Trial name
- ATTAACH (NCT05472766)
- Testing
- Direct Acting Oral Anticoagulant starting at Day 30, Direct Acting Oral Anticoagulant starting at Day 90
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Sunnybrook Health Sciences Centre
Stroke, Traumatic Brain Injury
Comparison of Gait Metrics in Patients With Stroke, Traumatic Brain Injury, and Multiple Sclerosis
People with neurological conditions often have difficulty walking, including problems such as foot drop. Functional electrical stimulation (FES) is a treatment that uses electrical signals to activate muscles and support walking.
- Conditions
- Stroke, Traumatic Brain Injury, Multiple Sclerosis
- Trial name
- NCT07492602
- Testing
- Functional Electrical Stimulation, Normal care
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Brain Injuries, Traumatic, Family
Medical and Resource Facilitation Intervention After Traumatic Brain Injury
Mayo Clinic's Traumatic Brain Injury (TBI) Model System Center (TBIMSC) will capitalize on longstanding collaborations with the non-profit Minnesota Brain Injury Alliance (MN BIA) and Minnesota Department of Health (MDH) to test…
- Conditions
- Brain Injuries, Traumatic, Family, Physician's Role
- Trial name
- MRFI (NCT03429322)
- Testing
- Medical Care and Resource Facilitation, Usual Care
- Where
- United States
- Volunteers
- 415 people
- Sponsor
- Mayo Clinic
Head Trauma Injury
Mild Head Trauma in the Emergency Room: Assessment of the Risk of Intracranial Hemorrhage in Patients Receving Platelet Inhibitors.
The clinical signs presented by a patient with a mild head injury are highly variable but remain strongly predictive of brain damage.
- Trial name
- Trauma-Head (NCT05589103)
- Where
- France
- Volunteers
- 1,692 people
- Sponsor
- University Hospital, Strasbourg, France
Stress Disorders, Post-Traumatic, Brain Injuries
Pathophysiological Understanding and Treatment of PTSD: an rTMS Approach
In Canada, the prevalence of PTSD is approximately 12%, similar to Canadian military personnel. Current treatments for PTSD are limited in efficacy and durability - indicating a dire need for novel interventions in this…
- Conditions
- Stress Disorders, Post-Traumatic, Brain Injuries, Transcranial Magnetic Stimulation, Magnetic Resonance Spectroscopy
- Trial name
- PTSD (NCT03840369)
- Testing
- Repetitive Transcranial Magnetic Stimulation to Right Dorsolateral Prefrontal Cortex, Repetitive Transcranial Magnetic Stimulation to Right Dorsomedial Prefrontal Cortex
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- University of Calgary
TBI (Traumatic Brain Injury), Brain Concussion
Dual-Task Exercise for Mild Traumatic Brain Injury (mTBI)
The investigators previously developed a virtual 14-day dual-task walking exercise program and tested its feasibility with individuals with mild traumatic brain injury (mTBI) history.
- Conditions
- TBI (Traumatic Brain Injury), Brain Concussion, Clinical Trial, Rehabilitation
- Trial name
- NCT06037603
- Testing
- Brain & Walk Exercise Every Day (BraW-Day)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Orthopaedic Injuries, Concussion (Diagnosis)
The TCU Division I Collegiate Athlete Study
The overall objective of this study is to identify risk factors for two of the most common types of injuries in collegiate athletics - orthopedic injuries and concussion injuries.
- Trial name
- NCT07006051
- Testing
- Exposed group
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Texas Christian University
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