Clinical trials: Traumatic Head Injury
Chronic Traumatic Brain Injury
Association of Amino Acid Prevalence and Chronic Brain Injury
Years after a suffering a brain injury, individuals remain in a physically and cognitively impaired state. The investigators believe that the concentrations of amino acids in the blood are chronically altered and yield negative…
- Trial name
- NCT02113124
- Where
- 3 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Brent Masel
Traumatic Brain Injury
Evaluation of the Physiopathological Phenomena and the Haemodynamic and Cerebral Metabolic Effects From Semi-seated Position to Lying Position in Patients With Brain Trauma
Brain trauma is an important burden in traumatologic intensive care. In these patients the treatment is guided by a cluster of multimodal monitoring parameters.
- Trial name
- PULSATILITY (NCT02832908)
- Testing
- Change from semi-seated position to supine
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Montpellier
Traumatic Brain Injury
Spectral Correlates of Impulsivity in Patients With Traumatic Brain Injury
Transcranial electrical stimulation (tES) is a non-invasive form of brain stimulation that has previously been to shown to have therapeutic potential in traumatic brain injury (TBI) patients.
- Trial name
- NCT04239274
- Testing
- transcranial direct current stimulation, transcranial pulsed current stimulation
- Sponsor
- Medical University of South Carolina
Locked-in Syndrome, Neuromuscular Diseases
Investigation on the Cortical Communication System
The goal of this clinical trial is to demonstrate communication through a brain implant in people in locked-in state, i.e. people with severe paralysis and communication problems.
- Conditions
- Locked-in Syndrome, Neuromuscular Diseases, Brainstem Stroke, Traumatic Brain Injury
- Trial name
- CortiCom (NCT06207591)
- Testing
- ECoG (electrocorticography) sensing
- Where
- Netherlands
- Volunteers
- 2 people
- Sponsor
- UMC Utrecht
Multiple Sclerosis, Traumatic Brain Injury
Remediation of Emotional Deficits in Multiple Sclerosis and Traumatic Brain Injury
This study will examine the efficacy of a clinical intervention for improving emotional processing in individuals with MS and TBI.(1)The main outcome measure will be changes in emotional processing measures from pre to post…
- Trial name
- NCT04408274
- Testing
- Emotional Processing Training
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Kessler Foundation
Traumatic Brain Injury (TBI) Patients
Saline Versus Balanced Crystalloid in Traumatic Brain Injury
The goal of this clinical trial is to determine which crystalloid (saline or balanced) should be used in the critical management of Traumatic Brain Injury (TBI) in moderate or severe TBI patients.
- Trial name
- FLUID-TBI (NCT06953674)
- Testing
- Normal Saline (0.9% NaCl), balanced crystalloid
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- University of Louisville
Traumatic Brain Injury, Mild Traumatic Brain Injury
Cerebrovascular Reactivity in American Football Players
Investigators will measure cerebrovascular reactivity (CVR) using functional near-infrared spectroscopy (fNIRS) and magnetic resonance imaging (MRI) during the chronic phase after repetitive mild traumatic brain injury (rmTBI) as…
- Conditions
- Traumatic Brain Injury, Mild Traumatic Brain Injury, Post-Concussion Syndrome
- Trial name
- NCT03417492
- Testing
- Sildenafil Citrate
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Pennsylvania
Mild Traumatic Brain Injury, Concussion
Effect of Early Rest on Recovery From Pediatric Concussion
The purpose of this study is to find out if strict rest for 5 days helps children get better after concussion.
- Conditions
- Mild Traumatic Brain Injury, Concussion, Post-concussive Syndrome
- Trial name
- NCT01101724
- Testing
- Mandated Rest, Intervention
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Medical College of Wisconsin
PTSD - Post Traumatic Stress Disorder, Cognitive Dysfunction
Trifecta Research Study
This observational study evaluates the impact of Ibogaine-Magnesium (IM), 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), Magnetic e-Resonance Therapy (MeRT), and Physiological Supplementation (PS) on posttraumatic stress disorder…
- Conditions
- PTSD - Post Traumatic Stress Disorder, Cognitive Dysfunction, Brain Injury, Depression - Major Depressive Disorder
- Trial name
- NCT07717866
- Testing
- Magnetic e-Resonance Therapy (MeRT), Ibogaine Hydrochloride with Magnesium Sulfate, 5-methoxy-N,N-dimethyltryptamine
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Axial Therapeutic Research
Traumatic and/or Non-traumatic Brain Injury, Critically Ill
Efficiency of a Small-peptide Enteral Feeding Formula Compared to a Whole-protein Formula
An early and efficient enteral nutritional support could improve the clinical outcomes of brain injured critically ill patients.
- Trial name
- NUTRI_REA (NCT01833624)
- Testing
- Peptamen® AF, Sondalis® HP
- Where
- France
- Volunteers
- 206 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Traumatic Brain Injury, Decompressive Craniectomy
Study on the Efficacy of Long-term Drainage of Subdural Effusion After Decompressive Craniectomy
Drilling or puncture drainage is commonly used in TBI patients with subdural effusion following decompressive craniectomy who fail to respond to conservative treatment, but there is no exact regulation or guideline recommendation…
- Conditions
- Traumatic Brain Injury, Decompressive Craniectomy, Subdural Effusion
- Trial name
- NCT06391203
- Testing
- Long-term Drainage, Short-term Drainage
- Where
- China
- Volunteers
- 160 people
- Sponsor
- RenJi Hospital
Chronic Subdural Hemorrhage (cSDH)
Chronic Subdural Hematoma Embolization With Detachable Coils
This is a prospective, multi-center, post market registry study designed to evaluate the safety and efficacy of treatment with Balt coils in patients with chronic subdural hematoma (cSDH).
- Trial name
- SEED (NCT07291427)
- Testing
- Balt coils: (Balt USA, LLC), MMA embolization
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Mild Traumatic Brain Injury
Remediation of Impaired Self-Regulation in Patients With Mild TBI
The ability to regulate impulses enables us to plan for the future, to maintain focus in the face of distractions (i.e. to encode memories), and to manage emotions.
- Trial name
- NCT02260570
- Testing
- Tolcapone
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
CSF Leakage
Comparison of Duration of CSF Leak in Post Traumatic Patients Managed by Early Lumbar Drain vs Conservative Treatment
As limited data is available locally and internationally regarding early Lumbar drain and its effect on duration of CSF leak we have decided to compare it conservative treatment.
- Trial name
- NCT05792683
- Testing
- lumbar drain
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Rawalpindi Medical College
Traumatic Brain Injury, Blood Brain Barrier Defect
Microvascular Injury and Blood-brain Barrier Dysfunction as Novel Biomarkers and Targets for Treatment in Traumatic Brain Injury
Traumatic brain injury (TBI) is a leading cause of death and disability around the world. The social and economic burden of TBI is tremendous and the cost of TBI is estimated at $1 billion per year in Canada- $650 million in care…
- Trial name
- NCT03139682
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Nova Scotia Health Authority
Chronic Subdural Hematoma
Neuroendoscopy-assisted Drainage Versus Burr Hole Drainage for Chronic Subdural Hematoma
Chronic subdural hematoma (CSDH) is a frequent condition in neurosurgery, leading to fluid accumulation between the meninges, brain compression, neurological dysfunction, and potentially herniation.
- Trial name
- URANUS (NCT07144423)
- Testing
- Endoscope-assisted hematoma drainage, Burr hole hematoma drainage
- Where
- 24 sites in China
- Volunteers
- 770 people
- Sponsor
- Beijing Tiantan Hospital
Traumatic Brain Injury (TBI) Patients, Intracranial Pressure
Role of Non-Selective Beta-Adrenergic Blocker in Severe TBI
The role of nonselective beta adrenergic blocker as antistress agent in severe traumatic brain injury
- Conditions
- Traumatic Brain Injury (TBI) Patients, Intracranial Pressure, Intensive Care Unit, Mortality
- Trial name
- NCT06870370
- Testing
- propranolol, normal saline IV
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Injury, Brain, Traumatic, Traumatic Brain Injury
Study of Airway Pressure Release Ventilation and Intracranial Pressure in Patients With Severe Traumatic Brain Injury
The investigators will conduct an observational crossover study. The investigators aim to recruit 50 participants with severe Traumatic Brain Injury (TBI) requiring intracranial pressure (ICP) monitoring during their stay at the…
- Trial name
- NCT02507973
- Testing
- Airway Pressure Release Ventilation, Low Tidal Volume Ventilation
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Maryland, Baltimore
Acute Ischemic Stroke, Intracranial Arterial Stenosis
Post-Market Active Surveillance and Health Economic Evaluation of Cerebrovascular Diagnostic and Therapeutic Devices
The research focuses on "post-market active surveillance and health economic evaluation of non-pharmacological therapies and innovative cerebrovascular diagnostic and therapeutic devices".
- Conditions
- Acute Ischemic Stroke, Intracranial Arterial Stenosis, Extracranial Arterial Stenosis, Intracranial Aneurysms
- Trial name
- NCT07828379
- Testing
- Endovascular Treatment for Acute Ischemic Stroke
- Volunteers
- 2,000 people
- Sponsor
- Changhai Hospital
Traumatic Brain Injury
Progesterone Treatment of Blunt Traumatic Brain Injury
The purpose of this study is to determine if progesterone treatment safely reduces brain swelling and damage after injury.
- Trial name
- NCT00048646
- Testing
- IV Progesterone
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- David Wright
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