Clinical trials: Traumatic Head Injury
Acquired Brain Injury
SAFIR© : An Early Intervention for Supporting Families of Patients With Acquired Brain Injuries
The aim of the study is to evaluate the feasibility of a newly developed intervention to improve family support for patient with acquired brain injury (ABI) in early phase of hospitalization (SAFIR): the main components are the…
- Trial name
- SAFIR© (NCT04138524)
- Testing
- SAFIR©
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Traumatic Brain Injury, Computed Tomography
Evaluation of Pediatric Procedural Sedation With Rectal Chloral Hydrate or Intranasal Midazolam
Thousands of children receive sedation for diagnostic and therapeutic interventions annually, and this number is expected to increase. Children are at higher risk for sedation-related complications than adults.
- Conditions
- Traumatic Brain Injury, Computed Tomography, Procedural Sedation
- Trial name
- NCT01402596
- Testing
- Midazolam, Chloral Hydrate
- Where
- Brazil
- Sponsor
- University of Sao Paulo
Chronic Subdural Hematoma
Tranexamic Acid in Chronic Subdural Hematomas
BACKGROUND Chronic subdural hematoma (CSDH) is one of the most frequent reasons for cranial neurosurgical consult. There is no widely accepted medical treatment for CSDH.
- Trial name
- TRACS (NCT02568124)
- Testing
- Tranexamic Acid
- Where
- 3 sites in Canada
- Volunteers
- 130 people
- Sponsor
- Centre de recherche du Centre hospitalier universitaire de Sherbrooke
Concussion, Brain, Musculoskeletal Pain
The Impact of Eye and Body Training on the Injury Rate of Concussions in Female Soccer Players
The research project aims to find out how special training influences the frequency and severity of injuries among female footballers in the top Swiss league.
- Trial name
- NCT06473883
- Testing
- Training recommendation
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- BrainCare Medical Group
Mild Traumatic Brain Injury
PROtein S100B for Mild Trauma of the HEad in Emergency Patients
Brain injury is a frequent purpose for consultation in emergency services. Management of brain injury is time and resource consuming, combining clinical monitoring and imaging.
- Trial name
- PROMETHEE (NCT03313505)
- Testing
- S100B protein dosage, Brain CT scan
- Where
- 15 sites in France, Monaco
- Volunteers
- 787 people
- Sponsor
- Centre Hospitalier Princesse Grace
Traumatic Brain Injury
Co-ultra PEALut Enhances Neuronal Recovery Following Moderate Traumatic Brain Injury
Traumatic brain injury (TBI) typically provokes secondary injury mechanisms, including the dynamic interplay between the ischemic, inflammatory, and cytotoxic processes.
- Trial name
- GLIA13 (NCT03818451)
- Testing
- Co-ultraPEALut (Glialia)
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Messina
Mild Traumatic Brain Injury
Pro-2-Cool Device Clinical Study
This study is being conducted to quantify the clinical safety and efficacy of head and neck cooling when applied up to 8 days after mild traumatic brain injury (mTBI) among adolescents participating in sporting activities.
- Trial name
- NCT03511339
- Testing
- TecTraum device
- Where
- 5 sites in United States
- Volunteers
- 174 people
- Sponsor
- TecTraum Inc.
Traumatic Brain Injury
Feasibility of the Radio-Frequency Microstimulator System to Improve Arm Function Following Traumatic Brain Injury
This study will evaluate the feasibility of using fully implanted microstimulators to rehabilitate arm function in patients who have suffered a traumatic brain injury.
- Trial name
- NCT01488981
- Testing
- Upper Extremity Therapy without stimulation, Upper Extremity Therapy with stimulation from the Radiofrequency Microstimulator (RFM) System (Alfred Mann Foundation, Santa Clarita, CA)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- The Alfred E. Mann Foundation for Scientific Research
Traumatic Brain Injury (TBI), Suicidal Behavior
Executive Dysfunction & Suicide: An Exploration Of Risk Factors In Traumatically Brain Injured Veterans
This is a study to learn more about traumatic brain injury (TBI) and suicidal behaviors. The purpose of this research is to find out more about the issues related to these conditions.
- Trial name
- NCT01118195
- Volunteers
- 54 people
- Sponsor
- VA Eastern Colorado Health Care System
Concussion Mild, Concussion, Brain
Sport-Related Concussion Recovery in Athletes
The goal of this study is to enhance the accuracy and sensitivity of concussion evaluation by integrating traditional assessment tools with emerging neuroimaging technologies, such as Functional Near-Infrared Spectroscopy…
- Trial name
- NCT06852300
- Testing
- Concussion Assessment Battery
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Central Arkansas
Traumatic Brain Injury, Depression
The Effect of Exercise on Mood After Traumatic Brain Injury
We proposed to examine the effect of an aerobic exercise intervention on depression in persons with Traumatic Brain Injury (TBI).
- Trial name
- NCT00571545
- Testing
- Aerobic exercise, No exercise
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Washington
Traumatic Brain Injury (TBI)
Hormonal Deficiency in the Quality of Life of Patients With Traumatic Brain Injury
The primary objective is to assess the long-term impact of hormonal deficiency on Quality of Life (QoL) in a large group of moderate and severe Traumatic Brain Injury (TBI) patients.
- Trial name
- INSPIRE-TC (NCT01512524)
- Testing
- MRI scan and endocrinology analysis
- Where
- France
- Volunteers
- 88 people
- Sponsor
- Hospices Civils de Lyon
Traumatic Brain Injury, Posttraumatic Stress Disorder
LED Treatment to Improve Cognition and Promote Recovery in TBI
This study investigates the efficacy of a novel neuromodulation treatment, light emitting diodes (LED), on cognition, neuropsychiatric status and quality of life in individuals with traumatic brain injury (TBI).
- Trial name
- LED-TBI (NCT02404402)
- Testing
- LED
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
Fatigue, Sleep Disorders and Endocrine Abnormalities in TBI Patients
This study will test if patients with moderate to severe traumatic brain injuries also have endocrine abnormalities, examine any existing relationships among fatigue, depression and endocrine abnormalities, and the relationship…
- Trial name
- NCT00775775
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Kessler Foundation
Chronic Subdural Hematoma
Tranexamic Acid in the Treatment of Residual Chronic Subdural Hematoma -2
Chronic subdural hematoma (CSDH), a common disease after minor head trauma, is characterized by blood collection in the subdural space, which can result in severe neurological impairment.
- Trial name
- TRACE-2 (NCT04898712)
- Testing
- Tranexamic Acid 500 MG
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- Unity Health Toronto
Traumatic Brain Injury, Subarachnoid Hemorrhage
Assess Safety and Efficacy of Levetiracetam(LEV;Keppra)for Seizure Prevention
To show that the use of intravenous levetiracetam(LEV;Keppra)for seizure prevention in patients in the Neuroscience Intensive Care Unit will result in fewer side effects compared to the current standard of care anticonvulsant and…
- Trial name
- Keppra (NCT00618436)
- Testing
- Levetiracetam, Phenytoin
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Cincinnati
Traumatic Brain INjury
IL-1ra Dose-range Study for Moderate-to-severe TBI Patients
Traumatic brain injury (TBI) is a common condition with high degree of morbidity and mortality (Hyder et al., 2007). Current treatment paradigms for TBI focus on mitigating secondary injury and maintaining cerebral physiology…
- Trial name
- IL1ra (NCT02997371)
- Testing
- Anakinra Prefilled Syringe, Isotonic saline
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Adel Helmy
Intracranial Hemorrhage, Traumatic, Embolism and Thrombosis
Traumatic Intracranial Hemorrhage in Users of Oral Antithrombotic Drugs
Oral antithrombotic medications (OAM) are used for the prevention and treatment of thrombotic disorders. Among hemorrhagic complications of OAMs, intracranial hemorrhage (ICH) may have particularly devastating consequences with…
- Conditions
- Intracranial Hemorrhage, Traumatic, Embolism and Thrombosis, Hematoma, Subdural, Intracranial
- Trial name
- NCT02996851
- Volunteers
- 6,279 people
- Sponsor
- St. Olavs Hospital
Disorder of Consciousness, Traumatic Brain Injury
Validity and Feasibility of the CRSR-FAST
The CRS-R is a standardized and validated bedside assessment of conscious awareness. It is used routinely for diagnosis and prognosis of patients with disorders of consciousness (DOC) as well as in research settings.
- Trial name
- CRSR-FAST (NCT03549572)
- Testing
- Coma Recovery Scale-Revised
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Massachusetts General Hospital
Neurologic Disorder, Stroke
Home Based Tele-exercise for People With Chronic Neurological Impairments
To assess the impact of a 12-week virtual seated physical intervention on cardiovascular health and wellness in people with chronic neurological impairments (CNI).
- Conditions
- Neurologic Disorder, Stroke, Spinal Cord Injuries, Cerebral Palsy
- Trial name
- Telex (NCT04564495)
- Testing
- Seated exercise
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Burke Medical Research Institute
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