Clinical trials: Traumatic Head Injury
Concussion, Brain, Pediatric Disorder
RECOVER Clinical Pathway for Pediatric Concussion
The project encompasses the development and implementation of an acute care, pediatric concussion clinical pathway at 5 pediatric emergency departments in the province of Alberta (Canada).
- Conditions
- Concussion, Brain, Pediatric Disorder, Mild Traumatic Brain Injury
- Trial name
- RECOVER (NCT05095012)
- Testing
- Pediatric Acute Care Concussion Clinical Pathway
- Where
- Canada
- Volunteers
- 2,878 people
- Sponsor
- University of Calgary
Muscle Spasticity, Spinal Cord Injury
Comparing Upper Limb Surgery and Botulinum Toxin for Spasticity: A Paired Design Study
Spasticity is a common complication following central nervous system injuries. Left untreated, spasticity can lead to various complications, hindering activities of daily living and diminishing independence.
- Conditions
- Muscle Spasticity, Spinal Cord Injury, Stroke, Traumatic Brain Injuries
- Trial name
- NCT06733025
- Testing
- Tendon lengthening surgery, BoNT Injections
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Vastra Gotaland Region
Brain Concussion, Brain Trauma
tDCS and Cognitive Training in Active Duty Service Members With Mild TBI: A Pilot Study
The proposed study will evaluate a new approach to cognitive rehabilitation of mild traumatic brain injury (mTBI) using a brain stimulation technique called transcranial direct current stimulation (tDCS).
- Conditions
- Brain Concussion, Brain Trauma, Attention Concentration Difficulty, Brain Injuries
- Trial name
- NCT04925453
- Testing
- active tDCS and cognitive training intervention
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- United States Naval Medical Center, San Diego
Traumatic Brain Injury
Growth Hormone and Insulin Growth Factor 1 Deficiencies in Children/Adolescents Following Traumatic Brain Injury: The Impact on Growth and Neuropsychological Development
The purpose of this study is to look at the relationship between growth hormones, and recovery from a TBI - traumatic brain injury. It is believed that a TBI may interfere with the body's ability to produce growth hormones.
- Trial name
- NCT00929045
- Testing
- Growth Hormone Replacement
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Traumatic Brain Injury, Intracerebral Hemorrhage
Clinical Decision Support System for Early Mobilization in the Neuro-ICU
This study aims to evaluate the feasibility, safety, and user acceptability of a tablet- and smartphone-based Clinical Decision Support System (CDSS) designed to guide early mobilization for patients with severe neurological…
- Conditions
- Traumatic Brain Injury, Intracerebral Hemorrhage, Subarachnoid Hemorrhage, Spontaneous, Acute Ischemic Stroke
- Trial name
- CDSS-EM-ICU (NCT07685145)
- Testing
- Clinical Decision Support System (CDSS) for Early Mobilization
- Where
- Taiwan
- Volunteers
- 25 people
- Sponsor
- National Taiwan University Hospital
Traumatic Brain Injury
Omega3 PUFA in Head Trauam
Traumatic brain injury (TBI) is major health problem that stands as a significant cause of death and permanent disability. TBI is considered as global public health epidemic.
- Trial name
- SMOFbrain (NCT02762539)
- Testing
- omega-3 enriched SMOF lipid emusion
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Mansoura University
Postconcussion Syndrome, Mild Traumatic Brain Injury
Effectiveness of Rehabilitation in Adults Suffering From Persistent Concussion Symptoms
Protocol Summary The present study was developed to better understand the effects and benefits of individualizing rehabilitative treatments based on subgroup classifications determined by a standardized clinical examination.
- Trial name
- NCT06069700
- Testing
- Non-pharmacological Individualized rehabilitative therapy, Non-pharmacological Usual care therapy
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Traumatic Brain Injury, TBI (Traumatic Brain Injury)
Cervical Transcutaneous SCS for TBI
The goal of this study is to test the effects of non-invasive electrical stimulation of the spinal cord (called transcutaneous spinal cord stimulation, or tSCS) on arm and hand movement in people with motor impairments after a…
- Trial name
- NCT07147816
- Testing
- Transcutaneous electrical stimulation of the cervical spinal cord (tSCS)
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Roberto de Freitas
Traumatic Brain Injury
Cognitive Rehabilitation and Brain Activity of Attention-Control Impairment in TBI
The purpose of this research study is to develop a method to improve thinking difficulties in individuals who have experienced a traumatic brain injury and report experiencing difficulties in attention and concentration.
- Trial name
- NCT04199130
- Testing
- BrainHQ, Goal Management Training
- Where
- United States
- Sponsor
- University of Florida
Concussion, Mild, Sport Injury
Sensorimotor Training for Injury Prevention in Collegiate Soccer Players II
The purpose of this project is to evaluate the effectiveness of an injury prevention intervention delivered primarily using headset virtual reality for collegiate soccer players.
- Trial name
- NCT04036916
- Testing
- Virtual Reality Sensorimotor Training
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Mississippi Medical Center
Traumatic Brain Injury, Posttraumatic Stress Disorders
Telepharmacy Robotic Medicine Delivery Unit "TRMDU" Assessment
The objective of this study is to evaluate whether use of TRMDU in addition to medication review leads to improved outcomes and reduced health care costs for patients when compared with medication review alone.
- Conditions
- Traumatic Brain Injury, Posttraumatic Stress Disorders, Trauma, Combat Disorders
- Trial name
- NCT01007006
- Testing
- TMRDU
- Where
- 3 sites in United States
- Sponsor
- University of Illinois Chicago
Traumatic Brain Injury
The Safety and the Efficiency of Hyperbaric Oxygen in Traumatic Brain Injury
The goal of this observational study is to learn about the safety and long-term effects of hyperbaric oxygen therapy in participants over the age of 18 with traumatic brain injury (TBI).
- Trial name
- NCT06816199
- Testing
- Hyperbaric oxygen exposure
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Traumatic Brain Injury
Validation Study of Simplified Chinese Version of LOTCA Scale in the Assessment of Cognitive Impairment in Patients with Traumatic Brain Injury
In this study, 300 patients aged ≥18 years old with traumatic brain injury (case group) and hospitalized patients without central nervous system disease or their family members and accompanying staff (control group) were selected…
- Trial name
- NCT06850584
- Testing
- Observation
- Where
- 4 sites in China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Nanjing Broad Biopharmaceutical Ltd.
Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder
Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History
This study will probe if the biological changes in amnestic mild cognitive impairment (aMCI) are related to a history of mild traumatic brain injury (mTBI) using high definition transcranial direct current stimulation (HD-tDCS)…
- Conditions
- Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder, Amnestic Mild Cognitive Impairment, Mild Traumatic Brain Injury
- Trial name
- PATH (NCT05446584)
- Testing
- High Definition Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Texas Southwestern Medical Center
Motor Vehicle Accidents, TBI (Traumatic Brain Injury)
Concussion in Motor Vehicle Accidents: The Concussion Identification Index
The primary goal of this study is to provide clinicians with a brief, patient self-administer instrument yielding a single composite score that reliably correlates with objective findings on standardized neurocognitive assessment…
- Conditions
- Motor Vehicle Accidents, TBI (Traumatic Brain Injury), Brain Contusion, Brain Injuries
- Trial name
- CIDI (NCT02858544)
- Testing
- The Concussion Identification Index, ImPACT
- Where
- United States
- Volunteers
- 1,790 people
- Sponsor
- Clionsky Neuro Systems Inc.
Post-Traumatic Headache
Treximet for Prevention of Post Traumatic Headache Associated With Cognitive Dysfunction
This study will evaluate the effectiveness of Treximet when taken for post traumatic headache by measuring any change in the number of headache days or any change in a subject's ability to think following treatment with study…
- Trial name
- NCT01053507
- Testing
- sumatriptan/naproxen sodium
- Where
- 3 sites in United States
- Volunteers
- 23 people
- Sponsor
- Cady, Roger, M.D.
Insomnia Disorder, Mild Traumatic Brain Injury
Sleep MAPP in the Polytrauma/TBI System of Care
This pilot implementation trial will evaluate the Sleep Disorder Management Assistance for Providers and Patients (Sleep MAPP) Care Pathway in one Veterans Health Administration Polytrauma/TBI System of Care clinic.
- Trial name
- Sleep MAPP (NCT07886398)
- Testing
- Sleep MAPP Care Pathway
- Where
- 2 sites in United States
- Volunteers
- 900 people
- Sponsor
- VA Office of Research and Development
Disorder of Consciousness, MMN
Excitatory Prefrontal Weak Current Stimulation in Vegetative Patients
In response to "conscious" EEG findings related to detectable cognitive function that reliably denote awareness in vegetative state patients, in the current study, we will assess the covert conscious EEG activity (as well as…
- Conditions
- Disorder of Consciousness, MMN, Modification of Cognitive Status Indication, Anoxic Brain Damage
- Trial name
- VEG-TDCS (NCT04614792)
- Testing
- Transcranial direct current stimulation
- Where
- Israel
- Volunteers
- 16 people
- Sponsor
- Oded Meiron
Posttraumatic Stress Disorder, Depression
Trauma Survivors Outcomes and Support Study IV
After traumatic injuries some people have difficulty returning to the routine of their everyday activities and may experience physical and emotional pain.
- Conditions
- Posttraumatic Stress Disorder, Depression, Suicide, Traumatic Brain Injury
- Trial name
- TSOS IV (NCT01625416)
- Testing
- Stepped Care Management
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- University of Washington
Acquired Brain Injury, Concussion, Brain
The Effect of Hypnotic Suggestion After Acquired Brain Injury or Concussion
A recent randomized clinical trial (RCT) demonstrated large effects of hypnotic suggestion on working memory following acquired brain injury.
- Trial name
- NCT05142007
- Testing
- Hypnosis, Mindfulness-based stress reduction
- Where
- Denmark
- Volunteers
- 77 people
- Sponsor
- Aalborg University
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