Clinical trials: Traumatic Injuries
Hematoma, Subdural, Chronic
Exhaustive Drainage Versus Fixed-time Drainage for Chronic Subdural Hematoma After One-burr Hole Craniostomy
A prospective, multicenter, randomized controlled trial is designed to compare the recurrence rates and clinical outcomes in patients with chronic subdural hematoma using exhaustive drainage or fixed-time drainage after one-burr…
- Trial name
- ECHO (NCT04573387)
- Testing
- Operation, Fixed-time drainage, Exhaustive drainage
- Where
- 17 sites in China
- Volunteers
- 309 people
- Sponsor
- Beijing Tiantan Hospital
Stress Disorders, Post-Traumatic, Combat Disorders
NightWare Randomized Trial 02
This study will provide preliminary estimates of safety and efficacy of the NightWare digital therapeutic system (iPhone + Apple watch + proprietary application) for the treatment of nightmare disorder associated with…
- Conditions
- Stress Disorders, Post-Traumatic, Combat Disorders, Ptsd, Nightmare
- Trial name
- TNT/NW (NCT04040387)
- Testing
- NightWare Therapeutic System
- Where
- 4 sites in United States
- Volunteers
- 270 people
- Sponsor
- NightWare
Surgery, Critical Illness
Sedation Optimisation Strategy (S.O.S.) Ventilation
Use of sedatives and analgesics is common in mechanically ventilated patients hospitalized in Intensive Care Unit (ICU). That is called " sedation " and aimed to reduce both pain and anxiety and also to allow an effective and…
- Conditions
- Surgery, Critical Illness, Mechanical Ventilation Complication, Organ Dysfunction Syndrome
- Trial name
- NCT01486121
- Testing
- Therapy strategy
- Where
- 3 sites in France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Montpellier
Pain, Pain Syndrome
Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Pain Due to Traumatic or Post-operative Peripheral Neuropathy
Over the last years a rising medical need for treatment of chronic pain was identified. Based on previous findings indicating the pain modulating effects of cannabinoids in chronic pain disorders, this clinical trial investigates…
- Conditions
- Pain, Pain Syndrome, Pain, Chronic, Chronic Pain
- Trial name
- NCT06071988
- Testing
- Adezunap (AP707)
- Where
- Germany
- Volunteers
- 558 people
- Sponsor
- Apurano Pharmaceuticals GmbH
Coma, Traumatic
Dopaminergic Disruption Induced by Traumatic Coma: Dopaminergic Pathways Abnormalities and Biomarkers of Recovery Using MRI and 18F-LBT-999 PET
The neural correlates of consciousness have been studied at the macroscopic level. However, the neurochemical basis of these processes remains poorly understood.
- Trial name
- ComaDopa (NCT06930261)
- Testing
- LBT-999
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Aggression, Post Traumatic Stress Disorders
Strength at Home Couples Program (PTSD-Focused Relationship Enhancement Therapy for Returning Veterans)
The purpose of the project is to develop and test a couples-based relationship enhancement group intervention for married or partnered Operation Enduring Freedom (OEF)/Operation Iraqi Freedom (OIF)/Operation New Dawn (OND)…
- Trial name
- NCT00827879
- Testing
- Strength at Home Couples Group, Supportive Group Therapy
- Where
- 2 sites in United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Boston VA Research Institute, Inc.
PTSD
Clinical Assessment of the Flash - Eye Movement Desensitization and Reprocessing
To assess the Flash version of EMDR in reductions of the disturbance of upsetting memories at post-intervention, and 1-month follow up within a double-blinded, online 2-arm randomized controlled trial (RCT) with self-report…
- Trial name
- Flash-EMDR (NCT05262127)
- Testing
- Flash Version of EMDR
- Where
- 2 sites in Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- York University
Concussion
Cortical Plasticity Assessment in Athletes With a History of Concussion
The purpose of this research is to determine whether athletes with concussion have changes in cortical excitability. Single and paired transcranial magnetic stimulation (TMS) can be used as reliable neurophysiological marker of…
- Trial name
- NCT01112761
- Testing
- Transcranial direct current stimulation
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Mild Traumatic Brain Injury
Balance and Mild Traumatic Brain Injury: The Effect of a Weighted Compression Vest
After a mild traumatic brain injury (mTBI) people often report balance problems. At Parkwood hospital we have noticed that balance is improved when patients with mTBI wear a weighted compression vest.
- Trial name
- NCT02084329
- Testing
- Weighted Compression Vest
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Mild to Moderate Traumatic Brain Injury
PoNS Clinical Experience Program (TBI)
Brief Summary: Prospective, cohort, open-label study. The cohort consists of people who have a chronic balance dysfunction due to a mild to moderate traumatic brain injury (TBI).
- Trial name
- NCT03881202
- Testing
- PoNS Treatment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Helius Medical Inc
PTSD, Post ICU Syndrome
Intensive Care Unit (ICU) Diary Project
Psychological morbidity in both patients and family members related to the intensive care unit (ICU) experience is an often overlooked, and potentially persistent, healthcare problem recognized by the Society of Critical Care…
- Trial name
- NCT04305353
- Testing
- Diary (blank journal) plus PTSD psycho-education, PTSD psycho-education alone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Tulane University School of Medicine
Acute Stress Disorder
Psychological Interventions in Children After Road Traffic Accidents or Burns
Within a randomized controlled design the effects of a brief early psychological intervention (child, parents) after road traffic accidents or burns shall be examined in a sample of 120 children and adolescents (aged 2 to 16…
- Trial name
- PICARTA-B (NCT01085370)
- Testing
- Early psychological intervention
- Where
- Switzerland
- Volunteers
- 108 people
- Sponsor
- University Children's Hospital, Zurich
Concussion, Brain, Concussion, Mild
BCAAs in Concussion 2.0
This study is a randomized, placebo-controlled, double-blinded, therapeutic exploratory clinical trial of branched chain amino acids (BCAAs) in the treatment of concussion.
- Conditions
- Concussion, Brain, Concussion, Mild, Concussion
- Trial name
- NCT06829498
- Testing
- BCAA
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Akiva Cohen
Traumatic Brain Injury
Improving Well-Being After TBI Through Structured Volunteer Activity
The purpose of this project is to determine if participating in volunteer activity improves the psychological well-being of individuals with traumatic brain injury (TBI).
- Trial name
- NCT01728350
- Testing
- HOPE - Helping Others through Purpose and Engagement
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Craig Hospital
Post Traumatic Stress Disorder, Major Depressive Disorder
Accelerated TMS to a Novel Brain Target in MDD and PTSD
This is a Clinical Trial designed to evaluate novel transcranial magnetic stimulation (TMS) methods for treating depression/PTSD. TMS is an FDA-approved procedure for treatment-resistant depression.
- Trial name
- NCT03114891
- Testing
- Transcranial Magnetic Stimulation (TMS), Task, fMRI-guided TMS target
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
Stroke, Traumatic Brain Injury
Study Examines the Feasibility, Safety and Benefits of Using a Specific Suspension Walking Device for Patients With Neurological Damage
This monocentric descriptive study addresses feasibility, safety and benefits of using a specific suspension walking device for patients with severe neurological injuries in the neuroICU of Montpellier University Hospital…
- Conditions
- Stroke, Traumatic Brain Injury, Incomplete Cervical Spinal Cord Injury, Other Brain Injuries
- Trial name
- Walk-Up (NCT04300491)
- Testing
- Suspension walking training
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Traumatic Brain Injury
Seizure Prevention in Traumatic Brain Injury With Levetiracetam and Lacosamide
The purpose of this study is to assess the incidence of early post-traumatic seizures. The study will also assess the benefit of lacosamide compared to levetiracetam in regards to agitation and behavioral adverse effects in…
- Trial name
- SEIZE-TBI (NCT06866691)
- Testing
- levetiracetam, lacosamide
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Wake Forest University Health Sciences
Posttraumatic Stress Disorder
Randomized Trial of Prolonged Exposure for the Treatment of Posttraumatic Stress Disorder (PTSD)
This project will examine the impact of PE therapy for the treatment of PTSD with a sample of Latinos. The need to provide effective treatment to Spanish-speaking Latinos with PTSD is critical given the high prevalence of PTSD…
- Trial name
- NCT02134691
- Testing
- Prolonged Exposure, Applied Relaxation
- Where
- Puerto Rico
- Volunteers
- 98 people
- Sponsor
- University of Puerto Rico
Traumatic Brain Injury
Efficacy of VAS203 (Ronopterin) in Patients With Moderate and Severe Traumatic Brain Injury
This study evaluates the efficacy of an infusion of Ronopterin (VAS203) on clinical outcome in patients with moderate and severe traumatic brain injury.
- Trial name
- NOSTRA-III (NCT02794168)
- Testing
- VAS203, Saline
- Where
- 29 sites in Austria, France and 3 more
- Volunteers
- 224 people
- Sponsor
- veriNOS operations GmbH
Traumatic Brain Injury
Becoming Traumatic Brain Injured Patients at Day 7 of Their Trauma
To study the future of traumatic brain injured patients at day 7 of their trauma Primary endpoint: Fate, classified as survival with or without sequelae, death.
- Trial name
- NCT04077268
- Testing
- GOS-E
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Poitiers University Hospital
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