Clinical trials: Traumatic Injuries
Posttraumatic Stress Disorder
Enhancement of PTSD Treatment With Computerized Executive Function Training
This study focuses on helping Iraq and Afghanistan Veterans with posttraumatic stress disorder (PTSD) benefit fully from therapy by first enhancing their thinking abilities.
- Trial name
- NCT03260127
- Testing
- Computerized executive function training plus CPT (CEFT-CPT), Word game training plus CPT (WT-CPT)
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- VA Office of Research and Development
PostTraumatic Stress Disorder
Equine Assisted Psychotherapy for PTSD
The purpose of this study is to assess the efficacy of Equine Assisted Psychotherapy on PTSD symptoms in veterans with PTSD as compared with existing care.
- Trial name
- NCT03039361
- Testing
- Equine Assisted Psychotherapy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Trauma, Shock, Traumatic
Discriminant Ability of the Shock Index, Modified Shock Index, and Reverse Shock Index Multiplied by the Glasgow Coma Scale on Mortality in Adult Trauma Patients: A PATOS Study
We evaluated a cohort of adult trauma patients transported to emergency departments. The first vital signs were used to calculate the SI, MSI, and rSIG.
- Conditions
- Trauma, Shock, Traumatic, Morality
- Trial name
- NCT05549986
- Testing
- Observational
- Volunteers
- 105,641 people, healthy volunteers welcome
- Sponsor
- Mackay Memorial Hospital
Chronic Post-Traumatic Stress Disorder
G.R.I.T. - Goal-directed Resilience Intervention Training
This research program has addressed three reactive adaptations evident in pain, PTSD, and obesity. In this project, the focus will be on PTSD as a model of stimulus-based reactive responses to unpredictability or threat, and the…
- Trial name
- GRIT (NCT03890029)
- Testing
- Intervention Training, Control Condition
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Morehouse School of Medicine
Mild Traumatic Brain Injury, Balance; Distorted
Can Early Initiation of Rehabilitation With Wearable Sensor Technology Improve Outcomes in mTBI?
Every year 1.7 million people sustain a traumatic brain injury (TBI) in the United States and of these, 84 % are considered mild TBI (mTBI).
- Conditions
- Mild Traumatic Brain Injury, Balance; Distorted, Gait, Unsteady, Quality of Life
- Trial name
- NCT03479541
- Testing
- Timing of Rehabilitation, Biofeedback
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Traumatic Brain Injury, Cerebral Oxygen Saturation
Effectiveness of Dexmedetomidine Versus Sufentanil on Cerebral Oxygen Saturation in Patients With Traumatic Brain Injury
This randomized controlled clinical trial aims to evaluate the effectiveness of dexmedetomidine compared with sufentanil on cerebral oxygen saturation in patients with traumatic brain injury (TBI) undergoing surgery under general…
- Conditions
- Traumatic Brain Injury, Cerebral Oxygen Saturation, NIR Spectroscopy
- Trial name
- DESTIN (NCT07244822)
- Testing
- Dexmedetomidine, Sufentanil
- Where
- Indonesia
- Volunteers
- 28 people
- Sponsor
- Universitas Jenderal Soedirman
Stroke, Brain Injuries
The Efficacy of Dynamic Hand Splint Treatment in Spastic Hemiparetic Patients
The purpose of this randomized controlled trial was designed to study the efficacy of dynamic hand splinting on spastic hemiparetic patients due to stroke or traumatic brain injury.
- Trial name
- NCT04441437
- Testing
- Task-oriented training with a dynamic hand splint, Task-oriented training without a dynamic hand splint
- Volunteers
- 35 people
- Sponsor
- Chang Gung Memorial Hospital
Post Traumatic Stress Disorder
Web-administered STAIR for Patients on Behavioral Health Waitlists
Posttraumatic stress disorder (PTSD) is a significant public health challenge with population prevalence rates in the US between 6.1 to 9.2%.
- Trial name
- webSTAIR (NCT06431022)
- Testing
- webSTAIR, CHW coaching
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Boston Medical Center
PTSD
Evaluation of an Algorithm for the Identification of Post-traumatic Stress Disorder
Post-traumatic stress disorder (PTSD) develops after a threat for oneself and/or others. It is frequent, particularly in the military, due to repeated exposure to traumatic events.
- Trial name
- Dstress (NCT06796556)
- Testing
- virtual reality exposition
- Where
- France
- Volunteers
- 134 people
- Sponsor
- Direction Centrale du Service de Santé des Armées
Acute Pain Due to Trauma, Analgesia
Timecost of Intranasal Versus Intravenous Analgesia in Traumatic Pain
Prehospital treatment of acute traumatic pain is common in military practice. Analgesics are usually administered intravenously (IV).
- Trial name
- NCT06351137
- Testing
- Intravenous administration, Intranasal administration
- Where
- Netherlands
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
PTSD
Non-invasive Nerve Stimulation and Sleep
People often have difficulty sleeping. Reasons are many. But, difficulty falling and staying asleep are common issues. Sleep difficulties are common in disorders such as Post Traumatic Stress Disorder.
- Trial name
- NINS (NCT04021537)
- Testing
- non-invasive nerve stimulation
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Shoulder Dislocation
Early arthroscoPic Stabilization veRsus rehabilitatiOn of the Shoulder in Adolescents With a trauMatic First-time Anterior Shoulder Dislocation ePisode
Each year within Canada and the US, more than 30,000 children and adolescents will have an injury to their shoulder resulting in a shoulder dislocation.
- Trial name
- PROMPT (NCT04887337)
- Testing
- Arthroscopic stabilization, Rehabilitation including a period of immobilization followed by physical therapy
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- McMaster University
Posttraumatic Stress Disorder
Efficacy of Yoga for Treatment-Resistant Posttraumatic Stress Disorder
The central question in this research proposal is: can a popular technique that specifically targets active mastery and improved affect regulation, yoga, which is utilized by approximately 4% of the US population each year (1)…
- Trial name
- NCT00839813
- Testing
- Yoga
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Justice Resource Institute
Major Depressive Disorder, Depression
Testing a Transdiagnostic TMS Treatment Target
The goal of this clinical trial is to test a new brain stimulation treatment target for individuals with depression plus at least one additional psychiatric disorder.
- Conditions
- Major Depressive Disorder, Depression, Psychiatric Disorder, Mood Disorders
- Trial name
- T5 (NCT06282146)
- Testing
- transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Brigham and Women's Hospital
Posttraumatic Stress Disorders
Ifenprodil Tartrate Treatment of Adolescents With Post-traumatic Stress Disorder: a Double-blind, Placebo-controlled Trial
Accumulating evidence suggests a key role of the N-methyl-D-aspartate (NMDA) receptor in the pathophysiology of post-traumatic stress disorder (PTSD).
- Trial name
- NCT01896388
- Testing
- Ifenprodil Tartrate
- Where
- Japan
- Volunteers
- 10 people
- Sponsor
- Chiba University
Phantom Limb
Virtual Integrated Environment in Decreasing Phantom Limb Pain
The purpose of this study is to determine if observing a virtual arm decreases phantom limb pain (PLP) in upper extremity amputees.
- Trial name
- VIE (NCT01462461)
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Traumatic Brain Injury
Intracranial Pressure (ICP) Monitoring Following Traumatic Brain Injury (TBI)
The aim of this retrospective cohort study is to evaluate complications rates, indications, and the utility of follow-up imaging studies of ICP measurement in severe TBI patients.
- Trial name
- NCT04428970
- Testing
- Invasive ICP monitoring
- Where
- Austria
- Volunteers
- 214 people
- Sponsor
- Medical University of Vienna
PTSD, Overweight
MOVE!+UP: Testing a Tailored Weight Management Program for Veterans With PTSD
Posttraumatic Stress Disorder (PTSD) is common among Veterans and results in poor psychological functioning, quality of life, and physical health.
- Conditions
- PTSD, Overweight, Obesity
- Trial name
- NCT04563741
- Testing
- MOVE!+UP, MOVE!
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- VA Office of Research and Development
Pediatric ALL, Concussion, Mild
Concussion Active Rehabilitation
In this study, the investigator plans a randomized trial of active rehabilitation and standard care for acute concussion management.
- Conditions
- Pediatric ALL, Concussion, Mild, Concussion, Brain, Concussion, Intermediate
- Trial name
- NCT04248218
- Testing
- Active Rehabilitation Group/Case
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Fatigue
Post-Traumatic Brain Injury (Post-TBI) Fatigue and Its Treatment
Randomized clinical trial of modafinil vs. placebo for treatment of fatigue after TBI.
- Trial name
- NCT00233090
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
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