Clinical trials: Traumatic Injuries
Non Traumatic Acute Brain Injury
Non Traumatic Neuro-Vascular Diseases Critical Complications : a Prospective Cohort Study
The purpose of this observational epidemiological study is to investigate the management and the complications associated with Non Traumatic Neuro-Vascular Diseases.
- Trial name
- ATLANREA (NCT02714387)
- Testing
- Collection of medical data
- Where
- 6 sites in France
- Volunteers
- 5,000 people
- Sponsor
- Nantes University Hospital
Substance Use Disorders, Drug Abuse
Leveraging Implementation Science to Increase Access to Trauma Treatment for Incarcerated Drug Users
The unmet need for effective addiction treatment within the criminal justice system "represents a significant opportunity to intervene with a high-risk population" according to NIDA's 2016-2020 strategic plan.
- Conditions
- Substance Use Disorders, Drug Abuse, Alcohol Abuse, Posttraumatic Stress Disorder
- Trial name
- NCT04007666
- Testing
- Cognitive Processing Therapy, Control Group
- Where
- 2 sites in United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Traumatic Brain Injury
Music Therapy for Comatose Brain Injured Patients
The goal of this single-arm observational study is to determine whether alpha music therapy, initiated early in the recovery period, can improve cognitive function for severe traumatic brain injury patients when compared to…
- Trial name
- NCT07544602
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Mercy Health Ohio
Brain Injuries, Brain Diseases
Influence of Physical Exercise on Cognitive Functioning of Traumatic Brain Injury Patients
The aim of this study is to determine the effects of an acute session of physical exercise on cognitive functioning and humor of traumatic brain injury patients and to investigate whether different cognitive responses can be…
- Conditions
- Brain Injuries, Brain Diseases, Central Nervous System Diseases, Craniocerebral Trauma
- Trial name
- NCT01395472
- Testing
- Acute Physical Exercise, Stretching protocol
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Traumatic Brain Injury With Prolonged Loss of Consciousness
Low-Intensity Focused Ultrasound on Individuals With Disorder of Consciousness of Traumatic Brain Injury
Low-intensity focused ultrasound can be effective in severe TBI patients with disorder of consciousness. This study is a prospective single arm, open-label and explorative clinical trial to evaluate the therapeutic effect of…
- Trial name
- NCT04306601
- Testing
- Low-Intensity Focused Ultrasound
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Seoul National University Hospital
Posttraumatic Stress Disorder
Improving Function Through Primary Care Treatment of Posttraumatic Stress Disorder (PTSD)
The proposed project will examine a promising brief therapy for posttraumatic stress Disorder (PTSD) for use in Veterans Health Administration (VHA) Primary Care and its impact on functional outcomes.
- Trial name
- PE-PC (NCT03581981)
- Testing
- Prolonged Exposure for Primary Care (PE-PC), Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- VA Office of Research and Development
Chronic Subdural Hematoma, Anticoagulant-induced Bleeding
Management of Anticoagulants and Antithrombotics in Patients With CSDH
Primary objective of the study will be to compare, up to 6 months after surgery, number of relapses (post operative re-bleeding) or intracerebral hemorrhage (others than subdural hematomas) and thromboembolic or cardiovascular…
- Conditions
- Chronic Subdural Hematoma, Anticoagulant-induced Bleeding, Thromboembolic Stroke, Cardiovascular Stroke
- Trial name
- THERCA (NCT05079295)
- Testing
- CSDH evacuation
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- University Hospital of Ferrara
Posttraumatic Stress Disorder (PTSD)
Integrated Health Care for PTSD
The goal of this clinical trial is to determine whether which types of integrative care, meaning a combination of psychotherapy and mind-body interventions, lead to the most changes in functioning among Veterans with…
- Trial name
- NCT07220681
- Testing
- Yoga and meditation, Wellness, Positive affect
- Where
- 5 sites in United States
- Volunteers
- 300 people
- Sponsor
- Veterans Medical Research Foundation
Stress Disorders, Post-Traumatic
Intensive Treatment for Chronic Pain and Posttraumatic Stress Disorder (PTSD)
This study is investigating the efficacy of an intensive (3 week) integrated treatment for Veterans with both pain and PTSD.
- Trial name
- NCT01120067
- Testing
- Intensive Treatment, Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- VA Office of Research and Development
Chronic Traumatic Encephalopathy
Tau Imaging of Chronic Traumatic Encephalopathy
Chronic traumatic encephalopathy (CTE) is a progressive degenerative brain disease with symptoms that include memory loss, problems with impulse control, and depression that can lead to suicide.
- Trial name
- NCT02191267
- Testing
- [F18]-T807, [F18]-Florbetapir, MRI/MRS
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Posttraumatic Stress Disorder, Insomnia
Treating Co-Morbid Sleep Difficulties in Veterans With Posttraumatic Stress Disorder (PTSD): A Pilot Study
A substantial number of US Veterans are suffering from Posttraumatic Stress Disorder (PTSD) following deployment in recent military conflicts, and sleep disturbance is a primary complaint of Veterans presenting to the VA with…
- Trial name
- NCT00734799
- Testing
- Sleep Intervention for PTSD (SIP).
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Durham VA Medical Center
Treatment-resistant PTSD
REVERSE: Improving Treatment-resistant Post Traumatic Stress Disorder (PTSD) with Glucocorticoid Receptor (GR) Antagonism
Rationale: Post-traumatic stress disorder (PTSD) is a psychiatric disorder that can develop in people who have experienced or witnessed a traumatic event.
- Trial name
- REVERSE (NCT06689254)
- Testing
- Mifepristone 1200 mg daily
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Christiaan Vinkers
Posttraumatic Stress Disorder
Biomolecular Characteristics of Reminder-Focused Positive-Psychiatry
Objective: Posttraumatic stress disorder (PTSD) is a prevalent neuropsychiatric disorder in children and is associated with increased neurovascular inflammation, suicidality, adulthood mental health disorder, and major adverse…
- Trial name
- RFPP (NCT04529031)
- Testing
- Reminder Focused Positive Psychiatry, attentional control condition (group process)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles
Traumatic Brain Injury
Multi-Arm Multi-Stage Adaptive Platform Trial (APT) for the Acute Treatment of Traumatic Brain Injury
The purpose of this study is to determine if experimental drug treatment improves recovery after TBI as compared to a control (placebo) group. Changes in recovery will be measured throughout the study.
- Trial name
- APT-TBI-01 (NCT05826912)
- Testing
- Atorvastatin Calcium, Minocycline Hydrochloride, Candesartan Cilexetil
- Where
- 18 sites in United States
- Volunteers
- 672 people
- Sponsor
- University of California, San Francisco
Stroke, Acute Traumatic Brain Injury
Clinimetric Application of FOUR Scale as in Treatment and Rehabilitation of Patients With Acute Cerebral Injury
The aim of this study is to increase the effectiveness of clinical monitoring of patients with acute cerebral insufficiency by improving the discriminative ability of the FOUR scale.
- Conditions
- Stroke, Acute Traumatic Brain Injury, Subarachnoid Hemorrhage
- Trial name
- FOURACI (NCT06043167)
- Testing
- The predictive value russian rendition the FOUR score.
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Surgut Clinical Trauma Hospital
Stress Disorders, Traumatic, Anxiety Disorders
Forgiveness-Based Writing to Prevent Post-Traumatic Stress Disorder (PTSD) in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) Veterans
The purpose of this study is to evaluate a forgiveness-based writing intervention in an open trial with 20 Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) veterans who have recently experienced combat-related trauma…
- Conditions
- Stress Disorders, Traumatic, Anxiety Disorders, PTSD
- Trial name
- NCT00861666
- Testing
- Forgiveness-Based Writing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- South Central VA Mental Illness Research, Education & Clinical Center
Posttraumatic Stress Disorder
Narrative Exposure Therapy (NET) for Victims of the Recent Flood Disaster in Burundi
In the aftermath of natural disasters, e.g., flood disasters, there is a great need for humanitarian assistance in the domain of psychological support.
- Trial name
- NCT02172066
- Testing
- Narrative Exposure Therapy (NET)
- Where
- Burundi
- Volunteers
- 51 people
- Sponsor
- University of Konstanz
Borderline Personality Disorder, Posttraumatic Stress Disorder
CPT Group for DBT Clients With Co-Occurring Borderline Personality Disorder and PTSD
Even though borderline personality disorder (BPD) and posttraumatic stress disorder (PTSD) commonly co-occur, few studies have examined PTSD treatment among individuals with BPD.
- Trial name
- CPTDBT (NCT02574429)
- Testing
- Cognitive Processing Therapy
- Where
- 2 sites in Canada
- Volunteers
- 45 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Obstructive Hydrocephalus, Subarachnoid Hemorrhage
VisAR Augmented Reality Navigation of Ventriculostomy
This study is intended to evaluate the feasibility of using VisAR augmented reality surgical navigation during placement of an external ventricular drain (EVD).
- Conditions
- Obstructive Hydrocephalus, Subarachnoid Hemorrhage, Brain Trauma
- Trial name
- NCT06132139
- Testing
- VisAR
- Volunteers
- 50 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Post-Concussion Syndrome
Move&Connect: A Program for Youth With Concussion and Their Caregivers.
Move\&Connect is an interdisciplinary group-based program co-designed with youth and caregivers that provides skills training, mental health support, and psychoeducation to caregivers and combines these tenets with active…
- Trial name
- NCT05631301
- Testing
- Exercise Circuits, Goal Setting, Psychoeducation-Youth
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
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