Clinical trials: Traumatic Injuries
Parenting Behaviors and PTSD Symptoms
Parenting Strength At Home- Parents Pilot
The overall goal of this work is to adapt, refine, and conduct an open trial of a parent-training intervention for Veterans with posttraumatic stress disorder (PTSD) symptoms using feedback from Veterans, VA clinicians, and…
- Trial name
- PSAH (NCT03403153)
- Testing
- SAHP
- Where
- 3 sites in United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
PTSD
A 40-week Study to Evaluate TNX-102 SL 5.6 mg Taken Daily at Bedtime in Patients With PTSD
Evaluate the long-term safety of TNX-102 SL 5.6 mg taken daily at bedtime over an additional 40 weeks in patients with PTSD who have participated in a double-blind lead-in study and completed an initial 12-week open-label…
- Trial name
- P306 (NCT03508700)
- Testing
- TNX-102 SL 5.6 mg
- Where
- 16 sites in United States
- Volunteers
- 93 people
- Sponsor
- Tonix Pharmaceuticals, Inc.
Brain Concussion, Blast Injuries
Metacognitive Training to Enhance Strategy Use in Blast-Related TBI
Enhanced Goal Management Training (GMT) is a 10-week group or individual therapy that teaches strategies to improve an individual's ability to complete everyday tasks.
- Trial name
- NCT00857207
- Testing
- Goal Management Training
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- VA Office of Research and Development
Stress Disorders, Post-Traumatic
Trial to Evaluate Efficacy of Magnetic Resonant Therapy (MRT) in PTSD
The purpose of this study is to establish the efficacy of Magnetic Resonant Therapy in treating Post Traumatic Stress Disorder in Veterans.
- Trial name
- NCT02268084
- Testing
- Magnetic EEG/ECG-guided Resonance Therapy
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Wave Neuroscience
Posttraumatic Stress Disorder
Comparative Effectiveness of Two Treatments for Veterans With PTSD
Interpersonal problems such as relationship conflict and social isolation are common among Veterans with PTSD and serve as barriers to successful posttraumatic adjustment.
- Trial name
- NCT02586064
- Testing
- Interpersonal Therapy for PTSD, Prolonged Exposure
- Where
- 2 sites in United States
- Volunteers
- 115 people
- Sponsor
- VA Office of Research and Development
Post Traumatic Stress Disorder, Depression
Does an Occupational Therapy Program Enhance Mental Health Outcomes for Veterans Who Scuba Dive
The purpose of the study is to investigate whether an occupational therapy program could enhance mental health outcomes for veterans who SCUBA dive.
- Conditions
- Post Traumatic Stress Disorder, Depression, Anxiety, Stress, Psychological
- Trial name
- NCT03928392
- Testing
- SCUBA with Occupational Therapy (OT), Self-Contained Underwater Breathing Apparatus (SCUBA) without OT
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Loma Linda University
Post-Traumatic Stress Disorder
Comparative Effectiveness Research in Veterans With PTSD
VA Cooperative Study CSP #591 is designed to compare the effectiveness of two types of psychotherapy, Prolonged Exposure (PE) and Cognitive Processing Therapy (CPT), for treating posttraumatic stress disorder (PTSD) in male and…
- Trial name
- CERV-PTSD (NCT01928732)
- Testing
- Cognitive Processing Therapy (CPT), Prolonged Exposure (PE)
- Where
- 18 sites in United States
- Volunteers
- 916 people
- Sponsor
- VA Office of Research and Development
Stress Disorders, Post-Traumatic
Image-guided, Robotically Delivered Transcranial Magnetic Stimulation Treatment for Combat-Related Post-Traumatic Stress Disorder
Mounting amounts of evidence suggests that non-invasive stimulation of the dorsolateral prefrontal cortex (DLPFC) using repetitive transcranial magnetic stimulation (rTMS) maybe a safe and effective treatment modality for…
- Trial name
- NCT02853032
- Testing
- Active repetitive transcranial magnetic stimulation, robotic arm
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Post Traumatic Stress Disorder
Quantifying the Efficacy and Role of Service Dogs for Military Veterans With PTSD
The purpose of this study is to quantify the therapeutic efficacy and role of trained service dogs on socio-emotional functioning among military veterans with posttraumatic stress disorder (PTSD).
- Trial name
- NCT03245814
- Testing
- Service Dog
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University of Arizona
PTSD, TBI (Traumatic Brain Injury)
Top-Down Executive Control in Traumatic Brain Injury (TBI), PTSD and Combined
This research investigates processes involved with one being able to focus on relevant information and ignore non-relevant information in veterans with PTSD and those with a history of traumatic brain injury.
- Trial name
- NCT01072006
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
Team Based Initiative Support
Traumatic brain injury (TBI) has been called the signature injury of the Iraq War. This pilot study investigated family needs of 6 rural families caring for a Veteran with TBI.
- Trial name
- NCT00771277
- Testing
- Support Teams
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- US Department of Veterans Affairs
Amputation, Traumatic, Traumatic Amputation of Lower Extremity
What is the Optimal Stiffness and Height of a Running-specific Prosthesis?
The proposed study aims to characterize the effects of running-specific leg prosthetic stiffness and height during on performance during running and sprinting to optimize running-specific prosthesis prescription.
- Conditions
- Amputation, Traumatic, Traumatic Amputation of Lower Extremity, Wounds and Injuries
- Trial name
- NCT02318979
- Testing
- Otto Bock prosthesis, Ossur prosthesis, Freedom Innovations prosthesis
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- VA Eastern Colorado Health Care System
Stress Disorders, Post-Traumatic, Brain Injuries, Traumatic
Interventions for Parent Caregivers of Injured Military/Veteran Personnel
This randomized clinical trial will test a behavioral caregiving intervention that has been used successfully for dementia and spinal cord injury caregivers to provide services to stressed and burdened parent caregivers of post…
- Trial name
- NCT03309046
- Testing
- REACH Individual Session, Education Webinar
- Where
- United States
- Volunteers
- 163 people
- Sponsor
- Memphis VA Medical Center
Posttraumatic Stress Disorder
IOK Treatment Study
The goals of this project are 1) to evaluate the effectiveness of a CBT treatment module addressing the mental health and functional impact of killing in the war zone, 2) to gather data on Veteran stakeholders' perceptions of…
- Trial name
- NCT01605799
- Testing
- IOK Killing Treatment, Wait list control group
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- VA Office of Research and Development
Non PTSD, PTSD
Neurobiology of Sleep and Sleep Treatment Response in Returning Veterans
The overarching objectives of this study are: 1) To investigate the neurobiology of posttraumatic stress disorder (PTSD) during Rapid Eye Movement (REM) and Non-Rapid Eye Movement (NREM) sleep relative to wakefulness; 2) To…
- Trial name
- NOSSTIP (NCT01637584)
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Ankle Fractures, Post-traumatic Osteoarthritis
Iterative Design of Custom Dynamic Orthoses to Reduce Articular Contact Stress
The proposed study evaluates the effect of carbon fiber brace design on forces across the ankle joint. Research suggests that ankle arthritis develops after ankle fracture, in part, due to elevated forces on the cartilage.
- Conditions
- Ankle Fractures, Post-traumatic Osteoarthritis, Osteoarthritis Ankle
- Trial name
- PRMRP-FPA2 (NCT04562896)
- Testing
- Custom Carbon Fiber Dynamic Orthosis (CDO)
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Posttraumatic Stress Disorder
Additional MDMA-assisted Therapy for People Who Relapsed After MDMA-assisted Therapy Trial
This study will consist of a single session of MDMA-assisted therapy with a full dose of MDMA for people who took part in a study of MDMA-assisted therapy in people with posttraumatic stress disorder (PTSD) whose PTSD symptoms…
- Trial name
- NCT01458327
- Testing
- Midomafetamine, Therapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Resilient Pharmaceuticals
Posttraumatic Stress Disorder
Nepicastat for Posttraumatic Stress Disorder (PTSD) in OIF/OEF Veterans
This study proposes a multi-site, randomized, double-blind, placebo-controlled clinical trial of the dopamine-ß-hydroxylase (DBH) inhibitor, nepicastat, for the treatment of posttraumatic stress disorder (PTSD) in outpatients who…
- Trial name
- Nepicastat (NCT00659230)
- Testing
- Nepicastat
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tuscaloosa Research & Education Advancement Corporation
Traumatic Brain Injury
Quantitative Automated Lesion Detection of Traumatic Brain Injury
The investigators propose to develop quantitative automated lesion detection (QALD) procedures to identify brain damage following traumatic brain injury more accurately than is possible with a normal magnetic resonance imaging…
- Trial name
- QALD (NCT01022307)
- Where
- United States
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Post Traumatic Stress Disorder, Major Depressive Disorder
Antidepressant Response in Older Adults With Comorbid PTSD and MDD
In the Investigator's ongoing studies of Posttraumatic Stress Disorder (PTSD) in older adults, it has been found that older adults with PTSD frequently meet the criteria for comorbid Major Depressive Disorder (MDD).
- Trial name
- NCT04697693
- Testing
- Escitalopram, Duloxetine
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- New York State Psychiatric Institute