Clinical trials: Traumatic Injuries
Traumatic Brain Injury
Effect of Intermittent Oro-esophageal Tube Feeding on Severe Traumatic Brain Injury Patients With Tracheostomy
This was a multicenter randomized controlled study of 98 severe Traumatic Brain Injury patients with tracheostomy. Patients enrolled were divided randomly into the observation group with Intermittent Oro-esophageal Tube Feeding…
- Trial name
- STBI (NCT06199778)
- Testing
- Rehabilitation therapy, Intermittent Oro-esophageal Tube Feeding, Nasogastric tube feeding
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Zeng Changhao
Traumatic Brain Injury With Loss of Consciousness
Effect of Early Coma Arousal Therapy on Conscious Level Recovery and Cognition in Traumatic Brain Injury
PURPOSE: The aim of this study is to investigate the effect of early coma arousal therapy on conscious level and cognitive function in sever traumatic brain injury patients.
- Trial name
- NCT05521815
- Testing
- Coma arousal therapy, Selected physiotherapy program
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Cairo University
Post Traumatic Stress Disorder
Using Mobile Technology to Address the Trauma Mental Health Treatment Gap
BounceBack Now (BBN) is a self-help, trauma-focused mental health mobile application (app) with automated assessment with treatment guidance and in-app evidence-based treatment support for depression, post-traumatic stress…
- Trial name
- NCT05374408
- Testing
- Aim 2: BounceBack Now (BBN) for Trauma Informed Care Deployment, Aim 1 Participant Focus Groups, Aim 1 BHP Focus Groups
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Post Traumatic Chronic Pain
The Biopsychosocial Model to Identify Risk Factors for Chronic Postoperative Pain in Orthopedic Trauma Surgery Patients
This study aims to assess multidimensional risk factors for chronic post-traumatic pain in orthopedic trauma surgery patients. The purpose is to better understand pain chronification mechanisms by quantifying the interaction…
- Trial name
- TRAUMA PAIN (NCT07685184)
- Testing
- • biological collection
- Volunteers
- 600 people
- Sponsor
- University Hospital, Montpellier
Posttraumatic Stress Disorder
Effects of Duloxetine on Fear Conditioning in Posttraumatic Stress Disorder (PTSD)
Chronic posttraumatic stress disorder (PTSD) is a debilitating disorder and treatment response to pharmacological interventions has been modest for these patients.
- Trial name
- NCT00763178
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Yale University
Stress, Psychological, Stress Disorders, Traumatic
Intergenerational Transmission of Traumatic Stress
Millions of U.S. parents have experienced trauma, putting them at risk for maladaptive parenting practices, which then confer vulnerabilities to their children.
- Conditions
- Stress, Psychological, Stress Disorders, Traumatic, Emotion Regulation, Behavior, Child
- Trial name
- NCT05264415
- Testing
- Families OverComing Under Stress (FOCUS) for Early Childhood (FOCUS-EC), Parenting Education Website
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of California, Los Angeles
Post-traumatic Stress Disorder
Increasing Engagement in Evidence-Based PTSD Therapy for Primary Care Veterans
The purpose of this study is to implement an evidence-based Referral Management System that will address patient and system-level barriers to the uptake of evidence-based psychotherapy for PTSD by Veterans Affairs primary care…
- Trial name
- NCT01984515
- Testing
- Referral Management System
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- VA Office of Research and Development
Anxiety Disorders, Trauma
Respiratory Training in the Treatment of Transdiagnostic Pathological Anxiety
Purpose of the Research: The primary aim of the proposed study is to conduct a randomized parallel-group 2-arm clinical trial investigating capnometry-guided respiratory intervention (CGRI) for pathological anxiety.
- Conditions
- Anxiety Disorders, Trauma, Generalized Anxiety Disorder, Panic Disorder
- Trial name
- NCT05427708
- Testing
- Capnometry-Guided Respiratory Intervention, Psycho-Education
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Texas at Austin
Hemorrhage, Shock
Tranexamic Acid Mechanisms and Pharmacokinetics in Traumatic Injury
The purpose of this study is to evaluate the effects of TXA on the immune system, its pharmacokinetics, as well as safety and efficacy in severely injured trauma patients.
- Conditions
- Hemorrhage, Shock, Wounds and Injuries
- Trial name
- TAMPITI (NCT02535949)
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Washington University School of Medicine
Posttraumatic Stress Disorder
Dose Optimization of MDMA-Assisted Therapy for PTSD
This open label, within-subjects dose optimization trial will investigate the optimal number of MDMA-Assisted Therapy treatment cycles (i.e., one MDMA session and three integration sessions) in a sample of U.S.
- Trial name
- DosOp (NCT06418178)
- Testing
- Midomafetamine, Psychotherapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Bronx VA Medical Center
Posttraumatic Stress Disorder
Deep Brain Stimulation of the Amygdala for Combat Post-Traumatic Stress Disorder
Posttraumatic stress disorder (PTSD) affects approximately 30 % of American veterans returning from Iraq and Afghanistan. Although the current therapy is effective, a percentage of patients will fail to improve and will develop…
- Trial name
- NCT02091843
- Testing
- DBS of the Basolateral Nucleus of the Amygdala, Medtronic Activa PC DBS of the Basolateral Nucleus of the Amygdala
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- VA Greater Los Angeles Healthcare System
Chronic Post Traumatic Headache
Treatment of Chronic Post-Traumatic Headache With OnabotulinumtoxinA
This study will provide evidence on whether the use of an FDA-approved drug therapy for the treatment of chronic migraine (OnabotulinumtoxinA) shows similar efficacy for treatment of chronic headaches caused by traumatic injury…
- Trial name
- NCT02160535
- Testing
- OnabotulinumtoxinA
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Washington
Cervical Spinal Cord Injury
Incomplete Cervical SCI Without Instability
A multicenter, international, prospective, observational case series patient cohort with incomplete cervical SCI without instability will be enrolled to obtain information and data that could inform the feasibility of…
- Trial name
- NCT05653206
- Testing
- Nonsurgical treatment, Surgical treatment
- Where
- 10 sites in United States, Brazil and 4 more
- Volunteers
- 50 people
- Sponsor
- AO Foundation, AO Spine
Posttraumatic Stress Disorder, Tobacco Dependence
Tobacco Treatment as Augmentation for Cognitive Processing Therapy for PTSD
The purpose of this study is to examine whether tobacco affects recovery from PTSD. There are 3 goals of the study; (1) to test if quitting tobacco prior to PTSD treatment affects treatment success, (2) to test how PTSD symptoms…
- Trial name
- NCT02012452
- Testing
- Tobacco treatment, Health Education
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder (PTSD)
Brain Imaging of Psychotherapy for Posttraumatic Stress Disorder (PTSD)
The investigators are seeking people who have been exposed to a traumatic event in the past and have symptoms of posttraumatic stress disorder (PTSD) currently.
- Trial name
- NCT01507948
- Testing
- Prolonged exposure
- Where
- 2 sites in United States
- Volunteers
- 94 people
- Sponsor
- Stanford University
Post-Traumatic Stress Disorder
Guitars for Vets: Evaluating Psychological Outcome of a Novel Music Therapy
Post traumatic Stress disorder (PTSD) is a common condition for persons who have served in the Armed services during combat or deployment.
- Trial name
- NCT01229904
- Testing
- music therapy with guitar lessons
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- US Department of Veterans Affairs
Stroke, Traumatic Brain Injury
Targeting Osteosarcopaenia and Multimorbidity for Frailty Prevention
The aging population and its accompanying burden from non-communicable chronic diseases predicts an increasing impact imposed by frailty on healthcare systems.
- Conditions
- Stroke, Traumatic Brain Injury, Knee Osteoarthritis, Breast Cancer
- Trial name
- OPTIMA-C (NCT06073106)
- Where
- Singapore
- Volunteers
- 500 people
- Sponsor
- Tan Tock Seng Hospital
Trauma, Wounds and Injuries
Restrictive vs. Liberal Oxygen Therapy for Trauma Patients
The objective of this trial is to investigate whether treatment with oxygen in the early phases after a trauma plays a role in recovery.
- Trial name
- TRAUMOX (NCT03491644)
- Testing
- Titrated Oxygen, Liberal Oxygen
- Where
- Denmark
- Volunteers
- 41 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Lower Limb Amputation, Prosthesis Users
Dual-Task Balance Training in Traumatic Lower-Limb Prosthesis Users
This randomized controlled trial will evaluate the effectiveness of dual-task balance training on balance, mobility, and mental health among traumatic lower-limb prosthesis users in the Gaza Strip.
- Conditions
- Lower Limb Amputation, Prosthesis Users, Balance Impairment, Mobility Limitations
- Trial name
- DTBT-LLA (NCT07706452)
- Testing
- Dual-Task Balance Training, Standard Rehabilitation
- Where
- Palestinian Territories
- Volunteers
- 63 people
- Sponsor
- Al-Azhar University - Gaza
Spinal Cord Injuries, Injury, Brain, Traumatic
Incidence of Neurogenic Paraosteoarthropathies in a Population of Brain Traumatized and Spinal Cord Injured Patients and Specific Markers of Early NPOA Development"
Neurogenic paraosteoarthropathies are peri-articular bone formations that may occur as a result of central neurological injury. Their occurrence limits reeducation and recovery capacities.
- Trial name
- BENTHOS (NCT04273347)
- Testing
- standard of care for patient with brain trauma and spinal cord injury
- Volunteers
- 118 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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