Clinical trials: Traumatic Injuries
Traumatic Brain Injury
Effect of Namenda on Short Term Memory and Attention in Patients With Mild to Moderate Traumatic Brain Injury
The purpose of this study is to determine whether memantine (Namenda) improves memory and attention in patients with mild to moderate traumatic brain injury.
- Trial name
- NCT00462228
- Testing
- Memantine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Missouri-Columbia
Post-traumatic Stress Disorder, Insomnia
Pimavanserin for Insomnia In Veterans With Posttraumatic Stress Disorder
This preliminary, open-label study assesses the feasibility of 34mg at bedtime for 6 weeks in Veterans with Posttraumatic Stress Disorder and insomnia.
- Trial name
- PIP (NCT04188392)
- Testing
- Pimavanserin
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Baylor College of Medicine
Traumatic Brain Injury, Posttraumatic Stress Disorder
Cognitively Augmented Behavioral Activation for Veterans With Comorbid TBI/PTSD
The primary objective of this study is to evaluate the efficacy of Cognitively Augmented Behavioral Activation (CABA), a new hybrid treatment for Veterans diagnosed with comorbid mild Traumatic Brain Injury (mTBI) and…
- Trial name
- CABA (NCT02391402)
- Testing
- Cognitively Augmented Behavioral Activation, Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 73 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Depression
Feasibility Study of Duloxetine in the Treatment of Depression in Patients With Traumatic Brain Injury
The primary objective of the study is to compare the efficacy of duloxetine 60 mg by mouth daily with placebo in the prevention of depression associated with mild/moderate traumatic brain injury and to enhance cognitive function.
- Trial name
- Duloxetine (NCT01223001)
- Testing
- Duloxetine, Sugar pill
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Rehabilitation Hospital of Indiana
Major Depressive Disorder, Post Traumatic Stress Disorder
Positive Processes and Transition to Health
The R61 will be an open trial to determine if Positive Processes and Transition to Health (PATH) engages the proposed targets: unproductive processing, avoidance, and reward deficits in a sample of 45 adults who have experienced…
- Trial name
- PATH (NCT04678232)
- Testing
- Positive Processes and Transition to Health (PATH)
- Where
- 3 sites in United States
- Volunteers
- 45 people
- Sponsor
- Case Western Reserve University
Posttraumatic Stress Disorder
A Retrospective And Multicenter Survey To Investigate The Dosage, Efficacy And Safety Of Sertraline In Posttraumatic Stress Disorder Patients
This is a multicenter retrospective study to investigate the dosage regimens of sertraline in the treatment of Posttraumatic Stress Disorder (PTSD) under current medical practice and the efficacy and safety of this drug in…
- Trial name
- NCT01607593
- Testing
- sertraline (Zoloft)
- Where
- 4 sites in Japan
- Volunteers
- 123 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Persistent Post Traumatic Headache, Mild Traumatic Brain Injury
Remotely Supervised tDCS for Persistent Post-traumatic Headache
This pilot study is designed to provide preliminary data for a large scale, randomized clinical trial to evaluate the efficacy of remotely administrated at home transcranial Direct Current Stimulation (tDCS) with real-time…
- Trial name
- tDCS for PTH (NCT04012853)
- Testing
- transcranial direct current stimulation
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- VA Office of Research and Development
Upper Extremity Wound, Lower Extremity Wound
VAC Bioburden Wound Care Assessment
The purpose of this study is to compare the microbiologic burden and need for further operative debridement of patients undergoing primary surgical debridement of infected tissue, soft tissue abscesses, or traumatic wounds of the…
- Conditions
- Upper Extremity Wound, Lower Extremity Wound, Soft Tissue Abscesses, Traumatic Wounds
- Trial name
- NCT04826965
- Testing
- Wound Vac is applied
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Duke University
Traumatic Brain Injury, Cognitive Impairment
Rivastigmine Patch in Veterans With Cognitive Impairment Following TBI
Difficulties with intellectual functioning, particularly memory functions, are common and source of long-term disability after Traumatic Brain Injury (TBI).
- Trial name
- RIVET (NCT01670526)
- Testing
- Rivastigmine Transdermal Patch
- Where
- 8 sites in United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder, Anger
Mobile Intervention for Veterans With PTSD and Anger
Anger is the mostly commonly reported reintegration concern among combat Veterans, especially those with PTSD. Problematic anger is associated with significant functional impairment.
- Trial name
- NCT03733028
- Testing
- Mobile Intervention for Reducing Anger (MIRA), Mindfulness Intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- VA Office of Research and Development
Moral Injury
A Novel Posttraumatic Stress Disorder Treatment for Veterans With Moral Injury
The objective of this project is to test the efficacy of an individual treatment for post-traumatic stress disorder (PTSD) stemming from moral injury called Impact of Killing (IOK), compared to a present-centered therapy (PCT)…
- Trial name
- IOK (NCT03764033)
- Testing
- Impact of Killing (IOK), Present Centered Therapy
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Post Traumatic Stress Disorder, Problem Drinking
Tools for Health and Resilience Implemented After Violence Exposure (Project THRIVE)
Sexual assault victimization is a common and particularly harmful form of trauma that is associated with increased risk for high-risk drinking and other conditions of public health concern, such as PTSD.
- Trial name
- NCT03703258
- Testing
- App-based intervention
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Washington
Endocrine Dysfunction, Trauma
Neuroendocrine Dysfunction in Traumatic Brain Injury: Effects of Testosterone Therapy
The purpose of this study was to address 3 short term objectives; (1) Determine the effects of physiologic testosterone (T) therapy on neurological function and functional independence following traumatic brain injury (TBI) in…
- Conditions
- Endocrine Dysfunction, Trauma, Brain Injury
- Trial name
- NCT01201863
- Testing
- Androgel (Testosterone Gel)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Craig Hospital
Traumatic Brain Injury
Progesterone for the Treatment of Traumatic Brain Injury III
The ProTECT study will determine if intravenous (IV) progesterone (started within 4 hours of injury and given for a total of 96 hours), is more effective than placebo for treating victims of moderate to severe acute traumatic…
- Trial name
- ProTECT (NCT00822900)
- Testing
- Progesterone
- Where
- 36 sites in United States
- Volunteers
- 882 people
- Sponsor
- David Wright
Posttraumatic Stress Disorder
Evaluating a Novel Working Memory Training Program to Decrease Symptoms of PTSD
The study is designed to evaluate the effect of a novel computer training program on PTSD.
- Trial name
- NCT02139137
- Testing
- Computerized Cognitive Training - active
- Volunteers
- 47 people
- Sponsor
- Rick Gulizia
Stress Disorder, Post Traumatic
Dopamine Enhancement of Fear Extinction Learning in PTSD (1R21MH108753)
The purpose of this study is to investigate a new use for a medication called levodopa (L-DOPA). L-DOPA has been approved for use in Parkinson 's disease, but not for Posttraumatic Stress Disorder (PTSD).
- Trial name
- NCT02560389
- Testing
- Levodopa
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- University of Wisconsin, Madison
Post Traumatic Stress Disorder
Iloperidone for Symptoms of Arousal in Post Traumatic Stress Disorder (PTSD)
A Double-Blind Placebo-Controlled Random Order Crossover Pilot Study of Iloperidone for Symptoms of Arousal in PTSD.
- Trial name
- NCT01917318
- Testing
- Iloperidone
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Colorado, Denver
Stress Disorders, Post-Traumatic
Safety Aid Reduction Treatment for PTSD Among Veterans
The purpose of this project is to examine the acceptability, feasibility, and utility of a safety aid reduction treatment (START) among Veterans with posttraumatic stress disorder (PTSD).
- Trial name
- START-PTSD (NCT04515784)
- Testing
- Safety Aid Reduction Treatment for PTSD
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- VA Office of Research and Development
Arm Spasticity
Comparing Lower-concentration Dysport Treatment Targeted to the Neuromuscular Junction With Current Clinical Practice
The aim of the study was to compare Dysport treatment results (as assessed by Modified Ashworth Scale (MAS) in the elbow joint 4 weeks post treatment) following two treatment techniques: the current clinical practice injection…
- Trial name
- NMJ (NCT01682148)
- Testing
- Botulinum toxin type A
- Where
- 23 sites in Denmark, Finland and 2 more
- Volunteers
- 100 people
- Sponsor
- Ipsen
Traumatic Brain Injury
Test of Chamber Pressure to Divers and Chamber Attendants
SCUBA divers and chamber inside attendants will undergo a brief hyperbaric chamber excursion and will be asked to what chamber pressure they were compressed and what gas they breathed.
- Trial name
- TOP-DIVER (NCT01430325)
- Testing
- Hyperbaric Oxygen (1.5 atm abs)
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Intermountain Health Care, Inc.