Clinical trials: Traumatic Injuries
Stress Disorders, Post-Traumatic, Bulimia Nervosa
Effectiveness of Prazosin in Bulimic Patients Experiencing Nightmares Due to PTSD
This research is being done to find out how effective Prazosin is in the treatment of bulimic patients experiencing distressing nightmares using subjective and objective measures.
- Trial name
- NCT02382848
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Milton S. Hershey Medical Center
Moral Injury, TEPT
A Comprehensive Group Intervention for Psychosocial Personnel at Risk of Stress and Moral Injury
The objective of this randomized controlled trial is to evaluate the effectiveness of the CARE-MI group intervention in reducing symptoms of post-traumatic stress and moral injury in support staff working with individuals…
- Trial name
- CARE-MI-PsychS (NCT07140263)
- Testing
- CARE MI, TAU: Treatment as usual
- Where
- Spain
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Stress Disorders, Post Traumatic
Treatment of Post-traumatic Stress Disorder With High Doses of Escitalopram
The study evaluates the hypothesis that large doses of Escitalopram will reduce symptoms of chronic post-traumatic stress disorder (PTSD) in adult civilian survivors of traumatic events.
- Trial name
- NCT00736021
- Testing
- Escitalopram
- Where
- Israel
- Volunteers
- 38 people
- Sponsor
- Hadassah Medical Organization
Post-traumatic Stress Disorder (PTSD), Anxiety Symptoms
The Impact of Playing Tetris on Migrants' Mental Health
This study examines if playing Tetris prevents the development of Post-traumatic stress disorder or related anxiety and depressive symptoms. The investigators recruit 300 participants in total in Greece and in the Netherlands.
- Conditions
- Post-traumatic Stress Disorder (PTSD), Anxiety Symptoms, Depression Symptoms
- Trial name
- NCT06773338
- Testing
- Tetris, No intervention
- Where
- 2 sites in Greece, Netherlands
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tilburg University
Traumatic Brain Injury
Imaging of Traumatic Brain Injury
This project aims to study the prognostic ability of various MRI imaging markers in the evaluation of TBI patients. Cognitive, social, and occupational recovery will be measured at each time point, and compared to MRI findings.
- Trial name
- Imaging of TBI (NCT01196299)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Traumatic Brain Injury
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for TBI
This trial will study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells for the treatment of traumatic brain injury
- Trial name
- NCT05018832
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells
- Where
- Antigua and Barbuda
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Chronic Pain, Post-traumatic Stress Disorder
Treatment of Post-Traumatic Stress Disorder (PTSD) and Chronic Pain After Traumatic Orthopedic Injury
The purpose of this study is to examine the efficacy of multiple treatment options in addressing the co-morbidity between pain and PTSD symptoms.
- Trial name
- NCT00957164
- Testing
- Brief Prolonged Exposure Protocol, Chronic Pain Management Treatment, Self-Care
- Where
- 4 sites in United States
- Volunteers
- 51 people
- Sponsor
- The University of Texas at Arlington
Mental Health Issue, Trauma, Psychological
R34 Family Navigator Enhancing Early Engagement
For the current study, the investigators will develop, implement, and evaluate web-based and consultative training for Family Advocates employed at Children's Advocacy Centers (CACs) across the United States to enhance children's…
- Trial name
- NavE3 (NCT04221633)
- Testing
- Enhancing Early Engagement (E3) webinar, Consultation for E3 training
- Where
- 2 sites in United States
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Fracture, Scoliosis Idiopathic Adolescent
Opioid Analgesia Impacts on Neurological Development
Background: Pain in childhood - whether from injuries like fractures or long-term conditions like scoliosis - is often treated with opioid medicines. These drugs are effective for pain relief.
- Conditions
- Fracture, Scoliosis Idiopathic Adolescent, Traumatic Injury, Adolescent
- Trial name
- OPAL (NCT07855952)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Nottingham
Traumatic Brain Injury
Transcranial Direct Current Stimulation and Computer-based Training for the Traumatic Brain Injury Rehabilitation
Traumatic Brain Injury (TBI) is a serious public health problem due to its high mortality and morbidity rates, mainly affecting young adult males.
- Trial name
- NCT03382626
- Testing
- anodal tDCS, Computer-assisted training
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo General Hospital
Post-traumatic Stress Disorder
An Advanced Digital Phenotype System Among People Suffering From Post-traumatic Stress Disorder
Psychiatric diagnosis is based mainly on questioning the patient and subjective impression rather than a quantitative assessment.
- Trial name
- NCT03788278
- Testing
- BioBeat
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nadav Goldental
Trauma, Traumatic Injury
ErythroPOietin Alfa to Prevent Mortality and Reduce Severe Disability in Critically Ill TRAUMA Patients
The EPO-TRAUMA study is a prospective, multi-centre, double-blind, phase III, randomised controlled trial evaluating the efficacy of epoetin alfa compared to placebo in reducing mortality and severe disability at six months in…
- Conditions
- Trauma, Traumatic Injury, Traumatic Brain Injury, Wounds and Injuries
- Trial name
- EPO-TRAUMA (NCT04588311)
- Testing
- Epoetin Alfa 40000 UNT/ML, Sodium Chloride 0.9%
- Where
- 41 sites in Australia, Belgium and 7 more
- Volunteers
- 2,500 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Amputation, Traumatic
Isokinetic Parameters and the Amputee Mobility Predictor Scale
There is very limited research examining isokinetic parameters and activity level in patients with amputation.. Therefore, the aims of this study were to illustrate isokinetic measurements including strength and proprioception…
- Trial name
- NCT05188599
- Testing
- İsokinetic assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Traumatic Brain Injury, Suicidality
Executive Dysfunction and Suicide in Psychiatric Outpatients and Inpatients
Those with traumatic brain injury (TBI) are at increased risk for suicidal behavior, and suicidality is associated with executive dysfunction.
- Trial name
- NCT01043432
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Traumatic Brain Injury
Developing Process-Specific Verbal Memory Interventions for Veterans With Tramatic Brain Injury (TBI)
Blast-related and blunt traumatic brain injury is a key priority area of Rehabilitation Research \& Development (RR\&D) and represents a critically important public health problem facing the Veteran population.
- Trial name
- DPSVM (NCT02310633)
- Testing
- Memory Strategy Training, Errorless Learning, Retrieval Practice
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Depressive Disorder, Major, Post Traumatic Stress Disorder
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response, Pilot Trial
The proposed study will assess the combined effect of perampanel and ketamine on the anti-depressant response in individuals with treatment resistant depression.
- Conditions
- Depressive Disorder, Major, Post Traumatic Stress Disorder, Bipolar Disorder
- Trial name
- NCT03367533
- Testing
- Ketamine, Perampanel
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Yale University
Posttraumatic Stress Disorder
Variable-length Cognitive Processing Therapy for Combat-Related PTSD
The primary goal of this study is to improve the overall efficacy of cognitive processing therapy-cognitive-only version (CPT-C) in a sample of 130 active-duty service members through a variable length treatment.
- Trial name
- NCT02313818
- Testing
- Cognitive Processing Therapy-Cognitive Only
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Duke University
Brain Injuries, Traumatic, Concussion, Brain
Objective Brain Function Assessment of mTBI/Concussion in High School Athletes
This study (Part 2) is designed to build a database including EEG, neurocognitive performance, clinical symptoms, history and other relevant data, which will be used to derive a multimodal EEG based algorithm for the…
- Conditions
- Brain Injuries, Traumatic, Concussion, Brain, Concussion, Mild, Concussion, Intermediate
- Trial name
- AheadCAS-HS (NCT02661633)
- Testing
- BrainScope Ahead 200iD, Advanced MRI Neuroimaging
- Where
- 4 sites in United States
- Volunteers
- 177 people
- Sponsor
- BrainScope Company, Inc.
Traumatic Brain Injury (TBI) Patients, Stroke Hemorrhagic
Non-invasive Intracranial Pressure Monitoring to Improve Emergency Care in Brazil's Public Health System
The goal of this observational study is to evaluate the diagnostic accuracy of non-invasive intracranial pressure (ICP) and intracranial compliance (ICC) pulse morphology and associated parameters (such as the P2/P1 ratio and…
- Conditions
- Traumatic Brain Injury (TBI) Patients, Stroke Hemorrhagic, Stroke Ischemic
- Trial name
- NCT07210333
- Testing
- non-invasive intracranial pressure monitoring
- Where
- 3 sites in Brazil
- Volunteers
- 300 people
- Sponsor
- Braincare USA Corp
Brain Injuries, Intracranial Aneurysm
Hypopituitarism Following Traumatic Brain Injury or Spontaneous Subarachnoidal Haemorrhages
The purpose of this study is to assess the prevalence and predictors of pituitary dysfunction, as well as secondary out-come in patients with traumatic brain injury or spontaneous subarachnoidal haemorrhages.
- Trial name
- NCT00435006
- Where
- Denmark
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
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