Clinical trials: Traumatic Injuries
Post-Traumatic Stress Disorder
Cognitive Behavioral Treatment for Post-Traumatic Stress Disorder in People With Additional Serious Mental Illnesses
This study will evaluate the effectiveness of tailored cognitive behavioral therapy in treating post-traumatic stress disorder in people with additional mental illnesses.
- Trial name
- NCT00494650
- Testing
- Cognitive behavioral therapy (CBT), Brief PTSD treatment
- Where
- 5 sites in United States
- Volunteers
- 200 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Postpartum Complication, Posttraumatic Stress Symptoms
Labor Education to Reduce Postpartum Traumatic Stress
The goal of this randomized controlled trial is determine if education on common events in labor in nulliparous women can reduce the postpartum traumatic symptoms.
- Trial name
- LEPT (NCT06992791)
- Testing
- Prenatal Education on Childbirth
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Post Traumatic Stress Disorder
The Effect of Intranasal Oxytocin on Emphatic Abilities in Patients With Post Traumatic Stress Disorder (PTSD)
Oxytocin (OT) - a neurohormone and neuromodulator which is mainly synthesized in the hypothalamus - is a key mediator of complex social and affective behaviors, including emotional empathy.
- Trial name
- NCT01325168
- Testing
- syntocinon nasal spray
- Where
- 2 sites in Israel
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Traumatic Brain Injury, Depression
Treatment of Post-TBI Depression
Randomized clinical trial that compares the effects of cognitive behavioral therapy (CBT) and supportive psychotherapy for depression.
- Trial name
- NCT00211835
- Testing
- Cognitive behavioral therapy, Supportive psychotherapy
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Posttraumatic Stress Disorder
Dose-Response Study of MDMA-assisted Psychotherapy in People With PTSD
The goal of this clinical trial is to learn if MDMA in combination with therapy is safe and effective in people with chronic, treatment-resistant PTSD.
- Trial name
- NCT01793610
- Testing
- Comparator Dose (40mg) MDMA HCl, Active Dose 2 (100 mg) MDMA HCl, Active Dose 1 (125 mg) MDMA HCl
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Resilient Pharmaceuticals
Spinal Cord Injuries
Effects of Rimonabant on Walking Abilities in Incomplete Spinal Cord Injury
Randomized placebo-controlled safety and feasibility study with crossover design (3 arms). Placebo or Rimonabant 2.5mg or Rimonabant 5mg will be administered for 5 days.
- Trial name
- RIMOFATSCI-1 (NCT05398913)
- Testing
- Rimonabant
- Where
- Spain
- Volunteers
- 8 people
- Sponsor
- Hospital Nacional de Parapléjicos de Toledo
Traumatic Brain Injury, Acquired Brain Injury
Evaluation of a Skill-Building, Supportive, and Educational Intervention for Couples
1. To evaluate the efficacy of a structured outpatient couples intervention program (Therapeutic Couples Intervention, TCI) on couples' marital quality after acquired brain injury (ABI). 2.
- Trial name
- NCT01935609
- Testing
- Couples counseling
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Virginia Commonwealth University
Spinal Cord Injuries
The Effect of FES and Therapeutic Exercise on SCI Patients Skeletal Muscles, Sitting Balance, Posture and Quality of Life
Aim of the current study is to evaluate the effect functional electrical stimulation and therapeutic exercise on traumatic spinal cord injured participants'skeletal muscle characteristics, sitting balance, lung function and…
- Trial name
- NCT03517787
- Testing
- FES+TE, TE, REF-FES+TE
- Where
- Estonia
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Tartu University Hospital
Multimodal Monitoring
Effect of Multimodal Monitoring Cluster Management on Patients with Severe Traumatic Brain Injury
Traumatic brain injury (TBI) is a serious global health problem, with about 27 million new cases each year. Severe head trauma can lead to intracranial hypertension and a range of complications such as cerebral edema and hypoxia…
- Trial name
- NCT06583252
- Testing
- multimodal monitoring cluster management
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xiangya Hospital of Central South University
Traumatic Brain Injury
Autologous Adipose-Derived Mesenchymal Stem Cells for Chronic Traumatic Brain Injury
The global objective of this study is to establish the safety and investigate the potential treatment effect of an intravenous infusion of HB-adMSCs (Hope Biosciences adipose-derived mesenchymal stem cells) on brain structure…
- Trial name
- NCT05951777
- Testing
- Autologous HB-adMSCs, Normal Saline
- Where
- 2 sites in United States
- Volunteers
- 51 people
- Sponsor
- Hope Biosciences LLC
Post-traumatic Stress Disorder, Moral Injury
Psychosocial Rehabilitation After Moral Injury and Loss With Adaptive Disclosure
The aim of this study was to determine the efficacy of Adaptive Disclosure for Moral Injury and Loss (AD-MIL), a combat-specific psychotherapy for war-related PTSD stemming from Moral Injury (MI) and traumatic loss (TL) with Iraq…
- Conditions
- Post-traumatic Stress Disorder, Moral Injury, Traumatic Loss
- Trial name
- NCT03056157
- Testing
- Adaptive Disclosure for Moral Injury and Loss, Present Centered Therapy
- Where
- 5 sites in United States
- Volunteers
- 174 people
- Sponsor
- VA Office of Research and Development
Hemorrhagic Shock, Traumatic Injury
Type O Whole Blood and Assessment of Age During Prehospital Resuscitation Trial
Open label, multi-center, pre-hospital randomized trial utilizing 10 level-1 trauma centers designed to determine the efficacy and safety of low titer whole blood resuscitation as compared to standard of care resuscitation in…
- Trial name
- TOWAR (NCT04684719)
- Testing
- low titer whole blood, Standard Care
- Where
- 10 sites in United States
- Volunteers
- 1,020 people
- Sponsor
- Jason Sperry
Aphasia, Traumatic Brain Injury
Narrative Comprehension by People With Acquired Brain Injury
The purpose of this two phase study is to evaluate comprehension by people with acquired brain injury. The phase 1 portion of the study will examine comprehension of narrative paragraphs under 3 conditions: (a) written text only…
- Trial name
- NCT03309930
- Testing
- Comprehension Acquired Brain Injury
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Miami University
Posttraumatic Stress Disorder
Randomized Placebo-controlled Study of MDMA-assisted Therapy in People With PTSD - Israel
The goal of this clinical trial is to learn if MDMA-assisted therapy can treat PTSD in participants with PTSD. Researchers will compare two sessions of MDMA-assisted therapy with two sessions of low dose (active placebo)…
- Trial name
- NCT00402298
- Testing
- Full Dose Midomafetamine HCl, Low Dose Midomafetamine HCl
- Where
- Israel
- Volunteers
- 5 people
- Sponsor
- Resilient Pharmaceuticals
Veterans Family, Military Family
Family Psychoeducation for Military Veterans: A Pilot Study
Operational Stress Injuries (OSIs), including post traumatic stress disorder (PTSD), are prevalent among veterans deployed in recent combat missions, the effects of which are experienced within their families.
- Conditions
- Veterans Family, Military Family, Trauma, Psychological
- Trial name
- NCT04180293
- Testing
- Pilot psychoeducation program, Program evaluation
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Traumatic Brain Injury
Effects of TT301 on Cytokine Levels Post Endotoxin Challenge
This study will evaluate the effects of TT301 on cytokine levels in healthy male volunteers participating in an endotoxin challenge.
- Trial name
- NCT01357421
- Testing
- TT301
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- OPKO Health, Inc.
Posttraumatic Stress Disorder
Predicting Responses to PTSD Treatment With Iris and Cardiovascular Tests
Post-traumatic stress disorder (PTSD) affects many individuals who experience a traumatic event. There are a variety of treatment options for PTSD, including psychotherapy (talk therapy) options, as well as medications, such as…
- Trial name
- PREDICT (NCT03539614)
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, CVA (Cerebrovascular Accident)
The Brain Injury Neurorehabilitation Project
The primary objective of The Brain Injury Neurorehabilitation Project is a systematic effort to generate cutting edge research in brain injury and cognitive rehabilitation that will advance neurorehabilitation research.
- Trial name
- NCT06556316
- Testing
- Cognitive Intervention with the Categorization Program, Social Cognitive Communication Program, Non-Invasive Brain Stimulation with tDCS
- Where
- Cyprus
- Volunteers
- 200 people
- Sponsor
- University of Cyprus
Traumatic Brain Injury
Transcranial Doppler on Admission of Patients With Mild to Moderate Traumatic Brain Injury
Patients with mild to moderate traumatic brain injury (TBI) are at risk for secondary neurological deterioration. Their outcome within the first week after injury could be predicted by clinical signs, brain CT scan and…
- Trial name
- TCD (NCT01291706)
- Testing
- Transcranial Doppler
- Where
- 21 sites in France
- Volunteers
- 369 people
- Sponsor
- University Hospital, Grenoble
Posttraumatic Stress Disorder (PTSD)
MDMA-AT for PTSD in Young Adults With Childhood Trauma
This study is testing a new, emerging treatment for young adults (ages 18-26) with Posttraumatic Stress Disorder (PTSD). The treatment is combining the substance, MDMA, with up to three psychotherapy sessions, also known as…
- Trial name
- NCT07765693
- Testing
- MDMA assisted psychotherapy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Jenna M. Traynor
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