Clinical trials: Traumatic Injuries
Depression, Anxiety
Self-Defense Training in Women With Trauma
Previous research has shown that self-defense training can lead to gains in women's assertiveness, self-esteem, self-efficacy, and physical competence, and decreases in anxiety, helplessness, fear, and avoidant behaviors.
- Conditions
- Depression, Anxiety, Stress Disorders, Post-Traumatic
- Trial name
- NCT01380379
- Testing
- Life skills and self-defense training
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Stanford University
PTSD
Substance P Antagonist in the Treatment of Posttraumatic Stress Disorder
This study, conducted at the NIH and the Mount Sinai School of Medicine, will examine the effectiveness of a substance P or NK1 antagonist study drug known as GR205171 in treating the symptoms of posttraumatic stress disorder…
- Trial name
- NCT00383786
- Testing
- NK1 Antagoist (GR205171), Psychophysiology (Trauma Script), Psychophysiology (Verbal Threat)
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- Baylor College of Medicine
Traumatic Brain Injury, Word Finding Difficulty
Treating Civilian Traumatic Brain Injury With High Definition Transcranial Direct Current Stimulation (ciTBI-HDtDCS)
The purpose of the study is to test whether low level electric stimulation, called transcranial Direct Current Stimulation (tDCS), on the part of the brain (i.e., pre-supplementary motor area) thought to aid in memory will…
- Conditions
- Traumatic Brain Injury, Word Finding Difficulty, Acquired Brain Injury, Cognitive Change
- Trial name
- NCT05408975
- Testing
- Active Transcranial direct current stimulation
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- The University of Texas at Dallas
PTSD, Depression
Synchronized Transcranial Magnetic Stimulation for PTSD
The investigators propose a small, two-site, sham-controlled pilot study of synchronized Transcranial Magnetic Stimulation (sTMS) in patients with comorbid post-traumatic stress disorder (PTSD) and depression.
- Trial name
- sTMS (NCT02981381)
- Testing
- NEST-1, NEST-2
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Providence VA Medical Center
Traumatic Brain Injury (TBI)
Effect of Exercise Training on Physical, Cognitive, and Behavioral Function in People With TBI
Background: Traumatic brain injury (TBI) often causes problems with moving and balance, and thinking and emotions. Exercise can improve these things in people with other brain damage.
- Trial name
- NCT02504866
- Testing
- Vigorous exercise, Light to moderate exercise
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Brain Injuries, Traumatic
Acute Intermittent Hypoxia in Traumatic Brain Injury
This study is designed to answer questions related to safety and preliminary efficacy of Acute Intermittent Hypoxia (AIH) in Traumatic Brain Injury (TBI) survivors.
- Trial name
- AIH (NCT04890639)
- Testing
- Acute Intermittent Hypoxia
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Shirley Ryan AbilityLab
Traumatic Brain Injury
The Impact of Yoga-based Physical Therapy for Individuals With Traumatic Brain Injury
This study aims to explore if a yoga-based physical therapy session would promote improved (increased) heart rate variability in subjects with traumatic brain injuries.
- Trial name
- NCT03701594
- Testing
- Yoga-based physical therapy group, Seated Rest, Conventional Physical Therapy
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Shirley Ryan AbilityLab
Brain Injuries, Traumatic
Beta Blockade in in Traumatic Brain Injury
The purpose of this study is test the effect of beta-adrenergic blockade on mortality in patients with traumatic brain injury with the hypothesis being that the addition of beta blockade to the treatment regime of this patient…
- Trial name
- NCT02957331
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Tennessee
Schizophrenia, Schizoaffective Disorder
Get Moving and Get Well - Pilot Study
Individuals with serious mental illness have greater morbidity from physical illness and mortality than the general population, but tend not to initiate or sustain engagement in health promotion interventions.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder, Major Depression
- Trial name
- GMGWP (NCT01884025)
- Testing
- Get Moving and Get Well, Health and Humor Class
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Fatigue
Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy
Patients with a history of mild traumatic brain injury (mTBI) or post acute sequelae of SARS-CoV-2 (PASC) and abnormal growth hormone secretion, as measured by glucagon stimulation test, will be treated with replacement growth…
- Conditions
- Traumatic Brain Injury, Fatigue, Cognitive Impairment, COVID-19
- Trial name
- NCT03554265
- Testing
- Somatropin
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Post Traumatic Stress Disorders, Burns
Cranial Electrotherapy Stimulation in Burned Patients
To find out if Cranial Electrotherapy Stimulation is a useful treatment for people who have been burned and have Post Traumatic Stress Disorder. CES may be helpful in giving relief to some or all of those symptoms.
- Trial name
- CES (NCT00723008)
- Testing
- Alpha Stim 100 (Cranial Electrotherapy Stimulation)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- United States Army Institute of Surgical Research
Post Traumatic Stress Disorder
Using Mobile Technology to Address the Trauma Mental Health Treatment Gap
BounceBack Now (BBN) is a self-help, trauma-focused mental health mobile application (app) with automated assessment with treatment guidance and in-app evidence-based treatment support for depression, post-traumatic stress…
- Trial name
- NCT05374408
- Testing
- Aim 2: BounceBack Now (BBN) for Trauma Informed Care Deployment, Aim 1 Participant Focus Groups, Aim 1 BHP Focus Groups
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Post-traumatic Stress Disorder
Increasing Engagement in Evidence-Based PTSD Therapy for Primary Care Veterans
The purpose of this study is to implement an evidence-based Referral Management System that will address patient and system-level barriers to the uptake of evidence-based psychotherapy for PTSD by Veterans Affairs primary care…
- Trial name
- NCT01984515
- Testing
- Referral Management System
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- VA Office of Research and Development
Hemorrhage, Shock
Tranexamic Acid Mechanisms and Pharmacokinetics in Traumatic Injury
The purpose of this study is to evaluate the effects of TXA on the immune system, its pharmacokinetics, as well as safety and efficacy in severely injured trauma patients.
- Conditions
- Hemorrhage, Shock, Wounds and Injuries
- Trial name
- TAMPITI (NCT02535949)
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Washington University School of Medicine
Chronic Post Traumatic Headache
Treatment of Chronic Post-Traumatic Headache With OnabotulinumtoxinA
This study will provide evidence on whether the use of an FDA-approved drug therapy for the treatment of chronic migraine (OnabotulinumtoxinA) shows similar efficacy for treatment of chronic headaches caused by traumatic injury…
- Trial name
- NCT02160535
- Testing
- OnabotulinumtoxinA
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Washington
Posttraumatic Stress Disorder, Tobacco Dependence
Tobacco Treatment as Augmentation for Cognitive Processing Therapy for PTSD
The purpose of this study is to examine whether tobacco affects recovery from PTSD. There are 3 goals of the study; (1) to test if quitting tobacco prior to PTSD treatment affects treatment success, (2) to test how PTSD symptoms…
- Trial name
- NCT02012452
- Testing
- Tobacco treatment, Health Education
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
Brain Injury Rehabilitation Improving the Transition Experience
Each year, about 2.8 million people sustain a traumatic brain injury (TBI) in the United States, and at least 25 percent of these injuries are classified as moderate to severe.
- Trial name
- BRITE (NCT03422276)
- Testing
- Rehabilitation Discharge Plan, Rehabilitation Transition Plan
- Where
- 6 sites in United States
- Volunteers
- 1,555 people
- Sponsor
- University of Washington
Traumatic Brain Injury
Study to Evaluate the Efficacy and Safety of Armodafinil as Treatment for Patients With Excessive Sleepiness Associated With Mild or Moderate Closed Traumatic Brain Injury
The primary objective of the study is to determine whether armodafinil treatment is more effective than placebo treatment in patients with excessive sleepiness associated with mild or moderate closed traumatic brain injury (TBI).
- Trial name
- NCT00893789
- Testing
- Armodafinil
- Where
- 73 sites in United States, Germany and 2 more
- Volunteers
- 117 people
- Sponsor
- Cephalon, Inc.
Post Traumatic Stress Disorder
Novel Treatment of Emotional Dysfunction in Post Traumatic Stress Disorder (PTSD)
The objective will be to determine if adding repetitive transcranial magnetic stimulation prior to Cognitive Processing Therapy significantly enhances recovery from hyperarousal symptoms in individuals with combat related post…
- Trial name
- NCT01391832
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS), Cognitive Processing Therapy, Repetitive Transcranial Magnet Stimulation (rTMS)
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
Posttraumatic Stress Disorder
Dose-Response Study of MDMA-assisted Psychotherapy in People With PTSD
The goal of this clinical trial is to learn if MDMA in combination with therapy is safe and effective in people with chronic, treatment-resistant PTSD.
- Trial name
- NCT01793610
- Testing
- Comparator Dose (40mg) MDMA HCl, Active Dose 2 (100 mg) MDMA HCl, Active Dose 1 (125 mg) MDMA HCl
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Resilient Pharmaceuticals