Clinical trials: Traumatic Injury
Traumatic Injury, Venous Thromboembolism
Evaluation of Venous Thromboembolism Prevention in High-Risk Trauma Patients
This is a pilot study to determine if anti-thrombin III (AT-III) serum concentrations differ between patients with normal versus subtherapeutic anti-Xa trough concentrations when placed on enoxaparin 30 mg twice daily for VTE…
- Trial name
- NCT02412982
- Testing
- Enoxaparin 40 mg q12h, Enoxaparin 30 mg q8h
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- University of Cincinnati
Post Traumatic Stress Disorder
An Evaluation of the Safety and Efficacy of Methylone for the Treatment of PTSD
This study is evaluating the safety and efficacy of methylone in adults with PTSD. The study is conducted in two parts. Part A is open-label and will enroll up to 15 participants with PTSD Part B is randomized (1:1:1)…
- Trial name
- IMPACT-2 (NCT06215261)
- Testing
- Methylone
- Where
- 12 sites in United States, Australia and 1 more
- Volunteers
- 62 people
- Sponsor
- Transcend Therapeutics
Glenohumeral Internal Rotation Deficit (GIRD)
Effect of Joint Mobilization and Movement Control Exercises on Shoulder Pain and Function in Fast Bowlers (RCT)
The goal of this clinical trial is to determine combined effects of the Kinetic control for shoulder on pain, range, and function among fast bowlers.
- Trial name
- RCT (NCT07229274)
- Testing
- Kinetic control for shoulder internal rotation with mobilization with movement, stretches, strengthening and mobilization with movement
- Where
- 2 sites in Pakistan
- Volunteers
- 50 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Concussion, Mild, Post-Concussion Symptoms
Bright Light Therapy for Treatment of Sleep Problems Following Mild Traumatic Brain Injury
The purpose of the research study is to understand the effectiveness of a six-week course of light exposure on cognitive functioning, mood, activity, and sleep in people that have suffered a head injury leading to a concussion.
- Conditions
- Concussion, Mild, Post-Concussion Symptoms, Sleep Problems
- Trial name
- NCT02374918
- Testing
- mTBI wavelength-1 bright light, mTBI wavelength-2 bright light, HC wavelength-1 bright light
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Posttraumatic Stress Disorder
Imaginal Exposure & D-Cycloserine (DCS) for Posttraumatic Stress Disorder (PTSD)
This study proposes to evaluate the effects of D-cycloserine (DCS) combined with cognitive-behavioral treatment with exposure therapy in a sample of patients who developed posttraumatic stress disorder (PTSD) as a consequence of…
- Trial name
- NCT00875342
- Testing
- DCS
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Weill Medical College of Cornell University
Post-Traumatic Headache
Prazosin for Post-Concussive Headaches
Mild traumatic brain injury (mTBI) caused by blast effects of explosive devices has been called the "signature injury" of soldiers who served in the Iraq and Afghanistan conflicts.
- Trial name
- NCT02965027
- Testing
- Prazosin
- Where
- 2 sites in United States
- Volunteers
- 89 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Grade I/II Ankle Sprain
Evaluate the Efficacy and Safety of Diclofenac Diethylamine 2.32% Gel Applied Twice or Three Times Daily in Patients With Acute Ankle Sprain
The main purpose of this trial is to compare the efficacy and safety of diclofenac diethylamine 2.32% gel applied twice (b.i.d) or three times a day (t.i.d.) with placebo in the treatment of acute ankle sprains (distortions).
- Trial name
- NCT00955513
- Testing
- diclofenac diethylamine gel 2.32%
- Where
- 5 sites in Germany
- Volunteers
- 242 people
- Sponsor
- Novartis
Sleep Apnea, Obstructive, Brain Injuries, Traumatic
Feasibility of Improving Sleep Apnea Treatment Adherence After Brain Injury
Background: Obstructive sleep apnea (OSA) is a sleep disorder common among Veterans with moderate-to-severe traumatic brain injury (TBI).
- Trial name
- FISATABI (NCT04221009)
- Testing
- MI and CBT 4-session manualized intervention
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury, Spinal Cord Injuries
Testosterone Plus Finasteride Treatment After Spinal Cord Injury
The purpose of this study is to determine whether testosterone plus finasteride treatment will improve musculoskeletal health, neuromuscular function, body composition, and metabolic health in hypogonadal men who have experienced…
- Conditions
- Spinal Cord Injury, Spinal Cord Injuries, Trauma, Nervous System, Wounds and Injuries
- Trial name
- NCT02248701
- Testing
- Testosterone Enanthate, Finasteride
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- VA Office of Research and Development
Isolated Cartilage Injury of the Knee
Sprifermin (AS902330) in Cartilage Injury Repair (CIR)
Several people all over the world suffer from cartilage injuries in the knee. Symptoms include pain, joint swelling, and loss of function. Without repair, cartilage injury may ultimately lead to osteoarthritis (OA).
- Trial name
- NCT01066871
- Testing
- Sprifermin (AS902330) 10 mcg, Sprifermin (AS902330) 30 mcg, Sprifermin (AS902330) 100 mcg
- Where
- Germany
- Volunteers
- 74 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Spinal Cord Injuries
Effects of Caffeine and Intermittent Hypoxia on Leg Function in Human Spinal Cord Injury
Accumulating evidence suggests that repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) is a safe and effective treatment strategy to promote meaningful functional recovery in persons with…
- Trial name
- NCT02323698
- Testing
- Caffeine, AIH
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
PostTraumatic Stress Disorder
Closed Loop Vagal Nerve Stimulation for Patients With Posttraumatic Stress Disorder
The tasks of the project are to map the potency and kinetics of the neurologic, autonomic peripheral, inflammatory, and behavioral responses to vagal nerve stimulation (VNS) vs.
- Trial name
- NCT02992899
- Testing
- GammaCore/electroCore non-invasive VNS device, O-15 water
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Emory University
Traumatic Brain Injury, Headaches Posttraumatic
Adjunct VR Pain Management in Acute Brain Injury
Severe and refractory pain after acute injury is a known-risk factor for chronic opioid use disorder. In this study, the investigators will use Virtual Reality (VR) immersion as a non-pharmacological adjunct to treat pain…
- Conditions
- Traumatic Brain Injury, Headaches Posttraumatic, Trauma, Pain, Acute
- Trial name
- NCT04356963
- Testing
- Virtual Reality Session (VR Blu), Tablet-based Session (Tablet Blu), Use of Virtual Reality Head Mounted Display without Content (VR Blank)
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Maryland, Baltimore
Acute Kidney Injury
Aortix Therapy for Perioperative Reduction of Kidney Injury
The study is a prospective, non-randomized feasibility study to evaluate the safety and performance of providing support with the Aortix System to patients at heightened risk of acute kidney injury (AKI) undergoing cardiovascular…
- Trial name
- A Priori (NCT04999163)
- Testing
- Aortix System
- Where
- 5 sites in Australia
- Volunteers
- 20 people
- Sponsor
- Procyrion
Ureteral Stent Occlusion, Exposure Laser
Recovery Following Desflurane Versus Sevoflurane for Outpatient Urologic Surgery in Elderly Females
Numerous studies demonstrate that patients have improved immediate recovery characteristics following desflurane anesthesia compared to other volatile agents, including sevoflurane.
- Conditions
- Ureteral Stent Occlusion, Exposure Laser, Ureterostomy; Functional Disturbance, Vaginal Diseases
- Trial name
- NCT01310582
- Testing
- Desflurane, Sevoflurane
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Hahnemann University Hospital
Street-crossing Ability, Pedestrian Safety
Using Virtual Reality to Train Children in Pedestrian Safety
Pedestrian injuries are among the leading causes of morbidity and mortality in American children ages 7-8, but existing behavior-oriented interventions achieve only modest success.
- Trial name
- NCT00850759
- Testing
- virtual pedestrian environment, computer and video, streetside training
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Social Skills, Self-Criticism
Development and Pilot Trial of an Intervention to Reduce Disclosure Recipients Negative Social Reactions and Victims Psychological Distress and Problem Drinking
The purpose of this randomized controlled trial is to evaluate an intervention, Supporting Survivors and Self: An Intervention for Social Supports of Survivors of Partner Abuse and Sexual Aggression (SSS).
- Conditions
- Social Skills, Self-Criticism, Post-traumatic Stress Disorder, Depression
- Trial name
- NCT03488927
- Testing
- Supporting Survivors and Self: An Intervention for Social Supports of Survivors of Partner Abuse and Sexual Aggression (SSS)
- Where
- United States
- Volunteers
- 1,268 people, healthy volunteers welcome
- Sponsor
- University of New Hampshire
Healthy Volunteer, Pressure Distribution
Comparison of Sacral Interface Pressure in Healthy Volunteers on Two Dynamic Pressure-Prevention Support Surfaces
The purpose of the research study is to investigate the peak sacral interface pressures of two separate hospital bed systems in the supine and 30 degrees head-of-bed elevation position.
- Trial name
- NCT06661954
- Testing
- Bed A - Head of Bed 0 degrees, Bed B - Head of Bed 0 degrees, Bed A - Head of bed at 30 degrees
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Traumatic Brain Injury
A Pilot Study of NSICU Assessment of Seizure Prophylaxis With Lacosamide
Trial to determine if seizure prophylaxis with IV LCM in NSICU patients experiencing mental status changes due to severe traumatic brain injury (sTBI) will result in improved short- and long-term outcomes and better immediate…
- Trial name
- NCT01110187
- Testing
- lacosamide, Fosphenytoin
- Where
- 3 sites in United States
- Volunteers
- 11 people
- Sponsor
- University of Alabama at Birmingham
Traumatic Brain Injury
Prospective, Interventional Study Evaluating the Feasibility and Safety of the Esophageal Cooling Device
The aim of this prospective, interventional study is to assess the feasibility and safety of the Esophageal Cooling Device in patients from suffering from traumatic brain injury who the treating physician is treating with…
- Trial name
- NCT02420639
- Testing
- Esophageal Cooling Device (ECD), manufactured by Advanced Cooling Therapy, Inc.
- Where
- Ukraine
- Volunteers
- 12 people
- Sponsor
- Advanced Cooling Therapy, Inc., d/b/a Attune Medical
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