Clinical trials: Traumatic Injury
Spine Disease, Spinal Stenosis
CEUS For Intraoperative Spinal Cord Injury
Spinal cord injury following posterior decompression in patients suffering from chronic, cervicothoracic spinal cord compression is a known complication with multiple etiologies.
- Conditions
- Spine Disease, Spinal Stenosis, Spinal Injury, Spinal Cord Diseases
- Trial name
- NCT05530798
- Testing
- Definity Perflutren Lipid Microsphere Ultrasound Contrast
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Hemorrhagic Shock, Acute Blood Loss Anemia
Low-Titer O Positive Whole Blood Versus Component Therapy for Emergent Transfusion in Trauma Patients
Adult male patients brought to the emergency department as Level A trauma activations who are receiving emergency blood transfusion. Objectives 1.
- Conditions
- Hemorrhagic Shock, Acute Blood Loss Anemia, Traumatic Brain Injury
- Trial name
- NCT05081063
- Testing
- Routine labs
- Where
- United States
- Volunteers
- 199 people
- Sponsor
- Loma Linda University
Concussion, Traumatic Brain Injury
Concussion Device Audiological Measures
Significant morbidity, mortality, and related costs are caused by traumatic brain injury (TBI). A simple, effective, and lightweight device worn by athletes or war fighters in the field, designed to mitigate TBI resulting from…
- Trial name
- NCT02262507
- Testing
- Device Wearing
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Acute Lung Injury, Acute Respiratory Distress Syndrome
Ganciclovir/Valganciclovir for Prevention of CMV Reactivation in Acute Injury of the Lung and Respiratory Failure
To evaluate whether administration of ganciclovir reduces serum IL-6 levels (i.e. reduction between baseline and 14 days post-randomization) in immunocompetent adults with severe sepsis or trauma associated respiratory failure.
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome, Respiratory Failure
- Trial name
- GRAIL (NCT01335932)
- Testing
- IV Ganciclovir
- Where
- 14 sites in United States
- Volunteers
- 160 people
- Sponsor
- Fred Hutchinson Cancer Center
Acute Decompensated Heart Failure, Acute Kidney Injury
Acute Kidney Injury Neutrophil Gelatinase-Associated Lipocalin Evaluation of Symptomatic Heart Failure Study
AKINESIS is a clinical study to assess the utility of blood and urine NGAL tests in predicting worsening kidney function in patients who present with acute heart failure (AHF) and who are treated with diuretics.
- Trial name
- AKINESIS (NCT01291836)
- Where
- 13 sites in United States, Greece and 5 more
- Volunteers
- 930 people
- Sponsor
- Alere San Diego
Quadriplegia, Spinal Cord Injury
Evaluation of a Tongue Operated Assistive Technology for Individuals With Severe Paralysis
This study was intended to evaluate a new assistive neuro-technology, known as the Tongue Drive System (TDS), by its potential end-users, i.e.
- Conditions
- Quadriplegia, Spinal Cord Injury, ALS
- Trial name
- TDS-1 (NCT01124292)
- Testing
- Tongue Piercing, Usability assessment
- Where
- 4 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Georgia Institute of Technology
Coronary Artery Bypass, Cardiopulmonary Bypass
Role of Glutamine as Myocardial Protector in Elective On-Pump CABG Surgery With Low EF
Coronary artery disease has the highest mortality rate worldwide and coronary artery bypass grafting (CABG) is the most common cardiac surgery performed in patients with coronary artery disease to revascularize the heart.
- Conditions
- Coronary Artery Bypass, Cardiopulmonary Bypass, Coronary Artery Disease
- Trial name
- NCT04560309
- Testing
- L-alanyl-L-glutamine dipeptide
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Stress Disorders, Post-Traumatic, Depressive Symptoms
Treatment for Veterans With Military Sexual Trauma
The purpose of this study is to evaluate the effectiveness of Cognitive Processing Therapy (CPT) versus Present-Centered Therapy (PCT) in treating current post-traumatic stress symptoms associated with sexual assault that…
- Conditions
- Stress Disorders, Post-Traumatic, Depressive Symptoms, Anxiety Symptoms, Quality of Life
- Trial name
- NCT00371644
- Testing
- Cognitive Processing Therapy, Present-Centered Therapy
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- US Department of Veterans Affairs
Traumatic Brain Injury, Suicidality
Executive Dysfunction and Suicide in Psychiatric Outpatients and Inpatients
Those with traumatic brain injury (TBI) are at increased risk for suicidal behavior, and suicidality is associated with executive dysfunction.
- Trial name
- NCT01043432
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Post-Traumatic Stress Disorder
Post-Traumatic Stress Disorder (PTSD) and Seroquel
This 8 weeks study will investigate therapeutic responses to Seroquel pharmacotherapy in PTSD.
- Trial name
- NCT01066156
- Testing
- Seroquel
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Cambridge Health Alliance
Traumatic Brain Injury
VR-based EF Rehabilitation for Pediatric TBI
Childhood traumatic brain injury (TBI) poses significant impairment in children's executive functions (EFs) for moderate to severe injuries, yet interventions specifically designed for children's EF rehabilitation post-TBI and…
- Trial name
- NCT03611062
- Testing
- VR Executive Functions Training
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Massachusetts, Lowell
Injuries, Sports Injury
Preventing Youth Soccer Injury
A study is proposed to test whether adding additional referees to youth soccer matches may reduce the risk of injury to the children playing soccer.
- Conditions
- Injuries, Sports Injury, Sports Injuries in Children
- Trial name
- NCT04266925
- Testing
- 3 referees present, 1 referee present
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Acute Respiratory Distress Syndrome
LIPS-A: Lung Injury Prevention Study With Aspirin
The primary hypothesis was that early aspirin administration will decrease the rate of developing acute lung injury during the first 7 days after presentation to the hospital.
- Trial name
- NCT01504867
- Testing
- Aspirin, Lactose powder
- Where
- 16 sites in United States
- Volunteers
- 400 people
- Sponsor
- Mayo Clinic
Post Traumatic Stress Disorder, Problem Drinking
Tools for Health and Resilience Implemented After Violence Exposure (Project THRIVE)
Sexual assault victimization is a common and particularly harmful form of trauma that is associated with increased risk for high-risk drinking and other conditions of public health concern, such as PTSD.
- Trial name
- NCT03703258
- Testing
- App-based intervention
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Washington
Smoking, Vascular System Injuries
Melatonin in Smoke-induced Vascular Injury
The main purpose of this study was to evaluate the effects of melatonin in the regulation of the vascular injury in smokers through population-based, randomized, double-blind, placebo-controlled trial.
- Trial name
- NCT02591238
- Testing
- non-smoker oral melatonin, smoker oral melatonin
- Where
- China
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Spinal Cord Injury
Functional Electrical Stimulation (FES) Driven Stepping in Individuals With Spinal Cord Injury
The research is being done to find out if Functional Electrical Stimulation (FES) stepping can improve the function of people with spinal cord injury that paralyzes.
- Trial name
- NCT01479777
- Testing
- FES Stepping (RT600 from Restorative Therapies, INC.)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Spinal Cord Injury, Spinal Cord Injuries
Testosterone Plus Finasteride Treatment After Spinal Cord Injury
The purpose of this study is to determine whether testosterone plus finasteride treatment will improve musculoskeletal health, neuromuscular function, body composition, and metabolic health in hypogonadal men who have experienced…
- Conditions
- Spinal Cord Injury, Spinal Cord Injuries, Trauma, Nervous System, Wounds and Injuries
- Trial name
- NCT02248701
- Testing
- Testosterone Enanthate, Finasteride
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- VA Office of Research and Development
TBI (Traumatic Brain Injury)
Improving Functions in MTBI Patients With Headache by rTMS
Due to recent wars in Afghanistan and Iraq, the number of Veteran suffering from Mild traumatic brain(MTBI) injury and PTSD increases rapidly.
- Trial name
- NCT01948947
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- VA Office of Research and Development
Fall Related Injury, Social Isolation
KOSO (Keep On Stepping On)/ Stepping Online
The overall purpose of this multi-phase study is to develop (Phase 1) and test potential effectiveness and feasibility of Keep On Stepping On (KOSO)/Stepping Online, an online falls prevention maintenance program for Stepping On…
- Trial name
- NCT02774889
- Testing
- Stepping Online
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Abdominal Injury
Contrast-Enhanced Ultrasound in the Evaluation of Abdominal Injuries in Children
This study proposes to evaluate the accuracy of contrast-enhanced ultrasound (CEUS) in diagnosing abdominal solid organ injuries in pediatric patients. 146 subjects will be enrolled across approximately 8 sites in the US.
- Trial name
- NCT03147690
- Testing
- Lumason
- Where
- 8 sites in United States
- Volunteers
- 74 people
- Sponsor
- David Mooney
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