Clinical trials: Traumatic Injury
Posttraumatic Stress Disorders
Eszopiclone for the Treatment of Posttraumatic Stress Disorder
The purpose of this study is to determine if eszopiclone relative to placebo (sugar pill) is effective and tolerable for people with posttraumatic stress disorder (PTSD)-related sleep disturbance.
- Trial name
- NCT01605253
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Rush University Medical Center
Congestive Heart Failure, Ischemic Cardiomyopathy
Feasibility and Effectiveness of Micronutrients as Palliative Care Therapy in Patients With Congestive Heart Failure
The purpose of this project is to conduct a preliminary test of the feasibility of a multi-micronutrient intervention to improve micronutrient status, cardiac function and quality of life in Veterans with Congestive Heart Failure…
- Trial name
- NCT01474486
- Testing
- Micronutrients
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Phoenix VA Health Care System
Posttraumatic Stress Disorders, Chronic Insomnia
Integrated CBT-I and PE on Sleep and PTSD Outcomes (Impact Study)
This study aims to examine whether integrating insomnia and PTSD treatment will enhance sleep, PTSD, and quality of life outcomes.
- Trial name
- NCT02774642
- Testing
- CBTI-PE, Hygiene-PE
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injuries, Metabolic Syndrome
Spinal Cord Injury Exercise and Nutrition Conceptual Engagement
Evaluate and compare the health benefits of an at home exercise program using functional electrical stimulation (FES) for lower extremity exercise with diet versus a diet alone group in adults with spinal cord injury.
- Conditions
- Spinal Cord Injuries, Metabolic Syndrome, Dietary Modification, Paraplegia
- Trial name
- SCIENCE (NCT03495986)
- Testing
- Functional Electrical Stimulation Leg Cycle Ergometry, Diet
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of Miami
Contrast-induced Acute Kidney Injury
Biochemical Effects of Remote Ischemic Pre-Conditioning on Contrast-induced Acute Kidney Injury
This a prospective, double-blind, sham-controlled, randomized clinical trial to study the effects of remote ischemic preconditioning on acute kidney injury, vascular and renal biomarkers in patients with non-ST elevation…
- Trial name
- BRICK (NCT03236441)
- Testing
- RIPC
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- Oladipupo Olafiranye, MD, MS
Rotator Cuff Injuries, Shoulder Pain
ASHCOM Shoulder System and Its Related Instruments
The objectives of this study are to confirm safety, performance and clinical benefits of the ASHCOM Shoulder System and its related instruments by analysis of standard scoring systems, radiographs and adverse event records.
- Conditions
- Rotator Cuff Injuries, Shoulder Pain, Arthropathy; Traumatic, Arthroplasty Complications
- Trial name
- NCT04258605
- Testing
- ASHCOM Shoulder System
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Zimmer Biomet
Early Allograft Dysfunction, Ischemic Reperfusion Injury
Evaluation of Preimplantation Portal Vein and Hepatic Artery Flushing With Tacrolimus
The purpose of this study is to determine whether the Tacrolimus added to histidine-tryptophan-ketoglutarate (HTK) solution given through intraportal and intraarterial infusion during back-table procedure is capable of reducing…
- Conditions
- Early Allograft Dysfunction, Ischemic Reperfusion Injury, Liver Transplantation, Hyperfibrinolysis
- Trial name
- PATAC (NCT01887171)
- Testing
- Tacrolimus
- Where
- Belarus
- Volunteers
- 86 people
- Sponsor
- Republican Scientific and Practical Center for Organ and Tissue Transplantation
Post Traumatic Stress Disorder, Depression
Randomized Control Trial on Trauma Focused CBT in Zambia
The purpose of this study is to study the effectiveness of Trauma Focused Cognitive Behavioral Therapy in subset of children who are affected by trauma with significant mental health symptomatology in order to 1) examine the…
- Conditions
- Post Traumatic Stress Disorder, Depression, Risk Behaviors
- Trial name
- NCT01624298
- Testing
- Trauma Focused Cognitive Behavioral Therapy
- Where
- Zambia
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Injuries, Injury Arm
Virtual Reality for Pain in Acute Orthopedic Injuries
The goal of this study is to pilot test a skills-based virtual reality (VR) for acute orthopedic injury. It will measure the feasibility, signals of improvement, exploratory pain mechanisms, and user experience of an established…
- Conditions
- Injuries, Injury Arm, Injury;Sports, Injury, Knee
- Trial name
- NCT05552430
- Testing
- RelieveVRx
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Bronchopulmonary Dysplasia
Study of Nasal Ventilation In Preterm Infants To Decrease Time on The Respirator
Very premature infants often cannot breathe on their own and require assistance with a respirator. Conventional respirators deliver air or oxygen via a breathing tube placed through the mouth to the airway (endotracheal tube).
- Trial name
- NCT01440647
- Testing
- Extubation to NIPPV, Extubation to CPAP
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Women and Infants Hospital of Rhode Island
HIV, Trauma Exposure
Improving the Health of South African Women With Traumatic Stress in HIV Care (C0147)
In this study, the investigators propose to develop Improving AIDS Care after Trauma (ImpACT), an intervention based on theories of stress and coping and evidence-based treatment for traumatic stress.
- Trial name
- ImpACT (NCT02223390)
- Testing
- Improving AIDS Care after Trauma (ImpACT)
- Where
- South Africa
- Volunteers
- 64 people
- Sponsor
- Duke University
Insomnia, Traumatic Brain Injury
Cognitive-Behavioral Therapy for Veterans With TBI
Many Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn era Veterans have suffered a mild traumatic brain injury (mTBI), and now cope with multiple post-injury symptoms, including sleep disturbances (especially…
- Trial name
- NCT02658669
- Testing
- Cognitive-Behavioral Therapy for Insomnia, Sleep Education
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- VA Office of Research and Development
Rib Fractures
Intercostal Cryoneurolysis Following Traumatic Rib Fractures
Rib fractures are one of the most common injuries in trauma patients. These fractures are associated with significant pain as well as decreased ability to inspire deeply or cough to clear secretions, which together lead to…
- Trial name
- NCT03917823
- Testing
- Cryoneurolysis
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of California, San Diego
Cervical Spinal Cord Injruy
Improving SCI Rehabilitation Interventions by Retraining the Brain
The Long-term goal of this project is to develop upper limb rehabilitation interventions that can be utilized for cervical Spinal Cord Injury survivors.
- Trial name
- NCT03892746
- Testing
- Active tDCS + task oriented practice
- Where
- 4 sites in United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Childhood Traumatic Grief, Post Traumatic Stress
Randomized Controlled Trial of Trauma-focused CBT in Tanzania and Kenya
The primary goal is to study the effectiveness of Trauma-focused Cognitive Behavioral Therapy (TF-CBT) in treating traumatic grief and traumatic stress for orphaned children and young adolescents in two East African sites with…
- Conditions
- Childhood Traumatic Grief, Post Traumatic Stress, Post Traumatic Stress Disorder, Depressive Symptoms
- Trial name
- NCT01822366
- Testing
- Trauma-focused Cognitive Behavioral Therapy
- Where
- 3 sites in United States, Kenya and 1 more
- Volunteers
- 1,280 people
- Sponsor
- Duke University
Rehabilitation, ACL Reconstruction
Neuromuscular Intervention Targeted to Mechanisms of ACL Load in Female Athletes
The overall goal of this project is to reduce risk of second anterior cruciate ligament (ACL) injury in vulnerable populations (active athletes between 14 = 24 years old) through the identification of relative injury risk groups…
- Trial name
- NCT03190889
- Testing
- HOME, TNMT
- Where
- 4 sites in United States
- Volunteers
- 150 people
- Sponsor
- Mayo Clinic
Abdominal Trauma
BEFAST (Bubble-Enhanced FAST) for the Evaluation of Solid Organ Injury
The Focused Assessment with Sonography for Trauma (FAST) exam is widely used and accepted as part of advanced trauma life support (ATLS) protocol, but its low sensitivity for identifying solid organ injury in the absence of…
- Trial name
- BEFAST (NCT05025449)
- Testing
- Focused Assessment with Sonography for Trauma (FAST), Bubble-Enhanced FAST (BEFAST)
- Where
- United States
- Volunteers
- 267 people
- Sponsor
- Emory University
Burns, Smoke Inhalation Injury
Helping Children's Centres to Enhance Home Safety
Many children have accidents, some are very serious and they are a major cause of death in children aged 1-4 years. Many accidents are preventable This study aims to find out the best way to help Children's Centres to provide…
- Trial name
- NCT01452191
- Testing
- Injury Prevention Briefing Plus facilitation, Injury Prevention Briefing
- Where
- 4 sites in United Kingdom
- Volunteers
- 1,112 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Traumatic Brain Injury, Dementia Alzheimers
Optimizing Cognitive, Environmental, and Neuromotor Stimulation in Traumatic Brain Injury
Patients with a history of traumatic brain injury (TBI) are at elevated risk for Alzheimer's disease and related dementias (ADRD). Improvements in TBI treatment may mitigate this risk.
- Conditions
- Traumatic Brain Injury, Dementia Alzheimers, Military Activity
- Trial name
- OCEANS-TBI (NCT04073225)
- Testing
- MindPod Dolphin, 10 Keys to Healthy Aging
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Johns Hopkins University
Alcohol Dependence, Stress Disorders, Post-Traumatic
Prazosin for Treatment of Patients With Alcohol Dependence (AD) and Post Traumatic Stress Disorder (PTSD).
Prazosin is an alpha-1 adrenergic receptor antagonist that has been used successfully in the treatment of trauma nightmares and sleep disturbance in combat veterans with PTSD, and alcohol dependence.
- Trial name
- NCT00744055
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Yale University
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