Clinical trials: Traumatic Injury of the Spinal Cord
Spinal Cord Injuries
Individual Patient Expanded Access IND of Hope Biosciences Autologous Adipose-derived Mesenchymal Stem Cells for Spinal Cord Injury
HBSCI02: This protocol is part of an FDA Individual Patient Non-emergency Expanded Access Request submitted on behalf of a 38-year-old father and husband who on August 4, 2017 at about 4:30pm, slipped off a boat head-first while…
- Trial name
- NCT04064957
- Testing
- HB-adMSCs
- Where
- United States
- Sponsor
- Hope Biosciences Research Foundation
Pressure Ulcers
HP011-101, HP828-101, and Standard Care for Pressure Ulcers
Testing a drug and a device for the treatment of pressure ulcers, compared with current treatments.
- Trial name
- NCT01273428
- Testing
- HP011-101, HP-828-101, Standard Care
- Sponsor
- Healthpoint
Spasticity, Cerebrovascular Accident
Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity
Phase 2/3, randomized, double-blind, placebo-controlled, single-treatment, multicenter trial assessing the efficacy and safety of MYOBLOC for the treatment of upper limb spasticity in adults followed by an open-label extension…
- Conditions
- Spasticity, Cerebrovascular Accident, Multiple Sclerosis, Traumatic Brain Injury
- Trial name
- NCT04815967
- Testing
- Phase 2; Low Dose MYOBLOC (10,000 Units), Phase 2; High Dose MYOBLOC (20,000 Units), Phase 3; MYOBLOC
- Where
- 9 sites in United States, Hungary and 1 more
- Volunteers
- 32 people
- Sponsor
- Solstice Neurosciences, LLC, a subsidiary of MDD US Operations, LLC
Acute Cervical Spinal Cord Injury
Safety and Efficacy of Cethrin® in Adult Subjects With Acute Cervical Spinal Cord Injury
This is a multicenter, randomized, double-blind, placebo-controlled, Phase IIb study to be conducted in North America and Europe and will include male and female subjects with acute cervical SCI, 18 to 62 years of age, who…
- Trial name
- NCT00610337
- Testing
- Cethrin® (BA-210)
- Sponsor
- BioAxone BioSciences, Inc.
Amyotrophic Lateral Sclerosis (ALS), Angina, Stable
Quest to Analyze One Thousand Humans Meditating
This study will be focused on assessing the molecular, physiological, and emotional correlates of an intensive meditation experience in the context of a retreat setting in a large 2000 plus-person cohort comprised of healthy and…
- Conditions
- Amyotrophic Lateral Sclerosis (ALS), Angina, Stable, Anxiety, Asthma
- Trial name
- QUANTUM (NCT06583395)
- Testing
- Advanced multi-component meditation practice
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Tobias Moeller-Bertram
Spinal Cord Injury
Autologous Incubated Macrophages for Patients With Complete Spinal Cord Injuries
Autologous Incubated Macrophages (ProCord) is being developed as a therapy for acute, complete spinal cord injury (SCI). The therapy is intended to reverse the loss of motor and sensory function.
- Trial name
- NCT00073853
- Testing
- Autologous Incubated Macrophages (cell therapy)
- Where
- 7 sites in United States, Israel
- Volunteers
- 61 people
- Sponsor
- Proneuron Biotechnologies
Neurogenic Bladder, Urinary Retention
Connected Catheter - Safety and Effectiveness Study
The Connected Catheter is a fully internal, urethral indwelling urinary prosthesis designed for improved bladder management in males with urinary retention disorders requiring catheterization.
- Conditions
- Neurogenic Bladder, Urinary Retention, Urologic Diseases
- Trial name
- NCT04059159
- Testing
- Connected Catheter
- Where
- 3 sites in United States
- Volunteers
- 8 people
- Sponsor
- Spinal Singularity
Spinal Cord Injury
HP184 in Chronic Spinal Cord Injury Subjects
The purpose of this study is to determine whether HP184 is effective in the treatment of chronic spinal cord injury (CSCI).
- Trial name
- NCT00093275
- Testing
- HP184
- Where
- 5 sites in United States, Australia and 3 more
- Volunteers
- 262 people
- Sponsor
- Sanofi
Urinary Catheter Blockage and Encrustation
Study to Evaluate NVC-422 for Urinary Catheter Blockage and Encrustation
NVC-422 is a topical, non-antibiotic, fast-acting, broad-spectrum anti-microbial, which exhibits the potential to prevent the growth of urinary pathogens, including Proteus and others.
- Trial name
- NCT01243125
- Testing
- NVC-422, 0.2%, Sterile normal saline, 0.9%
- Where
- 8 sites in United States
- Volunteers
- 67 people
- Sponsor
- NovaBay Pharmaceuticals, Inc.
Spinal Cord Injury
A Trial on the Clinical and Socioeconomic Impact of Wearable Exoskeletons for Spinal Cord Injury Rehabilitation in the Spanish Healthcare System
This clinical trial aims to collect evidence on the clinical benefits and the socioeconomic impact of integrating a novel wearable powered lower-limb exoskeleton for gait rehabilitation in acute/subacute spinal cord injured…
- Trial name
- NCT07036107
- Testing
- ABLE Exoskeleton, Conventional therapy
- Where
- 2 sites in Spain
- Volunteers
- 80 people
- Sponsor
- ABLE Human Motion S.L.
Neurologic Disorder, Paralysis
SWITCH II Early Feasibility Study: Implantable BCI to Control a Digital Device for People With Paralysis
The Synchron Motor Neuroprosthesis (MNP) is intended to be used in subjects with severe motor impairment, unresponsive to medical or rehabilitative therapy and a persistent functioning motor cortex.
- Conditions
- Neurologic Disorder, Paralysis, Paralysis; Stroke, Amyotrophic Lateral Sclerosis
- Trial name
- NCT05041114
- Testing
- Motor Neuroprosthesis
- Where
- 3 sites in Australia
- Sponsor
- Synchron Medical, Inc.
Tetraplegia/Tetraparesis, Quadriplegia
CAN-PRIME: Precise Robotically Implanted Brain-Computer Interface for the Control of External Devices
The CAN-PRIME Study is to test the safety and functionality of Neuralink's N1 Implant and R1 Robot in people who have difficulty moving their arms and legs (tetraparesis or tetraplegia).
- Conditions
- Tetraplegia/Tetraparesis, Quadriplegia, Quadriplegia/Tetraplegia, Cervical Spinal Cord Injury
- Trial name
- CAN-PRIME (NCT06700304)
- Testing
- N1 Implant, R1 Robot
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Neuralink Corp
Spinal Cord Injuries, Respiratory Complication
Effectiveness of Jamboxx Respiratory Therapy Device: Study 1
The Effectiveness of the Jamboxx Respiratory Therapy Device in Treatment of Patients with Decreased Respiratory Function is a proposal for investigation of the application of gaming to improving respiratory health.
- Trial name
- NCT03533400
- Testing
- Jamboxx Respiratory Therapy Device, Jamboxx Musical Device
- Where
- United States
- Sponsor
- My Music Machines Inc.
Spinal Cord Injury
Safety and Pharmacokinetics Study of MT-3921 in Spinal Cord Injury
The purpose of this study is to assess the safety, tolerability and pharmacokinetics of MT-3921 in subjects with spinal cord injury.
- Trial name
- NCT04096950
- Testing
- MT-3921 Low dose
- Where
- 13 sites in United States
- Volunteers
- 3 people
- Sponsor
- Tanabe Pharma America, Inc.
Neurogenic Detrusor Overactivity
Open-label, Long-term Safety, Efficacy, and Pharmacokinetics Study of Vibegron in Pediatric Subjects 2 Years to < 18 Years of Age With NDO and on CIC
The purpose of this study is to evaluate the safety, efficacy, and PK of Vibegron in pediatric participants with NDO who are regularly using CIC
- Trial name
- KANGUROO (NCT05491525)
- Testing
- Vibegron
- Where
- 38 sites in United States, Belgium and 14 more
- Volunteers
- 71 people
- Sponsor
- Urovant Sciences GmbH