Clinical trials: Traumatic Intracranial Hemorrhage
Chronic Subdural Hematoma, Recurrence
High Concentration Oxygen for Pneumocephalus After Evacuation of Chronic Subdural Haematoma
Normobaric oxygen therapy was shown to be effective in reducing post craniotomy pneumocephalus. Theoretical assessment of normobaric oxygen therapy in treating pneumocephalus has shown that a higher level of oxygen concentration…
- Conditions
- Chronic Subdural Hematoma, Recurrence, Oxycephaly
- Trial name
- HOPE (NCT04725851)
- Testing
- High concentration Oxygen therapy, Control: Room Air or Low concentration Oxygen
- Where
- Hong Kong
- Volunteers
- 36 people
- Sponsor
- Chinese University of Hong Kong
Cerebral Hemorrhage, Head Injury
Biomarkers Correlation With Volemia
The purpose of this study is to determine whether the Biomarkers (pro adrenomedullin (MR proADM), pro arginin vasopressin (CT proAVP), pro atrial natriuretic peptid (MR proANP), Pro Endothelin) changes at Day 2, Day 5 and Day 7…
- Conditions
- Cerebral Hemorrhage, Head Injury, Non Traumatic Post Surgery, Poly Trauma Patients Without Heart Failure
- Trial name
- ENVOL (NCT01858675)
- Testing
- Biomarkers, red blood cells and plasma assessment
- Where
- France
- Volunteers
- 66 people
- Sponsor
- ThermoFisher Scientific Brahms Biomarkers France
Neurologic Decompensation, Acute, Traumatic Brain Injury
Ventilatory Parameters in Acute Neurological Injury
The goal of this observational study is to test the association between baseline ventilatory parameters (in particular mechanical power (MP), mechanical power normalized to predicted body weight (MP/PBW) and driving pressure (DP)…
- Conditions
- Neurologic Decompensation, Acute, Traumatic Brain Injury, Stroke, Subarachnoid Hemorrhage
- Trial name
- NCT06192342
- Where
- Argentina
- Volunteers
- 19 people
- Sponsor
- Ramos Mejía Hospital
Coagulation Disorder, Brain Injuries, Traumatic
Thromboelastometry-identified Haemostatic Changes in Isolated Traumatic Brain Injury
A prospective open-label case-control study will be performed aiming to assess the utility of thromboelastometry (ROTEM) for identification of hemostatic changes, goal-directed coagulation management, and prognosis of…
- Conditions
- Coagulation Disorder, Brain Injuries, Traumatic, Bleeding
- Trial name
- THROMBIN (NCT03616808)
- Testing
- Thromboelastometry-guided haemostatic treatment
- Where
- Lithuania
- Volunteers
- 142 people
- Sponsor
- Lithuanian University of Health Sciences
Chronic Subdural Hematoma, Epilepsy; Seizure
Generating Evidence on NonEpileptic, Stereotypical and Intermittent Symptoms (NESIS) in Chronic Subdural Hematomas
Some patients with chronic subdural hematomas and transient neurological symptoms do not respond to standard antiepileptic drugs.
- Conditions
- Chronic Subdural Hematoma, Epilepsy; Seizure, Cortical Depression; Cortical Depolarization, Nonepileptic, Stereotypical and Intermittent Symptoms
- Trial name
- GENESIS (NCT04759196)
- Testing
- Topamax, Levetiracetam
- Where
- Canada
- Volunteers
- 56 people
- Sponsor
- Université de Sherbrooke
Chronic Subdural Hematoma
The Swedish Study of Irrigation Fluid Temperature in the Evacuation of Chronic Subdural Hematoma
The study will be a multicenter randomised controlled trial of the use of irrigation fluid of body temperature versus irrigation fluid of room temperature during burr hole evacuation of chronic subdural hematoma.
- Trial name
- SIC! (NCT02757235)
- Testing
- Irrigation fluid of body temperature, Irrigation fluid of room temperature
- Where
- 3 sites in Sweden
- Volunteers
- 588 people
- Sponsor
- Sahlgrenska University Hospital
Traumatic Intracranial Haemorrhage
OPtimal Timing of Thromboprophylaxis in Traumatic IntraCranial Haemorrhage (OPTTTICH Feasibility Study)
Victims of trauma with severe head injury who have bled into their brains are at high risk of developing blood clots in their legs. These blood clots can break off and travel through the bloodstream to the lungs causing death.
- Trial name
- OPTTTICH (NCT01589393)
- Testing
- Enoxaparin
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- McMaster University
Chronic Subdural Hematoma, Chronic Subdural Hematomas
Implementation of an Enhanced Recovery Pathway for Burr-hole Drainage in Patients With a Chronic Subdural Hematoma
A chronic subdural hematoma (cSDH) is a type of intracranial hematoma that primarily affects older adults. The rising incidence of this condition, coupled with the high healthcare burden of this disease, calls for an update of…
- Trial name
- ERP-cSDH (NCT07421453)
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Traumatic Brain Injury, Ischemic Stroke
Detection of Cerebral Ischemia With a Noninvasive Neurometabolic Optical Monitor
The goals of the project are to evaluate a noninvasive monitor of brain metabolism and blood flow in critically ill humans. If validated, such a reliable noninvasive brain blood flow and metabolism monitor, by allowing…
- Conditions
- Traumatic Brain Injury, Ischemic Stroke, Intracerebral Hemorrhage, Subarachnoid Hemorrhage
- Trial name
- NNOM (NCT02983786)
- Testing
- Indocyanine Green
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Pennsylvania
Brain Injuries, Brain Trauma
Evaluation of qSOFA in Neurosurgical Patients
The aim of the study is to look if Quick Sequential Organ Failure Assessment Score score in detecting a eary Sepsis is afflicted by neurosurgical disorders
- Conditions
- Brain Injuries, Brain Trauma, Subarachnoid Hemorrhage
- Trial name
- NCT04265404
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Goethe University
TBI (Traumatic Brain Injury), Brain Edema
Teen Online Problem Solving (TOPS) - An Online Intervention Following TBI
The purpose of this study is to learn if using the World Wide Web to train teens and their families in problem-solving, communication skills, and stress management strategies can help them to cope better following traumatic brain…
- Conditions
- TBI (Traumatic Brain Injury), Brain Edema, Craniocerebral Trauma, Hematoma
- Trial name
- TOPS (NCT00409058)
- Testing
- Teen Online Problem Solving
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Craniocerebral Trauma, Cerebral Hemorrhage
Mild Head Injury, Antiplatelets, and Anticoagulants
Approximately 20% of patients with mild head injury presenting to the Emergency Department (ED) is taking antiplatelet agents and 10% is taking oral anticoagulants.
- Trial name
- NCT04741334
- Testing
- direct anticoagulant, antiplatelet drugs, Dicumarols
- Where
- Italy
- Volunteers
- 2,127 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Chronic Subdural Hematoma
General Anesthesia Versus Locoregional Anesthesia for Evacuation of Chronic Subdural Hematoma
This study compare general anesthesia versus locoregional anesthesia for evacuation of chronic subdural hematoma. Half of participant will be operated under general anesthesia, while the other half will be operated under…
- Trial name
- NCT03666949
- Testing
- All General anesthesia, All Locoregional anesthesia
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Caen
Acute Brain Injury, Mechanical Ventilation
Regional Ventilation Evaluation During Neuro-injury Weaning Study
This study evaluates changes in regional lung ventilation using thoracic electrical impedance tomography (EIT) during the weaning process from mechanical ventilation in ICU patients with acute brain injury.
- Conditions
- Acute Brain Injury, Mechanical Ventilation, Prolonged Weaning, Traumatic Brain Injury
- Trial name
- ReVENtS (NCT07067671)
- Testing
- Internal Thoracic Impedance
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Subdural Hematoma
Middle Meningeal Artery Embolization for Treatment of Chronic Subdural Hematoma
Middle meningeal artery (MMA) embolization via a minimally invasive endovascular approach has been attempted with the goal of eliminating the arterial supply to the vascularized membrane.
- Trial name
- NCT03307395
- Testing
- Middel Meningeal Artery Embolization
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Weill Medical College of Cornell University
Traumatic Intracranial Hemorrhage, Brain Injuries
Mild Traumatic Brain Injury and the Risk for Traumatic Intracranial Hemorrhage
Management of traumatic brain injuries causes significant efforts on emergency departments (ED) and overall health care. Patients on antithrombotic treatment with even minor trauma to the head, although without significant…
- Trial name
- NCT05609721
- Testing
- no intervention, only observational study
- Where
- Sweden
- Volunteers
- 2,044 people
- Sponsor
- Umeå University
Chronic Subdural Hematoma
Randomized Controlled Trial Investigating Optimal Treatment for Chronic Subdural Hematoma
Setup of comparative trial The goal of this study is to determine whether one surgical treatment for chronic subdural hematoma is better than the other.
- Trial name
- NCT02655445
- Testing
- Mini-craniotomy, Twist Drill Craniostomy, Burr Hole Craniostomy
- Where
- Belgium
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Chronic Subdural Hematoma, Surgical Procedures, Operative
A National Study Examining the Most Effective Drainage Method After Burr Hole Evacuation of Chronic Subdural Hematoma
Chronic subdural hematoma (CSDH) is a common disease. The main treatment is neurosurgical evacuation and subsequent hematoma drainage.
- Conditions
- Chronic Subdural Hematoma, Surgical Procedures, Operative, Recurrence, Mortality
- Trial name
- SUPERDURA (NCT06621407)
- Testing
- 24 hours active subperiostal drainage, 24 hours passive subdural drainage
- Where
- 4 sites in Denmark
- Volunteers
- 354 people
- Sponsor
- Aalborg University Hospital
Chronic Subdural Hematoma
A Study to Evaluate Endoscope-assisted, Minimally-invasive Cortical Access System for Chronic Subdural Evacuation
The purpose of this study is to evaluate a less-invasive alternative to the currently available method of removing aging blood in the subdural space.
- Trial name
- NCT04502745
- Testing
- Minimally Invasive Cortical Access System (MICAS)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Mayo Clinic
Aneurysmal Subarachnoid Hemorrhage, Vasospasm, Intracranial
Chemical and Mechanical Angioplasty for Vasospasm (SAVEBRAIN)
This is a monocentric randomized prospective trial comparing 2 different endovascular strategies of intracranial arterial angioplasty in case of refractory intracranial arterial vasospastic stenosis : chemical angioplasty…
- Conditions
- Aneurysmal Subarachnoid Hemorrhage, Vasospasm, Intracranial, Stenosis, Ruptured Cerebral Aneurysm
- Trial name
- SAVEBRAIN (NCT05268445)
- Testing
- Chemical and Mechanical Angioplasty for Refractory Intracranial Arterial Vasospastic Stenosis
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- Erasme University Hospital