Clinical trials: Traumatic Nerve Injury
Traumatic Brain Injury
Vitamin B12 vs B3 for Nerve Regeneration and Functional Recovery After Pediatric Traumatic Brain Injury
A traumatic brain injury (TBI) is among the most frequent reasons for neurological impairment in young people. The investigators investigated whether vitamin B12 vs B3 therapy could reduce the severity of traumatic brain injury…
- Trial name
- NCT05958277
- Testing
- Vitamin B3, Vitamin B12
- Where
- Pakistan
- Volunteers
- 300 people
- Sponsor
- KRL Hospital, Islamabad
Head Injury, Minor, Concussion, Mild
Heading in Football: Impact on Neural Blood Biomarkers
The goal of this observational study is to evaluate the safety of heading in football. We will study the release of biomarkers in blood that reflect microscopic neural damage.
- Conditions
- Head Injury, Minor, Concussion, Mild, CTE - Chronic Traumatic Encephalopathy, Neurodegeneration
- Trial name
- HEADLINE (NCT06147596)
- Testing
- Head impact exposure
- Where
- Netherlands
- Volunteers
- 335 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Post Traumatic Stress Disorder
Targeted Plasticity Therapy for Posttraumatic Stress Disorder
Posttraumatic stress disorder is a debilitating condition that develops in the aftermath of a traumatic experience, leading to hyperarousal, heightened anxiety, and uncontrolled fear that can be driven by intrusive memories or…
- Trial name
- NCT04064762
- Testing
- Paired Vagus Nerve Stimulation
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Baylor Research Institute
Neurofibromatosis 1, Diagnoses Disease
Study About Annoucement of the Diagnosis of Neurofibromatosis 1 in de Novo Forms
Neurofibromatosis type 1 (NF1) is one of the most common autosomal dominant genetic disorders. The aim of our study was to evaluate post-traumatic stress disorder (PTSD) in patients and their families following the disclosure of…
- Conditions
- Neurofibromatosis 1, Diagnoses Disease, Post Traumatic Stress Disorder
- Trial name
- NF1 (NCT03298438)
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Brest
Blepharoptosis, Ptosis, Eyelid
Clinical Trial Comparing Two Non-Surgical Treatments for Severe Blepharoptosis
This clinical trial will evaluate two non-surgical devices designed to improve eye lid opening for patients with severe Blepharoptosis (incomplete opening of the eyelids).
- Conditions
- Blepharoptosis, Ptosis, Eyelid, Myasthenia Gravis, Stroke
- Trial name
- NCT04678115
- Testing
- Magnetic Levator Prosthesis (MLP), Kinesiotape Frontalis Sling (KTFS)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Spinal Cord Injuries, Acute Traumatic Spinal Cord Injury
Spinal Decompression Plus Nerve Graft Implantation Following TSCI
This is a single-blinded (with outcome assessors blinded to treatment allocation), 12-month pilot study to evaluate of the safety, feasibility, and preliminary efficacy of dorsal myelotomy and expansive duraplasty performed…
- Trial name
- NCT06243211
- Testing
- DMED, ANGI
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Francis Farhadi
PTSD, mTBI
Vagal Nerve Stimulation in mTBI
Mild traumatic brain injury (mTBI) and posttraumatic stress disorder (PTSD) are important conditions for the Veterans Administration (VA) that frequently occur together in combat Veterans from the conflicts in Afghanistan and…
- Trial name
- VNS mTBI (NCT04437498)
- Testing
- nVNS
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- VA Office of Research and Development
Neuropathic Pain, Amputation, Traumatic
Postamputation Pain: Peripheral Mechanisms
Stump and phantom pain after amputation are common, but the responsible mechanisms are still not clarified. It has been suggested that phantom limb pain can be reduced by regional anaesthesia and in several recent studies, pain…
- Conditions
- Neuropathic Pain, Amputation, Traumatic, Nerve Block, Phantom Limb Pain
- Trial name
- NCT03317600
- Testing
- Lidocaine
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Danish Pain Research Center
Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury
Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)
This is a research study that aims to examine whether Veterans with mild Traumatic Brain Injuries are at risk for dementia by studying their memory, brain wave activity, brain structure and proteins that can be elevated after…
- Conditions
- Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury, Mild Cognitive Impairment
- Trial name
- NCT04124029
- Testing
- No Intervention is used for this study but all subjects will be asked to complete electroencephalogram (EEG) testing and an MRI scan., No intervention is used for this study but all subjects will be asked to complete a venous blood draw procedure and a lumbar puncture procedure.
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Mild Traumatic Brain Injury, Vestibular Neuropathy
Incremental Velocity Error as a New Treatment in Vestibular Rehabilitation
The objective for this study is to compare outcome measures from vestibular rehabilitation (VPT) delivered in a traditional method against a new device Incremental Velocity Error (IVE) that improves physiologic performance of the…
- Trial name
- INVENT (NCT03846830)
- Testing
- Incremental Velocity Error (IVE), Traditional Vestibular Rehabilitation (VPT)
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Johns Hopkins University
Mild Concussion, Post Concussion Syndrome
Clinical Evaluation of a Novel Balance, Vestibular and Oculomotor Assessment Tool
The iDETECT (Integrated Display Enhanced Testing for Concussion and mild traumatic brain injury) system is a novel portable, open access platform that enables immediate and rapid assessment of multimodal neurologic function.
- Conditions
- Mild Concussion, Post Concussion Syndrome, Vestibular Neuritis
- Trial name
- NCT02171312
- Testing
- iDETECT Assessment, Routine Balance and Vestibular Testing
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Emory University
Traumatic Brain Injury, Rebound Intracranial Hypertension
ONSD Trajectory in Rebound ICH
The goal of this prospective observational study is to determine whether the trajectory of optic nerve sheath diameter (ONSD) after osmotherapy weaning can predict rebound intracranial hypertension in adult patients with…
- Conditions
- Traumatic Brain Injury, Rebound Intracranial Hypertension, Cerebral Edema
- Trial name
- ONSD/ INH (NCT07722702)
- Testing
- Optic Nerve Sheath Diameter Ultrasonography
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
This Study is Testing the Use of MatriDerm
Nerve Grafting Using MATRIderm® in Traumatic Digital Nerve Injuries: a Randomized, Single-center, Controlled Study
Hand and wrist injuries are very common, with nearly 2 million cases each year in France. Many injuries involve cuts that damage important structures such as nerves, tendons, blood vessels, bones, or joints.
- Trial name
- MATRINERVE (NCT07292415)
- Testing
- Standard peripheral nerve repair under regional anesthesia with magnification; epineural sutures placed, followed by 2-week immobilization if needed., Peripheral nerve repair under regional anesthesia with epineural sutures; nerve wrapped along its length with 1 mm MatriDerm® collagen-elastin matrix before standard skin closure.
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Traumatic Optic Neuropathy
The Neuroprotective Effect of PEG-GCSF in the Traumatic Optic Neuropathy
The clinical trial will be a phase 1, semi-experimental trial, which will be performed in Hualien Tzu Chi Hospital. Twenty patients will be recruited in this study starting from the 2nd year of the project to the 3rd year of the…
- Trial name
- NCT06168188
- Testing
- Neulasta® (pegfilgrastim)
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Acute Respiratory Distress Syndrome, Acute Lung Injury
Non-invasive Vagal Neurostimulation (nVNS) for Traumatic Brain Injury (TBI)-Induced Acute Respiratory Distress
This is a prospective, randomized, two-arm, controlled 30-day investigational pilot trial using the gammaCore Sapphire S non-invasive vagus nerve stimulation (nVNS) device + standard of care (SOC) in newly-hospitalized patients…
- Conditions
- Acute Respiratory Distress Syndrome, Acute Lung Injury, Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Traumatic Brain Injury
- Trial name
- NCT04935697
- Testing
- nVNS, SOC
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
TBI (Traumatic Brain Injury), Ocular Motility Disorders
Frontoparietal Priority Maps as Biomarkers for MTBI
The purpose of this study is to determine whether there is a quantitative relationship between brain processes seen by a MRI and visual deficits caused by mild to moderate traumatic brain injuries (mTBI).
- Trial name
- NCT02251002
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Post-Traumatic Headache
Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 1
The acute and subacute sensations that occur on the scalp with injection of different concentrations of bupivacaine for grater occipital nerve blockade will be compared.
- Trial name
- NCT06069791
- Testing
- Bupivacaine Injection
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Spinal Cord Injuries
Ultrasound and Peripheral Nerve Stimulator Guided Femoral Nerve Block
A pre-post descriptive study was performed to examine the immediate effects of ultrasound (US) guided femoral nerve block with phenol (UGFNBwP) in managing lower limb spasticity of individuals with traumatic spinal cord injury…
- Trial name
- NCT03468439
- Testing
- Femoral nerve block with phenol
- Volunteers
- 14 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Facial Nerve Injuries, Facial Trauma
Neurorrhaphy Only vs Neurorrhaphy Plus PRF vs Neurorrhaphy Plus Nano-fat in Management of Traumatic Facial Nerve Injury
The current clinical trial aims to identify the most significant intervention that improves the outcome of post-traumatic facial nerve injury by comparing the following different modalities: neurorrhaphy alone, neurorrhaphy with…
- Trial name
- facialinjury (NCT06977607)
- Testing
- Platelets Rich Fibrin, Nano-fat stem cells (NFSCs), Repair only
- Where
- Egypt
- Volunteers
- 21 people
- Sponsor
- Assiut University
Traumatic Optic Neuropathy
Traumatic Optic Neuropathy Treatment Trial 2
After introducing intravenous erythropoietin (EPO) as an option for treatment of patients with indirect traumatic optic neuropathy in 2011 and publishing non inferiority trial in Oct.2017), TONTT2 is aiming to find out the best…
- Trial name
- TONTT-2 (NCT03308448)
- Testing
- Recombinant human erythropoietin
- Where
- 3 sites in Iran
- Volunteers
- 93 people
- Sponsor
- Iran University of Medical Sciences