Clinical trials: Traumatic Nerve Injury
Acute Stress Reaction, Cognitive Performance
Effect of Transcutaneous Auricular Neurostimulation on Cognitive Performance in a Laboratory Model of Acute Stress Reaction
The objective of this study is to test the effects of transcutaneous auricular neurostimulation (tAN) in treating or preventing performance degradation after an acute stressor.
- Trial name
- ASR (NCT06390267)
- Testing
- Sparrow Hawk (Active)
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Spark Biomedical, Inc.
Mild Traumatic Brain Injury
Cranial-nerve Non-invasive Neuromodulation (CN-NINM) for Balance Deficits After Mild Traumatic Brain Injury (Pilot Trial)
The purpose of this study is to determine the feasibility of combining PoNS therapy with standard vestibular and balance therapy with the proposed double-blind design; evaluate preliminary indications of efficacy.
- Trial name
- NCT02109198
- Testing
- Active CN-NINM PoNS
- Where
- 2 sites in United States
- Sponsor
- U.S. Army Medical Research and Development Command
Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders
Integrating Metabolism, Connectivity, and Mesoscale Imaging at Ultra-high Field to Decipher Mechanisms of Resilience and Neurodegeneration in Neurological Diseases and Healthy Aging
The MESO7 study is a prospective observational research project designed to investigate the mechanisms of resilience and neurodegeneration in neurological diseases and healthy aging.
- Conditions
- Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders, Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD), Alzheimer Disease
- Trial name
- MESO7 (NCT07202494)
- Testing
- Imaging Techniques (MRI 3T & 7T, Functional, Structural, and Metabolic Imaging)
- Where
- France
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Aphasia, Apraxia of Speech
taVNS for Speech and Language Recovery in Aphasia
The goal of this research study is to evaluate a novel approach to improving speech recovery in those with acquired apraxia of speech.
- Trial name
- NCT07563387
- Testing
- taVNS
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Florida
Intracranial Pressure Increase, Traumatic Brain Injuries
TCD and ONSD for Noninvasive Assessment of Increased ICP in TBI
This study will evaluate two non-invasive ultrasound methods, transcranial Doppler (TCD) and optic nerve sheath diameter (ONSD) ultrasound, for detecting signs of increased intracranial pressure in adults with traumatic brain…
- Trial name
- TCD ONSD TBI (NCT07816588)
- Testing
- Transcranial Doppler (TCD), Optic Nerve Sheath Diameter (ONSD) Ultrasound
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Cerebral Concussion, Brain Injuries
The Effects of Head Trauma on Collegiate Athletes
Recently, researchers and clinicians have examined many different forms of concussion testing aimed to assess if a brain injury has occurred and to what degree it affects the individual being tested.
- Trial name
- NCT02354469
- Where
- United States
- Volunteers
- 437 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Minimally Conscious States Due to Traumatic Brain Injury, Persistently Vegetative States Due to Traumatic Brain Injury
Vagus Nerve Stimulation to Augment Recovery From Minimally Conscious or Persistently Vegetative States After Traumatic Brain Injury
Traumatic brain injury has a high morbidity and mortality in both civilian and military populations. Blast and other mechanisms of traumatic brain injury damage the brain by causing neurons to disconnect and atrophy.
- Trial name
- NCT01260090
- Testing
- Vagus nerve stimulation;, No stimulation
- Where
- United States
- Sponsor
- VA New York Harbor Healthcare System
Brain Concussion, mTBI - Mild Traumatic Brain Injury
Screening Instruments for Measuring Visual Symptoms in Victims of Concussion
Visual dysfunction after mild traumatic brain injury (mTBI) is common but often remain undiscovered during longer periods of time. No valid, reliable and easy-to-use screening instrument for uncovering visual dysfunction exists.
- Trial name
- VisCom (NCT05862571)
- Where
- Denmark
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Traumatic Brain Injury
Modulating Inflammation in Neuro-Trauma
MINT is a single-site, prospective, randomized, double-blind, sham-controlled pilot trial evaluating the safety and feasibility of transcutaneous auricular vagus nerve stimulation (taVNS) in patients with moderate to severe…
- Trial name
- MINT (NCT07510074)
- Testing
- Nurosym taVNS
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Brain Injuries, Acute, Brain Tumor Adult
PIRe 2.0: A Stepped-Care Model for Involving Relatives Across Sectors
Serious brain diseases and injuries affect not only the person who becomes ill or injured, but also their family. Relatives of people with acquired brain injury (ABI) or malignant brain tumor (MBT) often take on a major role in…
- Conditions
- Brain Injuries, Acute, Brain Tumor Adult, Brain (Nervous System) Cancers, Traumatic Brain Injuries
- Trial name
- PIRe (NCT07590726)
- Testing
- Supportive Care
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Mild Traumatic Brain Injury
Cranial-nerve Non-invasive Neuromodulation (CN-NINM) for Balance Deficits After Mild Traumatic Brain Injury (Full Trial)
The purpose of this study is to evaluate improvement in balance after receiving physical therapy when augmented by CN-NINM than when augmented by a placebo (sham CN-NINM).
- Trial name
- CN-NINM (NCT02125591)
- Testing
- Active CN-NINM PoNS
- Where
- 2 sites in United States
- Sponsor
- U.S. Army Medical Research and Development Command
Post-Traumatic Stress Disorder
Neuromodulation for Post-Traumatic Stress Disorder
The investigators propose to use a clinical trial to test Trigeminal Nerve Stimulation (TNS) to examine the efficacy of TNS as a new treatment for Post Traumatic Stress Disorder (PTSD) in veterans.
- Trial name
- NCT02377089
- Testing
- Trigeminal Nerve Stimulation
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of California, Los Angeles
Mild Cognitive Impairment, Traumatic Brain Injury
Neuromodulation and fMRI in Neurodegenerative Diseases Study
In addition to neuronal loss, dysfunction in brain network connectivity has been identified as a correlate of cognitive deficits in neurodegenerative and post-traumatic brain injury states.
- Conditions
- Mild Cognitive Impairment, Traumatic Brain Injury, Neurodegeneration
- Trial name
- NCT06873750
- Testing
- Transcranial Alternating Current Stimulation
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Traumatic Brain Injury, Cerebral Hemorrhage
Effect of Median Nerve Electrical Stimulation Combined With Auricular Acupuncture on Consciousness Disturbance in Patients With Craniocerebral Injury
This study aims to evaluate the effects of auricular press needle therapy, combined with conventional treatment and median nerve electrical stimulation, on promoting arousal and neurological recovery in patients with disorders of…
- Trial name
- ANECT-CCI (NCT07273864)
- Testing
- Conventional Neurosurgical and Supportive Care, Right Median Nerve Electrical Stimulation, Auricular Press-Needle Therapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Li Hai
Traumatic Brain Injury, Severe Traumatic Brain Injury
Vagus Nerve Stimulation in Patients in Comatose State
Some patients with severe traumatic brain injury cannot respond at the bedside, yet about 1 in 4 may be aware but unable to show it - a hidden state called cognitive motor dissociation.
- Conditions
- Traumatic Brain Injury, Severe Traumatic Brain Injury, Disorders of Consciousness Due to Severe Brain Injury, Coma, Traumatic
- Trial name
- NCT07719595
- Testing
- Dual-Site Transcutaneous Auricular Nerve Stimulation (taVNS + taTNS)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Sima Mofakham
Brain Injuries, Traumatic
Noninvasive Neuromodulation for Treatment of Symptoms Due to Mild or Moderate Traumatic Brain Injury
The investigators hypothesis is that electrical stimulation to the tongue that directly stimulates two cranial nerve nuclei (Trigeminal and Facial Nerve Nuclei), will excite neural impulses to the brainstem and cerebellum.
- Trial name
- NCT02158494
- Testing
- Balance and Gait Training using neurostimulation modulation.
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Wisconsin, Madison
Nerve Damage, Trauma Nervous System
"Evaluation of the Epidemiology of Surgically Treated Acute Traumatic Peripheral Nerve Injuries of the Upper Extremity and Their Long-Term Effects on Sensory and Motor, Functional Status, and Quality of Life"
Assessment of the Outcomes of Hand Nerve Injuries
- Trial name
- NCT07402655
- Testing
- Peripheral Nerve Injury Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Suleyman Demirel University
Elbow Dislocation, Elbow Fractures
Neuro-Inflammation in Extremity Trauma: Risk Verification in Elbow Trauma: The NERVE Study
The primary goal of this proposal is to improve the understanding of the mechanisms causing persistent pain and disability in elbow fracture patients and their associated functional limitations.
- Conditions
- Elbow Dislocation, Elbow Fractures, Inflammation Biomarkers, TBI Traumatic Brain Injury
- Trial name
- NERVE (NCT07259382)
- Testing
- Biomarkers evaluation
- Volunteers
- 60 people
- Sponsor
- Université de Montréal
Chronic Pain, Anxiety
Nu-V3 Non-Invasive Nerve Stimulation Device Trial for Chronic Pain, Anxiety, Depression, Sleeplessness
The Nu-V3 Clinical Study is a prospective, single-arm, open-label, multi-center study using the Nu-V3 cranial nerve stimulation treatment device in patients with chronic pain, anxiety, depression, and/or sleeplessness.
- Conditions
- Chronic Pain, Anxiety, Depression, Sleeplessness
- Trial name
- Nu-V3 (NCT05335980)
- Testing
- Nu-V3
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Nu-Life Solutions
Nerve Injury, Orofacial Pain
Post-traumatic Neuropathy of the Trigeminal Nerve
This is retrospective research mainly aims to determine the patterns of symptoms, clinical and radiological findings and outcomes in patients with trigeminal neuropathy following trauma or iatrogenic damage and how this…
- Conditions
- Nerve Injury, Orofacial Pain, Trigeminal Nerve Injuries, Trigeminal Neuropathy
- Trial name
- NCT04612855
- Testing
- Groupwise comparison of primary and secondary outcomes
- Where
- Belgium
- Volunteers
- 1,333 people
- Sponsor
- KU Leuven