Clinical trials: Traumatic Stress Disorder
PTSD
Yoga and Physical Activity for Veterans
Posttraumatic stress disorder (PTSD) is a major health problem for the nation's Veterans, leading to significant physical and mental health morbidity and mortality.
- Trial name
- NCT03509909
- Testing
- Hatha yoga, Supportive physical activity
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorders, Combat Disorders
Integrated Treatment of OEF/OIF Veterans With PTSD & Substance Use Disorders
In comparison to the general population, U.S. military and Veterans are at an increased risk for developing both substance use disorders (SUD) and Post Traumatic Stress Disorder (PTSD).
- Conditions
- Posttraumatic Stress Disorders, Combat Disorders, Alcohol Dependence, Drug Dependence
- Trial name
- COPE (NCT01338506)
- Testing
- Concurrent Treatment with Prolonged Exposure (COPE)
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Medical University of South Carolina
Combat Disorders, Stress Disorders, Post-Traumatic
A Placebo-Controlled Trial of D-Cycloserine and Exposure Therapy for Combat-PTSD
The primary aim of this project is to examine whether administration of D-Cycloserine (DCS), a partial N-methyl-D-aspartate (NMDA) receptor agonist that has been shown to facilitate fear extinction, enhances the therapeutic…
- Trial name
- NCT00371176
- Testing
- Exposure therapy, D-Cycloserine
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- US Department of Veterans Affairs
Brain Concussion
Enhanced Problem-Solving Training
Mild traumatic brain injury (mTBI) is among the most common injuries sustained by Veterans of Operations Enduring and Iraqi Freedom.
- Trial name
- E-PST (NCT03759223)
- Testing
- Enhanced Problem-Solving Training (E-PST), Healthy Living Messages (HLM), Enhanced Problem-Solving Training (E-PST) (non-randomized)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Siblings, Childhood Cancer
SibACCESS: Developing a Telehealth Intervention to Address Unmet Psychosocial Needs of Siblings of Children With Cancer
This study aims to address barriers to psychosocial care for siblings of children with cancer by piloting a group-based telehealth program for adolescent siblings of youth with cancer.
- Conditions
- Siblings, Childhood Cancer, Pediatric Cancer, Posttraumatic Stress Disorder
- Trial name
- R03 CA259898 (NCT04889755)
- Testing
- SibACCESS
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Post Traumatic Stress Disorder
Quantifying the Efficacy and Role of Service Dogs for Military Veterans With PTSD
The purpose of this study is to quantify the therapeutic efficacy and role of trained service dogs on socio-emotional functioning among military veterans with posttraumatic stress disorder (PTSD).
- Trial name
- NCT03245814
- Testing
- Service Dog
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Post-Traumatic Stress Disorder, Chronic Low Back Pain
Yoga and Mantram for Chronic Pain and PTSD
PTSD is prevalent among Veterans and is associated with physical and functional impairments in addition to PTSD symptoms. Veterans with PTSD experience more chronic pain and pain-related functional limitations than Veterans…
- Conditions
- Post-Traumatic Stress Disorder, Chronic Low Back Pain, Chronic Neck Pain
- Trial name
- NCT03816007
- Testing
- Yoga and Mantram Repetition, Veteran Calm
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Study of Safety and Effects of MDMA-assisted Psychotherapy for Treatment of PTSD (Canada)
The goal of this clinical trial is to learn if MDMA-assisted therapy is safe and effective at reducing PTSD symptoms in people with at least severe PTSD.
- Trial name
- NCT03485287
- Testing
- Midomafetamine HCl, Manualized therapy
- Where
- 2 sites in Canada
- Volunteers
- 4 people
- Sponsor
- Resilient Pharmaceuticals
Posttraumatic Stress Disorder, Depression
A Study of Sertraline to Prevent PTSD
The broad, long-term objectives of this proposal are to prevent the emergence of posttraumatic stress and depressive symptoms in children admitted for an acute burn, reconstructive surgery, or non-burn injury.
- Trial name
- NCT00182078
- Testing
- Sertraline
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Massachusetts General Hospital
PTSD
Novel EEG Coherence Biomarkers for PTSD Assessment
Current practice for diagnosing and managing PTSD relies primarily on subjective clinical assessments by clinicians as well as patient self-report.
- Trial name
- NCT04209387
- Testing
- Acceptance and Commitment Therapy to Improve Social Support for Veterans with PTSD ( ACT-SS)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Lung Diseases, Medication Compliance
Uncontrolled Lower Respiratory Symptoms in the WTC Survivor Program
The purpose of this study is to understand why patients in the World Trade Center program have continuing breathing problems. This study will improve investigators understanding of breathing problems among individuals with World…
- Trial name
- NCT02024204
- Testing
- Fluticasone propionate 230mcg for 3 Months, Current Treatment or no treatment, Salmeterol 21mcg for 3 Months
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Acute Stress Reaction
Explorative Open Label Study of Efficacy Profile of Neurexan® in Experimental Acute Stress Setting in Healthy Subjects
The purpose of this study is to explore the efficacy of acutely dosed Neurexan using an experimental stress test called the Trier Social Stress Test
- Trial name
- NEUPRO-OL (NCT01703832)
- Testing
- Neurexan®
- Where
- 2 sites in Germany
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Biologische Heilmittel Heel GmbH
Low Back Pain, PTSD
Care Outcomes for Chiropractic Outpatient Veterans
The primary objectives of this pilot trial are to evaluate the feasibility, safety and acceptability of an integrative care pathway that includes chiropractic care, for the coordinated care for Veterans Administration (VA)…
- Conditions
- Low Back Pain, PTSD, Depression, Anxiety
- Trial name
- COCOV (NCT03254719)
- Testing
- Study assessments
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Palmer College of Chiropractic
Posttraumatic Stress Disorder
Acupuncture for PTSD
Current treatments for Veterans with PTSD include medications and therapy where the patient talks about traumatic events in order to desensitize to them.
- Trial name
- NCT02869646
- Testing
- Procedure: Acupuncture
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- VA Office of Research and Development
PTSD
Sequenced Treatment Effectiveness for Posttraumatic Stress
Individuals with PTSD are more likely to engage in unhealthy behaviors such as tobacco use, drug use, alcohol misuse, and have high rates of morbidity/mortality.
- Trial name
- STEPS (NCT04597190)
- Testing
- Selective serotonin reuptake inhibitor, Serotonin-norepinephrine reuptake inhibitor, Written Exposure Therapy
- Where
- 15 sites in United States
- Volunteers
- 700 people
- Sponsor
- University of Washington
Drug Use, Drug Abuse
Prevention of Post Sexual Assault Stress
The purpose of this study is to evaluate whether a brief intervention in video format, that includes education about reactions to assault and modeling of adaptive coping strategies, designed to reduce post assault drug use or…
- Conditions
- Drug Use, Drug Abuse, Posttraumatic Stress Disorder
- Trial name
- NCT01430624
- Testing
- PPRS, PIRI
- Where
- 2 sites in United States
- Volunteers
- 245 people
- Sponsor
- Medical University of South Carolina
Moral Injury
Thriving in the Midst of Moral Pain: The Acceptability and Feasibility of Acceptance and Commitment Therapy for Moral Injury (ACT-MI) Among Warzone Veterans
The need for moral injury interventions is increasingly being recognized as a domain in Veteran care that must be addressed. Consequences of exposure to morally injurious events include risk for suicide, substance abuse, and…
- Trial name
- NCT03760731
- Testing
- Acceptance and Commitment Therapy for Moral Injury (ACT-MI), Present Centered Therapy for Moral Injury (PCT-MI)
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorder
Family Involvement in Treatment for PTSD
Post-traumatic stress disorder (PTSD), prevalent among returning OEF/OIF/OND Veterans, has a powerful impact on family functioning.
- Trial name
- NCT00893152
- Where
- 2 sites in United States
- Volunteers
- 83 people
- Sponsor
- US Department of Veterans Affairs
Stress Disorders, Post-traumatic
Information Processing Modification in PTSD (Oct. 18)
The purpose of this study is to determine whether a computerized intervention designed to change the nature of attention biases will be effective in reducing the symptoms of post traumatic stress disorder (PTSD) in American…
- Trial name
- NCT00601952
- Testing
- Attention Bias Modification (ABM), Attention Control Condition (ACC)
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- San Diego State University
Insomnia, Suicidal Ideation
RCT of Brief CBT-I in Primary Care Veterans With Suicidal Thoughts
There is a strong association between insomnia and suicidal thoughts and behaviors. Insomnia also frequently co-occurs with other common conditions associated with suicide such as depression and posttraumatic stress disorder.
- Trial name
- NCT03603717
- Testing
- Cognitive Behavioral Therapy for Insomnia, Sleep Hygiene
- Where
- 3 sites in United States
- Volunteers
- 283 people
- Sponsor
- VA Office of Research and Development