Clinical trials: Traumatic Stress Disorder
Traumatic Brain Injury, Closed Head Injury
Photobiomodulation to Improve Cognition in TBI, With fMRI
The purpose of this small, research study is to examine effectiveness of an at-home application of an experimental intervention, on thinking and memory in mild-moderate, closed-head, traumatic brain injury cases.
- Conditions
- Traumatic Brain Injury, Closed Head Injury, Cognitive Dysfunction
- Trial name
- NCT04230577
- Testing
- Real LED Intervention
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Boston VA Research Institute, Inc.
Substance Use Disorders, Drug Abuse
Leveraging Implementation Science to Increase Access to Trauma Treatment for Incarcerated Drug Users
The unmet need for effective addiction treatment within the criminal justice system "represents a significant opportunity to intervene with a high-risk population" according to NIDA's 2016-2020 strategic plan.
- Conditions
- Substance Use Disorders, Drug Abuse, Alcohol Abuse, Posttraumatic Stress Disorder
- Trial name
- NCT04007666
- Testing
- Cognitive Processing Therapy, Control Group
- Where
- 2 sites in United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Stress Disorders, Post-Traumatic
Propranolol Reactivation Mismatch (PRM) Treatment for PTSD
The aim of the proposed work is to gather pilot data from an attempt to enhance the ability of propranolol reactivation (PR) to improve PTSD symptoms by incorporating into the design a mismatch (PRM) between what is expected and…
- Trial name
- NCT03652922
- Testing
- Reactivation Mismatch
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Post-Traumatic Neck Pain, Whiplash-associated Disorders
StressModex for Post-Traumatic Neck Pain
Post-traumatic neck pain is a common consequence of traffic-related and other accidental injuries. While many individuals recover, a subgroup develops persistent pain, disability, and psychological distress.
- Trial name
- StressModex (NCT07824557)
- Testing
- StressModex plus Treatment as Usual
- Where
- 3 sites in Denmark
- Volunteers
- 30 people
- Sponsor
- University of Southern Denmark
Posttraumatic Stress Disorder
Effectiveness and Acceptability of Stellate Ganglion Block for Posttraumatic Stress Disorder Symptoms - Acceptability
This qualitative study will use focus groups, small group interviews, and individual interviews (both in person and over the phone) to compile a range of perspectives on service members' decision-making processes and information…
- Trial name
- NCT03302312
- Where
- 3 sites in United States, Germany
- Volunteers
- 54 people
- Sponsor
- RTI International
Substance-Related Disorders, Depression
Wraparound for High-risk Families with Substance Use Disorders: Examining Family, Child, and Parent Outcomes
The investigators propose a Hybrid Type 1 effectiveness-implementation quasi-experimental trial. Participants are drawn from two different communities contemporaneously.
- Conditions
- Substance-Related Disorders, Depression, Stress Disorders, Post-Traumatic, Child Abuse
- Trial name
- NCT04637581
- Testing
- Wraparound
- Where
- 4 sites in United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Stress Disorders, Post-Traumatic, Depressive Symptoms
Treatment for Veterans With Military Sexual Trauma
The purpose of this study is to evaluate the effectiveness of Cognitive Processing Therapy (CPT) versus Present-Centered Therapy (PCT) in treating current post-traumatic stress symptoms associated with sexual assault that…
- Conditions
- Stress Disorders, Post-Traumatic, Depressive Symptoms, Anxiety Symptoms, Quality of Life
- Trial name
- NCT00371644
- Testing
- Cognitive Processing Therapy, Present-Centered Therapy
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- US Department of Veterans Affairs
Cardiovascular Diseases, Coronary Artery Disease
Depressive Symptoms After Cardiac Surgery
The primary goal of this project is to develop a predictive model for clinically significant depressive symptoms (CSDS) in patients undergoing coronary artery bypass graft (CABG) surgery, using pre- and perioperative data.
- Conditions
- Cardiovascular Diseases, Coronary Artery Disease, Heart Diseases, Depression
- Trial name
- PCD (NCT06706323)
- Where
- 2 sites in Switzerland
- Volunteers
- 300 people
- Sponsor
- Roland von Känel
Post-Traumatic Stress Disorder
Responsive Neurostimulation for Post-Traumatic Stress Disorder
Post-traumatic stress disorder (PTSD) refractory to treatment is marked by failure of fear extinction and its biological substrate, amygdala reactivity to trauma reminders.
- Trial name
- NCT04152993
- Testing
- NeuroPace® RNS® System
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- VA Greater Los Angeles Healthcare System
PTSD
Paroxetine Treatment in Outpatients With Comorbid PTSD and Substance Dependence
Pharmacotherapy has demonstrated efficacy in a number of controlled trials in the treatment of PTSD. The selective serotonin reuptake inhibitors have proven particularly useful in treating this disorder.
- Trial name
- NCT00330239
- Testing
- Paroxetine CR
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Medical University of South Carolina
PTSD
An Open-Label Trial of Memantine for Cognitive Impairment in Patients With Post-Traumatic Stress Disorder
Twenty six veterans with PTSD and cognitive impairment received 16 weeks of memantine in an open label fashion. Cognition was assessed using the Spatial Span, Logical Memory I, and Letter-Number Sequencing subtests of the…
- Trial name
- NCT02258828
- Testing
- Memantine
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Sriram Ramaswamy
Posttraumatic Stress Disorder, PTSD
Women Overcoming and Managing Adversity Now (WOMAN) Study
The goal of the study is to evaluate the efficacy of a two therapeutic models designed to enhance women's skills for managing reactive emotions in their current lives as well as to educate them about how using these skills can…
- Trial name
- WOMAN (NCT01324765)
- Testing
- TARGET, SGT
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- UConn Health
PTSD, Post-traumatic Stress Disorder
Sensory Motor Arousal Regulation Treatment (SMART) Study
This study will investigate whether a movement and body-based treatment can benefit adults with Post-traumatic Stress Disorder (PTSD).
- Trial name
- SMART (NCT06035809)
- Testing
- SMART
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Depression, PTSD
DDBT Adapted Problem Solving Treatment for Primary Care
Evidence-based psychosocial interventions are rarely used in part because of their design complexity. Although many implementation frameworks do address the importance of EBPI characteristics, adapting and modifying EBPIs to…
- Trial name
- PST-NA (NCT03514394)
- Testing
- Usual Care, Modified Behavioral Activation (Task Sharing)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Washington
Posttraumatic Stress Disorder, Acute Stress Disorder
Prevention of Intrusive Memories and Posttraumatic Stress Symptoms After Emergency Cesarean Section
This pilot study aims to investigate the effects of a brief computerized intervention (the computer game "Tetris") on intrusive memories and other posttraumatic stress symptoms following an emergency cesarean section.
- Trial name
- NCT02502513
- Testing
- Brief computerized intervention
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Posttraumatic Stress Disorder, PTSD
TDCS-Augmented Prolonged Exposure Therapy
The purpose of this study is to determine the effects of a brain stimulation technique known as transcranial direct current stimulation, or tDCS, on the benefits of Prolonged Exposure therapy, or PE, which is an effective…
- Conditions
- Posttraumatic Stress Disorder, PTSD, Anxiety, Depression
- Trial name
- NCT04327362
- Testing
- Transcranial Direct Current Stimulation (tDCS), Prolonged Exposure Therapy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
PTSD
Group MDMA-therapy for Veterans With PTSD
This Phase 2a, open-label, non-randomized, 3-cohort study assesses the feasibility and safety of MDMA-assisted group therapy for the treatment of PTSD in veterans.
- Trial name
- Group-MVP (NCT05961527)
- Testing
- MDMA, Group Therapy
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Portland VA Research Foundation, Inc
Post-Traumatic Stress Disorder
Risperidone Augmentation for PTSD
The purpose of this study is to (1) compare the response of civilians with Posttraumatic Stress Disorder(PTSD) currently receiving sertraline without an optimal response to risperidone augmentation vs.
- Trial name
- NCT00215241
- Testing
- sertraline and risperidone
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Duke University
PTSD
TF-CBT for Adjudicated Youth in Residential Treatment
Adjudicated youth often have traumatic stress responses but rarely receive treatment for these problems. This study is a randomized controlled trial to evaluate two alternative implementation strategies for providing an…
- Trial name
- NCT02402205
- Testing
- TF-CBT
- Volunteers
- 210 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Posttraumatic Stress Disorder
Optimal Dose of Early Intervention to Prevent PTSD
The overall aim of this study is to determine the optimal dose, 3-session exposure intervention versus 1-session exposure intervention compared to no treatment, for the delivery of exposure therapy in the immediate aftermath of…
- Trial name
- NCT01959620
- Testing
- 1-Session Exposure Therapy, 3-Session Exposure Therapy
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Emory University