Clinical trials: Treated Hypertension
Glaucoma, Open-Angle, Ocular Hypertension
Observational Study of Lumigan® 0.01% Treatment for Patients With Primary Open Angle Glaucoma or Ocular Hypertension
This study will assess the efficacy, safety, tolerability and persistence of use of Lumigan ® 0.01% in patients diagnosed with primary open-angle glaucoma or ocular hypertension who are treated per routine clinical practice.
- Trial name
- NCT01489670
- Testing
- bimatoprost 0.01% ophthalmic solution
- Where
- Switzerland
- Volunteers
- 387 people
- Sponsor
- Allergan
Hypertension
Telmisartan and Hydrochlorothiazide Antihypertensive Treatment Study in High Sodium Intake Population
In this research, the investigators aim to compare the antihypertensive efficacy and safety of monotherapy of routine dose angiotensin receptor antagonist telmisartan (ARB) and diuretic Hydrochlorothiazide (HCTZ) in high sodium…
- Trial name
- NCT02255253
- Testing
- Telmisartan, Hydrochlorothiazide
- Where
- 14 sites in China
- Volunteers
- 1,410 people
- Sponsor
- The George Institute for Global Health, China
Pulmonary Arterial Hypertension
Extension to CQTI571A2102 to Evaluate Long-term Safety, Tolerability and Efficacy of Imatinib in Severe Pulmonary Arterial Hypertension (PAH)
This study was an extension to study CQTI571A2102 and was to evaluate the long-term safety, tolerability and efficacy of QTI571 (imatinib) in severe pulmonary arterial hypertension patients.
- Trial name
- NCT01392495
- Testing
- Imatinib
- Where
- 7 sites in United States, Australia and 5 more
- Volunteers
- 17 people
- Sponsor
- Novartis Pharmaceuticals
Coronary Artery Disease, Cardiac Rehabilitation
Electronic Cardiac Rehabilitation (eCardiacRehab) Feasibility Study
In Norway, more than 11,000 patients undergo percutaneous coronary intervention (PCI) annually. However, a very recent study utilizing registry data show a national average of cardiac rehabilitation (CR) participation of only…
- Conditions
- Coronary Artery Disease, Cardiac Rehabilitation, Ethics, Continuity of Patient Care
- Trial name
- eCardiacRehab (NCT06759805)
- Testing
- eCardiacRehab
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Haukeland University Hospital
Refractory Hypertension or Drug-intolerant Hypertension
Laparoscopic Adventitial Renal Denervation (RDN) for Refractory Hypertension
This is a first-in-human study to test the safety and effectiveness of a new device-based treatment for high blood pressure that is difficult to control with medicine. This condition is known as refractory hypertension.
- Trial name
- NCT07108829
- Testing
- Renal Artery Radiofrequency Ablation Clamp
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Glaucoma, Hypertension
Efficiency of XAL-EASE Device in Glaucoma and/or Ocular Hypertension (OHT) Patients, Treated With Xalatan or Xalacom
Xal-Ease is a novel Pfizer-Pharmacia device aimed to significantly facilitate the Xalatan/Xalacom instillation and to avoid loss of Xalatan/Xalacom eye drops due to incorrect instillation.
- Trial name
- NCT01125306
- Testing
- Xal-Ease
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Meir Medical Center
Pulmonary Arterial Hypertension (PAH)
A Study of HS135 for the Treatment of Pulmonary Arterial Hypertension in Adults
A Study of HS135 for the Treatment of Pulmonary Arterial Hypertension in Adults
- Trial name
- NCT06493461
- Testing
- HS135
- Where
- 2 sites in Canada, Germany
- Volunteers
- 5 people
- Sponsor
- 35Pharma Inc
Metabolic Syndrome
Assessing The Treatment Effect in Metabolic Syndrome Without Perceptible diabeTes (ATTEMPT)
The objective of this protocol is to improve awareness, treatment, and control of metabolic syndrome, within primary prevention of cardiovascular disease, by implementing guidelines, after training of the participating physicians.
- Trial name
- ATTEMPT (NCT00416741)
- Testing
- Implementation of guidelines
- Where
- Greece
- Volunteers
- 2,000 people
- Sponsor
- Hellenic Atherosclerosis Society
Open-Angle Glaucoma
A Multi-Dose Study With a Treatment for Open-Angle Glaucoma
The purpose of this study is to determine whether Anecortave Acetate is effective for lowering intraocular pressure caused by open-angle glaucoma.
- Trial name
- NCT00705770
- Testing
- Anecortave Acetate
- Sponsor
- Alcon Research
Liver Cirrhosis, Portal Hypertension
ABMSC Infusion Through Hepatic Artery in Portal Hypertension Surgery for the Treatment of Liver Cirrhosis
In recent years, the safety and efficacy of autologous bone marrow stem cells infusion (ABMSCi) therapy were confirmed. The investigators attempted to infuse autologous bone marrow stem cells (ABMSC) through inserting a catheter…
- Conditions
- Liver Cirrhosis, Portal Hypertension, Hepatic Decompensation, Surgery
- Trial name
- NCT01560845
- Testing
- Autologous bone marrow stem cells infusion （ABMSCi） plus abdominal portal hypertension surgery, open abdominal portal hypertension surgery
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Wenzhou Medical University
Juvenile Idiopathic Arthritis
Retrospective Analysis of Pulmonary Arterial Hypertension (PAH) and Related Complications in Juvenile Idiopathic Arthritis (JIA) Participants Treated With Biologic and Non-biologic Disease-modifying Anti-rheumatic Drugs (DMARDs)
This study is designed to analyze the frequency and incidence rate of pulmonary complications in JIA participants who received biological DMARDs and non-biologic DMARDs.
- Trial name
- NCT02784808
- Testing
- Biological DMARDs, Non-Biologic DMARDs
- Volunteers
- 4,557 people
- Sponsor
- Hoffmann-La Roche
Hypertension
Screen-and-treat Program for Chronic Kidney Disease- High Risk Persons
The overall hypothesis of this trial is that screening for chronic kidney disease, followed by education or treatment program will improve blood pressure control among hypertensive non-diabetic persons.
- Trial name
- NCT02059408
- Testing
- Screen-Educate, Screen-Educate and Intensify Treatment
- Where
- United States
- Volunteers
- 1,819 people
- Sponsor
- University of California, San Francisco
Cardiovascular Disease, Hypertension
Phase II Study of Heart Polypill Safety and Efficacy in Primary Prevention of Cardiovascular Disease
Cardiovascular is a major cause of mortality in Iran, accounting for 45.7% of deaths. In Golestan (North Eastern Iran) preliminary findings from follow-up of the Golestan Cohort are consistent with national figures: with 45% (at…
- Conditions
- Cardiovascular Disease, Hypertension, Hyperlipidemia, Heart Disease
- Trial name
- Polypill (NCT00603590)
- Testing
- Polypill
- Where
- Iran
- Volunteers
- 475 people, healthy volunteers welcome
- Sponsor
- Tehran University of Medical Sciences
Hypertension, OSA - Obstructive Sleep Apnea
Primary Prevention Long-term Registry Study in OSA and Hypertension. Survival Analysis 2010-2022
Hypertension and obstructive sleep apnea (OSA) are both common conditions that independently increase the risk cardiovascular disease including atrial fibrillation, ischemic heart disease, heart failure and stroke.
- Conditions
- Hypertension, OSA - Obstructive Sleep Apnea, MACE, Survival Analysis
- Trial name
- DISCOVERY-HT (NCT06930989)
- Testing
- Positive airway pressure (PAP)
- Where
- Sweden
- Volunteers
- 148,467 people
- Sponsor
- Vastra Gotaland Region
Hypertension
Hypertension in Long-Term Care Facilities
This study is exploratory in nature and seeks to describe hypertension diagnosis and management among patients in long-term care (LTC) facilities.
- Trial name
- NCT03046420
- Testing
- Chart review
- Where
- United States
- Volunteers
- 139 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Hypertension
Economic Evaluation of Baroreceptor STIMulation for the Treatment of Resistant HyperTensioN
Medico-economics assessment (cost-effectiveness) of the unilateral carotid barostimulation with Barostim NeoTM compared to usual care in patients with resistant hypertension (multicenter randomized, PROBE trial), followed-up for…
- Trial name
- ESTIM-rHTN (NCT02364310)
- Testing
- Baroreceptor stimulation with Barostim Neo TM
- Where
- 15 sites in France
- Volunteers
- 132 people
- Sponsor
- Pr Patrick ROSSIGNOL
Resistant Hypertension
A Study of CIN-107 in Adults With Treatment-Resistant Hypertension (rHTN)
This is a randomized, double-blind, placebo-controlled, dose-ranging Phase 2 study to evaluate the efficacy and safety of CIN-107 as compared to placebo after 12 weeks of treatment in patients with treatment-resistant…
- Trial name
- BrigHTN (NCT04519658)
- Testing
- CIN-107
- Where
- 80 sites in United States
- Volunteers
- 275 people
- Sponsor
- CinCor Pharma, Inc.
Pulmonary Arterial Hypertension, Children
A Randomized, Double-Blind, Placebo-Controlled Study of Sildenafil in Children With Pulmonary Arterial Hypertension.
This is a clinical research study designed to evaluate sildenafil for the treatment of Pulmonary Arterial Hypertension in children, aged 1 to 17 years.
- Trial name
- NCT00159913
- Testing
- Sildenafil citrate
- Where
- 41 sites in United States, Brazil and 15 more
- Volunteers
- 235 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Pregnancy, Preeclampsia
Abbreviated MgSO4 Therapy in Post-partum Preeclampsia
Magnesium sulfate is used for seizure prophylaxis in pregnancies complicated by preeclampsia. There is debate as to how long to continue this therapy after delivery of the pregnancy.
- Trial name
- NCT00344058
- Testing
- abbreviation of magnesium sulfate therapy (12 hours versus the traditional 24 hours after delivery)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Case Western Reserve University
Hypertension,Essential
Hypertension Treatment Adherence Improving Trial
Persistent adherence to lifestyle modifications and blood pressure lowering medications were the best way to control blood pressure.
- Trial name
- NCT04565548
- Testing
- Educational program for hypertensive patients, Usual care
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 148 people
- Sponsor
- The Hong Kong Polytechnic University