Clinical trials: Treatment
Seasonal Allergic Rhinoconjunctivitis
Safety and Tolerance Study of Grass Pollen-derived Peptides to Treat Allergic Rhinitis
The purpose of this study is to determine whether the oral administration of grass pollen peptides to treat allergic rhinitis is safe and well tolerated.
- Trial name
- NCT00813046
- Testing
- gpASIT+TM
- Where
- Belgium
- Volunteers
- 8 people
- Sponsor
- BioTech Tools S.A.
Obstructive Sleep Apnea (OSA), CPAP
Sleep Apnea Biomarkers and Adherence to Continuous Positive Airway Pressure
Obstructive sleep apnea (OSA) is commonly assessed using the apnea-hypopnea index, although this measure does not fully reflect cardiovascular risk or the physiological impact of the disease.
- Conditions
- Obstructive Sleep Apnea (OSA), CPAP, Biomarkers for Prediction of OA Treatment Efficacy
- Trial name
- BIOSA (NCT07792746)
- Testing
- Continuous Positive Airway Pressure
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Clinique du Millenaire
Arsenical Melanosis, Arsenical Keratosis
Selenium in the Treatment of Arsenic Toxicity and Cancers
Context: Approximately 100 million people throughout the world consume water contaminated with arsenic at levels above carcinogenic thresholds, including 40 million in Bangladesh alone, with up to one-fourth of deaths attributed…
- Conditions
- Arsenical Melanosis, Arsenical Keratosis, Arsenical Cancers, Arsenicosis
- Trial name
- SETAC (NCT01442727)
- Testing
- sodium selenite
- Where
- Bangladesh
- Volunteers
- 819 people
- Sponsor
- Texas Tech University
Treatment Outcome, Vascular Access
Reduction of Complications Associated With PICC Management
The present study aims to analyze different care routes of the peripheral access central venous catheter to assess which alternative allows a moderate reduction in the level of complications associated with prolonged care…
- Conditions
- Treatment Outcome, Vascular Access, Vascular Access Device, Vascular Access Complication
- Trial name
- PICC managemen (NCT06944327)
- Testing
- MANAGEMENT CARE, traditional care
- Volunteers
- 460 people
- Sponsor
- Fundacion Miguel Servet
Acute Gouty Arthritis
Canakinumab in the Treatment of Gouty Arthritis Flare(s) and Prevention of New Flares in Patients With Chronic Kidney Disease
The purpose of this study is to confirm the efficacy and safety results obtained in a chronic kidney disease (CKD) subgroup of patients participating in Phase III studies in a larger, independent patient population with difficult…
- Trial name
- NCT01593527
- Testing
- ACZ885, Triamcinelone acetonide
- Sponsor
- Novartis Pharmaceuticals
Chronic Pain
Safety and Effectiveness of Spinal Cord Stimulation With Automatic Control to Treat Chronic Pain in an Extended Trial
The aims of the study are to compare automatic control of spinal cord stimulation with manual control in patients with chronic pain of the trunk and limbs
- Trial name
- Panorama (NCT02161627)
- Testing
- Saluda Medical External Trial System
- Where
- 10 sites in United States
- Volunteers
- 69 people
- Sponsor
- Saluda Medical Pty Ltd
Erectile Dysfunction (ED)
The Feasibility of Using Dornier Machine in Patients With Erectile Dysfunction, a Pilot Study.
Extracorporeal Shockwave Therapy (ESWT) is a well-established modality for treating various urological and musculoskeletal conditions.
- Trial name
- DED-Pilot (NCT07331961)
- Testing
- extracorporeal shock wave therpy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Tonsillitis, Airway Obstruction
Acetaminophen's Efficacy For Post-operative Pain
The purpose of this study is to compare IV acetaminophen to oral acetaminophen for pain control in children undergoing tonsillectomy with or without adenoidectomy.
- Conditions
- Tonsillitis, Airway Obstruction, Difficulty Swallowing
- Trial name
- NCT01721486
- Testing
- IV acetaminophen, PO acetaminophen
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Kaveh Aslani, MD
Diabetes Mellitus
Efficacy and Safety of Alogliptin Combined With Metformin in Participants With Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the efficacy and safety of alogliptin, once daily (QD), combined with metformin in adults with type 2 diabetes mellitus.
- Trial name
- NCT00286442
- Testing
- Alogliptin and metformin, Metformin
- Where
- 56 sites in United States, Argentina and 15 more
- Volunteers
- 527 people
- Sponsor
- Takeda
Benign Brain Tumors, Proton Therapy
Changes in the MRI Signal in Patients With Benign Tumors of the Brain and Meninges Treated With Proton Therapy: Impact of TEL and the Biological Dose Received
The main objective is to detect with TESLA multiparametric 3 MRI, the MRI secondary changes to protontherapy irradiation and to correlate them with TEL mapping, physical dose and biological dose.
- Trial name
- BRAIN TEL (NCT04584086)
- Testing
- MRI 3 tesla
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Francois Baclesse
Breast Cancer, Metastatic Breast Cancer
Phase II Study for Solid Metastatic Tumors
1. To induce immunity-mediated tumor response outside the radiation field (abscopal effect) after chemo-radiation of a metastatic site in metastatic breast cancer patients. 2. To monitor the induction of a T cell response. 3.
- Conditions
- Breast Cancer, Metastatic Breast Cancer, Solid Tumor
- Trial name
- NCT02474186
- Testing
- Radiation therapy, Xeloda, paclitaxel
- Volunteers
- 41 people
- Sponsor
- NYU Langone Health
Multiple Sclerosis, Fatigue
Bright Light Therapy as Possible Treatment Option for MS-Fatigue
This study aims to investigate the effect of a 2-week trial of bright light therapy (BLT, 10.000 lx) on fatigue in multiple sclerosis (MS) patients.
- Trial name
- NCT04681586
- Testing
- bright light therapy, dim red light
- Where
- Austria
- Volunteers
- 36 people
- Sponsor
- Medical University of Vienna
Healthy
Single-center Study Evaluating the Safety and Efficacy of Viscogel® as Adjuvant in Act-HIB® Vaccine
The purpose of this study is to show that ViscoGel® is safe when administrated alone and as an adjuvant together with Act-HIB® vaccine in healthy volunteers and to evaluate the quantitative and qualitative effect on the immune…
- Trial name
- VSG-2011-101 (NCT01578070)
- Testing
- 0.2μg Act-HIB®, ViscoGel® and 0.2μg Act-HIB®, ViscoGel® and 2μg Act-HIB®
- Where
- Sweden
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Viscogel AB
Psychiatric &or Mood Disorder
Effect of Massage Therapy on Aggression in a Psychiatric Inpatient Unit
The purpose of this study is to investigate whether relaxation massage therapy is effective in reducing the levels of arousal and aggression on a young adult inpatient unit.
- Trial name
- NCT00421070
- Testing
- Massage therapy
- Where
- Australia
- Volunteers
- 47 people
- Sponsor
- Melbourne Health
Accidental Falls, Recurrent Falls
Multicomponent Versus Balance Exercise for Older Adults With Recurrent Falls
To compare the short-term effects and 6-month durability of supervised multicomponent exercise, balance exercise alone, and fall-prevention education on balance, strength, walking performance, and health-related quality of life…
- Trial name
- NCT07739173
- Testing
- Multicomponent exercise, Balance exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Balikesir University
Elevated LDL-C and High Cholesterol
A Study of STX-1150 in Participants With Elevated Low-Density Lipoprotein Cholesterol (LDL-C)
STX-1150 is an investigational therapy designed to lower LDL-C by silencing a gene called PCSK9 in the liver. STX-1150 does not edit or permanently change the gene.
- Trial name
- STX-1150-01 (NCT07428473)
- Testing
- STX-1150
- Where
- 3 sites in Australia, New Zealand
- Volunteers
- 64 people
- Sponsor
- Monash University
Rhinoscleroma
Efficacy Of Doxycycline & Versus Rifampin In Treatment Of Rhinoscleroma
The study is conducted To evaluate the Efficacy of Doxycycline (alone and in combination with Ciprofloxacin) as an alternative to the regular regimen in treating rhinoscleroma, especially for cases with contraindication to the…
- Trial name
- NCT05431673
- Testing
- Doxycycline, Ciprofloxacin, Rifampin
- Volunteers
- 45 people
- Sponsor
- Assiut University
Healthy Volunteers, Diaphragm
High Flow Oxygen Therapy Effect on Healthy Subjects
The use of high-flow nasal cannula (HFNC) has increased. Diaphragmatic ultrasonography is a tool that, as a noninvasive complement to esophageal pressure (Pes) measurement, allows the evaluation of diaphragm function and…
- Conditions
- Healthy Volunteers, Diaphragm, Respiratory Rate
- Trial name
- NCT06086769
- Testing
- High flow nasal canula
- Where
- Argentina
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Argentinian Intensive Care Society
Healthy
A 5-treatment, Study in Healthy Volunteers to Assess The Safety, Tolerability, and Pharmacokinetics of Four Controlled Release (CR) Pregabalin Tablet Formulations and the Immediate Release (IR) Formulation Administered Fasted
This study is an open-label, single dose, randomized, 5-period, 5-treatment, 4-sequence cross-over with a fixed 5th treatment arm.
- Trial name
- NCT01443169
- Testing
- Sequence 1 - Treatment A: Controlled Release Pregabalin, Sequence 1 - Treatment B: Controlled Release Pregabalin, Sequence 1 - Treatment C:Controlled Release Pregabalin
- Where
- Belgium
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Osteoarthritis, Hallux Rigidus
Artelon Metatarsophalangeal (MTP) Spacer
The aim of this prospective, case series is to evaluate the surgical treatment of painful and disabling osteoarthrosis in the MTP-I joint by insertion of an Artelon MTP Spacer.
- Trial name
- NCT01028469
- Testing
- Artelon MTP Spacer
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- Artimplant AB