Clinical trials: Treatment Of Obesity
Morbid Obesity
Effects of Preoperative Respiratory Physical Therapy on Postoperative Respiratory Function After Bariatric Surgery
Background. Morbidly obese patients show an increased risk of hypoxemia and a higher incidence of postoperative pulmonary complications during the postoperative period resulting in prolonged hospital length of stay when compared…
- Trial name
- NCT01828632
- Testing
- Respiratory Physical Therapy
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Diabetes Mellitus, Type 2, Nutrition Disorders
Comparison of a Plant Protein Diet to a Animal Protein Diet Emphasized in Type 2 Diabetics
This 6-week parallel randomised prospective dietary intervention study with type 2 Diabetes investigates the nutrition influence of animal protein in comparison to plant protein on the glucose metabolism.
- Conditions
- Diabetes Mellitus, Type 2, Nutrition Disorders, Obesity, Body Weight
- Trial name
- LeguAN (NCT02402985)
- Testing
- High animal protein diet group, High plant protein diet group
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- German Institute of Human Nutrition
Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2
Drug Interactions From Simultaneous Administration Of Metformin And GSK189075 To Subjects With Type 2 Diabetes
GSK189075 is intended for use as a single treatment or in combination with other treatments for tye 2 diabetes mellitus (T2DM). Metformin is widely used in Europe and the USA for the treatment of T2DM.
- Trial name
- NCT00376038
- Testing
- GSK189075 oral tablets, metformin tablets
- Where
- Mexico
- Volunteers
- 13 people
- Sponsor
- GlaxoSmithKline
Human Immunodeficiency Virus, Obesity
Adipose Tissue and Immune Activation in HIV
The prevalence of HIV-associated wasting declined dramatically with the introduction of effective antiretroviral therapy (ART), but as patients survive longer on treatment the proportion of overweight (body mass index [BMI] >25…
- Trial name
- AIAC (NCT04439448)
- Testing
- dual-energy X-ray absorptiometry (DEXA) scan, Carotid and branchial artery ultrasound, 2-hour oral glucose tolerace test
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Obesity
Weight Loss With Exenatide Treatment
The investigators are conducting a study that will investigate the possible mechanisms of weight loss associated with exenatide treatment and the metabolic characteristics of high responders (i.e.
- Trial name
- NCT01590433
- Testing
- Exenatide, Dietary counseling
- Where
- United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Jody Dushay
Obesity, Diabetes
Effect of a Treatment of Lifestyle Changes on the Prevalence of Metabolic Syndrome and Body Weight in Mexican Women
The metabolic syndrome is a group of cardiometabolic risk factors that reflect a sedentary lifestyle and the excessive intake of food among the risk factors that comprise it are located the obesity, hyperglycemia, dyslipidemia…
- Conditions
- Obesity, Diabetes, High Blood Pressure, Dyslipidemia
- Trial name
- MPATPCDNC (NCT02247635)
- Testing
- Healthy lifestyle and adherence
- Where
- Mexico
- Volunteers
- 180 people
- Sponsor
- Mexican National Institute of Public Health
Sleep Apnea, Obstructive, Obesity Hypoventilation Syndrome (OHS)
Evaluation of An Optical Measurement Algorithm Combined With Patient and Provider Input to Reduce Mask Exchanges During Initial Positive Airway Pressure Therapy
Continuous positive airway pressure and non-invasive ventilation are common treatment modalities for obstructive sleep apnea, central sleep apnea, and chronic alveolar hypoventilation from a variety of causes.
- Conditions
- Sleep Apnea, Obstructive, Obesity Hypoventilation Syndrome (OHS), Sleep Apnea Syndromes
- Trial name
- NCT04688125
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Mayo Clinic
Obesity, Type 2 Diabetes
Ability of Almonds to Improve Nutrition During GLP-1 Treatment
This 8-week randomized controlled pilot trial is to test the hypothesis that, compared to a Usual Diet control group, almond intake will increase vitamin E (alpha-tocopherol) levels in the blood and improve diet quality (Healthy…
- Trial name
- NCT07796204
- Testing
- Almond Diet
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Pennington Biomedical Research Center
Type 2 Diabetes, Diabetes
The Effects of Anti-Inflammatory Treatment on Insulin Resistance in Healthy Volunteers
This study, conducted at the Phoenix Indian Medical Center, Phoenix, Arizona, will determine whether reducing subclinical inflammation lessens insulin resistance in healthy, obese volunteers.
- Trial name
- NCT00339833
- Testing
- Salsalate
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Obesity, Obesity, Morbid
Efficacy and Safety of Endoscopic Antral Myotomy as a Novel Weight Loss Procedure
Gastric myotomy has been performed for several years as a means of addressing chronic stenosis after sleeve gastrectomy and treating gastroparesis.
- Conditions
- Obesity, Obesity, Morbid, Obesity, Primary, Metabolic Disease
- Trial name
- PSAM (NCT05711758)
- Testing
- PSAM Treatment Patients
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Christopher C. Thompson, MD, MSc
Fatty Liver Disease, Nonalcoholic
Recombinant Leptin Therapy for Treatment of Nonalcoholic Steatohepatitis (NASH)
Nonalcoholic steatohepatitis (or NASH) is known to be caused by deposition of fat in the liver and development of scarring. This condition occurs more frequently in overweight and obese persons.
- Trial name
- NCT00596934
- Testing
- metreleptin
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Elif Oral
Obesity
Multi-Center Feasibility Study of Trans-oral Endoscopic Restrictive Implant System (TERIS) for Treatment of Obesity
The Barosense Trans-oral Endoscopic Restrictive Implant System (TERIS) is an investigational system being evaluated for safety The system uses endoscopic guidance to trans-orally implant a restrictive reservoir for food entering…
- Trial name
- NCT00707720
- Testing
- TERIS procedure
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- BaroSense Inc.
Obese and Metabolic Disorders
Safety and Pharmacokinetics of HRS-1597 Tablets in Healthy and Obese Participants: A Phase 1 Study
This is a Phase 1, single-center, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, and pharmacokinetics of HRS-1597 tablets following single-dose administration in healthy participants and…
- Trial name
- NCT07808918
- Testing
- HRS-1597
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Childhood Obesity, Insulin Resistance
Effectiveness of Antidiabetic Treatment Applied in Childhood Obesity
In our study, there are 33 healthy children with normal weight (control group) and 52 obese children who will be treated with metformin.
- Trial name
- NCT06266598
- Testing
- Metformin
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- HÜMEYRA ACIKAN
Diabetes
Initial Combination of Gemigliptin and Metformin on Microbiota Change
The purpose of this study is to investigate gut microbiota change and glucose lowering effect of initial combination therapy of gemigliptin and metformin compared to glimepiride and metformin in obese patients with type 2…
- Trial name
- INTESTINE (NCT02609815)
- Testing
- gemigliptin/metformin, glimepiride/metformin
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Seoul National University Bundang Hospital
Obesity, Morbid
FAECAL MICROBIOTA TRANSPLANTATION IN OBESITY
40 patients meeting the criteria for obesity surgery are enrolled. Fecal microbiota transplantation (FMT) will be administered in gastroscopy 6 months before obesity surgery.
- Trial name
- NCT03391817
- Testing
- Fecal microbiota transplantation
- Where
- 2 sites in Finland
- Volunteers
- 40 people
- Sponsor
- Joint Authority for Päijät-Häme Social and Health Care
Dysmenorrhea Primary, Obesity and Overweight
Bioptron Light Therapy for Dysmenorrhea in Obese Adolesences: RCT
Dysmenorrhea is the most common health problem in women in the reproductive age(Bakhsh et al., 2022). The primary dysmenorrhea starts shortly after the menarche the pain lasting 1 to 3 days that start just before or at the onset…
- Trial name
- NCT06992349
- Testing
- bioptron light therapy
- Where
- Egypt
- Volunteers
- 144 people
- Sponsor
- Alaa Noureldeen Kora
Healthy Participants, Obesity
A Study to Investigate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD1043 in Healthy Adult Participants Living With Overweight and/or Obesity.
The purpose of the study is to assess the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of AZD1043 following single and multiple ascending doses in healthy adult participants living with overweight and/or…
- Trial name
- NCT07511205
- Testing
- AZD1043
- Where
- 3 sites in United States, United Kingdom
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Childhood Obesity
Improving Cardiometabolic Health of Youth on Antipsychotic Medication
Pediatric antipsychotic treatment is associated with significant obesity-related side effects, including weight gain, increased blood sugar, abnormal cholesterol, and risk of new onset diabetes.
- Trial name
- NCT02877823
- Testing
- Treatment, Control
- Volunteers
- 302 people
- Sponsor
- University of Maryland, Baltimore
Patients After Metabolic-bariatric Surgery, Obesity, Morbid
Adipositas Care & Health Therapy
ACHT - Adipositas Care and Health Therapy - is a structured, digitally-supported, cross-sectoral and close to home program developed for the postoperative care of patients following obesity surgery.
- Trial name
- ACHT (NCT04768127)
- Testing
- early aftercare, mid-term to late aftercare
- Where
- 7 sites in Germany
- Volunteers
- 586 people
- Sponsor
- Wuerzburg University Hospital
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