Clinical trials: Treatment Of Obesity
Obesity
A Pilot Trial of Nabilone for the Treatment of Obesity
Obesity is a serious health problem which increases the likelihood of developing other life-changing medical conditions. Despite increasing knowledge about the neural and metabolic basis of obesity, the development of effective…
- Trial name
- NCT04801641
- Testing
- Nabilone
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Centre for Addiction and Mental Health
Utilization, Health Care, Obesity
Healthcare Utilization in Obese Caregiver Living Donors
The goal of this study is to estimate risk of post-donation healthcare use attributable to informal caregiving among obese living donors.
- Trial name
- NCT04341896
- Testing
- Caregivers, Non-caregivers
- Where
- United States
- Volunteers
- 784 people
- Sponsor
- University of Alabama at Birmingham
Hypertension, Obesity
Trial Comparing Metabolic Effects of Telmisartan and Amlodipine on Hypertensive Patients With Obesity and Diabetes
Recent studies have shown that obese people are more prone to high blood pressure. With the co-existence of obesity, hypertension and diabetes, patients were more susceptible to hyperlipidemia, coronary and cerebral…
- Conditions
- Hypertension, Obesity, Diabetes
- Trial name
- HOT-DM (NCT00847262)
- Testing
- Temisartan, Amlodipine
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Third Military Medical University
Type 2 Diabetes, Obesity
Enhancement of Brown Adipose Tissue Function Via Chronic Pharmacological Treatment
Obesity is epidemic in Australia, and current preventative strategies have had limited success in alleviating this health crisis.
- Conditions
- Type 2 Diabetes, Obesity, Cardiovascular Disease
- Trial name
- NCT02236962
- Testing
- Ephedrine, pioglitazone
- Where
- Australia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Obesity
Benefits of Endoscopic Bariatric Procedures
This 12-months long pilot study will include patients undergoing an endoscopic procedure (endoscopic sleeve gastroplasty [ESG] or transoral outlet reduction [TORe]) as clinically indicated, and subsequent follow up clinic visits…
- Trial name
- NCT05514288
- Testing
- Endobariatric procedure
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Adult Obesity, Weight Management
MIST (Metabolic Intervention With Semaglutide and THR-β Therapy) Trial
The primary objective of this trial is to evaluate the effect of oral ECC4703 on body weight reduction and in a sub-study on liver fat content as assessed by change in magnetic resonance imaging proton density fat fraction…
- Trial name
- NCT07505303
- Testing
- ECC4703, Semaglutide
- Where
- 15 sites in United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Eccogene
Diabetes Mellitus, Type 2, Obesity
Holding vs. Continuing Incretin-based Therapies Before Upper Endoscopy
To assess whether holding incretin-based therapy before endoscopy reduces the likelihood of clinically relevant Residual Gastric Volume (RGV).
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Gastroparesis
- Trial name
- NCT06533527
- Testing
- GLP-1 medication
- Where
- 2 sites in United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Obesity, Weight Loss
Effect of Liraglutide on Microbiome in Obesity
The purpose of the trial is to assess whether the beneficial effect of liraglutide on weight is mediated by changes in the composition of the intestinal Microbiome.
- Conditions
- Obesity, Weight Loss, Microbiome
- Trial name
- NCT04046822
- Testing
- Liraglutide 6 MG/ML [Saxenda]
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Federico II University
Bipolar Disorder, Obesity
The Effect of Dulaglutide as an Adjuvant Therapy on Cognitive Function in Bipolar Disorder Patients With Obesity
The primary objective of this study is to investigate the effect of dulaglutide adjuvant treatment in patients with bipolar disorder with obesity, in addition to exploring the effect of GLP-1RA on cognition of bipolar disorder.
- Conditions
- Bipolar Disorder, Obesity, Cognition
- Trial name
- NCT06331286
- Testing
- dulaglutide injection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Type 2 Diabetes Mellitus, Obesity
Long Term Free Living Study With Modified Foods and Type 2 Diabetics
Part 1 of this research demonstrated that type II diabetics are lacking in knowledge of how to best treat their illness with dietary controls. Most had little nutrition or diabetes knowledge.
- Trial name
- NCT00198913
- Testing
- lower fat food supplied and education, gift cards for grocery foods and written education
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Obesity, Overweight or Obesity
Effect of Psiguavin for Obesity Treatment (PSIGUAVIN)
The main objective of the project focuses on the study of the effectiveness of a functional component extracted from Psidium guava, psiguavin, as a potential inhibitor of pancreatic lipase and, therefore, as an adjuvant for the…
- Trial name
- PSIGUAVIN (NCT06512818)
- Testing
- Psiguavin
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Universidad Católica San Antonio de Murcia
Obesity
The Role of the Omentum in the Treatment of Morbid Obesity
The purpose of this research is to determine some of the reasons that blood sugar and insulin levels improve after bariatric surgery but before weight loss begins, as well as why people respond differently to weight loss surgery.
- Trial name
- NCT00212160
- Testing
- omentectomy
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Obesity, Lifestyle, Healthy
Twelve-year Follow-up on the Treatment of Obese Pregnant Women (TOP) Study
The participant (both mother and child) in the initial TOP study will be invited to a follow-up study to evaluate the effect of life style intervention during pregnancy on both mother and their offspring 12 years after the…
- Conditions
- Obesity, Lifestyle, Healthy, Diet, Healthy, Follow-up
- Trial name
- TOP12 (NCT05446220)
- Testing
- Lifestyle intervention
- Where
- Denmark
- Volunteers
- 497 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Obesity, Weight Loss
Obesity Treatment With a Very Low Energy Diet in Mexican Adults
Clinical practice guidelines recommend behavioral change protocols for obesity treatment, such as the Diabetes Prevention Program, which involves a low-energy diet, physical activity recommendations, behavioral therapy, and…
- Trial name
- NCT05631535
- Testing
- Intensive lifestyle change program with a very-low-energy diet, Intensive lifestyle change program with a low-energy diet
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Universidad de Sonora
Cardiovascular-kidney-metabolic Syndrome, Cardiovascular Disease Risk Factor
Early Add-On Combination of GLP-1 Receptor Agonist and SGLT2 Inhibitor in People With Cardiovascular-Kidney-Metabolic Stage 2-3
This retrospective observational target-trial emulation uses electronic health record data from the TriNetX US Collaborative Network to compare early treatment intensification strategies in adults with obesity, type 2 diabetes…
- Conditions
- Cardiovascular-kidney-metabolic Syndrome, Cardiovascular Disease Risk Factor, Kidney Disease, Type 2 Diabetes
- Trial name
- GLP1-SGLT2-CKM (NCT07465926)
- Testing
- GLP-1 receptor agonist, SGLT2 inhibitor
- Volunteers
- 451,036 people
- Sponsor
- Chung Shan Medical University
Obesity, Visceral, Obesity; Endocrine
Study of Lipolysis of Visceral Reserve Fat Using Tecar Therapy.
The Scope of this study is to assess the visceral and subcutaneous fat loss in patients having Tecar (Radiofrequency) Therapy and its effects on other anthropometric variables, adipokines and inflammation.
- Trial name
- NCT06377358
- Testing
- Tecar Therapy
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- CAPENERGY MEDICAL, SL
Obesity (Disorder), GLP-1 Receptor Agonist Treatment
Probiotics in Obese Patients Treated With Semaglutide
This randomized, double-blind, placebo-controlled trial evaluated the effects of a four-strain probiotic formulation in adults with obesity receiving semaglutide.
- Conditions
- Obesity (Disorder), GLP-1 Receptor Agonist Treatment, Probiotic Intervention, Diabetes Mellitus Type 2
- Trial name
- ProSem (NCT07847593)
- Testing
- Four-strain probiotic formulation
- Where
- 3 sites in Poland
- Volunteers
- 102 people
- Sponsor
- Nordic Biotic Sp. z o.o.
Supplemental Oxygen, Gynecological Cancer
Supplemental High Flow Oxygen to Reduce Infections in Obese Gynecological Cancer Patients
The incidence of surgical-site infection (SSI) and complications related to wound healing reaches 10-20% of gynecological cancer patients.
- Conditions
- Supplemental Oxygen, Gynecological Cancer, Surgical Site Infections
- Trial name
- SAFE (NCT06780813)
- Testing
- Supplemental oxygen therapy
- Where
- Greece
- Volunteers
- 400 people
- Sponsor
- National and Kapodistrian University of Athens
Obesity, Morbid
Aspiration Therapy for Obese Adolescents
Interventional studies devoted to adolescents are relatively rare in the world. This has several reasons. Treatment and research on obesity are centered on advanced forms of obesity in adults, bearing in mind that social and…
- Trial name
- NCT03598920
- Testing
- AsspireAssist, Nutritional consulting
- Where
- 3 sites in Czechia
- Volunteers
- 20 people
- Sponsor
- University Hospital Ostrava
Psoriatic Arthritis, Obesity
Small Changes Behavioural Weight Loss Treatment Approach for Psoriatic Arthritis Patients With Comorbid Obesity
Psoriatic Arthritis (PsA) is a type of auto-immune condition that affects roughly 90,000 Canadians. Patients with PsA often experience joint pain, skin problems, and issues with mobility that negatively impact their quality of…
- Trial name
- NCT05225623
- Testing
- BWLT, Waitlist Control for BWLT
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- University of Calgary
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