Clinical trials: Treatment Of Obesity
Obstructive Sleep Apnea (OSA)
Evaluate the Efficacy and Safety of GZR18 Injection in Obese Subjects With Obstructive Sleep Apnea Receiving Positive Airway Pressure (PAP) Therapy
The study is a multicenter, randomized, double-blind, parallel-group, placebo-controlled Phase III clinical trial to evaluate the efficacy and safety of GZR18 injection in Chinese adult obese patients with moderate-to-severe…
- Trial name
- NCT07501832
- Testing
- GZR18 injection
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Gan & Lee Pharmaceuticals.
Obese Adults
A Phase 1 Study of VK2735 in Obese Adults Without Comorbidities
The goal of this Phase 1, randomized, double-blind, placebo-controlled study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of VK2735 in adults who are obese (BMI ≥ 30 kg/m2) without comorbidities.
- Trial name
- NCT07838740
- Testing
- VK2735 Drug
- Where
- 2 sites in United States
- Volunteers
- 270 people
- Sponsor
- Viking Therapeutics, Inc.
Obesity, Obesity, Morbid
Luso-Cor Stent Compared to Other Endoscopic Techniques for Management of Fistulas and Anastomotic Dehiscences(ES-LCCE-UDFM)
The global prevalence of obesity has prompted an increase in bariatric surgery, which is the only management strategy that provides long-term weight loss and improvement of obesity-related diseases.
- Conditions
- Obesity, Obesity, Morbid, Esophageal Cancer, Esophageal Neoplasms
- Trial name
- ES-LCCE-UDFM (NCT06862479)
- Testing
- Endoscopic management of fistulas with stents or vacum therapy
- Where
- Portugal
- Volunteers
- 180 people
- Sponsor
- Unidade Local de Saúde Santa Maria
Obesity, Weight Loss
Long-Term Effect of 10 mg Versus 20 mg Rimonabant in Overweight or Obese Patients
The primary objective of this study is to assess, over a period of 12 months, the effect on weight loss and weight maintenance of rimonabant 10 mg in comparison with rimonabant 20 mg in overweight/obese patients after an initial…
- Trial name
- MODERATO (NCT00678483)
- Testing
- rimonabant (SR141716)
- Where
- 5 sites in Croatia, Finland and 3 more
- Volunteers
- 331 people
- Sponsor
- Sanofi
Obesity, Emotional Trauma
Effects of EMDR Therapy in Patients With Severe Obesity
The aims of the study are to perform psychological intervention using EMDR Therapy (Eye Movement Desensitization and Reprocessing Therapy) in the preoperative period, evaluate the personality of each patient through the PFB test…
- Trial name
- NCT03555110
- Testing
- Personality Factor Battery Test (PFB Test), Eye Movement Desensitization and Reprocessing Therapy (EMDR)
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo General Hospital
Obesity
ULTIMATE Study for Weight Loss
The purpose of this study is to help find out more about how the Primary Obesity Surgery Endoluminal (POSE) procedure makes patients feel less hungry and fuller faster, leading to weight loss.
- Trial name
- ULTIMATE (NCT01771276)
- Testing
- g-Cath Suture Anchor Delivery Catheter
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- USGI Medical
Overweight and Obesity
Kg-Free: an Acceptance, Mindfulness and Compassionate-based Intervention for Women Struggling With Their Weight
This study aims to test the efficacy and feasibility of an acceptance, mindfulness and compassionate-based intervention for women with overweight and obesity without binge-eating disorder (Kg-Free).
- Trial name
- Kg-Free (NCT02850796)
- Testing
- Kg-Free, Treatment as Usual
- Volunteers
- 73 people
- Sponsor
- University of Coimbra
Overweight, Obesity
Evaluation of a Family Intervention Program for the Management of Overweight or Obese Children
Objectives: To evaluate the effectiveness of the Nereu program compared to standard care (advice on increased physical activity and nutrition) such as a health intervention tool for the childhood obesity management…
- Conditions
- Overweight, Obesity, Children
- Trial name
- NEREU (NCT01878994)
- Testing
- Counselling group, Nereu group
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Obesity (BMI>30)
OBEDIAM: Therapeutic Patient Education in Adults Living With Obesity, Diabetes, and Metabolic Disorders
The goal of this observational study is to learn about the acceptability and feasibility of a therapeutic patient education program in adults living with an obesity.
- Trial name
- OBEDIAM (NCT07668661)
- Testing
- Therapeutic patient education
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- CHU de Quebec-Universite Laval
Treatment Resistant Schizophrenia, Obesity & Overweight
Effects of Nitraria Retusa Infusion on Clozapine-induced Metabolic Side Effects
The primary objective of the study is to assess the efficacy and tolerability of a 90-day daily supplementation with a Nitraria retusa dried crushed leaves infusion on the iatrogenic metabolic side effects induced in patients…
- Conditions
- Treatment Resistant Schizophrenia, Obesity & Overweight, Abdominal Obesity
- Trial name
- NCT07817069
- Testing
- The Nitraria retusa arm
- Where
- Tunisia
- Volunteers
- 30 people
- Sponsor
- Faculty of Medicine, Sousse
Obesity, Metabolic Syndrome X
Treatment of Antipsychotic-associated Obesity With a GLP-1 Analogue
To examine if 3 months of treatment with a GLP-1 (glucagon-like-peptide-1) analogue can induce weight loss in obese, non-diabetic patients with a diagnosis within the schizophrenic spectrum.
- Conditions
- Obesity, Metabolic Syndrome X, Drug-induced Obesity, Schizophrenia
- Trial name
- TAO (NCT01794429)
- Testing
- Exenatide
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Bjorn H. Ebdrup
Obesity
Efficacy of Polyglucosamine Long Term Treatment
The polyglucosamine, specification L112, is a medical device and in this clinical trial used for weight reduction in moderately obese participants following a long term treatment lasting 12 months.
- Trial name
- NCT02682277
- Testing
- polygucosamine
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Certmedica International GmbH
Childhood Obesity
Childhood Obesity: a Study of Group Treatment Targeting Parents Behaviour
Long term effects of treatment of childhood obesity are not well documented but there is growing evidence that parental involvement and behavioral changes are strong predictors of children weight loss.
- Trial name
- NCT00842777
- Testing
- Parent manualized group treatment, Parent self-help groups
- Where
- Norway
- Volunteers
- 99 people
- Sponsor
- Norwegian University of Science and Technology
Obesity
Interdisciplinary Weight Loss Therapy Associate With the Use of Interactive Digital Technology
Obesity is a complex disease associate to metabolic alterations, which may lead to cardiometabolic risk in women with obesity. The use of interactive digital technology as adjuvante tool to the clinical practices in weight loss…
- Trial name
- NCT04034472
- Testing
- Interdisciplinary intervention in obesity
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Federal University of São Paulo
Obesity
A Study in People With Obesity to Test the Effects of BI 456906 Compared With Semaglutide on Glucagon Receptor Activity in the Liver
This study is open to adults with obesity. People with a body mass index (BMI) in the range from 30 to 40 kg/m2 and a body weight of 70 to 150 kg can participate in the study.
- Trial name
- NCT05202353
- Testing
- BI 456906, Semaglutide
- Where
- Netherlands
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Overweight and Obesity
Cognitive Therapy Plus Dietary Intervention for Obesity Treatment
This randomized clinical trial was carried out from January 2017 to December 2017 at the facilities of the Catholic University of Murcia. Written informed consent was required from each patient.
- Trial name
- COGNI-OB (NCT03749772)
- Testing
- Cognitive Training
- Volunteers
- 100 people
- Sponsor
- Universidad Católica San Antonio de Murcia
Healthy Overweight/Obese
The Metabolic Effects of Oral Tributyrin Administration
The goal of this double-blinded randomized clinical cross-over trial is to investigate the metabolic and appetite regulating effects of oral tributyrin (a butyrate pro-drug) administration vs placebo.
- Trial name
- TRIMET (NCT07463495)
- Testing
- tributyrin, Control
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- University of Aarhus
PCOS
Cavitation Ultrasound in Treatment of Patients With PCOS
The aim of the current work was to compare the efficacy of cavitation ultrasound, metformin or combination of both in obese women with polycystic ovary syndrome (PCOS) regarding clinical pregnancy rate, ovulation rate, insulin…
- Trial name
- NCT01622257
- Testing
- Cavitation US, Metformin, Cavitation US + Metformin
- Where
- Egypt
- Volunteers
- 198 people
- Sponsor
- Ain Shams University
Healthy
Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ZT003 Injection Following Single and Multiple Subcutaneous Administration in Healthy Volunteers/Overweight or Obese Volunteers
This is a Phase 1, randomized, double-blind, placebo-controlled, single-center study designed to evaluate the safety, tolerability, and pharmacokinetics of ZT003 following subcutaneous administration in healthy adult…
- Trial name
- NCT07184502
- Testing
- ZT003 - Part1 (Single ascending dose ), ZT003 - Part 2(Multiple ascending dose )
- Where
- 2 sites in Australia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Beijing QL Biopharmaceutical Co.,Ltd
Overweight , Obesity
Study of UBT37034 Injection
This is a study of UBT37034 for injection in participants who have obesity or are overweight. The main purpose is to learn more about the safety, tolerability, drug concentration, drug action and immune response of repeated…
- Trial name
- NCT07873645
- Testing
- UBT37034
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The United Bio-Technology (Hengqin) Co., Ltd.
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